| Definition | Streptococcus pneumoniae 70585, complete genome. |
|---|---|
| Accession | NC_012468 |
| Length | 2,184,682 |
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The map label for this gene is hsdR [H]
Identifier: 225858348
GI number: 225858348
Start: 518189
End: 520522
Strand: Reverse
Name: hsdR [H]
Synonym: SP70585_0568
Alternate gene names: 225858348
Gene position: 520522-518189 (Counterclockwise)
Preceding gene: 225858356
Following gene: 225858347
Centisome position: 23.83
GC content: 36.89
Gene sequence:
>2334_bases ATGGTTGAGTTTATAAAGTCTAAGAAAGAAATGAGTGAGGAGGATATTAAAGCAAATTTCATCACTCCTGCTATTGTATC CAAAGGATGGAAAAATGGTGAGCATATCGCTTACGAAGAATACTTCACTGATGGTCGAATTGAAGTTAGAGGAGATAAGG CTCGTCGTAAAGAAGGAAAAAAATCAGACTATTCACTGTATTACCAATTTGGAACTCGAATTGCAATTGTTGAGGCAAAG GATAATAAACACAGCGTTCGAGCAGGATTACAACAAGCTATTGAATATGGAGAGATTTTAGATGTTCCATTTGTTTATTC TTCGAATGGTGATGGCTTTATTGAACACGACCGTATCACGAGAGAAGAACGTGAGCTGGAGTTAGACGAATTCCCTACTC GTGAAGAATTATTTTCTCGTATGACGAAGGAAAAAGGATTGACGTACGAAATTACAGAAGCTATCTCAACTCCATACTAT ACAGACGCCTTCTCAATGAAAACGCCACGCTATTATCAGCAAATAGCTATCAACCGTACTATTGAAACAGTTGCCAGAGG ACAAAAACGAGTAATGTTTGTGATGGCAACAGGAACGGGGAAAACGTTCATGGCTTTTCAAATTATTCATCGCCTTCGAA AAGCTGGTTTGGCTAAACGAGTTTTATTCTTAGCAGATAGAAACATCTTAGTAGACCAAACGATGGCTGAAGACTTTAGG CCATTCGAAAAGGTAATGACGAAAATTACACCAAAACTTTTGACTGCTCCTGAAAAATTAAATTCTTTTGAAATTTATCT AGGGCTTTATCAGCAACTAACTGGTGAAGATGGAACTGAAACACATTATCAAAAATTTGACAAAGACTTCTTTGATTTAA TCGTAATTGATGAAGCACACCGTGGTTCAGCTAAGGAAAACAGTAACTGGCGTAAGGTAATTGATTATTTCAGTTCTGCG ACACAGATTGGGATGACCGCTACTCCTAAAGAAACCAAGAATGCTTCCAATACGGAATACTTTGGTGAGCCAATCTATAC TTATAGTTTAAAACAGGGAATCGAGGATGGTTTTTTGGCTCCATATCGTGTTATGAGGGTTAATTTAGATGTGGATGTGG ATGGTTATCGTCCAGAAACTGGAAAAGTTGATGCTAACGGACAATTAATAGAAGATAGGTACTACGGCAGGAAAGATTTT GATAAAACCATTGTCATTGATGATAGAACGCAAAGAGTTGCCAAGTTTGTTTCTGATTATATGAAGCAAAACAATGCACG ATTTGATAAAACAATTGTTTTTTGTGTTGATATTGACCATGCCGAGCGAATGCGTGCTGCACTTGTAAAAGAGAATCTAG ACTTAGTCCAAGAAGACTATCGTTATGTCATGCAAGTAACTGGTGACAACGCTGAAGGAAAAGCTCAACTGGATAACTTT ATGGATGTCAATTCTAATTTTCCCGCTATTGTAACAACGTCTAAATTATTAACGACAGGAGTTAATGCTAAAACATGTCG TTTGATTGTTTTAGACTCTAATATCCAATCCATGACTGAATTTAAACAAATTATTGGTCGTGGCACACGTCTTTATCCTC AAAAGGGGAAAGAATTTTTTACGATTATTGATTTTCGAAATGTTACCAATTTGTTTGCTGACCCTGATTTTGATGGTGAG CCAGTGAAGGTGCTGGAAACAGGTGCGAAAACAGTCAGTGGTTCTACGCCCGGTTTCGTAGATGAGGAAGGTGACCCAGT AGAAAAATATATCGTTACAGACAAGCAGGTTACCATTCTTAATTCTACTGTTCAAGTATTGGATGAAAACGGGAAACTGA TTACCGAAAGCCTGACCGACTACACTCGGAAGAATATCTTAGGTAGCTACGCCACTTTGAACGATTTTATCACAGTTTGG CATACGGCGGATAAAAAGAAGCTTATCTTAGACGAACTTTATAAAAAAGGAGTTTATCTAGATGCTATTCGAGAGTCGGA GGGAATATCAGAACAAGAAATCGATGATTTTGATTTACTCCTAAAACTTGCCTATGGTCAAAAAGAATTAACCAAAACGG AACGTATCAATAAACTCAAACAAAGCGGATATTTATATAAATATAGTGAGGAAGCGCGTGCTGTTTTGGAAATTTTACTG AACAAATACATGGATAAAGGTATTGGAGAACTCGAAAGCATTGAAACATTAAAACTTCCAGAATTTCAGATATATGGTGG AACCTTCAAAATCATCAATACTTATTTTGGAGATAAAAAACGATATTTACAAGCAATTAAAGAATTGGAGCAAGAGCTAT TTACAGTAGCTTAA
