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The map label for this gene is gluP [H]

Identifier: 225861910

GI number: 225861910

Start: 1953266

End: 1953943

Strand: Reverse

Name: gluP [H]

Synonym: SPT_2103

Alternate gene names: 225861910

Gene position: 1953943-1953266 (Counterclockwise)

Preceding gene: 225861911

Following gene: 225861898

Centisome position: 92.51

GC content: 43.07

Gene sequence:

>678_bases
ATGAAGGAAATCTTTGATAGACGTTACCCTGTGACGAGTTTCTTCCTCTTAGTGACGGCCTTGGTATTTTTACTAATGTT
GGTCACTGCAGGCGGAAACTTTGACAGGGCAGATACATTATTTCGATTTGGAGCCATGTATGGGCCAGCTATTCGCCTCT
TTCCCGAGCAGGTTTGGCGTCTCTTGTCTGCCATTTTTGTTCATATTGGGTGGGAACATTTCATTGTTAATATGCTTTCA
CTTTATTATCTTGGAAGGCAGGTAGAGGAGATTTTCGGCTCTAAGCAGTTCTTTTTTCTCTATCTCTTATCAGGAATGAT
GGGCAATCTCTTTGTTTTTGTATTTAGTCCTAAATCCTTAGCAGCAGGCGCCTCTACCTCTCTTTATGGGCTATTTGCCG
CGATTATTGTTCTTCGCTATGCAACTCGCAATCCTTATATCCAACAGCTAGGGCAATCCTATCTGACACTTTTTGTGGTT
AACATTATTGGAAGTGTTCTGATTCCAGGAATCAGCCTAGCAGGCCATATCGGTGGTGCAGTTGGTGGCGCATTTCTAGC
AGTTATCTTTCCAGTTAGAGGAGAAAAACGGATGTATAATACCAGCCAGAGATTAGGAGCGGTAGTCTTGTTCGTAGGAC
TCGCCATTTTGCTTTTCTACAAGGGAATGGGAATGTGA

Upstream 100 bases:

>100_bases
GAACATTTTTCTGGTCATACTTTGAGTACGGTTCATCCTTGTCAAATTCAGGACTTTATACCTGAAAACCATGATATTCC
TGTTCAGGAGGTATTAATTG

Downstream 100 bases:

>100_bases
CGAAGTTGAAAGAAAATTTGTGTAATGAAAAAAGATAAGGCATTTTTTGAACCTTATCTTTTTATTTTATTTTATTCCTT
CTCAGTCAATTCTTTTCCAA

Product: peptidase, S54

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKEIFDRRYPVTSFFLLVTALVFLLMLVTAGGNFDRADTLFRFGAMYGPAIRLFPEQVWRLLSAIFVHIGWEHFIVNMLS
LYYLGRQVEEIFGSKQFFFLYLLSGMMGNLFVFVFSPKSLAAGASTSLYGLFAAIIVLRYATRNPYIQQLGQSYLTLFVV
NIIGSVLIPGISLAGHIGGAVGGAFLAVIFPVRGEKRMYNTSQRLGAVVLFVGLAILLFYKGMGM

Sequences:

>Translated_225_residues
MKEIFDRRYPVTSFFLLVTALVFLLMLVTAGGNFDRADTLFRFGAMYGPAIRLFPEQVWRLLSAIFVHIGWEHFIVNMLS
LYYLGRQVEEIFGSKQFFFLYLLSGMMGNLFVFVFSPKSLAAGASTSLYGLFAAIIVLRYATRNPYIQQLGQSYLTLFVV
NIIGSVLIPGISLAGHIGGAVGGAFLAVIFPVRGEKRMYNTSQRLGAVVLFVGLAILLFYKGMGM
>Mature_225_residues
MKEIFDRRYPVTSFFLLVTALVFLLMLVTAGGNFDRADTLFRFGAMYGPAIRLFPEQVWRLLSAIFVHIGWEHFIVNMLS
LYYLGRQVEEIFGSKQFFFLYLLSGMMGNLFVFVFSPKSLAAGASTSLYGLFAAIIVLRYATRNPYIQQLGQSYLTLFVV
NIIGSVLIPGISLAGHIGGAVGGAFLAVIFPVRGEKRMYNTSQRLGAVVLFVGLAILLFYKGMGM

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Caenorhabditis elegans, GI115532986, Length=141, Percent_Identity=32.6241134751773, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133901888, Length=141, Percent_Identity=32.6241134751773, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115534507, Length=142, Percent_Identity=31.6901408450704, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 25063; Mature: 25063

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIFDRRYPVTSFFLLVTALVFLLMLVTAGGNFDRADTLFRFGAMYGPAIRLFPEQVWR
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHH
LLSAIFVHIGWEHFIVNMLSLYYLGRQVEEIFGSKQFFFLYLLSGMMGNLFVFVFSPKSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEECCHHH
AAGASTSLYGLFAAIIVLRYATRNPYIQQLGQSYLTLFVVNIIGSVLIPGISLAGHIGGA
HCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VGGAFLAVIFPVRGEKRMYNTSQRLGAVVLFVGLAILLFYKGMGM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKEIFDRRYPVTSFFLLVTALVFLLMLVTAGGNFDRADTLFRFGAMYGPAIRLFPEQVWR
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHH
LLSAIFVHIGWEHFIVNMLSLYYLGRQVEEIFGSKQFFFLYLLSGMMGNLFVFVFSPKSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEEECCHHH
AAGASTSLYGLFAAIIVLRYATRNPYIQQLGQSYLTLFVVNIIGSVLIPGISLAGHIGGA
HCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VGGAFLAVIFPVRGEKRMYNTSQRLGAVVLFVGLAILLFYKGMGM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]