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The map label for this gene is yccK [H]

Identifier: 222527356

GI number: 222527356

Start: 5131822

End: 5132820

Strand: Reverse

Name: yccK [H]

Synonym: Chy400_4145

Alternate gene names: 222527356

Gene position: 5132820-5131822 (Counterclockwise)

Preceding gene: 222527357

Following gene: 222527346

Centisome position: 97.42

GC content: 51.25

Gene sequence:

>999_bases
ATGAAACAACGCAGGCTGGGCAATAGCGATTTGAACGTCTCGGCGATTGGTTTAGGCTGCATGACCATGACCGGTGGCTA
CAGTGTTTCTCCGAATCGTCAAGAGATGATCGCACTATTGCGCAAAGCTGTTGAGTTGGGGGTCACATTCTTCGATACTG
CCGAAGTGTATGGTCCATTCATTAACGAGGAACTTGTCGGCGAAGCTCTCGAACCATTTAAGGGGCAGGTTGTTATTGCC
ACCAAGTTCGGATTCAAGCATGATCACAACAATCGCCCTACCCCTGCTGCGGGTTTAGACAGTCGCCCTGAACAGATCAA
ACGAGTTGCCGAAGCATCATTGAAGAGATTAAGAGTGGAAGCAATCGATCTCTTCTATCAGCATCGGGTTGATCCGAATG
TGCCTATCGAAGAGGTGGCAGGGGCGGTGAAAGATTTAATCCAGGCCGGAAAGGTCAGATACTTTGGCATGTCAGAAGCG
GGGGCGCATACGCTTCGGCGTGCACACGCAGTTTGTACGGTGACGGCAGTCCAATACGAATACTCGCTATGGTGGCGACG
CCCTGAGCAAGACATCCTCCCTCTTTGTGAAGAGTTGGGAATCGGTTTTGTCCCGTACAGTCCTTTGGGGAAAGGATTCC
TTACCGGGAAAATAGATGCAACGACCCACTTTGATAGCACCGATTTGCGTAGTCGTATCCCGCGCTTTACATCAGAGGCA
CGCAAAGCTAATCAGGCGCTGGTTGATCTCCTCGACGAGATTGCCCGCCAACATCATGCCACACCGGCGCAGATTGCACT
GGCCTGGTTATTAGCTCAGAAGCCCTGGATTGTGCCTATCCCGGGTACAACGAAACTGCATCGTCTCGAAGAGAATATCG
GTGCAGTGAAGGTTGAGCTGACGTCATCTGATCTACAAAGAATCAATGATGCAGTGGCTCTGATCCCCATTCAGGGCGCA
CGCTATCCTGAAGAATTGGAGCGGATGACCTATCTGTAG

Upstream 100 bases:

>100_bases
ACTATCGAATTGCCAACGACGTATCTTTATTTGATCCGCTGGTCGTGAAGGCACCAGATGACAGGCAACTTCACGCATAA
GCCTGGAAGGAGTACCATGT

Downstream 100 bases:

>100_bases
AACGTACCCCAACATGTATGATGCCGTTGTAAAAATGATCATAGCCGACAGTTGGCTTTGAGGTACATCCTTAAATATCT
TCAGGATGAAGGATCATATC

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKQRRLGNSDLNVSAIGLGCMTMTGGYSVSPNRQEMIALLRKAVELGVTFFDTAEVYGPFINEELVGEALEPFKGQVVIA
TKFGFKHDHNNRPTPAAGLDSRPEQIKRVAEASLKRLRVEAIDLFYQHRVDPNVPIEEVAGAVKDLIQAGKVRYFGMSEA
GAHTLRRAHAVCTVTAVQYEYSLWWRRPEQDILPLCEELGIGFVPYSPLGKGFLTGKIDATTHFDSTDLRSRIPRFTSEA
RKANQALVDLLDEIARQHHATPAQIALAWLLAQKPWIVPIPGTTKLHRLEENIGAVKVELTSSDLQRINDAVALIPIQGA
RYPEELERMTYL

Sequences:

>Translated_332_residues
MKQRRLGNSDLNVSAIGLGCMTMTGGYSVSPNRQEMIALLRKAVELGVTFFDTAEVYGPFINEELVGEALEPFKGQVVIA
TKFGFKHDHNNRPTPAAGLDSRPEQIKRVAEASLKRLRVEAIDLFYQHRVDPNVPIEEVAGAVKDLIQAGKVRYFGMSEA
GAHTLRRAHAVCTVTAVQYEYSLWWRRPEQDILPLCEELGIGFVPYSPLGKGFLTGKIDATTHFDSTDLRSRIPRFTSEA
RKANQALVDLLDEIARQHHATPAQIALAWLLAQKPWIVPIPGTTKLHRLEENIGAVKVELTSSDLQRINDAVALIPIQGA
RYPEELERMTYL
>Mature_332_residues
MKQRRLGNSDLNVSAIGLGCMTMTGGYSVSPNRQEMIALLRKAVELGVTFFDTAEVYGPFINEELVGEALEPFKGQVVIA
TKFGFKHDHNNRPTPAAGLDSRPEQIKRVAEASLKRLRVEAIDLFYQHRVDPNVPIEEVAGAVKDLIQAGKVRYFGMSEA
GAHTLRRAHAVCTVTAVQYEYSLWWRRPEQDILPLCEELGIGFVPYSPLGKGFLTGKIDATTHFDSTDLRSRIPRFTSEA
RKANQALVDLLDEIARQHHATPAQIALAWLLAQKPWIVPIPGTTKLHRLEENIGAVKVELTSSDLQRINDAVALIPIQGA
RYPEELERMTYL

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=338, Percent_Identity=28.9940828402367, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI4504825, Length=335, Percent_Identity=28.955223880597, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI27436964, Length=341, Percent_Identity=31.0850439882698, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI27436966, Length=341, Percent_Identity=30.791788856305, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI27436962, Length=341, Percent_Identity=30.2052785923754, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI27436971, Length=336, Percent_Identity=31.547619047619, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI223718702, Length=208, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI41327764, Length=202, Percent_Identity=29.7029702970297, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI41152114, Length=186, Percent_Identity=31.1827956989247, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI87081735, Length=331, Percent_Identity=33.8368580060423, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789375, Length=332, Percent_Identity=30.421686746988, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788070, Length=318, Percent_Identity=30.188679245283, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787674, Length=307, Percent_Identity=28.9902280130293, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788081, Length=315, Percent_Identity=27.9365079365079, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789199, Length=344, Percent_Identity=29.0697674418605, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI48994888, Length=285, Percent_Identity=27.0175438596491, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17550248, Length=302, Percent_Identity=25.1655629139073, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17566692, Length=301, Percent_Identity=23.5880398671096, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=339, Percent_Identity=28.023598820059, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6325384, Length=343, Percent_Identity=28.2798833819242, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6323998, Length=302, Percent_Identity=26.8211920529801, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6319958, Length=303, Percent_Identity=26.4026402640264, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319951, Length=318, Percent_Identity=26.7295597484277, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322615, Length=254, Percent_Identity=25.5905511811024, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45549126, Length=343, Percent_Identity=24.198250728863, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640980, Length=343, Percent_Identity=24.198250728863, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646159, Length=172, Percent_Identity=31.3953488372093, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 37022; Mature: 37022

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRRLGNSDLNVSAIGLGCMTMTGGYSVSPNRQEMIALLRKAVELGVTFFDTAEVYGPF
CCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHCCC
INEELVGEALEPFKGQVVIATKFGFKHDHNNRPTPAAGLDSRPEQIKRVAEASLKRLRVE
CCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AIDLFYQHRVDPNVPIEEVAGAVKDLIQAGKVRYFGMSEAGAHTLRRAHAVCTVTAVQYE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHEEEEEEEEE
YSLWWRRPEQDILPLCEELGIGFVPYSPLGKGFLTGKIDATTHFDSTDLRSRIPRFTSEA
EEHEECCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCHHHHHH
RKANQALVDLLDEIARQHHATPAQIALAWLLAQKPWIVPIPGTTKLHRLEENIGAVKVEL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCEEEEEE
TSSDLQRINDAVALIPIQGARYPEELERMTYL
CHHHHHHHCCCEEEEEECCCCCHHHHHHHCCC
>Mature Secondary Structure
MKQRRLGNSDLNVSAIGLGCMTMTGGYSVSPNRQEMIALLRKAVELGVTFFDTAEVYGPF
CCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEHHHHHCCC
INEELVGEALEPFKGQVVIATKFGFKHDHNNRPTPAAGLDSRPEQIKRVAEASLKRLRVE
CCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AIDLFYQHRVDPNVPIEEVAGAVKDLIQAGKVRYFGMSEAGAHTLRRAHAVCTVTAVQYE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHEEEEEEEEE
YSLWWRRPEQDILPLCEELGIGFVPYSPLGKGFLTGKIDATTHFDSTDLRSRIPRFTSEA
EEHEECCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCHHHHHH
RKANQALVDLLDEIARQHHATPAQIALAWLLAQKPWIVPIPGTTKLHRLEENIGAVKVEL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCEEEEEE
TSSDLQRINDAVALIPIQGARYPEELERMTYL
CHHHHHHHCCCEEEEEECCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]