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The map label for this gene is lolC [H]

Identifier: 225852337

GI number: 225852337

Start: 821212

End: 822480

Strand: Direct

Name: lolC [H]

Synonym: BMEA_A0863

Alternate gene names: 225852337

Gene position: 821212-822480 (Clockwise)

Preceding gene: 225852336

Following gene: 225852338

Centisome position: 38.63

GC content: 57.05

Gene sequence:

>1269_bases
GTGAAGGCGCCGAAGTCCGGCCCTTTTTCGGCTTTTGAACGGATGATCGCGTGGCGATATCTTCGTGCGCGCCGCCGTGA
AACCTTCATTTCGGTCATTGCCGGCTTTTCTTTCACCGGCATCATGCTGGGTGTTGCGACCCTCATCATCGTTATGGCGG
TGATGAACGGTTTTCGCGCCGAGCTTCTGACGCGCATTCTGGGCATCAATGGCCACCTCATCATGCAGCCGATCGACCGT
CCACTGGATGATTATGCCGACCTTATCAAGCGTGTGGATGCCATTCCGGGTATCAAGTTTGCTATTCCCGTTGTGGAAGG
GCAGGCGCTCGTGCAGGGCAATATTGGTGCGGGAACGGGCGCACTCGTGCGGGGTTTGCGTGAGGAAGACCTCGACAAGC
TGAAGCTCATATCGTCCAATATCCGTCAGGGCACGCTGAAAGGTTTCGACCACAGTGGCGGCGTGGCCATTGGTACGCGA
ATGGCTGAAAATCTGGGGCTTTCCGTGGGCGATACGCTGCGCGTTATTTCGCCGGATGGCGATGTGACGCCCTTTGGCGT
CAATCCGCGTGTCAAAGCCTATCCGATTGTTGCGATCTTCGAGATCGGCATGTCGGAATATGATTCCTCTATTGTCATGA
TGCCGCTTTCCGAGGCGCAGCTTTTCTTCAATCAGGAAGGAAAGGTGCAGTCGCTGGAAATTTTTGTCGATAATCCCGAT
AAGGTCGATGCGATGCGGGCACCCGTTGAGGAGGCCGCAGCGCGCCAGCTTTCGCTTGTCGATTGGCGTCAGCGCAATCA
GACCTTCTTTTCCGCGCTGGAGGTGGAGCGCAACGTGATGTTCATGATCCTGACGCTGATCGTGCTCGTCGCCGCGCTGA
ATATTATTTCGGGCCTCATCATGCTGGTGAAGGACAAGGGGCATGACATTGCGATCCTGCGCACCATGGGCGCGACACGC
GGCGCGGTGATGCGCATATTCCTGATGACGGGCGCTGCCATCGGTGTCACCGGCACGGTGGCGGGCGTCATTCTGGGCGT
TGTCGTGTGCCTCAATGTCGAGCGCCTGCGCGAATTCTTCTCGTGGCTTTCCGGCACGACGCTTTTCAACCCGGAGCTTT
ATTTCCTGAGCCAGCTTCCGGCCAAGATGGACCCCGGCGAAACCCTTTCCGTCATCGTCATGGCTCTGGTGCTTTCGTTT
ATTGCCACCATCTTTCCCGCCTGGCGCGCAGCCAAGCTCGATCCGGTCGAAGCATTGAGATACGAATAA

Upstream 100 bases:

>100_bases
GCGAACGCCAGAGCCTGGGTATTGAAGCAGCAATCAACATGTTGACGGCACAAGCATGAGCAACGCGGCGGCAAAGTCCG
GAGGGAAGGCCACGGCAGCC

Downstream 100 bases:

>100_bases
TGGCGGCAGAAATCATCCTGCGGCTAGAGCGCATCGGCCGCGCCTATAAGGAAGCCGACCGCGAGCTGATTATCCTGAAC
GATGCCGATTTCACGCTTCG

Product: lipoprotein releasing system, transmembrane protein, LolC/E family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKAPKSGPFSAFERMIAWRYLRARRRETFISVIAGFSFTGIMLGVATLIIVMAVMNGFRAELLTRILGINGHLIMQPIDR
PLDDYADLIKRVDAIPGIKFAIPVVEGQALVQGNIGAGTGALVRGLREEDLDKLKLISSNIRQGTLKGFDHSGGVAIGTR
MAENLGLSVGDTLRVISPDGDVTPFGVNPRVKAYPIVAIFEIGMSEYDSSIVMMPLSEAQLFFNQEGKVQSLEIFVDNPD
KVDAMRAPVEEAAARQLSLVDWRQRNQTFFSALEVERNVMFMILTLIVLVAALNIISGLIMLVKDKGHDIAILRTMGATR
GAVMRIFLMTGAAIGVTGTVAGVILGVVVCLNVERLREFFSWLSGTTLFNPELYFLSQLPAKMDPGETLSVIVMALVLSF
IATIFPAWRAAKLDPVEALRYE

Sequences:

>Translated_422_residues
MKAPKSGPFSAFERMIAWRYLRARRRETFISVIAGFSFTGIMLGVATLIIVMAVMNGFRAELLTRILGINGHLIMQPIDR
PLDDYADLIKRVDAIPGIKFAIPVVEGQALVQGNIGAGTGALVRGLREEDLDKLKLISSNIRQGTLKGFDHSGGVAIGTR
MAENLGLSVGDTLRVISPDGDVTPFGVNPRVKAYPIVAIFEIGMSEYDSSIVMMPLSEAQLFFNQEGKVQSLEIFVDNPD
KVDAMRAPVEEAAARQLSLVDWRQRNQTFFSALEVERNVMFMILTLIVLVAALNIISGLIMLVKDKGHDIAILRTMGATR
GAVMRIFLMTGAAIGVTGTVAGVILGVVVCLNVERLREFFSWLSGTTLFNPELYFLSQLPAKMDPGETLSVIVMALVLSF
IATIFPAWRAAKLDPVEALRYE
>Mature_422_residues
MKAPKSGPFSAFERMIAWRYLRARRRETFISVIAGFSFTGIMLGVATLIIVMAVMNGFRAELLTRILGINGHLIMQPIDR
PLDDYADLIKRVDAIPGIKFAIPVVEGQALVQGNIGAGTGALVRGLREEDLDKLKLISSNIRQGTLKGFDHSGGVAIGTR
MAENLGLSVGDTLRVISPDGDVTPFGVNPRVKAYPIVAIFEIGMSEYDSSIVMMPLSEAQLFFNQEGKVQSLEIFVDNPD
KVDAMRAPVEEAAARQLSLVDWRQRNQTFFSALEVERNVMFMILTLIVLVAALNIISGLIMLVKDKGHDIAILRTMGATR
GAVMRIFLMTGAAIGVTGTVAGVILGVVVCLNVERLREFFSWLSGTTLFNPELYFLSQLPAKMDPGETLSVIVMALVLSF
IATIFPAWRAAKLDPVEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=407, Percent_Identity=29.7297297297297, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1787360, Length=411, Percent_Identity=29.9270072992701, Blast_Score=165, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 46179; Mature: 46179

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAPKSGPFSAFERMIAWRYLRARRRETFISVIAGFSFTGIMLGVATLIIVMAVMNGFRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ELLTRILGINGHLIMQPIDRPLDDYADLIKRVDAIPGIKFAIPVVEGQALVQGNIGAGTG
HHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCHH
ALVRGLREEDLDKLKLISSNIRQGTLKGFDHSGGVAIGTRMAENLGLSVGDTLRVISPDG
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHCCCCCCCEEEEECCCC
DVTPFGVNPRVKAYPIVAIFEIGMSEYDSSIVMMPLSEAQLFFNQEGKVQSLEIFVDNPD
CCCCCCCCCCCCCEEEHHHEECCHHHCCCCEEEEECHHHHHHCCCCCCEEEEEEEECCCC
KVDAMRAPVEEAAARQLSLVDWRQRNQTFFSALEVERNVMFMILTLIVLVAALNIISGLI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVKDKGHDIAILRTMGATRGAVMRIFLMTGAAIGVTGTVAGVILGVVVCLNVERLREFF
HHEECCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHH
SWLSGTTLFNPELYFLSQLPAKMDPGETLSVIVMALVLSFIATIFPAWRAAKLDPVEALR
HHHCCCEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHC
YE
CC
>Mature Secondary Structure
MKAPKSGPFSAFERMIAWRYLRARRRETFISVIAGFSFTGIMLGVATLIIVMAVMNGFRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ELLTRILGINGHLIMQPIDRPLDDYADLIKRVDAIPGIKFAIPVVEGQALVQGNIGAGTG
HHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCHH
ALVRGLREEDLDKLKLISSNIRQGTLKGFDHSGGVAIGTRMAENLGLSVGDTLRVISPDG
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHCCCCCCCEEEEECCCC
DVTPFGVNPRVKAYPIVAIFEIGMSEYDSSIVMMPLSEAQLFFNQEGKVQSLEIFVDNPD
CCCCCCCCCCCCCEEEHHHEECCHHHCCCCEEEEECHHHHHHCCCCCCEEEEEEEECCCC
KVDAMRAPVEEAAARQLSLVDWRQRNQTFFSALEVERNVMFMILTLIVLVAALNIISGLI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVKDKGHDIAILRTMGATRGAVMRIFLMTGAAIGVTGTVAGVILGVVVCLNVERLREFF
HHEECCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHH
SWLSGTTLFNPELYFLSQLPAKMDPGETLSVIVMALVLSFIATIFPAWRAAKLDPVEALR
HHHCCCEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHC
YE
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]