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The map label for this gene is frlR [H]

Identifier: 226222660

GI number: 226222660

Start: 26274

End: 27014

Strand: Direct

Name: frlR [H]

Synonym: Lm4b_00023

Alternate gene names: 226222660

Gene position: 26274-27014 (Clockwise)

Preceding gene: 226222658

Following gene: 226222661

Centisome position: 0.9

GC content: 33.47

Gene sequence:

>741_bases
ATGGCGGAACCAAAGTACGCTATTATTATCAATGATATCAAGCGATTAATTAGTGACGGAACTTTTAAGCCAGGGGAAAA
AATTTATTCGGAAGATGAACTGAAAAAGAAATACAATGTTAGTAATACGACAGTTGTTCGAGCATTACATGAATTAGTAC
GAGCTGGGATTTTAGCTCGTTATCAAGGAAAAGGCACATACGTGAGTAAGTCTATTATTAACGAAGAAGTTATTTTTAAT
GAATATACGACAGTGCCGAACGGAAGATTCAATCGTAAAACAAAAATTACTAACGAACATACAAAGGTAGTTGCAATAAA
TGAAATTCAGGATGCGCGAATTGCTAAAAAATTGCAGATTCCCCCTGAAAATATGATTGTTCATTTTCAACGAATCCGCC
TTATTGATGATGTGCCTTGGACCGTACAAAATAACTATATGGCAAAATCCAATTTGATCAACGTAGATTTAACCAATTTC
GAAAGATTTAATTCTTTATCTGAAGTAATTAAAGAGCTTTATGGTATTAATATTCTGCACGAAGCGATGAAGGAGCGAAT
TGAAGTCGAATTTCCAGTAAAAGACAAAAATAATTTTAAATTACTCGAAATTGACTCCGAGTTACCACTTTACCACATTG
AAAGAATAACCTATGTGCCAGAGGGGCAACCCTATGAATATATTGAAAGCTACTTGCGGCATAATTTTTACTCTATTGAA
ATTGAAAAGAAAAAACAATAG

Upstream 100 bases:

>100_bases
ATAGCAGGCTAATTCAAGTTTGCAATCAAAAAATTATCATGGTACCATTAACCTAAAACTTAACGTGTTAACGCGCGGGA
TGCTTTAGGGGGAATTTGTT

Downstream 100 bases:

>100_bases
AAGGGAGTTAATTACTTGAATTTTATTATCGCAGCACATGGCCGGTACGCACAGGAAGTGAAAAATAGCTGTCAGATGAT
TACTGGCCAAACAACTAATA

Product: transcriptional regulator (GntR family)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MAEPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSIINEEVIFN
EYTTVPNGRFNRKTKITNEHTKVVAINEIQDARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSNLINVDLTNF
ERFNSLSEVIKELYGINILHEAMKERIEVEFPVKDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYSIE
IEKKKQ

Sequences:

>Translated_246_residues
MAEPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSIINEEVIFN
EYTTVPNGRFNRKTKITNEHTKVVAINEIQDARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSNLINVDLTNF
ERFNSLSEVIKELYGINILHEAMKERIEVEFPVKDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYSIE
IEKKKQ
>Mature_245_residues
AEPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILARYQGKGTYVSKSIINEEVIFNE
YTTVPNGRFNRKTKITNEHTKVVAINEIQDARIAKKLQIPPENMIVHFQRIRLIDDVPWTVQNNYMAKSNLINVDLTNFE
RFNSLSEVIKELYGINILHEAMKERIEVEFPVKDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYSIEI
EKKKQ

Specific function: May regulate the transcription of the frlABCD operon [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=243, Percent_Identity=26.3374485596708, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786950, Length=225, Percent_Identity=27.1111111111111, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28912; Mature: 28780

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS50949 HTH_GNTR ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILAR
CCCCCEEEEHHHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHEE
YQGKGTYVSKSIINEEVIFNEYTTVPNGRFNRKTKITNEHTKVVAINEIQDARIAKKLQI
ECCCCCEEHHHHHCHHHEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCC
PPENMIVHFQRIRLIDDVPWTVQNNYMAKSNLINVDLTNFERFNSLSEVIKELYGINILH
CCHHHEEEHHHHEECCCCCCEECCCEEECCCEEEEEECCHHHHHHHHHHHHHHHCCHHHH
EAMKERIEVEFPVKDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYSIE
HHHHHHEEEEECCCCCCCEEEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHCCEEEEE
IEKKKQ
EECCCC
>Mature Secondary Structure 
AEPKYAIIINDIKRLISDGTFKPGEKIYSEDELKKKYNVSNTTVVRALHELVRAGILAR
CCCCEEEEHHHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHEE
YQGKGTYVSKSIINEEVIFNEYTTVPNGRFNRKTKITNEHTKVVAINEIQDARIAKKLQI
ECCCCCEEHHHHHCHHHEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCC
PPENMIVHFQRIRLIDDVPWTVQNNYMAKSNLINVDLTNFERFNSLSEVIKELYGINILH
CCHHHEEEHHHHEECCCCCCEECCCEEECCCEEEEEECCHHHHHHHHHHHHHHHCCHHHH
EAMKERIEVEFPVKDKNNFKLLEIDSELPLYHIERITYVPEGQPYEYIESYLRHNFYSIE
HHHHHHEEEEECCCCCCCEEEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHCCEEEEE
IEKKKQ
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]