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The map label for this gene is thiD [H]

Identifier: 225851745

GI number: 225851745

Start: 227095

End: 227970

Strand: Reverse

Name: thiD [H]

Synonym: BMEA_A0225

Alternate gene names: 225851745

Gene position: 227970-227095 (Counterclockwise)

Preceding gene: 225851748

Following gene: 225851744

Centisome position: 10.72

GC content: 62.67

Gene sequence:

>876_bases
ATGGACCAGAAACAGAGTTTCTCCCCAACCAATCCAACCGATAACCATGCGGCATCCGTGCCCATATGCGTCACCATTGC
GGGGTCCGACTCCAGCGGCGGCGCGGGCATTCAGGCCGACCTCAAGGCGTTTTCGGCGCTTGGCGTCTATGGCGCAAGCG
TGATTGCCGCCATCACCGTGCAGAACACTCGCACCGTCAGCGCCGTGCATGATGTGCCGCCGCAGATCGTGGCGGGCCAG
ATAGACGCCGTCTTCAGCGATCTCGATGTCGCCGCCGTCAAGATCGGCATGGTTTCCGTGCCAGAAACCATCGAAGCCAT
TGCGCACGGCCTTGCACATTTTTCCGGTCCCATCGTGCTCGACCCGGTGATGGTTGCAAAATCCGGCGACCGGCTGTTGA
GCGAGACCGCGATTTCATCCCTGCGTAAAAAGCTGCTGCCGCTTGCAACACTGCTCACCCCCAACCGGCCGGAAGCCGCC
TGCCTGCTCGACACAGGCACAGCCGGGAGTGATGCCGAGGCGGAAGAACAGGGCCGCGCCCTGCTCGACCTCGGTGCCAA
GGCCGTCCTGATGAAAGGCGGCCATGCGGAAGGAGCGATCTGCACCGATCTTCTGATCCGCCGCGACCGGCCGACCCTGC
GCATCGAAGCGCCGCGCATTCTCACCAACAACACGCATGGCACCGGCTGCACGCTTTCATCCGCCATTGCTGCCGGGCTT
TCGCGCAACCTTTCGCTCGAAACAGCGCTCGCGCAGGCCCATGCCTATCTGCAAGGCGCAATCCGCGCGGCTGACAGTCT
GAAGGTCGGTCAGGGCCATGGGCCGGTGCATCATTTTCACGCCCTTTGGAAACAGGCAGAAAGGGAGGCGATCTGA

Upstream 100 bases:

>100_bases
GAGTTTGGCGCGTCGCGGACGGGGTTCATTCCCCATCGGGGCTTATGCTCCATCAAGGTTCATGACGTCTCATTTTCCGT
TCGGAATGAGAGACGTCGAA

Downstream 100 bases:

>100_bases
TGCGCGTGACAATCATCGGAGCGGGTGTCGCTGGCCTTGCCACCGCCGCGGAATTTACCGATCAGGGCCATGCCGTCACC
GTCATCGCCAAAAGTGCCGA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MDQKQSFSPTNPTDNHAASVPICVTIAGSDSSGGAGIQADLKAFSALGVYGASVIAAITVQNTRTVSAVHDVPPQIVAGQ
IDAVFSDLDVAAVKIGMVSVPETIEAIAHGLAHFSGPIVLDPVMVAKSGDRLLSETAISSLRKKLLPLATLLTPNRPEAA
CLLDTGTAGSDAEAEEQGRALLDLGAKAVLMKGGHAEGAICTDLLIRRDRPTLRIEAPRILTNNTHGTGCTLSSAIAAGL
SRNLSLETALAQAHAYLQGAIRAADSLKVGQGHGPVHHFHALWKQAEREAI

Sequences:

>Translated_291_residues
MDQKQSFSPTNPTDNHAASVPICVTIAGSDSSGGAGIQADLKAFSALGVYGASVIAAITVQNTRTVSAVHDVPPQIVAGQ
IDAVFSDLDVAAVKIGMVSVPETIEAIAHGLAHFSGPIVLDPVMVAKSGDRLLSETAISSLRKKLLPLATLLTPNRPEAA
CLLDTGTAGSDAEAEEQGRALLDLGAKAVLMKGGHAEGAICTDLLIRRDRPTLRIEAPRILTNNTHGTGCTLSSAIAAGL
SRNLSLETALAQAHAYLQGAIRAADSLKVGQGHGPVHHFHALWKQAEREAI
>Mature_291_residues
MDQKQSFSPTNPTDNHAASVPICVTIAGSDSSGGAGIQADLKAFSALGVYGASVIAAITVQNTRTVSAVHDVPPQIVAGQ
IDAVFSDLDVAAVKIGMVSVPETIEAIAHGLAHFSGPIVLDPVMVAKSGDRLLSETAISSLRKKLLPLATLLTPNRPEAA
CLLDTGTAGSDAEAEEQGRALLDLGAKAVLMKGGHAEGAICTDLLIRRDRPTLRIEAPRILTNNTHGTGCTLSSAIAAGL
SRNLSLETALAQAHAYLQGAIRAADSLKVGQGHGPVHHFHALWKQAEREAI

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=261, Percent_Identity=52.8735632183908, Blast_Score=266, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6325378, Length=278, Percent_Identity=30.5755395683453, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6324997, Length=283, Percent_Identity=32.1554770318021, Blast_Score=108, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6324517, Length=279, Percent_Identity=31.1827956989247, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30086; Mature: 30086

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQKQSFSPTNPTDNHAASVPICVTIAGSDSSGGAGIQADLKAFSALGVYGASVIAAITV
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEE
QNTRTVSAVHDVPPQIVAGQIDAVFSDLDVAAVKIGMVSVPETIEAIAHGLAHFSGPIVL
CCCEEEEHHHCCCHHHHHHHHHHHHHCCCCHHHEEECCCCHHHHHHHHHHHHHHCCCEEE
DPVMVAKSGDRLLSETAISSLRKKLLPLATLLTPNRPEAACLLDTGTAGSDAEAEEQGRA
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHCCC
LLDLGAKAVLMKGGHAEGAICTDLLIRRDRPTLRIEAPRILTNNTHGTGCTLSSAIAAGL
HHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCEEEECCCCCCCCHHHHHHHHHH
SRNLSLETALAQAHAYLQGAIRAADSLKVGQGHGPVHHFHALWKQAEREAI
HCCCHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDQKQSFSPTNPTDNHAASVPICVTIAGSDSSGGAGIQADLKAFSALGVYGASVIAAITV
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEE
QNTRTVSAVHDVPPQIVAGQIDAVFSDLDVAAVKIGMVSVPETIEAIAHGLAHFSGPIVL
CCCEEEEHHHCCCHHHHHHHHHHHHHCCCCHHHEEECCCCHHHHHHHHHHHHHHCCCEEE
DPVMVAKSGDRLLSETAISSLRKKLLPLATLLTPNRPEAACLLDTGTAGSDAEAEEQGRA
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHCCC
LLDLGAKAVLMKGGHAEGAICTDLLIRRDRPTLRIEAPRILTNNTHGTGCTLSSAIAAGL
HHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCEEEECCCCCCCCHHHHHHHHHH
SRNLSLETALAQAHAYLQGAIRAADSLKVGQGHGPVHHFHALWKQAEREAI
HCCCHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]