Upstream 100 bases:
>100_bases TTAGCAGAGTATTTTTATAAGTGTGATATAATAGAAGTATAATTTGTTCTGATAGTTTATTTTATGGAGAAGTAGATTTT TAGAATGCGGAGGGTTCAAT
Downstream 100 bases:
>100_bases TGAAAGGAAAGTATGTCAATTACATCATTTGTAAAAAGAATTCAAGATATCACTCGAAACGATGCTGGTGTTAATGGTGA TGCTCAACGTATTGAGCAAA
Product: type I restriction-modification system, R subunit
Products: NA
Alternate protein names: R.EcoAI [H]
Number of amino acids: Translated: 777; Mature: 777
Protein sequence:
>777_residues MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTDGRIEVRGDKARRKEGKKSDYSLYYQFGTRIAIVEAK DNKHSVRAGLQQAIEYGEILDVPFVYSSNGDGFIEHDRITREERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYY TDAFSMKTPRYYQQIAINRTIETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLAKRVLFLADRNILVDQTMAEDFR PFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGEDGTETHYQKFDKDFFDLIVIDEAHRGSAKENSNWRKVIDYFSSA TQIGMTATPKETKNASNTEYFGEPIYTYSLKQGIEDGFLAPYRVMRVNLDVDVDGYRPETGKVDANGQLIEDRYYGRKDF DKTIVIDDRTQRVAKFVSDYMKQNNARFDKTIVFCVDIDHAERMRAALVKENLDLVQEDYRYVMQVTGDNAEGKAQLDNF MDVNSNFPAIVTTSKLLTTGVNAKTCRLIVLDSNIQSMTEFKQIIGRGTRLYPQKGKEFFTIIDFRNVTNLFADPDFDGE PVKVLETGAKTVSGSTPGFVDEEGDPVEKYIVTDKQVTILNSTVQVLDENGKLITESLTDYTRKNILGSYATLNDFITVW HTADKKKLILDELYKKGVYLDAIRESEGISEQEIDDFDLLLKLAYGQKELTKTERINKLKQSGYLYKYSEEARAVLEILL NKYMDKGIGELESIETLKLPEFQIYGGTFKIINTYFGDKKRYLQAIKELEQELFTVA
Sequences:
>Translated_777_residues MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTDGRIEVRGDKARRKEGKKSDYSLYYQFGTRIAIVEAK DNKHSVRAGLQQAIEYGEILDVPFVYSSNGDGFIEHDRITREERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYY TDAFSMKTPRYYQQIAINRTIETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLAKRVLFLADRNILVDQTMAEDFR PFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGEDGTETHYQKFDKDFFDLIVIDEAHRGSAKENSNWRKVIDYFSSA TQIGMTATPKETKNASNTEYFGEPIYTYSLKQGIEDGFLAPYRVMRVNLDVDVDGYRPETGKVDANGQLIEDRYYGRKDF DKTIVIDDRTQRVAKFVSDYMKQNNARFDKTIVFCVDIDHAERMRAALVKENLDLVQEDYRYVMQVTGDNAEGKAQLDNF MDVNSNFPAIVTTSKLLTTGVNAKTCRLIVLDSNIQSMTEFKQIIGRGTRLYPQKGKEFFTIIDFRNVTNLFADPDFDGE PVKVLETGAKTVSGSTPGFVDEEGDPVEKYIVTDKQVTILNSTVQVLDENGKLITESLTDYTRKNILGSYATLNDFITVW HTADKKKLILDELYKKGVYLDAIRESEGISEQEIDDFDLLLKLAYGQKELTKTERINKLKQSGYLYKYSEEARAVLEILL NKYMDKGIGELESIETLKLPEFQIYGGTFKIINTYFGDKKRYLQAIKELEQELFTVA >Mature_777_residues MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTDGRIEVRGDKARRKEGKKSDYSLYYQFGTRIAIVEAK DNKHSVRAGLQQAIEYGEILDVPFVYSSNGDGFIEHDRITREERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYY TDAFSMKTPRYYQQIAINRTIETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLAKRVLFLADRNILVDQTMAEDFR PFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGEDGTETHYQKFDKDFFDLIVIDEAHRGSAKENSNWRKVIDYFSSA TQIGMTATPKETKNASNTEYFGEPIYTYSLKQGIEDGFLAPYRVMRVNLDVDVDGYRPETGKVDANGQLIEDRYYGRKDF DKTIVIDDRTQRVAKFVSDYMKQNNARFDKTIVFCVDIDHAERMRAALVKENLDLVQEDYRYVMQVTGDNAEGKAQLDNF MDVNSNFPAIVTTSKLLTTGVNAKTCRLIVLDSNIQSMTEFKQIIGRGTRLYPQKGKEFFTIIDFRNVTNLFADPDFDGE PVKVLETGAKTVSGSTPGFVDEEGDPVEKYIVTDKQVTILNSTVQVLDENGKLITESLTDYTRKNILGSYATLNDFITVW HTADKKKLILDELYKKGVYLDAIRESEGISEQEIDDFDLLLKLAYGQKELTKTERINKLKQSGYLYKYSEEARAVLEILL NKYMDKGIGELESIETLKLPEFQIYGGTFKIINTYFGDKKRYLQAIKELEQELFTVA
Specific function: The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification [H]
COG id: COG4096
COG function: function code V; Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 helicase C-terminal domain [H]
Homologues:
Organism=Escherichia coli, GI226510991, Length=575, Percent_Identity=28, Blast_Score=153, Evalue=4e-38, Organism=Escherichia coli, GI1788511, Length=407, Percent_Identity=24.0786240786241, Blast_Score=79, Evalue=8e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR014001 - InterPro: IPR001650 - InterPro: IPR014021 - InterPro: IPR006935 - InterPro: IPR013670 - InterPro: IPR007409 [H]
Pfam domain/function: PF08463 EcoEI_R_C; PF04313 HSDR_N; PF04851 ResIII [H]
EC number: =3.1.21.3 [H]
Molecular weight: Translated: 89320; Mature: 89320
Theoretical pI: Translated: 5.16; Mature: 5.16
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTDGRIEVRGDKARRKEGK CCHHHHHHHHCCHHHHHHHCCCHHHHHCCCCCCCEEEEHHHCCCCEEEECCCHHHHCCCC KSDYSLYYQFGTRIAIVEAKDNKHSVRAGLQQAIEYGEILDVPFVYSSNGDGFIEHDRIT CCCCEEEEEECCEEEEEEECCCCHHHHHHHHHHHHHCCEECCCEEEECCCCCCEECCHHC REERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYYTDAFSMKTPRYYQQIAINRT CHHHHCCHHCCCCHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHH IETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLAKRVLFLADRNILVDQTMAEDFR HHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEHHHHHHCC PFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGEDGTETHYQKFDKDFFDLIVIDEAH HHHHHHHHHCHHHHCCHHHCCCEEEHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEECCC RGSAKENSNWRKVIDYFSSATQIGMTATPKETKNASNTEYFGEPIYTYSLKQGIEDGFLA CCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCEEEEHHHHCCCCCCCC PYRVMRVNLDVDVDGYRPETGKVDANGQLIEDRYYGRKDFDKTIVIDDRTQRVAKFVSDY