Definition Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence.
Accession NC_012442
Length 1,185,518

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The map label for this gene is fumC

Identifier: 225686047

GI number: 225686047

Start: 176464

End: 177855

Strand: Reverse

Name: fumC

Synonym: BMEA_B0192

Alternate gene names: 225686047

Gene position: 177855-176464 (Counterclockwise)

Preceding gene: 225686048

Following gene: 225686046

Centisome position: 15.0

GC content: 59.77

Gene sequence:

>1392_bases
ATGGCCGCCACGCGTACCGAAACAGACACTTTCGGACCGATCGATGTTCCCGCAGACCGTTATTGGGGCGCACAGACACA
GCGTTCCCTGCAAAATTTCAGGATCGGCGGCGAGCGCATGCCCCTGCCCCTGGTTCACGCGCTGGGCGTGGTAAAGCGCG
CGGCGGCGGAAACCAATATCGCGCTCGGCAAGCTTGATCCCGTCCTGGGTCAGGTGATTGCGGTTGCCGCTTCCGAAGTC
ATTGAGGGCAAGCTCGACGACCATTTCCCGCTCGTAGTCTGGCAGACAGGCTCCGGCACGCAATCGAACATGAATGCCAA
TGAAGTGATCTCGAACCGGGCTATCGAGTTGCTCGGCGGGGAAATGGGCTCCAAAAAGCCGATCCACCCGAACGACCATG
TCAATATGAGCCAGTCTTCCAATGACAGTTTCCCGACGGCGATCCACATCGCCACGGCGGTCGAAACCGTCAACCGGCTC
TATCCCGCGCTCGAACACCTCACCAAAGCCCTGAAGGTCAAGGAAGAAGCATTCAAGGACATCATCAAGATTGGCCGCAC
CCACACGCAGGACGCAACACCTGTGACGCTGGGGCAGGAATTTTCGGGCTACCGCGCGGCACTTGAATATGCCCGCCATC
GGCTCGAACAATCGCTTGCCGACGTCTTCCTGCTGGCGCAGGGCGGCACGGCTGTCGGCACCGGTCTCAACGCACCTGTC
GGTTTCGACAAGGGCTTTGCCGAAGCGGTGAGCGAGATTACCGGGCTTTCCTTCAAGACCGCGCCAAACAAGTTCGAGGC
GCTGGCAAGCCACGGCGCCGTTCTCAACTTCCACGGCAGCCTGAATGCGCTTGCAGCCGATCTCTTCAAGATCGCCAACG
ATATCCGGTTTCTCGGTTCCGGCCCGCGTTCCGGCCTTGGCGAGCTTTCTCTGCCGGAAAACGAACCCGGCTCCTCCATC
ATGCCGGGCAAGGTCAACCCCACACAGGCCGAAGCCATGACCATGGTGGCAACCCAGGTTTTCGGCAACCAGACCGCCGT
AACCGTCGCCGCCAGCCAGGGGCATTTCGAGCTGAACGTCTTCAAACCGGTCATTGCCTATAATGTGCTGCAATCGATCC
GGCTTTTGAGCGACACCATGGTTTCCTTTGCCGATCATTGCGTCGAGGGGATTGAACCCAATACGGCCCGCATCAAGGAA
TTGCTGGAACGCTCGCTCATGCTCGTCACGGCGCTTGCGCCTGCCATCGGCTATGACAATGCGGCCAGGATCGCCAAAAC
CGCCCATAAGAACGGCACCACGCTTCGCGAGGAAGCATTGGCAAGCGGCCTCGTATCGGAAGAAGATTATGACCGGCTGG
TGCGCGCCGAGCGGATGATCGCCCCACAATGA

Upstream 100 bases:

>100_bases
TCATGTGTTCATCAATTAAACGTTTTGCCCGCCAGCAATCTGGCAGTGCTATAGAATGCGAAAAGGGCTCGTCCGAGCCT
CAGCCAGCCGGAGACATGAA

Downstream 100 bases:

>100_bases
ATTGCACGCAAATAGTGAACAAACTGTCGAGAATTAAGCATCTTTTCTTGACAATTACGAATCGCTAATTGATGGATCAA
TTCAACAGGAGAAAGCCCAC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MAATRTETDTFGPIDVPADRYWGAQTQRSLQNFRIGGERMPLPLVHALGVVKRAAAETNIALGKLDPVLGQVIAVAASEV
IEGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGEMGSKKPIHPNDHVNMSQSSNDSFPTAIHIATAVETVNRL
YPALEHLTKALKVKEEAFKDIIKIGRTHTQDATPVTLGQEFSGYRAALEYARHRLEQSLADVFLLAQGGTAVGTGLNAPV
GFDKGFAEAVSEITGLSFKTAPNKFEALASHGAVLNFHGSLNALAADLFKIANDIRFLGSGPRSGLGELSLPENEPGSSI
MPGKVNPTQAEAMTMVATQVFGNQTAVTVAASQGHFELNVFKPVIAYNVLQSIRLLSDTMVSFADHCVEGIEPNTARIKE
LLERSLMLVTALAPAIGYDNAARIAKTAHKNGTTLREEALASGLVSEEDYDRLVRAERMIAPQ

Sequences:

>Translated_463_residues
MAATRTETDTFGPIDVPADRYWGAQTQRSLQNFRIGGERMPLPLVHALGVVKRAAAETNIALGKLDPVLGQVIAVAASEV
IEGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGEMGSKKPIHPNDHVNMSQSSNDSFPTAIHIATAVETVNRL
YPALEHLTKALKVKEEAFKDIIKIGRTHTQDATPVTLGQEFSGYRAALEYARHRLEQSLADVFLLAQGGTAVGTGLNAPV
GFDKGFAEAVSEITGLSFKTAPNKFEALASHGAVLNFHGSLNALAADLFKIANDIRFLGSGPRSGLGELSLPENEPGSSI
MPGKVNPTQAEAMTMVATQVFGNQTAVTVAASQGHFELNVFKPVIAYNVLQSIRLLSDTMVSFADHCVEGIEPNTARIKE
LLERSLMLVTALAPAIGYDNAARIAKTAHKNGTTLREEALASGLVSEEDYDRLVRAERMIAPQ
>Mature_462_residues
AATRTETDTFGPIDVPADRYWGAQTQRSLQNFRIGGERMPLPLVHALGVVKRAAAETNIALGKLDPVLGQVIAVAASEVI
EGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGEMGSKKPIHPNDHVNMSQSSNDSFPTAIHIATAVETVNRLY
PALEHLTKALKVKEEAFKDIIKIGRTHTQDATPVTLGQEFSGYRAALEYARHRLEQSLADVFLLAQGGTAVGTGLNAPVG
FDKGFAEAVSEITGLSFKTAPNKFEALASHGAVLNFHGSLNALAADLFKIANDIRFLGSGPRSGLGELSLPENEPGSSIM
PGKVNPTQAEAMTMVATQVFGNQTAVTVAASQGHFELNVFKPVIAYNVLQSIRLLSDTMVSFADHCVEGIEPNTARIKEL
LERSLMLVTALAPAIGYDNAARIAKTAHKNGTTLREEALASGLVSEEDYDRLVRAERMIAPQ

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=63.7744034707158, Blast_Score=596, Evalue=1e-170,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=54.5454545454545, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=58.2608695652174, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=37.7440347071584, Blast_Score=318, Evalue=5e-88,
Organism=Caenorhabditis elegans, GI17553882, Length=465, Percent_Identity=65.8064516129032, Blast_Score=629, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=64.9390243902439, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=63.9913232104121, Blast_Score=604, Evalue=1e-174,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=64.2857142857143, Blast_Score=607, Evalue=1e-174,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=64.2857142857143, Blast_Score=606, Evalue=1e-173,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=61.3390928725702, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=60.9071274298056, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=53.2327586206897, Blast_Score=508, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_BRUME (Q8YB50)

Other databases:

- EMBL:   AE008918
- PIR:   AB3641
- RefSeq:   NP_542029.2
- ProteinModelPortal:   Q8YB50
- SMR:   Q8YB50
- GeneID:   1198823
- GenomeReviews:   AE008918_GR
- KEGG:   bme:BMEII1051
- HOGENOM:   HBG284369
- OMA:   RIEKDTM
- PhylomeDB:   Q8YB50
- ProtClustDB:   PRK00485
- BioCyc:   BMEL224914:BMEII1051-MONOMER
- BRENDA:   4.2.1.2
- HAMAP:   MF_00743
- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00979

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 49625; Mature: 49494

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 100-100

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATRTETDTFGPIDVPADRYWGAQTQRSLQNFRIGGERMPLPLVHALGVVKRAAAETNI
CCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
ALGKLDPVLGQVIAVAASEVIEGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIELLGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EMGSKKPIHPNDHVNMSQSSNDSFPTAIHIATAVETVNRLYPALEHLTKALKVKEEAFKD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPVTLGQEFSGYRAALEYARHRLEQSLADVFLLAQGGTAVGTGLNAPV
HHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEECCCCCCCC
GFDKGFAEAVSEITGLSFKTAPNKFEALASHGAVLNFHGSLNALAADLFKIANDIRFLGS
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCC
GPRSGLGELSLPENEPGSSIMPGKVNPTQAEAMTMVATQVFGNQTAVTVAASQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEH
FKPVIAYNVLQSIRLLSDTMVSFADHCVEGIEPNTARIKELLERSLMLVTALAPAIGYDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AARIAKTAHKNGTTLREEALASGLVSEEDYDRLVRAERMIAPQ
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AATRTETDTFGPIDVPADRYWGAQTQRSLQNFRIGGERMPLPLVHALGVVKRAAAETNI
CCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
ALGKLDPVLGQVIAVAASEVIEGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIELLGG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EMGSKKPIHPNDHVNMSQSSNDSFPTAIHIATAVETVNRLYPALEHLTKALKVKEEAFKD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPVTLGQEFSGYRAALEYARHRLEQSLADVFLLAQGGTAVGTGLNAPV
HHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEECCCCCCCC
GFDKGFAEAVSEITGLSFKTAPNKFEALASHGAVLNFHGSLNALAADLFKIANDIRFLGS
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCC
GPRSGLGELSLPENEPGSSIMPGKVNPTQAEAMTMVATQVFGNQTAVTVAASQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEH
FKPVIAYNVLQSIRLLSDTMVSFADHCVEGIEPNTARIKELLERSLMLVTALAPAIGYDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AARIAKTAHKNGTTLREEALASGLVSEEDYDRLVRAERMIAPQ
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688