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The map label for this gene is nanK [H]

Identifier: 226222677

GI number: 226222677

Start: 40834

End: 41799

Strand: Direct

Name: nanK [H]

Synonym: Lm4b_00041

Alternate gene names: 226222677

Gene position: 40834-41799 (Clockwise)

Preceding gene: 226222674

Following gene: 226222678

Centisome position: 1.4

GC content: 40.99

Gene sequence:

>966_bases
TTGGACATACAAGAATCTGTCATCGGAATTGATCTAGGTGGCACTAAAATTTTAATTGGCGAAGTAACAAAAGATGGTGA
GGTGCTAAATTCCAAGAGTTACCCAAGTAATACGGAGAATCAGACCAAAGCTACCGAAACATTGTTAAAGGTTTTAGATG
ATTACACGCAAAATATTGGTTTTATAGCACCAAAACAAACGGGTATTGGTGTAGGATTAGTTGGTCGTGTGAATCACAAG
TCAGGTGTTTGGTTAGAGATTGAACCTGGAAAAAGCAATCCAACCCCGCTCGCAGACATTTTAGAAGCAAAAACAGGATT
ACCTGTAAGTCTGGGCAATGATGTTGTTTGTGCCACAATGGCCGAAAAGCAATTTGGTTGGGGACAAGAAACAAACGATT
TTATTTATTTAAATGTTGGTACTGGTCTTGCTGCTGGGTTTGTGGTGGATGGACGAATTATACAAGGCGGGCACTTTAAC
GCGGGTGAAATCGGTCATGCTGTAGTAGATATTCATAGTGATGTACTCTGTGGTTGCGGTAGACGTGGTTGTGTGGAACG
ACTTGCTTCCGGTCTTGGGATTAAAGAAGAGGCACTGAGACGTTTAAATAACTACCCGACATCCATACTTGCTGAAGCCG
AAACAGAACTAACTGGAAAAATGGTTCTTCATGCAGCGGAGCAAAAAGATGAGCTTGCAGAGGAAATTATTGATAATGCA
ACGTTTCAGCTAGCTAATTTGATTATGAATTTAGTCCGTACAACCGACCCTGAATGCGTAATTCTTGGCGGAGGCGTGAC
GCAAAATGAGCATTTTTTCCAAAAGATACTAGGTAATCTTCAAAGCAATACAATTCGTTTTGTTACAAAAGGTGTTGTCC
GCTCTAAGCTTGAGAAGGATAAGGTTGGCTTAATTGGTGCAGCCGTTATTGGAATGAGACTAGGAAATGAAGGAGGAAAA
GAATGA

Upstream 100 bases:

>100_bases
AAAGGGTTGACATATTAAAAATATCCGGTTATTCTATGGTAGAAAGCGCTATCAACAAACGTTTTAATTTGGTAACGTTA
CCAAAAATGAGGTGGAATAG

Downstream 100 bases:

>100_bases
AGCCAAGTATGAAACGACAAATTGCGCAAACTGGTATTATTCATCGACCACTCCCTATTGAAACCAAGCATGCGTTAGAA
ACTTTAGCGAAAAAGAAACA

Product: xylose repressor and to glucokinase

Products: NA

Alternate protein names: ManNAc kinase; N-acetyl-D-mannosamine kinase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MDIQESVIGIDLGGTKILIGEVTKDGEVLNSKSYPSNTENQTKATETLLKVLDDYTQNIGFIAPKQTGIGVGLVGRVNHK
SGVWLEIEPGKSNPTPLADILEAKTGLPVSLGNDVVCATMAEKQFGWGQETNDFIYLNVGTGLAAGFVVDGRIIQGGHFN
AGEIGHAVVDIHSDVLCGCGRRGCVERLASGLGIKEEALRRLNNYPTSILAEAETELTGKMVLHAAEQKDELAEEIIDNA
TFQLANLIMNLVRTTDPECVILGGGVTQNEHFFQKILGNLQSNTIRFVTKGVVRSKLEKDKVGLIGAAVIGMRLGNEGGK
E

Sequences:

