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The map label for this gene is mutL [H]

Identifier: 225686071

GI number: 225686071

Start: 203255

End: 205126

Strand: Reverse

Name: mutL [H]

Synonym: BMEA_B0218

Alternate gene names: 225686071

Gene position: 205126-203255 (Counterclockwise)

Preceding gene: 225686072

Following gene: 225686070

Centisome position: 17.3

GC content: 62.34

Gene sequence:

>1872_bases
ATGACAATCCGGCACTTGAGCGAAACCATCATCAACCAGATCGCGGCGGGCGAGGTTATCGAACGCCCTGCAAGCGTCAT
CAAGGAGCTTGTGGAAAACGCCATCGACGCAGGCGCAACCCGCATCGAGGTCGTAACCGCAGGCGGCGGGAAGACGCTGC
TGCGCGTCACCGATAATGGCTCCGGCATTCCCGCTGATGAGCTTGCTCTCGCCGTTTCGCGCCATTGCACATCCAAGCTG
ACCGACGATGTGCATGATATTCGAGCGCTCGGTTTTCGCGGCGAGGCCCTGCCCTCCATCGGCTCGGTGTCGAAGCTGAC
GCTCAAGTCCCGCCCGCAGGATGCCGATAGCGGCTTTGAAGTGTGCGTTACCGGCGGGCATCTCGATGGACCGCGCCCGA
CGGCGCTCAATCGCGGCACGATCGTGGAAGTGCGCGACCTCTTTTACGCCACGCCCGCGCGCCTGAAATTCATGAAGACG
GATCGGGCTGAGGCCACGGCCATAACCGACGTGGTAAAGCGCATTGGCATCGCCTTTCCGCATATCCGTTTTTCCCTCGC
CGGAACCGACCGCACCCCCTTTGAAATGCCCGCCACCGGCACTGGCGCAGAGGCGACGCTGGAGCGTATCGGGCAGGTGC
TGGGCCGGGAATTCGGTGAAAACGCGCTTGCCATTGATGCCGAACGCGATGGCGTAAGGCTCGCAGGTTTCGTGGGCATC
CCCTCCTTTAATCGCGGCAATGCCCTGCACCAGTTCGCCTATGTGAACGGGCGGCCCGTACGCGACAAACAGATTTTCGG
CGCCCTGCGCGGCGCTTATTCGGATGTGATCGCACGGGACCGGCACCCGGTCGCCGTCCTGTTCCTGACACTCGATCCGG
CTTTGGTGGATGTAAACGTTCACCCGGCAAAGGCCGATGTGCGCTTTCGCGATCCGGGCCTCGTGCGCGGGCTGATCGTC
GGTGCGATCAAGCAGGCGCTGGCACAATCCGGCATTCGCCCCGCCACCAGCGGCGCGGAAGCAATGCTTCAGGCCTTTCG
CGCTGAAGGTTTTGGCGCGCAGCAATCTGCCCCGCGACCGGCAAATAGCTATTCACCGGCAAGCTGGCGCACCGCGCCGC
CTGCACCCCGCAGCGAATGGTCGCCACAGACCGCGCAGACCGCCCACCGCCCGCTGGACCTGCAAGCTGCCCCGGCACTC
CGGGAAAACGGACAGGCTGTCCTGGGTGACGTTGCCGTGCCGGCATCAGATGCACGGGCAAGCGTGGCGGAAGCCCCCGT
TGAACTTATGCAAAAGCCGCTGGGTGCGGCACGCGCGCAAATTCATGAAAACTATATCGTCGCCCAGACGGAGGACAGTC
TGGTCATTGTGGACCAGCACGCAGCGCATGAACGCCTTGTCTATGAAGCCTTGAAAAATGCGCTTCATGCACGGCCCATC
GCCGGGCAAATGTTGCTGATTCCCGAAATCGTCGATCTGCCGGAAGAAGATGCACAGCGGCTGGCAGGCCATGCCGAAAC
ATTGGCCAGGTTCGGGTTGGGGGTGGAGCAGTTCGGCCCCGGAGCAATCGCCGTGCGCGAAACACCGGCCATGCTCGGCG
AAATGAACGTGCAGCAGCTTATTCGCGATCTTGCCGATGAGATTGCGGAACACGACACGGCAGACGGACTCAAGGCCATG
CTGCATCATGTGGCGGCCACCATGGCCTGCCATGGTTCGGTTCGTTCAGGCCGACGGCTGAAACCGGAAGAAATGAACGC
CCTCCTGCGCGACATGGAGGCAACACCCGGTTCCGGCACCTGCAACCATGGACGCCCGACCTATATCGAGCTGAAACTCA
CCGATATCGAGCGGCTCTTCGGCAGACGCTAA

Upstream 100 bases:

>100_bases
TTTGGGGTCAGATATGGGAGGCCAGATATAAAACCGGATATATCGGTGACAACTTCAATGACCGGTTCTGTGTGCTGGCG
AATCCTTCTATAGTCGCCGC

Downstream 100 bases:

>100_bases
TGCATGTCTGCCAAACGTGGGAACCGGTTTTGCGAGACATGGTCTGGACGCAAGGCGGCCTGCTCTGCTAAAGTTCGCTA
CAAAGGGTTTTAGGCACATG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 623; Mature: 622

Protein sequence:

>623_residues
MTIRHLSETIINQIAAGEVIERPASVIKELVENAIDAGATRIEVVTAGGGKTLLRVTDNGSGIPADELALAVSRHCTSKL
TDDVHDIRALGFRGEALPSIGSVSKLTLKSRPQDADSGFEVCVTGGHLDGPRPTALNRGTIVEVRDLFYATPARLKFMKT
DRAEATAITDVVKRIGIAFPHIRFSLAGTDRTPFEMPATGTGAEATLERIGQVLGREFGENALAIDAERDGVRLAGFVGI
PSFNRGNALHQFAYVNGRPVRDKQIFGALRGAYSDVIARDRHPVAVLFLTLDPALVDVNVHPAKADVRFRDPGLVRGLIV
GAIKQALAQSGIRPATSGAEAMLQAFRAEGFGAQQSAPRPANSYSPASWRTAPPAPRSEWSPQTAQTAHRPLDLQAAPAL
RENGQAVLGDVAVPASDARASVAEAPVELMQKPLGAARAQIHENYIVAQTEDSLVIVDQHAAHERLVYEALKNALHARPI
AGQMLLIPEIVDLPEEDAQRLAGHAETLARFGLGVEQFGPGAIAVRETPAMLGEMNVQQLIRDLADEIAEHDTADGLKAM
LHHVAATMACHGSVRSGRRLKPEEMNALLRDMEATPGSGTCNHGRPTYIELKLTDIERLFGRR

Sequences:

>Translated_623_residues
MTIRHLSETIINQIAAGEVIERPASVIKELVENAIDAGATRIEVVTAGGGKTLLRVTDNGSGIPADELALAVSRHCTSKL
TDDVHDIRALGFRGEALPSIGSVSKLTLKSRPQDADSGFEVCVTGGHLDGPRPTALNRGTIVEVRDLFYATPARLKFMKT
DRAEATAITDVVKRIGIAFPHIRFSLAGTDRTPFEMPATGTGAEATLERIGQVLGREFGENALAIDAERDGVRLAGFVGI
PSFNRGNALHQFAYVNGRPVRDKQIFGALRGAYSDVIARDRHPVAVLFLTLDPALVDVNVHPAKADVRFRDPGLVRGLIV
GAIKQALAQSGIRPATSGAEAMLQAFRAEGFGAQQSAPRPANSYSPASWRTAPPAPRSEWSPQTAQTAHRPLDLQAAPAL
RENGQAVLGDVAVPASDARASVAEAPVELMQKPLGAARAQIHENYIVAQTEDSLVIVDQHAAHERLVYEALKNALHARPI
AGQMLLIPEIVDLPEEDAQRLAGHAETLARFGLGVEQFGPGAIAVRETPAMLGEMNVQQLIRDLADEIAEHDTADGLKAM
LHHVAATMACHGSVRSGRRLKPEEMNALLRDMEATPGSGTCNHGRPTYIELKLTDIERLFGRR
>Mature_622_residues
TIRHLSETIINQIAAGEVIERPASVIKELVENAIDAGATRIEVVTAGGGKTLLRVTDNGSGIPADELALAVSRHCTSKLT
DDVHDIRALGFRGEALPSIGSVSKLTLKSRPQDADSGFEVCVTGGHLDGPRPTALNRGTIVEVRDLFYATPARLKFMKTD
RAEATAITDVVKRIGIAFPHIRFSLAGTDRTPFEMPATGTGAEATLERIGQVLGREFGENALAIDAERDGVRLAGFVGIP
SFNRGNALHQFAYVNGRPVRDKQIFGALRGAYSDVIARDRHPVAVLFLTLDPALVDVNVHPAKADVRFRDPGLVRGLIVG
AIKQALAQSGIRPATSGAEAMLQAFRAEGFGAQQSAPRPANSYSPASWRTAPPAPRSEWSPQTAQTAHRPLDLQAAPALR
ENGQAVLGDVAVPASDARASVAEAPVELMQKPLGAARAQIHENYIVAQTEDSLVIVDQHAAHERLVYEALKNALHARPIA
GQMLLIPEIVDLPEEDAQRLAGHAETLARFGLGVEQFGPGAIAVRETPAMLGEMNVQQLIRDLADEIAEHDTADGLKAML
HHVAATMACHGSVRSGRRLKPEEMNALLRDMEATPGSGTCNHGRPTYIELKLTDIERLFGRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=312, Percent_Identity=33.6538461538462, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI4505913, Length=346, Percent_Identity=26.3005780346821, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI310128478, Length=346, Percent_Identity=26.878612716763, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=26.1538461538462, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=26.1538461538462, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI189458896, Length=325, Percent_Identity=25.2307692307692, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=27.0642201834862, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=25.4180602006689, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI91992160, Length=371, Percent_Identity=23.989218328841, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI91992162, Length=371, Percent_Identity=23.989218328841, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790612, Length=577, Percent_Identity=35.0086655112652, Blast_Score=267, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=34.0557275541796, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=396, Percent_Identity=24.7474747474747, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=316, Percent_Identity=33.2278481012658, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324247, Length=337, Percent_Identity=29.673590504451, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136968, Length=330, Percent_Identity=34.5454545454545, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI17136970, Length=347, Percent_Identity=25.3602305475504, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 66795; Mature: 66664

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRHLSETIINQIAAGEVIERPASVIKELVENAIDAGATRIEVVTAGGGKTLLRVTDNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEECCC
SGIPADELALAVSRHCTSKLTDDVHDIRALGFRGEALPSIGSVSKLTLKSRPQDADSGFE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCE
VCVTGGHLDGPRPTALNRGTIVEVRDLFYATPARLKFMKTDRAEATAITDVVKRIGIAFP
EEEECCCCCCCCCCCCCCCCEEEEHHHHHCCCHHEEEEECCCHHHHHHHHHHHHHCCCCC
HIRFSLAGTDRTPFEMPATGTGAEATLERIGQVLGREFGENALAIDAERDGVRLAGFVGI
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEC
PSFNRGNALHQFAYVNGRPVRDKQIFGALRGAYSDVIARDRHPVAVLFLTLDPALVDVNV
CCCCCCCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEEE
HPAKADVRFRDPGLVRGLIVGAIKQALAQSGIRPATSGAEAMLQAFRAEGFGAQQSAPRP
CCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
ANSYSPASWRTAPPAPRSEWSPQTAQTAHRPLDLQAAPALRENGQAVLGDVAVPASDARA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHCCCCEEEECEECCCCCHHH
SVAEAPVELMQKPLGAARAQIHENYIVAQTEDSLVIVDQHAAHERLVYEALKNALHARPI
HHHHHHHHHHHCCHHHHHHHHHCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHCCCC
AGQMLLIPEIVDLPEEDAQRLAGHAETLARFGLGVEQFGPGAIAVRETPAMLGEMNVQQL
CCCEEECCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEECCHHHHHCCCHHHH
IRDLADEIAEHDTADGLKAMLHHVAATMACHGSVRSGRRLKPEEMNALLRDMEATPGSGT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
CNHGRPTYIELKLTDIERLFGRR
CCCCCCEEEEEEECHHHHHHCCC
>Mature Secondary Structure 
TIRHLSETIINQIAAGEVIERPASVIKELVENAIDAGATRIEVVTAGGGKTLLRVTDNG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEECCC
SGIPADELALAVSRHCTSKLTDDVHDIRALGFRGEALPSIGSVSKLTLKSRPQDADSGFE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCE
VCVTGGHLDGPRPTALNRGTIVEVRDLFYATPARLKFMKTDRAEATAITDVVKRIGIAFP
EEEECCCCCCCCCCCCCCCCEEEEHHHHHCCCHHEEEEECCCHHHHHHHHHHHHHCCCCC
HIRFSLAGTDRTPFEMPATGTGAEATLERIGQVLGREFGENALAIDAERDGVRLAGFVGI
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEC
PSFNRGNALHQFAYVNGRPVRDKQIFGALRGAYSDVIARDRHPVAVLFLTLDPALVDVNV
CCCCCCCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEEE
HPAKADVRFRDPGLVRGLIVGAIKQALAQSGIRPATSGAEAMLQAFRAEGFGAQQSAPRP
CCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
ANSYSPASWRTAPPAPRSEWSPQTAQTAHRPLDLQAAPALRENGQAVLGDVAVPASDARA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHCCCCEEEECEECCCCCHHH
SVAEAPVELMQKPLGAARAQIHENYIVAQTEDSLVIVDQHAAHERLVYEALKNALHARPI
HHHHHHHHHHHCCHHHHHHHHHCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHCCCC
AGQMLLIPEIVDLPEEDAQRLAGHAETLARFGLGVEQFGPGAIAVRETPAMLGEMNVQQL
CCCEEECCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEECCHHHHHCCCHHHH
IRDLADEIAEHDTADGLKAMLHHVAATMACHGSVRSGRRLKPEEMNALLRDMEATPGSGT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
CNHGRPTYIELKLTDIERLFGRR
CCCCCCEEEEEEECHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA