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The map label for this gene is uppS [H]

Identifier: 222527071

GI number: 222527071

Start: 4795082

End: 4795807

Strand: Direct

Name: uppS [H]

Synonym: Chy400_3850

Alternate gene names: 222527071

Gene position: 4795082-4795807 (Clockwise)

Preceding gene: 222527070

Following gene: 222527072

Centisome position: 91.01

GC content: 54.55

Gene sequence:

>726_bases
ATGAGCGAGGATAATGTACTGGCCGGCGTAGCTATTCCGCAACATATTGCGGTCATTATGGATGGCAATGGACGTTGGGC
GCAGCAACGTGGTCTGCCGCGCATCGCCGGCCATCGCGCCGGAACAGAAAATATTCGGCCAATCGTGACCGAATGTGCCC
GAATTGGAGTACGGGTCTTAACCCTGTACGCCTTTTCGACGGAAAACTGGAATCGGCCATCGCTCGAAGTCCAGGGATTG
ATGCAAATCCTGGGCGAGTTTATCGACCGCGAGATCCAAAATTTGCACGCCCAAAATGTCCATCTGCGTCACCTTGGTCG
TCTCAGTGGCCTCAGTCCTCACTTGCGGGAAAAGGTCAACTACGCCATTGAACTTACCCGCCACAACACCGGCCTGACCC
TGGCAATCGCGTTTAATTACGGTGGCCGTGCCGATATTGTTGATGCTGTGCGGGCTATTGTTGCCAGTGGTATCCCTGCT
GACCAGATTACTGATGAGGTGATCAGTGCGCATCTCTCGACGCATGGATTACCCGATCCCGATATGATTATTCGTACCAG
TGGTGAACGTCGCCTCTCAAATTTTTTGATCTGGCAGTCGGCCTACAGCGAATACTGGTTCACGCCGGTGTTCTGGCCCG
ATTTTCGACCCGAGCATCTGCATCAGGCAATTCTTGACTATGGACGGCGCGAACGCCGCTTCGGCGGACTCCCCAAGCCG
GGCTAA

Upstream 100 bases:

>100_bases
AACAGTTGACTGATCGCTGCACCCGTGAGCTTGACCAGATCGGTGCGGAAAAAGAGGCAGAAGTGATGGCAGTTTAGCCA
TCACTGAGAGGCACTGTCGT

Downstream 100 bases:

>100_bases
TACGCTGGCAATTCGTGTGGCAAGTGTGGTAGTCCTGCTACCACTGATTATTGCCGGTGTCTGGTGGCCGCCGACCACTG
CATTGCTGGCCGGCCTCGTC

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSEDNVLAGVAIPQHIAVIMDGNGRWAQQRGLPRIAGHRAGTENIRPIVTECARIGVRVLTLYAFSTENWNRPSLEVQGL
MQILGEFIDREIQNLHAQNVHLRHLGRLSGLSPHLREKVNYAIELTRHNTGLTLAIAFNYGGRADIVDAVRAIVASGIPA
DQITDEVISAHLSTHGLPDPDMIIRTSGERRLSNFLIWQSAYSEYWFTPVFWPDFRPEHLHQAILDYGRRERRFGGLPKP
G

Sequences:

>Translated_241_residues
MSEDNVLAGVAIPQHIAVIMDGNGRWAQQRGLPRIAGHRAGTENIRPIVTECARIGVRVLTLYAFSTENWNRPSLEVQGL
MQILGEFIDREIQNLHAQNVHLRHLGRLSGLSPHLREKVNYAIELTRHNTGLTLAIAFNYGGRADIVDAVRAIVASGIPA
DQITDEVISAHLSTHGLPDPDMIIRTSGERRLSNFLIWQSAYSEYWFTPVFWPDFRPEHLHQAILDYGRRERRFGGLPKP
G
>Mature_240_residues
SEDNVLAGVAIPQHIAVIMDGNGRWAQQRGLPRIAGHRAGTENIRPIVTECARIGVRVLTLYAFSTENWNRPSLEVQGLM
QILGEFIDREIQNLHAQNVHLRHLGRLSGLSPHLREKVNYAIELTRHNTGLTLAIAFNYGGRADIVDAVRAIVASGIPAD
QITDEVISAHLSTHGLPDPDMIIRTSGERRLSNFLIWQSAYSEYWFTPVFWPDFRPEHLHQAILDYGRRERRFGGLPKPG

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=231, Percent_Identity=36.7965367965368, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI45580742, Length=231, Percent_Identity=36.7965367965368, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1786371, Length=232, Percent_Identity=47.4137931034483, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=36.0869565217391, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=227, Percent_Identity=35.2422907488987, Blast_Score=130, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=231, Percent_Identity=34.1991341991342, Blast_Score=122, Evalue=4e-29,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=35.7142857142857, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27107; Mature: 26976

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDNVLAGVAIPQHIAVIMDGNGRWAQQRGLPRIAGHRAGTENIRPIVTECARIGVRVL
CCCCCEEEEEECCCEEEEEECCCCCCHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
TLYAFSTENWNRPSLEVQGLMQILGEFIDREIQNLHAQNVHLRHLGRLSGLSPHLREKVN
HEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHC
YAIELTRHNTGLTLAIAFNYGGRADIVDAVRAIVASGIPADQITDEVISAHLSTHGLPDP
EEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
DMIIRTSGERRLSNFLIWQSAYSEYWFTPVFWPDFRPEHLHQAILDYGRRERRFGGLPKP
CEEEECCCHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCHHHHHCCCCCCC
G
C
>Mature Secondary Structure 
SEDNVLAGVAIPQHIAVIMDGNGRWAQQRGLPRIAGHRAGTENIRPIVTECARIGVRVL
CCCCEEEEEECCCEEEEEECCCCCCHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
TLYAFSTENWNRPSLEVQGLMQILGEFIDREIQNLHAQNVHLRHLGRLSGLSPHLREKVN
HEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHC
YAIELTRHNTGLTLAIAFNYGGRADIVDAVRAIVASGIPADQITDEVISAHLSTHGLPDP
EEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
DMIIRTSGERRLSNFLIWQSAYSEYWFTPVFWPDFRPEHLHQAILDYGRRERRFGGLPKP
CEEEECCCHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCHHHHHCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]