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The map label for this gene is fdh [H]

Identifier: 222527358

GI number: 222527358

Start: 5133579

End: 5134604

Strand: Reverse

Name: fdh [H]

Synonym: Chy400_4147

Alternate gene names: 222527358

Gene position: 5134604-5133579 (Counterclockwise)

Preceding gene: 222527360

Following gene: 222527357

Centisome position: 97.45

GC content: 53.51

Gene sequence:

>1026_bases
ATGCGCGGTACTGCGCTATATGGCCCATATGACGTGCGTTCAGAGTATGTTCCTGATCCGACGATCATCGAACCAACAGA
TGCCATTATTCGCTTGTCGGCAACCTGTATTTGTGGCTCAGATCTCTGGCCGTATCGGGGTGTTGATCCTATAACTCGTC
CTGTACCGATGGGTCATGAATATGTTGGGATTGTCGAGGAAGTTGGCAGTGCAGTCAAAATAATCAAGCCTGGTCAGTTT
GTTGTTGGCTCGTTCTTCGCTTCCGACAACACCTGTCCAATATGTCAGGCTGGTTATCAAACCTCGTGTGTGAATCGTCA
ACCGGGTGCACCTACTGGGGCGCAGGCGGAGTATGCGCGTATTCCACTGGCCGATGGGACATTGGTGCCTACACCTGATC
TCCCTCCTGCCGATTTGATTCCTGACCTGCTGGCAGCTTCGGATGTGCTGGGTACCGGCTGGTTTGCAGCCGTTGCGGCA
GAGGTCGGGCCTGGAAAAACGGTAGCTGTGGTTGGTGACGGTGCCGTCGGGTTACTGGCAGTTCTATCAGCGCGACAAAT
GGGTGCCGAACGGATTATTCTGATCGGAAGTCGCCATCCACAACGGCAGGCGCTGGCCCAAGAGTTTGGTGCAACGGATG
TTATTGAGGCGCGAGGTGATGAGGCGATTGAGATGCTCAAAGAGCTTACCGATGGCTTGGGTGTACACTCAACGATAGAA
GCTGTCGGTACGCAAGAGTCAATGATGCAGGCGATTCGGGCCACCCGGCCTGGTGGACATGTAGGTGTTGTCGGTGTTCT
CCACGATGTGGCTATTCCAGGTCGTGAGTTCTTCTTTTCACATGTTCACCTGCACGGTGGTCCTGCACCGGTGCGTCGTT
TTTTGCCGGAATTGATCAATCTCATCTGGCAACGTGTAATCAAACCCGGTAAAGTTTTTGACCTGACACTACCGCTGGAA
CAGGTTGCAGAAGGCTATCGTGCAATGGACGAGCGCCGGGCAATTAAGGTGCTACTGAAGCCATAG

Upstream 100 bases:

>100_bases
AATGCTGGACTATCATTCTATCACAGACACCTCTCCTTTCTCTACAATGACAAACAAGTCAAGAACACGAGGCTCCACCT
GCATGATATTAGGAGGGTAT

Downstream 100 bases:

>100_bases
GAGCGACATCAACATTTGTCGCCCATGATAAAAGCAAAGGCTAATCGGTTGTTGCAAGGAGGCTTGCCAATGAGTGTGTG
GAAACCCGAAGATATTGACG

Product: alcohol dehydrogenase zinc-binding domain-containing protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRGTALYGPYDVRSEYVPDPTIIEPTDAIIRLSATCICGSDLWPYRGVDPITRPVPMGHEYVGIVEEVGSAVKIIKPGQF
VVGSFFASDNTCPICQAGYQTSCVNRQPGAPTGAQAEYARIPLADGTLVPTPDLPPADLIPDLLAASDVLGTGWFAAVAA
EVGPGKTVAVVGDGAVGLLAVLSARQMGAERIILIGSRHPQRQALAQEFGATDVIEARGDEAIEMLKELTDGLGVHSTIE
AVGTQESMMQAIRATRPGGHVGVVGVLHDVAIPGREFFFSHVHLHGGPAPVRRFLPELINLIWQRVIKPGKVFDLTLPLE
QVAEGYRAMDERRAIKVLLKP

Sequences:

>Translated_341_residues
MRGTALYGPYDVRSEYVPDPTIIEPTDAIIRLSATCICGSDLWPYRGVDPITRPVPMGHEYVGIVEEVGSAVKIIKPGQF
VVGSFFASDNTCPICQAGYQTSCVNRQPGAPTGAQAEYARIPLADGTLVPTPDLPPADLIPDLLAASDVLGTGWFAAVAA
EVGPGKTVAVVGDGAVGLLAVLSARQMGAERIILIGSRHPQRQALAQEFGATDVIEARGDEAIEMLKELTDGLGVHSTIE
AVGTQESMMQAIRATRPGGHVGVVGVLHDVAIPGREFFFSHVHLHGGPAPVRRFLPELINLIWQRVIKPGKVFDLTLPLE
QVAEGYRAMDERRAIKVLLKP
>Mature_341_residues
MRGTALYGPYDVRSEYVPDPTIIEPTDAIIRLSATCICGSDLWPYRGVDPITRPVPMGHEYVGIVEEVGSAVKIIKPGQF
VVGSFFASDNTCPICQAGYQTSCVNRQPGAPTGAQAEYARIPLADGTLVPTPDLPPADLIPDLLAASDVLGTGWFAAVAA
EVGPGKTVAVVGDGAVGLLAVLSARQMGAERIILIGSRHPQRQALAQEFGATDVIEARGDEAIEMLKELTDGLGVHSTIE
AVGTQESMMQAIRATRPGGHVGVVGVLHDVAIPGREFFFSHVHLHGGPAPVRRFLPELINLIWQRVIKPGKVFDLTLPLE
QVAEGYRAMDERRAIKVLLKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=365, Percent_Identity=27.3972602739726, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=27.0777479892761, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI34577061, Length=343, Percent_Identity=27.4052478134111, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71565154, Length=348, Percent_Identity=28.1609195402299, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI71743840, Length=341, Percent_Identity=26.099706744868, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI262073058, Length=341, Percent_Identity=26.099706744868, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1786825, Length=399, Percent_Identity=31.8295739348371, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1788075, Length=347, Percent_Identity=27.6657060518732, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI87082125, Length=358, Percent_Identity=25.6983240223464, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788407, Length=251, Percent_Identity=26.6932270916335, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790045, Length=272, Percent_Identity=27.2058823529412, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786552, Length=348, Percent_Identity=27.8735632183908, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788073, Length=270, Percent_Identity=27.037037037037, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI226510992, Length=323, Percent_Identity=25.3869969040248, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787863, Length=322, Percent_Identity=23.9130434782609, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081918, Length=246, Percent_Identity=29.2682926829268, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17562876, Length=348, Percent_Identity=27.8735632183908, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=265, Percent_Identity=27.5471698113208, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=269, Percent_Identity=31.5985130111524, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=287, Percent_Identity=26.1324041811847, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=289, Percent_Identity=27.3356401384083, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=265, Percent_Identity=26.7924528301887, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=286, Percent_Identity=29.7202797202797, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=280, Percent_Identity=31.0714285714286, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=274, Percent_Identity=25.9124087591241, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=281, Percent_Identity=26.6903914590747, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17737895, Length=347, Percent_Identity=29.1066282420749, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137530, Length=266, Percent_Identity=30.0751879699248, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737897, Length=271, Percent_Identity=28.7822878228782, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 36391; Mature: 36391

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGTALYGPYDVRSEYVPDPTIIEPTDAIIRLSATCICGSDLWPYRGVDPITRPVPMGHE
CCCCCCCCCHHCCCCCCCCCCEECCCHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCCCH
YVGIVEEVGSAVKIIKPGQFVVGSFFASDNTCPICQAGYQTSCVNRQPGAPTGAQAEYAR
HHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
IPLADGTLVPTPDLPPADLIPDLLAASDVLGTGWFAAVAAEVGPGKTVAVVGDGAVGLLA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCHHHHHH
VLSARQMGAERIILIGSRHPQRQALAQEFGATDVIEARGDEAIEMLKELTDGLGVHSTIE
HHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCHHHHH
AVGTQESMMQAIRATRPGGHVGVVGVLHDVAIPGREFFFSHVHLHGGPAPVRRFLPELIN
HHCCHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCHHHHEEEEEECCCHHHHHHHHHHHHH
LIWQRVIKPGKVFDLTLPLEQVAEGYRAMDERRAIKVLLKP
HHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MRGTALYGPYDVRSEYVPDPTIIEPTDAIIRLSATCICGSDLWPYRGVDPITRPVPMGHE
CCCCCCCCCHHCCCCCCCCCCEECCCHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCCCH
YVGIVEEVGSAVKIIKPGQFVVGSFFASDNTCPICQAGYQTSCVNRQPGAPTGAQAEYAR
HHHHHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
IPLADGTLVPTPDLPPADLIPDLLAASDVLGTGWFAAVAAEVGPGKTVAVVGDGAVGLLA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCHHHHHH
VLSARQMGAERIILIGSRHPQRQALAQEFGATDVIEARGDEAIEMLKELTDGLGVHSTIE
HHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCHHHHH
AVGTQESMMQAIRATRPGGHVGVVGVLHDVAIPGREFFFSHVHLHGGPAPVRRFLPELIN
HHCCHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCHHHHEEEEEECCCHHHHHHHHHHHHH
LIWQRVIKPGKVFDLTLPLEQVAEGYRAMDERRAIKVLLKP
HHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]