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The map label for this gene is uvrC [H]

Identifier: 225852219

GI number: 225852219

Start: 705031

End: 707088

Strand: Reverse

Name: uvrC [H]

Synonym: BMEA_A0735

Alternate gene names: 225852219

Gene position: 707088-705031 (Counterclockwise)

Preceding gene: 225852220

Following gene: 225852218

Centisome position: 33.26

GC content: 59.52

Gene sequence:

>2058_bases
ATGGCCACCGGCGAGCAAACGCATCTGCCGCCCGATGACGAACAGGACGTTGCGGGCATCATTATCGGTGAGGCAGAAAC
CGAAGACGATGACGATGCGGCGGCAAACGGCGAGGAAGAGCCTGCCCGCATAGCTTCGGCTGCGGAATCCATCCAGTGGG
ATTCGTCGGACGGGCTGCCCGATACGGCGGGGCTCAGCGGCCCGGACATCATCAATGCCTTTGTGAAGCGCCTGCCCAAC
AATCCCGGTGTCTATCGCATGTTCAACAGCGATGGAGGCGTGCTTTATGTCGGCAAGGCGCGCAACCTCAAGAAGCGCGT
TTCCAATTATGCGCGCGGCATTGGCCATTCCAATCGCATCACACGCATGATCCGTGAAACCGTGACGATGGAATTCGTCG
TCACGCGCACGGAAACGGAAGCACTTCTGCTTGAAGCAAATCTCATCAAAAGATTGCGGCCACGCTTCAACGTGCTGATG
CGCGACGACAAGTCGTTTCCGTATATTCTGCTGACCGGCGGCCACCGCGCGCCGGGCATTTTCAAGCATCGCGGCGCACG
TTCGCGCAAGGGCGACTATTTCGGCCCCTTTGCTTCGACGGGGGCTGTGGGCCGCACCATCAACGCGCTCCAGCGCGCTT
TTTTACTGCGCACCTGCACCGATTCCGTCTTTGAAACCCGCACACGGCCCTGCCTGCTCTATCAGATCAAACGCTGCTCT
GCGCCCTGCACCTATGAAATCAGCGACGAGGACTATGCCGGGCTTGTGGCAGAGGCCAAGGCCTTTCTTTCCGGCAAGAG
CCAGTCGGTCAAGGATCATCTGGCAGCGGCAATGCAGGCAGCTTCCGCCGATCTCGATTTTGAACATGCCGCAGTCTATC
GCGACCGTCTCGCCGCGCTTTCACACGTCCAGTCCCATCAGGGTATCAATCCGCAAACGGTCGAGGAAGCCGATGTTTTC
GCCATCCATCAGGAAGGCGGCATGACCTGCATTCAGGTCTTCTTCTTCCGCACCGGCCAGAACTGGGGCAACCGCGCCTA
TTTTCCGAAAGCCGACAGTTCGCTCGGGCCAGCGGAAGTGCTGGGCGCTTTCCTGTCGCAGTTCTATGATGACAAGCCTT
GCCCGAAACTCGTTCTCCTTTCGGAAACGGTCGAAGAACAATCCCTTATCACCGAGGCGCTCTCCACGCGCGCCGGTCAT
AAGGTCCAGGTCTCGGTGCCGCAGCGCGGTGAAAAGAAAGAACTCGTGCAGCACGCGCTGACCAATGCGCGCGAAGCACT
TGGCCGCAGGCTGGCCGAAACCTCATCGCAGGCGCGCTTGCTACAGGGGCTTGCCGAAACATTCGGCCTGCCGCGCGCAC
CGCGCCGCATCGAGGTTTACGACAATTCCCACATCATGGGCACCAATGCGGTTGGCGGCATGATCGTCGCCGGGCCGGAA
GGCTTTGTGAAAAACCAGTATCGCAAGTTCAATATCCGTTCGACCGACATTACGCCGGGCGATGATTTCGGCATGATGCG
GGAGGTGATCGAGCGGCGCTTCTCACGTCTGGTAAAGGAACATGGAACCCCTGCCGGCGAGGTGAAGAACCCGGACGCCT
TCCCTGCCTGGCCTGATGTCATTCTCATTGATGGTGGCCAGGGACAGGTGGGCGCGGTGCGCCAGATACTCGGCGAGATG
GGCATCAGCGATCTGGTCACGGCAATCGGCATCGCCAAGGGCGTTGACCGCGAGGCAGGCCGCGAGCGGTTTTTCATGGA
AGGCAAGCAGCCATTTACCCTGCCCCCGCGCGATCCCGTTCTTTATTTCATCCAACGCCTGCGCGACGAGGCGCATCGCT
TTGCCATAGGCACCCACCGCGCACGACGCAAGAAGGAAATAGTCAGGAATCCGCTGGATGAAATTGCCGGCATAGGCCCT
ACGCGCAAGCGCGCCCTTTTACATCATTTTGGAACGGCAAAAGCGGTTTCGCGCGCCGCTGTCGAAGATCTGATGCAAAT
CGATGGTATTTCGGAAGCCATGGCGCGGGCGATCCACGACCACTTCCGGGACAAATGA

Upstream 100 bases:

>100_bases
ATTTCTGGGAAAACCGTTCCATTACCGGCCAGATGATTGCGCTCGACGGCGGGCAGCACCTGGCATGGGAAACACCCGAC
ATTGCAGGAATTACCGAATA

Downstream 100 bases:

>100_bases
CGTGATTTTGTATAATTTGGACATATTAGCGACGTTAGATTCCAGCATAACATATTCGCAGGTGTTGATTTTCTCCGTCA
TCCCTGTTGATGTGCCATCA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 685; Mature: 684

Protein sequence:

>685_residues
MATGEQTHLPPDDEQDVAGIIIGEAETEDDDDAAANGEEEPARIASAAESIQWDSSDGLPDTAGLSGPDIINAFVKRLPN
NPGVYRMFNSDGGVLYVGKARNLKKRVSNYARGIGHSNRITRMIRETVTMEFVVTRTETEALLLEANLIKRLRPRFNVLM
RDDKSFPYILLTGGHRAPGIFKHRGARSRKGDYFGPFASTGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQIKRCS
APCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRDRLAALSHVQSHQGINPQTVEEADVF
AIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSLGPAEVLGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALSTRAGH
KVQVSVPQRGEKKELVQHALTNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMIVAGPE
GFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVKNPDAFPAWPDVILIDGGQGQVGAVRQILGEM
GISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLPPRDPVLYFIQRLRDEAHRFAIGTHRARRKKEIVRNPLDEIAGIGP
TRKRALLHHFGTAKAVSRAAVEDLMQIDGISEAMARAIHDHFRDK

Sequences:

>Translated_685_residues
MATGEQTHLPPDDEQDVAGIIIGEAETEDDDDAAANGEEEPARIASAAESIQWDSSDGLPDTAGLSGPDIINAFVKRLPN
NPGVYRMFNSDGGVLYVGKARNLKKRVSNYARGIGHSNRITRMIRETVTMEFVVTRTETEALLLEANLIKRLRPRFNVLM
RDDKSFPYILLTGGHRAPGIFKHRGARSRKGDYFGPFASTGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQIKRCS
APCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRDRLAALSHVQSHQGINPQTVEEADVF
AIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSLGPAEVLGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALSTRAGH
KVQVSVPQRGEKKELVQHALTNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMIVAGPE
GFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVKNPDAFPAWPDVILIDGGQGQVGAVRQILGEM
GISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLPPRDPVLYFIQRLRDEAHRFAIGTHRARRKKEIVRNPLDEIAGIGP
TRKRALLHHFGTAKAVSRAAVEDLMQIDGISEAMARAIHDHFRDK
>Mature_684_residues
ATGEQTHLPPDDEQDVAGIIIGEAETEDDDDAAANGEEEPARIASAAESIQWDSSDGLPDTAGLSGPDIINAFVKRLPNN
PGVYRMFNSDGGVLYVGKARNLKKRVSNYARGIGHSNRITRMIRETVTMEFVVTRTETEALLLEANLIKRLRPRFNVLMR
DDKSFPYILLTGGHRAPGIFKHRGARSRKGDYFGPFASTGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQIKRCSA
PCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRDRLAALSHVQSHQGINPQTVEEADVFA
IHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSLGPAEVLGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALSTRAGHK
VQVSVPQRGEKKELVQHALTNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMIVAGPEG
FVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVKNPDAFPAWPDVILIDGGQGQVGAVRQILGEMG
ISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLPPRDPVLYFIQRLRDEAHRFAIGTHRARRKKEIVRNPLDEIAGIGPT
RKRALLHHFGTAKAVSRAAVEDLMQIDGISEAMARAIHDHFRDK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=616, Percent_Identity=39.4480519480519, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1788037, Length=191, Percent_Identity=30.3664921465969, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 75632; Mature: 75500

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGEQTHLPPDDEQDVAGIIIGEAETEDDDDAAANGEEEPARIASAAESIQWDSSDGLP
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
DTAGLSGPDIINAFVKRLPNNPGVYRMFNSDGGVLYVGKARNLKKRVSNYARGIGHSNRI
CCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCHHHH
TRMIRETVTMEFVVTRTETEALLLEANLIKRLRPRFNVLMRDDKSFPYILLTGGHRAPGI
HHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHCHHHCEEEECCCCCCEEEEECCCCCCCH
FKHRGARSRKGDYFGPFASTGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQIKRCS
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
APCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRDRLAAL
CCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
SHVQSHQGINPQTVEEADVFAIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSLGPAEV
HHHHHHCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCCCHHHH
LGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALSTRAGHKVQVSVPQRGEKKELVQHAL
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
TNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMIVAGPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCEEEECCC
GFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVKNPDAFPAWPDV
HHHHCCCEEEECEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
ILIDGGQGQVGAVRQILGEMGISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLPPRDPV
EEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHCHHHHHCCCCCCCCCCCCCHH
LYFIQRLRDEAHRFAIGTHRARRKKEIVRNPLDEIAGIGPTRKRALLHHFGTAKAVSRAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VEDLMQIDGISEAMARAIHDHFRDK
HHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATGEQTHLPPDDEQDVAGIIIGEAETEDDDDAAANGEEEPARIASAAESIQWDSSDGLP
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
DTAGLSGPDIINAFVKRLPNNPGVYRMFNSDGGVLYVGKARNLKKRVSNYARGIGHSNRI
CCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCHHHH
TRMIRETVTMEFVVTRTETEALLLEANLIKRLRPRFNVLMRDDKSFPYILLTGGHRAPGI
HHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHCHHHCEEEECCCCCCEEEEECCCCCCCH
FKHRGARSRKGDYFGPFASTGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQIKRCS
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
APCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRDRLAAL
CCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
SHVQSHQGINPQTVEEADVFAIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSLGPAEV
HHHHHHCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCCCHHHH
LGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALSTRAGHKVQVSVPQRGEKKELVQHAL
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
TNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMIVAGPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCEEEECCC
GFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVKNPDAFPAWPDV
HHHHCCCEEEECEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
ILIDGGQGQVGAVRQILGEMGISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLPPRDPV
EEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHCHHHHHCCCCCCCCCCCCCHH
LYFIQRLRDEAHRFAIGTHRARRKKEIVRNPLDEIAGIGPTRKRALLHHFGTAKAVSRAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VEDLMQIDGISEAMARAIHDHFRDK
HHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA