Click here to switch to the map view.

The map label for this gene is hisS [H]

Identifier: 225686042

GI number: 225686042

Start: 171024

End: 172532

Strand: Direct

Name: hisS [H]

Synonym: BMEA_B0187

Alternate gene names: 225686042

Gene position: 171024-172532 (Clockwise)

Preceding gene: 225686041

Following gene: 225686043

Centisome position: 14.43

GC content: 60.3

Gene sequence:

>1509_bases
ATGGCCGATAAAGCGGACAAGATGAAGGCGCGGTTGCCGCGCGGGTTTGTCGATCGGGTGCCGGACGATTTGCGCGCCGC
CGAAAAAATGATGGCGACCATCCGCGAAGTCTATGACCTTTATGGCTTCGAACCGGTGGAAACGCCGCTTGTCGAATATA
CCGATGCGCTTGGAAAATTCCTGCCGGATCAGGACCGTCCGAACGAGGGCGTTTTCTCGTTTCAGGATGATGATGAACAA
TGGCTCTCGCTGCGCTATGACCTGACTGCGCCGCTGGCGCGCTATGTGGCGGAAAATTTCGAGACCCTGCCGAAGCCTTA
TCGCAGCTATCGCAACGGCTGGGTGTTCCGCAATGAAAAGCCGGGGCCGGGCCGTTTCCGCCAGTTCATGCAGTTCGATG
CCGATACGGTCGGCGCGCCGAATGTCTCGGCTGACGCCGAAATGTGCATGATGATGGCCGATACGCTGGAGCGCCTTGGC
ATCCAGCGCGGCGATTATGCTATCCGCGTCAACAACCGCAAGGTTCTCGACGGCGTTCTCGACGCCATCGGCCTTGAAGG
CGAAGGCAATGCAGCCAAGCGTCTCAATGTGTTGCGCGCCATCGACAAGCTCGACAAATTCGGCCCGGAAGGTGTGCGCC
TCCTGCTTGGCAAGGGGCGTCTGGACGAGAGTGGCGACTTTACCAAGGGTGCGCAATTGCCGGAAGCGGCCATTGAAAAG
GTTCTGGCCTTCACCGCTGCCGGTGGCGCGGATGGGGCGCAAACCATCGCCAATCTTCAAGCGGTTGTGGCAGGCAATGC
CAAGGGTGAGGAAGGCGTACAGGAACTGGCCGACATGCAGGCGCTGTTCTTCGCTGGTGGTTATGAAGGCCGGGTGAAGA
TCGATCCCTCCGTCGTGCGCGGCCTGGAATATTATACCGGCCCGGTTTTTGAGGCGGAGCTTCTGTTCGACGTCACCAAT
GAGGACGGCCAGAAGGTCGTGTTCGGTTCGGTCGGTGGCGGCGGGCGCTATGACGGTCTCGTCTCGCGCTTCCGTGGCGA
GCCGGTTCCCGCGACGGGTTTCTCCATCGGTGTTTCGCGCCTGATGACCGCGCTGAAGAATCTCGGCAAGCTGGATGTTT
CCGACACGGTTGGCCCAGTGGTCGTGCTGGTGATGGACAAGGATACGCAAAACCTTAGCCGCTACCAGAAAATGGTTTCC
GATCTGCGCAAGGCAGGCATCCGCGCAGAAATGTATGTCGGCGGGTCCGGCATGAAGGCGCAGATGAAATATGCTGACCG
CCGCGCCGCACCTTGCGTCGTCATTCAGGGCTCGCAGGAGCGCGAGGCTGGTGAGGTGCAGATCAAGGATCTGGTGGAAG
GCAAGCGTCTTTCCGCCGAGATCGAGGATAATGTCACCTGGCGGGAAAGCCGCCCGGCGCAGATTACGGTCCGGGAAGAC
GGGCTGGTCGACGCTGTCCGCGAAATCCTTGATGCCCAGGCGCGCGACCGCGCCGAACAATCGAAGTGA

Upstream 100 bases:

>100_bases
CGCACTTGCCGCAACGGGCTTGATCGGTTAGGAAACCGGCAGCGAATGTGCCGGTTCCTTCCGGCGCGACAGGAACAAAA
TCAGCGATCAGGCAGGAAAA

Downstream 100 bases:

>100_bases
TCGTGACCATGGTTGGATCGCGCACATCGCCGATATTTAATGCGCTCCGCGTAGAGCTTAATGCGCGCGAAGCCGAACTG
GTGGAAATTCCGCTGATCCA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MADKADKMKARLPRGFVDRVPDDLRAAEKMMATIREVYDLYGFEPVETPLVEYTDALGKFLPDQDRPNEGVFSFQDDDEQ
WLSLRYDLTAPLARYVAENFETLPKPYRSYRNGWVFRNEKPGPGRFRQFMQFDADTVGAPNVSADAEMCMMMADTLERLG
IQRGDYAIRVNNRKVLDGVLDAIGLEGEGNAAKRLNVLRAIDKLDKFGPEGVRLLLGKGRLDESGDFTKGAQLPEAAIEK
VLAFTAAGGADGAQTIANLQAVVAGNAKGEEGVQELADMQALFFAGGYEGRVKIDPSVVRGLEYYTGPVFEAELLFDVTN
EDGQKVVFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSRLMTALKNLGKLDVSDTVGPVVVLVMDKDTQNLSRYQKMVS
DLRKAGIRAEMYVGGSGMKAQMKYADRRAAPCVVIQGSQEREAGEVQIKDLVEGKRLSAEIEDNVTWRESRPAQITVRED
GLVDAVREILDAQARDRAEQSK

Sequences:

>Translated_502_residues
MADKADKMKARLPRGFVDRVPDDLRAAEKMMATIREVYDLYGFEPVETPLVEYTDALGKFLPDQDRPNEGVFSFQDDDEQ
WLSLRYDLTAPLARYVAENFETLPKPYRSYRNGWVFRNEKPGPGRFRQFMQFDADTVGAPNVSADAEMCMMMADTLERLG
IQRGDYAIRVNNRKVLDGVLDAIGLEGEGNAAKRLNVLRAIDKLDKFGPEGVRLLLGKGRLDESGDFTKGAQLPEAAIEK
VLAFTAAGGADGAQTIANLQAVVAGNAKGEEGVQELADMQALFFAGGYEGRVKIDPSVVRGLEYYTGPVFEAELLFDVTN
EDGQKVVFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSRLMTALKNLGKLDVSDTVGPVVVLVMDKDTQNLSRYQKMVS
DLRKAGIRAEMYVGGSGMKAQMKYADRRAAPCVVIQGSQEREAGEVQIKDLVEGKRLSAEIEDNVTWRESRPAQITVRED
GLVDAVREILDAQARDRAEQSK
>Mature_501_residues
ADKADKMKARLPRGFVDRVPDDLRAAEKMMATIREVYDLYGFEPVETPLVEYTDALGKFLPDQDRPNEGVFSFQDDDEQW
LSLRYDLTAPLARYVAENFETLPKPYRSYRNGWVFRNEKPGPGRFRQFMQFDADTVGAPNVSADAEMCMMMADTLERLGI
QRGDYAIRVNNRKVLDGVLDAIGLEGEGNAAKRLNVLRAIDKLDKFGPEGVRLLLGKGRLDESGDFTKGAQLPEAAIEKV
LAFTAAGGADGAQTIANLQAVVAGNAKGEEGVQELADMQALFFAGGYEGRVKIDPSVVRGLEYYTGPVFEAELLFDVTNE
DGQKVVFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSRLMTALKNLGKLDVSDTVGPVVVLVMDKDTQNLSRYQKMVSD
LRKAGIRAEMYVGGSGMKAQMKYADRRAAPCVVIQGSQEREAGEVQIKDLVEGKRLSAEIEDNVTWRESRPAQITVREDG
LVDAVREILDAQARDRAEQSK

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=482, Percent_Identity=30.0829875518672, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI15029520, Length=477, Percent_Identity=30.188679245283, Blast_Score=178, Evalue=1e-44,
Organism=Escherichia coli, GI1788861, Length=466, Percent_Identity=25.9656652360515, Blast_Score=123, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71993686, Length=510, Percent_Identity=29.4117647058824, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71993693, Length=510, Percent_Identity=29.4117647058824, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6325290, Length=532, Percent_Identity=28.7593984962406, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24643061, Length=485, Percent_Identity=31.5463917525773, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24643059, Length=504, Percent_Identity=30.1587301587302, Blast_Score=172, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 55209; Mature: 55078

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKADKMKARLPRGFVDRVPDDLRAAEKMMATIREVYDLYGFEPVETPLVEYTDALGKF
CCCCHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LPDQDRPNEGVFSFQDDDEQWLSLRYDLTAPLARYVAENFETLPKPYRSYRNGWVFRNEK
CCCCCCCCCCCEECCCCCHHHHEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCEEEECCC
PGPGRFRQFMQFDADTVGAPNVSADAEMCMMMADTLERLGIQRGDYAIRVNNRKVLDGVL
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
DAIGLEGEGNAAKRLNVLRAIDKLDKFGPEGVRLLLGKGRLDESGDFTKGAQLPEAAIEK
HHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHH
VLAFTAAGGADGAQTIANLQAVVAGNAKGEEGVQELADMQALFFAGGYEGRVKIDPSVVR
HHHHHCCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECHHHHH
GLEYYTGPVFEAELLFDVTNEDGQKVVFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSR
HHHHHCCCCEEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
LMTALKNLGKLDVSDTVGPVVVLVMDKDTQNLSRYQKMVSDLRKAGIRAEMYVGGSGMKA
HHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCH
QMKYADRRAAPCVVIQGSQEREAGEVQIKDLVEGKRLSAEIEDNVTWRESRPAQITVRED
HHHHHHCCCCCEEEEECCCCCCCCCEEHHHHHCCCCCCCCCCCCCEECCCCCCEEEEECC
GLVDAVREILDAQARDRAEQSK
CHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADKADKMKARLPRGFVDRVPDDLRAAEKMMATIREVYDLYGFEPVETPLVEYTDALGKF
CCCHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LPDQDRPNEGVFSFQDDDEQWLSLRYDLTAPLARYVAENFETLPKPYRSYRNGWVFRNEK
CCCCCCCCCCCEECCCCCHHHHEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCEEEECCC
PGPGRFRQFMQFDADTVGAPNVSADAEMCMMMADTLERLGIQRGDYAIRVNNRKVLDGVL
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
DAIGLEGEGNAAKRLNVLRAIDKLDKFGPEGVRLLLGKGRLDESGDFTKGAQLPEAAIEK
HHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHH
VLAFTAAGGADGAQTIANLQAVVAGNAKGEEGVQELADMQALFFAGGYEGRVKIDPSVVR
HHHHHCCCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECHHHHH
GLEYYTGPVFEAELLFDVTNEDGQKVVFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSR
HHHHHCCCCEEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
LMTALKNLGKLDVSDTVGPVVVLVMDKDTQNLSRYQKMVSDLRKAGIRAEMYVGGSGMKA
HHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCH
QMKYADRRAAPCVVIQGSQEREAGEVQIKDLVEGKRLSAEIEDNVTWRESRPAQITVRED
HHHHHHCCCCCEEEEECCCCCCCCCEEHHHHHCCCCCCCCCCCCCEECCCCCCEEEEECC
GLVDAVREILDAQARDRAEQSK
CHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA