Definition Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence.
Accession NC_012442
Length 1,185,518

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The map label for this gene is ygbJ [C]

Identifier: 225686007

GI number: 225686007

Start: 141121

End: 142029

Strand: Reverse

Name: ygbJ [C]

Synonym: BMEA_B0150

Alternate gene names: 225686007

Gene position: 142029-141121 (Counterclockwise)

Preceding gene: 225686021

Following gene: 225686006

Centisome position: 11.98

GC content: 56.0

Gene sequence:

>909_bases
GTGATTATGGTGTCTTCAGATTACAGCGTATGTATCGTGGGCCTCGGCTCAATGGGTATGGGCGTCGCCCAATCCTGTAT
CGCGGCCGGTCTTCGCACCTATGGCATCGATCTTGATCCGGCCAAATGTGAGGCGATCATAAAGGCGGGCGCAATTGGCG
CTTCATCGCGGTGCGAAGCGGCAGGAAAACTGGATGCCCTGGTTCTGCTTGTGGTGAATGCCGCACAATGCAAGGCGGTG
CTGTTTGGAGAAAATGGCCTTGCCGCTCAAATGAAACCCGGCGCCGCCGTGATGGTTTCATCAACCATCTCAGCCGCCGA
TGCCAAGGAGATTGCGGCAGCACTCGAAGCCTATAATCTTCTGATGCTGGATGCGCCTGTTTCCGGCGGCGCGGCAAAAG
CGGCAAGCGGGGATATCACGGTTATGGCTTCCGGTTCGCGCGAAGCTTTCGAGAAATTGCGCCCCGTGCTCAATGCCGCC
GCTGGCAAGGTTTACGAGATCGGCCAGGAAATCGGGCTGGGAGCAACCGTCAAGATCATCCATCAATTGCTGGCAGGCGT
ACATATTGCAGCCGGTGCAGAAGCAATGGCGCTTGCCGCCCGTTCCGGCATTCCGCTCGACATCATGTATGACGTGGTTA
CACATGCGGCTGGCAATAGCTGGATGTTTGAAAACCGCATGAAACATGTGGTGGATGGCGATTATACGCCCAAATCCGCC
GTCGATATTTTTGTCAAGGATCTGCGCCTGGTGACGGAAACCGGGCTTTCCATGAACTTCCCGCTGCCGCTTGCAACAAC
GGCCTACAGCCTGTTCGCCAATGCCTCGAATGCCGGCTTTGGCAAAGAAGATGATGCCGCCGTTATCAAGACATATGCCG
GCATCAAACTTCCCGACAGGAGTGCATGA

Upstream 100 bases:

>100_bases
CGTACCATATTTTAACATATATCGCTTTTTTATGAGAATTTTTGATAAAATATGTTCATAATCGAATTGTTTTATTATAT
GATCCTCATAAACGCACGGA

Downstream 100 bases:

>100_bases
CATGCGCCTTGGCGTCATTGCAGACGATTTTACCGGAGCAACCGATATCGCAGGATTTCTGGTTGGCAACGGCCTGCGCA
CCATTCAGCTGAATGGCGTT

Product: 2-hydroxy-3-oxopropionate reductase

Products: acetoacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MIMVSSDYSVCIVGLGSMGMGVAQSCIAAGLRTYGIDLDPAKCEAIIKAGAIGASSRCEAAGKLDALVLLVVNAAQCKAV
LFGENGLAAQMKPGAAVMVSSTISAADAKEIAAALEAYNLLMLDAPVSGGAAKAASGDITVMASGSREAFEKLRPVLNAA
AGKVYEIGQEIGLGATVKIIHQLLAGVHIAAGAEAMALAARSGIPLDIMYDVVTHAAGNSWMFENRMKHVVDGDYTPKSA
VDIFVKDLRLVTETGLSMNFPLPLATTAYSLFANASNAGFGKEDDAAVIKTYAGIKLPDRSA

Sequences:

>Translated_302_residues
MIMVSSDYSVCIVGLGSMGMGVAQSCIAAGLRTYGIDLDPAKCEAIIKAGAIGASSRCEAAGKLDALVLLVVNAAQCKAV
LFGENGLAAQMKPGAAVMVSSTISAADAKEIAAALEAYNLLMLDAPVSGGAAKAASGDITVMASGSREAFEKLRPVLNAA
AGKVYEIGQEIGLGATVKIIHQLLAGVHIAAGAEAMALAARSGIPLDIMYDVVTHAAGNSWMFENRMKHVVDGDYTPKSA
VDIFVKDLRLVTETGLSMNFPLPLATTAYSLFANASNAGFGKEDDAAVIKTYAGIKLPDRSA
>Mature_302_residues
MIMVSSDYSVCIVGLGSMGMGVAQSCIAAGLRTYGIDLDPAKCEAIIKAGAIGASSRCEAAGKLDALVLLVVNAAQCKAV
LFGENGLAAQMKPGAAVMVSSTISAADAKEIAAALEAYNLLMLDAPVSGGAAKAASGDITVMASGSREAFEKLRPVLNAA
AGKVYEIGQEIGLGATVKIIHQLLAGVHIAAGAEAMALAARSGIPLDIMYDVVTHAAGNSWMFENRMKHVVDGDYTPKSA
VDIFVKDLRLVTETGLSMNFPLPLATTAYSLFANASNAGFGKEDDAAVIKTYAGIKLPDRSA

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=294, Percent_Identity=27.891156462585, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI40556376, Length=290, Percent_Identity=24.1379310344828, Blast_Score=101, Evalue=9e-22,
Organism=Escherichia coli, GI1789092, Length=294, Percent_Identity=70.0680272108844, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI145693186, Length=283, Percent_Identity=31.8021201413428, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1790315, Length=283, Percent_Identity=26.8551236749117, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786719, Length=279, Percent_Identity=25.089605734767, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17557316, Length=269, Percent_Identity=25.2788104089219, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28574115, Length=289, Percent_Identity=25.9515570934256, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24655230, Length=287, Percent_Identity=25.4355400696864, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19922568, Length=287, Percent_Identity=25.4355400696864, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.1.30

Molecular weight: Translated: 30945; Mature: 30945

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMVSSDYSVCIVGLGSMGMGVAQSCIAAGLRTYGIDLDPAKCEAIIKAGAIGASSRCEA
CEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCC
AGKLDALVLLVVNAAQCKAVLFGENGLAAQMKPGAAVMVSSTISAADAKEIAAALEAYNL
CCCHHEEEHEEECHHHEEEEEECCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHEE
LMLDAPVSGGAAKAASGDITVMASGSREAFEKLRPVLNAAAGKVYEIGQEIGLGATVKII
EEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHH
HQLLAGVHIAAGAEAMALAARSGIPLDIMYDVVTHAAGNSWMFENRMKHVVDGDYTPKSA
HHHHHCCCHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCHHH
VDIFVKDLRLVTETGLSMNFPLPLATTAYSLFANASNAGFGKEDDAAVIKTYAGIKLPDR
HHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCC
SA
CC
>Mature Secondary Structure
MIMVSSDYSVCIVGLGSMGMGVAQSCIAAGLRTYGIDLDPAKCEAIIKAGAIGASSRCEA
CEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCC
AGKLDALVLLVVNAAQCKAVLFGENGLAAQMKPGAAVMVSSTISAADAKEIAAALEAYNL
CCCHHEEEHEEECHHHEEEEEECCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHEE
LMLDAPVSGGAAKAASGDITVMASGSREAFEKLRPVLNAAAGKVYEIGQEIGLGATVKII
EEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHH
HQLLAGVHIAAGAEAMALAARSGIPLDIMYDVVTHAAGNSWMFENRMKHVVDGDYTPKSA
HHHHHCCCHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCHHH
VDIFVKDLRLVTETGLSMNFPLPLATTAYSLFANASNAGFGKEDDAAVIKTYAGIKLPDR
HHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCC
SA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-3-hydroxybutanoate; NAD+

Specific reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]