>Translated_321_residues
MDIQESVIGIDLGGTKILIGEVTKDGEVLNSKSYPSNTENQTKATETLLKVLDDYTQNIGFIAPKQTGIGVGLVGRVNHK
SGVWLEIEPGKSNPTPLADILEAKTGLPVSLGNDVVCATMAEKQFGWGQETNDFIYLNVGTGLAAGFVVDGRIIQGGHFN
AGEIGHAVVDIHSDVLCGCGRRGCVERLASGLGIKEEALRRLNNYPTSILAEAETELTGKMVLHAAEQKDELAEEIIDNA
TFQLANLIMNLVRTTDPECVILGGGVTQNEHFFQKILGNLQSNTIRFVTKGVVRSKLEKDKVGLIGAAVIGMRLGNEGGK
E
>Mature_321_residues
MDIQESVIGIDLGGTKILIGEVTKDGEVLNSKSYPSNTENQTKATETLLKVLDDYTQNIGFIAPKQTGIGVGLVGRVNHK
SGVWLEIEPGKSNPTPLADILEAKTGLPVSLGNDVVCATMAEKQFGWGQETNDFIYLNVGTGLAAGFVVDGRIIQGGHFN
AGEIGHAVVDIHSDVLCGCGRRGCVERLASGLGIKEEALRRLNNYPTSILAEAETELTGKMVLHAAEQKDELAEEIIDNA
TFQLANLIMNLVRTTDPECVILGGGVTQNEHFFQKILGNLQSNTIRFVTKGVVRSKLEKDKVGLIGAAVIGMRLGNEGGK
E

Specific function: Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family. NanK subfamily [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=269, Percent_Identity=30.1115241635688, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI298566325, Length=269, Percent_Identity=30.1115241635688, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4885285, Length=269, Percent_Identity=30.1115241635688, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI190014632, Length=269, Percent_Identity=30.1115241635688, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI87081733, Length=311, Percent_Identity=27.0096463022508, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082230, Length=289, Percent_Identity=31.4878892733564, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786891, Length=310, Percent_Identity=26.7741935483871, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787878, Length=256, Percent_Identity=29.296875, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787363, Length=316, Percent_Identity=22.7848101265823, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082127, Length=173, Percent_Identity=32.9479768786127, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.60 [H]

Molecular weight: Translated: 34310; Mature: 34310

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQESVIGIDLGGTKILIGEVTKDGEVLNSKSYPSNTENQTKATETLLKVLDDYTQNIG
CCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
FIAPKQTGIGVGLVGRVNHKSGVWLEIEPGKSNPTPLADILEAKTGLPVSLGNDVVCATM
EECCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHCCCCCEECCCCEEEEEE
AEKQFGWGQETNDFIYLNVGTGLAAGFVVDGRIIQGGHFNAGEIGHAVVDIHSDVLCGCG
HHHHCCCCCCCCCEEEEECCCCCEEEEEECCEEEECCCCCCCCCCCEEEEHHHHHHHCCC
RRGCVERLASGLGIKEEALRRLNNYPTSILAEAETELTGKMVLHAAEQKDELAEEIIDNA
CHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TFQLANLIMNLVRTTDPECVILGGGVTQNEHFFQKILGNLQSNTIRFVTKGVVRSKLEKD
HHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KVGLIGAAVIGMRLGNEGGKE
HCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDIQESVIGIDLGGTKILIGEVTKDGEVLNSKSYPSNTENQTKATETLLKVLDDYTQNIG
CCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
FIAPKQTGIGVGLVGRVNHKSGVWLEIEPGKSNPTPLADILEAKTGLPVSLGNDVVCATM
EECCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHCCCCCEECCCCEEEEEE
AEKQFGWGQETNDFIYLNVGTGLAAGFVVDGRIIQGGHFNAGEIGHAVVDIHSDVLCGCG
HHHHCCCCCCCCCEEEEECCCCCEEEEEECCEEEECCCCCCCCCCCEEEEHHHHHHHCCC
RRGCVERLASGLGIKEEALRRLNNYPTSILAEAETELTGKMVLHAAEQKDELAEEIIDNA
CHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TFQLANLIMNLVRTTDPECVILGGGVTQNEHFFQKILGNLQSNTIRFVTKGVVRSKLEKD
HHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KVGLIGAAVIGMRLGNEGGKE
HCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA