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The map label for this gene is pdhR [H]

Identifier: 225686032

GI number: 225686032

Start: 160978

End: 161790

Strand: Reverse

Name: pdhR [H]

Synonym: BMEA_B0177

Alternate gene names: 225686032

Gene position: 161790-160978 (Counterclockwise)

Preceding gene: 225686033

Following gene: 225686030

Centisome position: 13.65

GC content: 60.02

Gene sequence:

>813_bases
ATGGCCGACACAGTTTTTTCTCGTATACAAGCAAGCCGCACGGCGGACGACGTGGTTCACCAGATCGAATCGCTCATCCT
TGAGGGGGTTCTGCGCGGCGGTGATCGCCTTCCCGGCGAACGCGAGCTTGCGCGCCAGTTCGACATTTCCCGCCCCATCC
TGCGCGATGCGCTGAAGCGCCTTGAAACGGCAGGCCTGCTCACATCACGCCATGGCGGCGGCACCTTCGTTGCCGATGTC
ATCGGACAGGTTTTCAGCGCGCCTGTGGTGAAGCTCTTTGCCGATCATCACAAGGCCACCGCCGATTATCTCGAATATCG
CCGGGAGATTGAAAGCGTAGCCGCCGAATATGCCGCGCTGCGCGCCACGCCCGCCGACCGCGCGCTCCTGACCGAGATCA
TGAACGCGATGGAAAAGGCCCACGGCGCTGACGATTTCGCCACCGAGGCACGTCTCGACGTGGAACTGCACAATGCCATT
GGTGAGGCGGCGCATAATATTGTGCTGCTGCACACCTTGCGCTCCTGCTACCAGCTTTTGAAGGACGGTGTATTCTACAA
TCGCAGCGTGATCTATAATCACCCGGGCGTGGCCGATGTGTTCCTTTCCCAGCACCGCGCCATCTACGATGCGGTGATGG
CTGGAAACCCACAGGCCGCGCGCGAAGCAGTGCAGAAACATATCCGCTTCGTCGAACAGGCAACGCATGACTGCGCCTTG
AACGACGAACGTGAGAGGGTGGCGCGCCTTCGCTATCGCCAGCGCGCCGGCTCCAAGGAACTTAAAGAAATCAGGGAAGA
CGAGAGCGAATGA

Upstream 100 bases:

>100_bases
TTGCGGCGCTTACGTTTTTTCTTTTGCATCTCGTCGGACCACCGTTGCCCGGCACCGTCCTAAGGGCTACCTTGCCGGAG
AATAGAGGGTTTTTCACGGC

Downstream 100 bases:

>100_bases
ACGGCATCCCGTTCAAAGATGCGCGTTAAAACAAAGGATTAGAGCGCCGATCCGATTCATTCAGATCGAAACGCGCTTTA
ATGTGCGCTGGAAATACCGT

Product: GntR domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MADTVFSRIQASRTADDVVHQIESLILEGVLRGGDRLPGERELARQFDISRPILRDALKRLETAGLLTSRHGGGTFVADV
IGQVFSAPVVKLFADHHKATADYLEYRREIESVAAEYAALRATPADRALLTEIMNAMEKAHGADDFATEARLDVELHNAI
GEAAHNIVLLHTLRSCYQLLKDGVFYNRSVIYNHPGVADVFLSQHRAIYDAVMAGNPQAAREAVQKHIRFVEQATHDCAL
NDERERVARLRYRQRAGSKELKEIREDESE

Sequences:

>Translated_270_residues
MADTVFSRIQASRTADDVVHQIESLILEGVLRGGDRLPGERELARQFDISRPILRDALKRLETAGLLTSRHGGGTFVADV
IGQVFSAPVVKLFADHHKATADYLEYRREIESVAAEYAALRATPADRALLTEIMNAMEKAHGADDFATEARLDVELHNAI
GEAAHNIVLLHTLRSCYQLLKDGVFYNRSVIYNHPGVADVFLSQHRAIYDAVMAGNPQAAREAVQKHIRFVEQATHDCAL
NDERERVARLRYRQRAGSKELKEIREDESE
>Mature_269_residues
ADTVFSRIQASRTADDVVHQIESLILEGVLRGGDRLPGERELARQFDISRPILRDALKRLETAGLLTSRHGGGTFVADVI
GQVFSAPVVKLFADHHKATADYLEYRREIESVAAEYAALRATPADRALLTEIMNAMEKAHGADDFATEARLDVELHNAIG
EAAHNIVLLHTLRSCYQLLKDGVFYNRSVIYNHPGVADVFLSQHRAIYDAVMAGNPQAAREAVQKHIRFVEQATHDCALN
DERERVARLRYRQRAGSKELKEIREDESE

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=232, Percent_Identity=43.5344827586207, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1790032, Length=224, Percent_Identity=40.625, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789353, Length=226, Percent_Identity=33.1858407079646, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790780, Length=233, Percent_Identity=30.0429184549356, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082208, Length=208, Percent_Identity=27.4038461538462, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789621, Length=234, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 30238; Mature: 30107

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTVFSRIQASRTADDVVHQIESLILEGVLRGGDRLPGERELARQFDISRPILRDALKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHH
LETAGLLTSRHGGGTFVADVIGQVFSAPVVKLFADHHKATADYLEYRREIESVAAEYAAL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RATPADRALLTEIMNAMEKAHGADDFATEARLDVELHNAIGEAAHNIVLLHTLRSCYQLL
HCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDGVFYNRSVIYNHPGVADVFLSQHRAIYDAVMAGNPQAAREAVQKHIRFVEQATHDCAL
HCCCHHCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
NDERERVARLRYRQRAGSKELKEIREDESE
CHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure 
ADTVFSRIQASRTADDVVHQIESLILEGVLRGGDRLPGERELARQFDISRPILRDALKR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHH
LETAGLLTSRHGGGTFVADVIGQVFSAPVVKLFADHHKATADYLEYRREIESVAAEYAAL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RATPADRALLTEIMNAMEKAHGADDFATEARLDVELHNAIGEAAHNIVLLHTLRSCYQLL
HCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDGVFYNRSVIYNHPGVADVFLSQHRAIYDAVMAGNPQAAREAVQKHIRFVEQATHDCAL
HCCCHHCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
NDERERVARLRYRQRAGSKELKEIREDESE
CHHHHHHHHHHHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]