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The map label for this gene is mtnP [H]

Identifier: 222527120

GI number: 222527120

Start: 4849993

End: 4850859

Strand: Reverse

Name: mtnP [H]

Synonym: Chy400_3901

Alternate gene names: 222527120

Gene position: 4850859-4849993 (Counterclockwise)

Preceding gene: 222527123

Following gene: 222527119

Centisome position: 92.07

GC content: 59.05

Gene sequence:

>867_bases
ATGCATAGCGCAACAATCGGTGTGATTGGTGGTAGCGGTCTCTATGCCATGCCCGACCTCAAAAACCCGGAAGAGGTTCG
CCTGACTACACCGTTCGGCGATCCGAGCGATGCGTTTATCATCGGTGAACTGGAAGGGCGGCGGGTGGCGTTCCTACCGC
GGCATGGGCGTGGTCATCGCCTGAACCCCAGCGAAGTGCCGGCACGGGCGAATATCTATGCGTTTAAGCTGTTGGGAGTG
CGGGCGTTGATCTCGGTAAGTGCAGTTGGTTCGCTCCGCGAGGATTATGCCCCCGGCCACGCCGTGATTCCCGATCAGAT
TTTTGATCGCACCAAGGGCATTCGTCCGGCAACCTTCTTCGAGGGCGGCGTAGTGGCGCACGTGGCCTTTGATCGTCCAT
TCTGCCCGTATCTGAGCAATATTCTGCTGCATGCGGCGCAGGCTGCCGGCGCGGTTGTCCATCAGGGCGGAACACTGGTG
GTCATGGAGGGGCCGCAATTCTCGACCAAAGCCGAGAGCGAAGAGAACCGTCGCCGTGGTCATAGCCTGATCGGGATGAC
GGCGCTTCCCGAAGCAAAGCTGGCCCGTGAAGCCGAAATTGCCTACGCCACCCTGGCTATGGTCACCGACTACGATGTCT
GGCATCCCGAACACGATGCCGTGACCGCCGAGCAGGTGATAAAGGTGCTGAGCGCGAACGTAAACCTCTCGCAGCAGATT
GTGCGTCACGCTGTGGCCCAGATTGATGAGAACTTTACCAGCCCGGCACACGATGCACTACGCTATGCTATTGTTACTCA
TCCCGATCATATTCCGGCAGCCGTGAAAGAGCGTTTGGCCCCAATCGCCGGACGCTACTGGTCGTGA

Upstream 100 bases:

>100_bases
CCACCCTGGTCACGGAGCTTCACCCCGTCACCTTGTCACCCCGCGCCCCCTGCGGTATACTGCTCTATGGCGTAGTCTGC
TAGACAAAGGAGCATTCCCC

Downstream 100 bases:

>100_bases
GGCGTTATGCAAGGTGAGATACGGATTTTGCCGTTGCGCGGGATCGGTGAGGTGCAGCCGGGTGATGACCTGGTGGCAAT
ACTGGCTACGGCTATCGATG

Product: methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MHSATIGVIGGSGLYAMPDLKNPEEVRLTTPFGDPSDAFIIGELEGRRVAFLPRHGRGHRLNPSEVPARANIYAFKLLGV
RALISVSAVGSLREDYAPGHAVIPDQIFDRTKGIRPATFFEGGVVAHVAFDRPFCPYLSNILLHAAQAAGAVVHQGGTLV
VMEGPQFSTKAESEENRRRGHSLIGMTALPEAKLAREAEIAYATLAMVTDYDVWHPEHDAVTAEQVIKVLSANVNLSQQI
VRHAVAQIDENFTSPAHDALRYAIVTHPDHIPAAVKERLAPIAGRYWS

Sequences:

>Translated_288_residues
MHSATIGVIGGSGLYAMPDLKNPEEVRLTTPFGDPSDAFIIGELEGRRVAFLPRHGRGHRLNPSEVPARANIYAFKLLGV
RALISVSAVGSLREDYAPGHAVIPDQIFDRTKGIRPATFFEGGVVAHVAFDRPFCPYLSNILLHAAQAAGAVVHQGGTLV
VMEGPQFSTKAESEENRRRGHSLIGMTALPEAKLAREAEIAYATLAMVTDYDVWHPEHDAVTAEQVIKVLSANVNLSQQI
VRHAVAQIDENFTSPAHDALRYAIVTHPDHIPAAVKERLAPIAGRYWS
>Mature_288_residues
MHSATIGVIGGSGLYAMPDLKNPEEVRLTTPFGDPSDAFIIGELEGRRVAFLPRHGRGHRLNPSEVPARANIYAFKLLGV
RALISVSAVGSLREDYAPGHAVIPDQIFDRTKGIRPATFFEGGVVAHVAFDRPFCPYLSNILLHAAQAAGAVVHQGGTLV
VMEGPQFSTKAESEENRRRGHSLIGMTALPEAKLAREAEIAYATLAMVTDYDVWHPEHDAVTAEQVIKVLSANVNLSQQI
VRHAVAQIDENFTSPAHDALRYAIVTHPDHIPAAVKERLAPIAGRYWS

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=248, Percent_Identity=42.3387096774194, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71980569, Length=248, Percent_Identity=43.1451612903226, Blast_Score=193, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6323045, Length=307, Percent_Identity=37.1335504885993, Blast_Score=179, Evalue=3e-46,
Organism=Drosophila melanogaster, GI20130079, Length=248, Percent_Identity=40.7258064516129, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI221459247, Length=248, Percent_Identity=35.4838709677419, Blast_Score=165, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 31271; Mature: 31271

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSATIGVIGGSGLYAMPDLKNPEEVRLTTPFGDPSDAFIIGELEGRRVAFLPRHGRGHR
CCCCEEEEEECCCEEECCCCCCCCCEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCCC
LNPSEVPARANIYAFKLLGVRALISVSAVGSLREDYAPGHAVIPDQIFDRTKGIRPATFF
CCHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCEEE
EGGVVAHVAFDRPFCPYLSNILLHAAQAAGAVVHQGGTLVVMEGPQFSTKAESEENRRRG
CCCEEEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCEEEEECCCCCCCCCCCHHHHHHC
HSLIGMTALPEAKLAREAEIAYATLAMVTDYDVWHPEHDAVTAEQVIKVLSANVNLSQQI
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHH
VRHAVAQIDENFTSPAHDALRYAIVTHPDHIPAAVKERLAPIAGRYWS
HHHHHHHHHHCCCCCHHHHHEEEEEECCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHSATIGVIGGSGLYAMPDLKNPEEVRLTTPFGDPSDAFIIGELEGRRVAFLPRHGRGHR
CCCCEEEEEECCCEEECCCCCCCCCEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCCC
LNPSEVPARANIYAFKLLGVRALISVSAVGSLREDYAPGHAVIPDQIFDRTKGIRPATFF
CCHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCEEE
EGGVVAHVAFDRPFCPYLSNILLHAAQAAGAVVHQGGTLVVMEGPQFSTKAESEENRRRG
CCCEEEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCEEEEECCCCCCCCCCCHHHHHHC
HSLIGMTALPEAKLAREAEIAYATLAMVTDYDVWHPEHDAVTAEQVIKVLSANVNLSQQI
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHH
VRHAVAQIDENFTSPAHDALRYAIVTHPDHIPAAVKERLAPIAGRYWS
HHHHHHHHHHCCCCCHHHHHEEEEEECCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA