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The map label for this gene is bioF [H]

Identifier: 225686290

GI number: 225686290

Start: 454013

End: 455149

Strand: Reverse

Name: bioF [H]

Synonym: BMEA_B0468

Alternate gene names: 225686290

Gene position: 455149-454013 (Counterclockwise)

Preceding gene: 225686291

Following gene: 225686289

Centisome position: 38.39

GC content: 61.21

Gene sequence:

>1137_bases
GTGAAACTCGACACCTACCTGACAAGGCTGGAAAATCTGGAGCGCAAGGGGCGGCGGCGCAATCTTGCGCTGGCCGATGG
GCTTGATTTCAGTTCCAATGATTATCTGGGCCTTGCCACCCACCCCGGCATAAAGGCCGCCGTCGAGGCCGCCCTTCAGC
GTGGCGTTCCACTTGGCGCAACCGGCTCAAGGCTATTGCGCGGCAACCATGCGGAACACGAGGCGCTTGAAGCCGAAGCC
GCAGCACATTTCAGTGCCCCGCGCATGATCTATTTCGGCAGTGGCTACATGGCCAATCTGGCAGCACTTTCCACCTTGCC
CCAGCCGGGCGACCTGATCGTGTATGACGAACTCATCCATGCCAGCGCCCATGCGGGCATCCGTGCGGGCCGCGCCGAAG
CGGTTGGCGCCCGGCACAATGATGCACAGGCCTTCGAGGACCGGATAAGGGCCTGGCGCGAAAACGGCGGTCGCGGCACA
CCATGGATCGTGGTTGAAAGCATCTATTCCATGGATGGCGATCAGGCGCCGCTAAAGGCACTTCATGCCATCGCCACCCG
TTATGACGGTGTGCTTTATATCGACGAAGCCCATGCAACCGGGGTTTACGGCGCCAATGGCGGGGGATTTGCCGCTACTC
TTGGCGATGCGGAAAATATTGTCACGTTGCATACCTGCGGCAAGGCGCTTGGCGGCTCCGGTGCCTTGCTGGGCGCACAT
GCCACGCTGTGCGACTATCTCGTCAATCGTGCGAGCGGCTTCATCTTTACCACCGCCCCCTCGCCCTTGCAGGCCGCAGC
CCTGCGCGAGGCACTTCGGATATTGCGTGACCAGCCAGAGAGGCGCGCACGGCTTTTTTCGCGCATCAGCCATGCCAATG
AGCGGATCGCAACCGCTCTCGGCCAGCCGGTGAGCGGAACGCAGATCATTCCCATTATCGTGGGTGACAATGAGCGCGCT
GTTCGCCTTGCTGCACAGATGCAGGCACAAGGGTTCGATATTCGCGCCATCCGCCCGCCGACCGTCCCGCATGGCACGGC
GCGCCTGCGCATTTCCATCACGCTCAATGTCGGTCTCGCCGACATCGACCGCATGGTTGAAACGCTTTCCTACGCGACTT
TTAGAGAAGCAGCATGA

Upstream 100 bases:

>100_bases
TTATGGGCGACACCTTGCTCACAGCCGCCAACCCCGGCGACGACCGCGATTCCAGCCTGCTGCGCCGCCTCGGCATACAG
GCGGAAACGGAGCAGCCTGC

Downstream 100 bases:

>100_bases
ATTCCCGTTTGATCGTTACCGGCACGGATACTGGCATCGGCAAGACCGTGTTCAGCGCGGCGCTCTGCCATGCCTTGGGG
GCCGTCTATTGGAAACCCGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKLDTYLTRLENLERKGRRRNLALADGLDFSSNDYLGLATHPGIKAAVEAALQRGVPLGATGSRLLRGNHAEHEALEAEA
AAHFSAPRMIYFGSGYMANLAALSTLPQPGDLIVYDELIHASAHAGIRAGRAEAVGARHNDAQAFEDRIRAWRENGGRGT
PWIVVESIYSMDGDQAPLKALHAIATRYDGVLYIDEAHATGVYGANGGGFAATLGDAENIVTLHTCGKALGGSGALLGAH
ATLCDYLVNRASGFIFTTAPSPLQAAALREALRILRDQPERRARLFSRISHANERIATALGQPVSGTQIIPIIVGDNERA
VRLAAQMQAQGFDIRAIRPPTVPHGTARLRISITLNVGLADIDRMVETLSYATFREAA

Sequences:

>Translated_378_residues
MKLDTYLTRLENLERKGRRRNLALADGLDFSSNDYLGLATHPGIKAAVEAALQRGVPLGATGSRLLRGNHAEHEALEAEA
AAHFSAPRMIYFGSGYMANLAALSTLPQPGDLIVYDELIHASAHAGIRAGRAEAVGARHNDAQAFEDRIRAWRENGGRGT
PWIVVESIYSMDGDQAPLKALHAIATRYDGVLYIDEAHATGVYGANGGGFAATLGDAENIVTLHTCGKALGGSGALLGAH
ATLCDYLVNRASGFIFTTAPSPLQAAALREALRILRDQPERRARLFSRISHANERIATALGQPVSGTQIIPIIVGDNERA
VRLAAQMQAQGFDIRAIRPPTVPHGTARLRISITLNVGLADIDRMVETLSYATFREAA
>Mature_378_residues
MKLDTYLTRLENLERKGRRRNLALADGLDFSSNDYLGLATHPGIKAAVEAALQRGVPLGATGSRLLRGNHAEHEALEAEA
AAHFSAPRMIYFGSGYMANLAALSTLPQPGDLIVYDELIHASAHAGIRAGRAEAVGARHNDAQAFEDRIRAWRENGGRGT
PWIVVESIYSMDGDQAPLKALHAIATRYDGVLYIDEAHATGVYGANGGGFAATLGDAENIVTLHTCGKALGGSGALLGAH
ATLCDYLVNRASGFIFTTAPSPLQAAALREALRILRDQPERRARLFSRISHANERIATALGQPVSGTQIIPIIVGDNERA
VRLAAQMQAQGFDIRAIRPPTVPHGTARLRISITLNVGLADIDRMVETLSYATFREAA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=347, Percent_Identity=31.9884726224784, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=31.9884726224784, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI83977444, Length=350, Percent_Identity=33.1428571428571, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI83977442, Length=350, Percent_Identity=33.1428571428571, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI83977440, Length=350, Percent_Identity=33.1428571428571, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4502025, Length=337, Percent_Identity=33.8278931750742, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI40316939, Length=337, Percent_Identity=33.8278931750742, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4758668, Length=367, Percent_Identity=25.8855585831063, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI119220554, Length=387, Percent_Identity=23.7726098191214, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI5454084, Length=377, Percent_Identity=23.6074270557029, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=36.8876080691643, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1790046, Length=373, Percent_Identity=31.0991957104558, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71994529, Length=351, Percent_Identity=29.9145299145299, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI32566772, Length=358, Percent_Identity=25.6983240223464, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560914, Length=377, Percent_Identity=24.6684350132626, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560912, Length=377, Percent_Identity=24.6684350132626, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71982617, Length=290, Percent_Identity=23.7931034482759, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982625, Length=288, Percent_Identity=23.6111111111111, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320438, Length=387, Percent_Identity=29.7157622739018, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=23.9782016348774, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323954, Length=268, Percent_Identity=23.8805970149254, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137420, Length=365, Percent_Identity=32.6027397260274, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24662918, Length=348, Percent_Identity=29.8850574712644, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17136286, Length=257, Percent_Identity=28.7937743190661, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24653280, Length=289, Percent_Identity=27.3356401384083, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653276, Length=289, Percent_Identity=27.3356401384083, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653278, Length=289, Percent_Identity=27.3356401384083, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 40453; Mature: 40453

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDTYLTRLENLERKGRRRNLALADGLDFSSNDYLGLATHPGIKAAVEAALQRGVPLGA
CCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCC
TGSRLLRGNHAEHEALEAEAAAHFSAPRMIYFGSGYMANLAALSTLPQPGDLIVYDELIH
CCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEEHHHHH
ASAHAGIRAGRAEAVGARHNDAQAFEDRIRAWRENGGRGTPWIVVESIYSMDGDQAPLKA
HHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCHHHHH
LHAIATRYDGVLYIDEAHATGVYGANGGGFAATLGDAENIVTLHTCGKALGGSGALLGAH
HHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCEEEEEECCHHHCCCCCCHHHH
ATLCDYLVNRASGFIFTTAPSPLQAAALREALRILRDQPERRARLFSRISHANERIATAL
HHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GQPVSGTQIIPIIVGDNERAVRLAAQMQAQGFDIRAIRPPTVPHGTARLRISITLNVGLA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEEEECCHH
DIDRMVETLSYATFREAA
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLDTYLTRLENLERKGRRRNLALADGLDFSSNDYLGLATHPGIKAAVEAALQRGVPLGA
CCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCC
TGSRLLRGNHAEHEALEAEAAAHFSAPRMIYFGSGYMANLAALSTLPQPGDLIVYDELIH
CCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEEHHHHH
ASAHAGIRAGRAEAVGARHNDAQAFEDRIRAWRENGGRGTPWIVVESIYSMDGDQAPLKA
HHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCHHHHH
LHAIATRYDGVLYIDEAHATGVYGANGGGFAATLGDAENIVTLHTCGKALGGSGALLGAH
HHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCEEEEEECCHHHCCCCCCHHHH
ATLCDYLVNRASGFIFTTAPSPLQAAALREALRILRDQPERRARLFSRISHANERIATAL
HHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GQPVSGTQIIPIIVGDNERAVRLAAQMQAQGFDIRAIRPPTVPHGTARLRISITLNVGLA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEEEECCHH
DIDRMVETLSYATFREAA
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA