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The map label for this gene is ntdR [H]

Identifier: 226222882

GI number: 226222882

Start: 266396

End: 267391

Strand: Direct

Name: ntdR [H]

Synonym: Lm4b_00274

Alternate gene names: 226222882

Gene position: 266396-267391 (Clockwise)

Preceding gene: 226222881

Following gene: 226222883

Centisome position: 9.15

GC content: 35.04

Gene sequence:

>996_bases
ATGAATAAAGTGACGAAAATTGGAGATGTAGCAGAGAAAACGGGCTATTCTATAACTACTATTTCTCGAGCAATTAATGG
TAATCCAAATGTTTCAGATAAAACAAAAAAGAAAATTTTTGCTGCGATGAAAGAACTGAATTATTATCCTAATAATATTG
CTCAACAATTTCGAGGGCAGGGGACTAAGATGATTGGTGTTGTGATTTCCTTTATAACCAATCCTTTTTTTGCGTACCTT
GTTGATGCGATTGAACGCTATCTATCTCACAGAGGGTATCAGGTTGTCATGTTGCAAACTTTAGAAAATCCTGCAAAAGA
ATTACAATTTATCGAGATGTTACAAAAGAAACAGCTAGATGGATTGATTATGGCTAACTTAGAAAATGATACAGAAGAAA
TTAAATCACTCGTTGAAAGTGGCAAAATTGTTCTTTGTAATCGTTATCTGGGAAATGAAAATTTGACGATTATTAACATT
GATGAAACGAAAGCGGCTTATCAAGCAACGAATTATTTAATAAAGTGCGGTTATAAACGCCTTGCCTACTGTACTGGTGG
TATTAAAAATAAAAATGATTACCGTTTTAAAGGATTCATGCAAGCTGTAACAGAAAATGGACTTTCTTTTGATGAATCAT
TGTATTTTGAGAAGTTATTAACCATTAAAGATGGCGAAGAGCTTCTAGTTAATATTTTAGAAGAGAAATCTACTCTGCCG
GACGCAATTTTTTCAAATGGTGATACGGTTGCTGCTGGGATATTATATGCTGCAAAAAAATACGGGATAGCAGTGCCAGA
GGAGCTAGGAATCATAGGTTTTGATAATCAACCTATAGCGGAAGTTCTGAATCCGGCGTTGACAACTATTGAACAACCAA
TTAAAGAACTTGGTGAATATTCGGCGCAAGTTCTATTGGCTAATTTACAAGGAACGAGTGTGCCGGTAGCGCCAGACCTT
GAAACAAAACTAATAATAAGAGAGACTACCAAGTAA

Upstream 100 bases:

>100_bases
TGTTGTTAGAGTAGTGTTATAAGGAAATAAGTTCTCACTTTTTCTGTAATCTGATATAATAAATTAAAATAGATGAATTT
GAAATTTTAGGGAGATAGAT

Downstream 100 bases:

>100_bases
ATTCTCTCTTATTATTTTTATGAAAACGGTTGACATTTTGTAAGATAATTGATATTATTTTTACGATATATGAAACCGCT
TAAGCTAAAATGACAACCGG

Product: transcription regulator, lacI family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MNKVTKIGDVAEKTGYSITTISRAINGNPNVSDKTKKKIFAAMKELNYYPNNIAQQFRGQGTKMIGVVISFITNPFFAYL
VDAIERYLSHRGYQVVMLQTLENPAKELQFIEMLQKKQLDGLIMANLENDTEEIKSLVESGKIVLCNRYLGNENLTIINI
DETKAAYQATNYLIKCGYKRLAYCTGGIKNKNDYRFKGFMQAVTENGLSFDESLYFEKLLTIKDGEELLVNILEEKSTLP
DAIFSNGDTVAAGILYAAKKYGIAVPEELGIIGFDNQPIAEVLNPALTTIEQPIKELGEYSAQVLLANLQGTSVPVAPDL
ETKLIIRETTK

Sequences:

>Translated_331_residues
MNKVTKIGDVAEKTGYSITTISRAINGNPNVSDKTKKKIFAAMKELNYYPNNIAQQFRGQGTKMIGVVISFITNPFFAYL
VDAIERYLSHRGYQVVMLQTLENPAKELQFIEMLQKKQLDGLIMANLENDTEEIKSLVESGKIVLCNRYLGNENLTIINI
DETKAAYQATNYLIKCGYKRLAYCTGGIKNKNDYRFKGFMQAVTENGLSFDESLYFEKLLTIKDGEELLVNILEEKSTLP
DAIFSNGDTVAAGILYAAKKYGIAVPEELGIIGFDNQPIAEVLNPALTTIEQPIKELGEYSAQVLLANLQGTSVPVAPDL
ETKLIIRETTK
>Mature_331_residues
MNKVTKIGDVAEKTGYSITTISRAINGNPNVSDKTKKKIFAAMKELNYYPNNIAQQFRGQGTKMIGVVISFITNPFFAYL
VDAIERYLSHRGYQVVMLQTLENPAKELQFIEMLQKKQLDGLIMANLENDTEEIKSLVESGKIVLCNRYLGNENLTIINI
DETKAAYQATNYLIKCGYKRLAYCTGGIKNKNDYRFKGFMQAVTENGLSFDESLYFEKLLTIKDGEELLVNILEEKSTLP
DAIFSNGDTVAAGILYAAKKYGIAVPEELGIIGFDNQPIAEVLNPALTTIEQPIKELGEYSAQVLLANLQGTSVPVAPDL
ETKLIIRETTK

Specific function: Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=330, Percent_Identity=31.2121212121212, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787948, Length=323, Percent_Identity=30.6501547987616, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788474, Length=326, Percent_Identity=30.0613496932515, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1790194, Length=304, Percent_Identity=30.5921052631579, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789202, Length=294, Percent_Identity=30.6122448979592, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789068, Length=331, Percent_Identity=26.8882175226586, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI48994940, Length=307, Percent_Identity=28.6644951140065, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1787580, Length=322, Percent_Identity=27.3291925465839, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786540, Length=328, Percent_Identity=28.3536585365854, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787906, Length=308, Percent_Identity=23.3766233766234, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786268, Length=320, Percent_Identity=25.625, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790715, Length=311, Percent_Identity=23.7942122186495, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790689, Length=318, Percent_Identity=22.0125786163522, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1789456, Length=333, Percent_Identity=20.4204204204204, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36868; Mature: 36868

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVTKIGDVAEKTGYSITTISRAINGNPNVSDKTKKKIFAAMKELNYYPNNIAQQFRGQ
CCCCCHHHHHHHHCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GTKMIGVVISFITNPFFAYLVDAIERYLSHRGYQVVMLQTLENPAKELQFIEMLQKKQLD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHHHHHHCCC
GLIMANLENDTEEIKSLVESGKIVLCNRYLGNENLTIINIDETKAAYQATNYLIKCGYKR
CEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHCCHH
LAYCTGGIKNKNDYRFKGFMQAVTENGLSFDESLYFEKLLTIKDGEELLVNILEEKSTLP
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
DAIFSNGDTVAAGILYAAKKYGIAVPEELGIIGFDNQPIAEVLNPALTTIEQPIKELGEY
HHHHCCCCHHHHHHHHHHHHCCCCCCHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
SAQVLLANLQGTSVPVAPDLETKLIIRETTK
HHHEEEEECCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MNKVTKIGDVAEKTGYSITTISRAINGNPNVSDKTKKKIFAAMKELNYYPNNIAQQFRGQ
CCCCCHHHHHHHHCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GTKMIGVVISFITNPFFAYLVDAIERYLSHRGYQVVMLQTLENPAKELQFIEMLQKKQLD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHHHHHHCCC
GLIMANLENDTEEIKSLVESGKIVLCNRYLGNENLTIINIDETKAAYQATNYLIKCGYKR
CEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHCCHH
LAYCTGGIKNKNDYRFKGFMQAVTENGLSFDESLYFEKLLTIKDGEELLVNILEEKSTLP
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
DAIFSNGDTVAAGILYAAKKYGIAVPEELGIIGFDNQPIAEVLNPALTTIEQPIKELGEY
HHHHCCCCHHHHHHHHHHHHCCCCCCHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
SAQVLLANLQGTSVPVAPDLETKLIIRETTK
HHHEEEEECCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]