CEEEEEEEEEEECCCCCCCCCEECCCCCEECCCCCCCCCCCCEEEECCHHHHHHHHHHHH MKQNNARFDKTIVFCVDIDHAERMRAALVKENLDLVQEDYRYVMQVTGDNAEGKAQLDNF HHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHH MDVNSNFPAIVTTSKLLTTGVNAKTCRLIVLDSNIQSMTEFKQIIGRGTRLYPQKGKEFF HCCCCCCCEEEEEHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEECCCCCCEEE TIIDFRNVTNLFADPDFDGEPVKVLETGAKTVSGSTPGFVDEEGDPVEKYIVTDKQVTIL EEEEEHHHHHHHCCCCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCHHHEEECCCEEEEE NSTVQVLDENGKLITESLTDYTRKNILGSYATLNDFITVWHTADKKKLILDELYKKGVYL HHHHHHHCCCCCEEHHHHHHHHHHHHHCCHHHHHHHEEEEECCCCHHHHHHHHHHCCCEE DAIRESEGISEQEIDDFDLLLKLAYGQKELTKTERINKLKQSGYLYKYSEEARAVLEILL EEHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHH NKYMDKGIGELESIETLKLPEFQIYGGTFKIINTYFGDKKRYLQAIKELEQELFTVA HHHHHCCCCCHHCCCEECCCCEEEECCEEEEEHHHHCCHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTDGRIEVRGDKARRKEGK CCHHHHHHHHCCHHHHHHHCCCHHHHHCCCCCCCEEEEHHHCCCCEEEECCCHHHHCCCC KSDYSLYYQFGTRIAIVEAKDNKHSVRAGLQQAIEYGEILDVPFVYSSNGDGFIEHDRIT CCCCEEEEEECCEEEEEEECCCCHHHHHHHHHHHHHCCEECCCEEEECCCCCCEECCHHC REERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYYTDAFSMKTPRYYQQIAINRT CHHHHCCHHCCCCHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHH IETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLAKRVLFLADRNILVDQTMAEDFR HHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEHHHHHHCC PFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGEDGTETHYQKFDKDFFDLIVIDEAH HHHHHHHHHCHHHHCCHHHCCCEEEHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEECCC RGSAKENSNWRKVIDYFSSATQIGMTATPKETKNASNTEYFGEPIYTYSLKQGIEDGFLA CCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCEEEEHHHHCCCCCCCC PYRVMRVNLDVDVDGYRPETGKVDANGQLIEDRYYGRKDFDKTIVIDDRTQRVAKFVSDY CEEEEEEEEEEECCCCCCCCCEECCCCCEECCCCCCCCCCCCEEEECCHHHHHHHHHHHH MKQNNARFDKTIVFCVDIDHAERMRAALVKENLDLVQEDYRYVMQVTGDNAEGKAQLDNF HHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHH MDVNSNFPAIVTTSKLLTTGVNAKTCRLIVLDSNIQSMTEFKQIIGRGTRLYPQKGKEFF HCCCCCCCEEEEEHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEECCCCCCEEE TIIDFRNVTNLFADPDFDGEPVKVLETGAKTVSGSTPGFVDEEGDPVEKYIVTDKQVTIL EEEEEHHHHHHHCCCCCCCCCHHEEECCCCCCCCCCCCCCCCCCCCHHHEEECCCEEEEE NSTVQVLDENGKLITESLTDYTRKNILGSYATLNDFITVWHTADKKKLILDELYKKGVYL HHHHHHHCCCCCEEHHHHHHHHHHHHHCCHHHHHHHEEEEECCCCHHHHHHHHHHCCCEE DAIRESEGISEQEIDDFDLLLKLAYGQKELTKTERINKLKQSGYLYKYSEEARAVLEILL EEHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHH NKYMDKGIGELESIETLKLPEFQIYGGTFKIINTYFGDKKRYLQAIKELEQELFTVA HHHHHCCCCCHHCCCEECCCCEEEECCEEEEEHHHHCCHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8412658 [H]