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The map label for this gene is cysM [H]

Identifier: 222526981

GI number: 222526981

Start: 4680552

End: 4681478

Strand: Direct

Name: cysM [H]

Synonym: Chy400_3759

Alternate gene names: 222526981

Gene position: 4680552-4681478 (Clockwise)

Preceding gene: 222526980

Following gene: 222526982

Centisome position: 88.83

GC content: 60.09

Gene sequence:

>927_bases
ATGACGACTCTGCTCGATCTTGTTGGTCAAACACCGTTGTTGCCGCTCCACCACGTGCTCGATCTGCCGGCTGGCGTTGA
GCTGTACGGCAAGGCGGAGTGGTACAATCCCGGTGGTTCGGTAAAGGATCGGCCCGCGCTATGGATGATTCGCGACGGCG
AGCGGCGCGGTTTGTTGCGACCGGGGGTTCGCATCGCCGATGCAACTAGCGGTAACACCGGGATCGCTTACGCTACGATT
GGCGCAGCGCTCGGCTATGGGGTGACGCTGGCGATGCCGGCCAATGCCAGCATCGAACGACGGCGGATTCTCCGTGCGCT
TGGCGCTGAACTGATCCTGACCGATCCGGCTGAGGGAATGGATGCTGCGATCACGACCATCCGGCAACTGGTGGCCGAAC
ATCCTGACCGCTACTTTTACCCCGATCAATACAGCAATCCGGCCAATCCCCAGGCGCACTACGAGACAACCGGCCCGGAG
ATCTGGCAACAGACTGATGGCCGTGTCACCCATTTTGTGGCAGCATTGGGCACCAGTGGTACGTTTATGGGTACCAGTCG
ACGATTGCGCGAGTATAACCCCGCCATTCGTCTGATCGCCGTTCAGCCTGATAGCCCGTACCACGCACTGGAGGGAGTGA
AGCATATGGCTTCCACTCGGATCGTGCCCGCGATTTACCGGCCCGAACAGGCCGATGCAATTGTGGAAGTGCGGAGCGAA
GACGCTTTTGCCATGGCCCGGCATCTGGCGCGCCGGGCGGGATTGCTGGTGGGAATTTCAGCAGCCGCAAATGTGGTGGC
CGCAGCACGGGTCGCTCGTGAAGTCGGTCAGGGTGTGGTTGTGACCATTCTTTGCGATAGTGCGAATCGCTATCTCAGTG
AGCGCTTTTGGGAAGAACCGGGTTTCGCCGAAGGCGCCGGTATTTAG

Upstream 100 bases:

>100_bases
CGCATCGCCGGGGGCGGGGATGATAGGGTGCAATGACTGTTATTAAACCAGATTTGACATTATCGCCAATCCGTAGGATT
GATATCCAACGAGTGTATAT

Downstream 100 bases:

>100_bases
GTTTAAGGTGCGTATGACACTCATTATTCCTGATCAGGCCGCAGCAGCAATCGCTGCCCACGCTGAAGCAACGTATCCCG
ATGAATGTGTGGGCTTGCTG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTTLLDLVGQTPLLPLHHVLDLPAGVELYGKAEWYNPGGSVKDRPALWMIRDGERRGLLRPGVRIADATSGNTGIAYATI
GAALGYGVTLAMPANASIERRRILRALGAELILTDPAEGMDAAITTIRQLVAEHPDRYFYPDQYSNPANPQAHYETTGPE
IWQQTDGRVTHFVAALGTSGTFMGTSRRLREYNPAIRLIAVQPDSPYHALEGVKHMASTRIVPAIYRPEQADAIVEVRSE
DAFAMARHLARRAGLLVGISAAANVVAAARVAREVGQGVVVTILCDSANRYLSERFWEEPGFAEGAGI

Sequences:

>Translated_308_residues
MTTLLDLVGQTPLLPLHHVLDLPAGVELYGKAEWYNPGGSVKDRPALWMIRDGERRGLLRPGVRIADATSGNTGIAYATI
GAALGYGVTLAMPANASIERRRILRALGAELILTDPAEGMDAAITTIRQLVAEHPDRYFYPDQYSNPANPQAHYETTGPE
IWQQTDGRVTHFVAALGTSGTFMGTSRRLREYNPAIRLIAVQPDSPYHALEGVKHMASTRIVPAIYRPEQADAIVEVRSE
DAFAMARHLARRAGLLVGISAAANVVAAARVAREVGQGVVVTILCDSANRYLSERFWEEPGFAEGAGI
>Mature_307_residues
TTLLDLVGQTPLLPLHHVLDLPAGVELYGKAEWYNPGGSVKDRPALWMIRDGERRGLLRPGVRIADATSGNTGIAYATIG
AALGYGVTLAMPANASIERRRILRALGAELILTDPAEGMDAAITTIRQLVAEHPDRYFYPDQYSNPANPQAHYETTGPEI
WQQTDGRVTHFVAALGTSGTFMGTSRRLREYNPAIRLIAVQPDSPYHALEGVKHMASTRIVPAIYRPEQADAIVEVRSED
AFAMARHLARRAGLLVGISAAANVVAAARVAREVGQGVVVTILCDSANRYLSERFWEEPGFAEGAGI

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=322, Percent_Identity=36.6459627329193, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI295821200, Length=322, Percent_Identity=36.6459627329193, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI4557415, Length=322, Percent_Identity=36.6459627329193, Blast_Score=188, Evalue=5e-48,
Organism=Escherichia coli, GI2367138, Length=310, Percent_Identity=44.1935483870968, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1788754, Length=309, Percent_Identity=40.453074433657, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=308, Percent_Identity=41.5584415584416, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17562970, Length=309, Percent_Identity=42.0711974110032, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI32566674, Length=302, Percent_Identity=43.3774834437086, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17561720, Length=307, Percent_Identity=42.3452768729642, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=38.8888888888889, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI32566672, Length=219, Percent_Identity=42.0091324200913, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=321, Percent_Identity=31.4641744548287, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17534315, Length=321, Percent_Identity=30.8411214953271, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6321594, Length=328, Percent_Identity=32.9268292682927, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=34.5454545454545, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24643623, Length=331, Percent_Identity=34.7432024169184, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI20129101, Length=331, Percent_Identity=34.7432024169184, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33377; Mature: 33246

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLLDLVGQTPLLPLHHVLDLPAGVELYGKAEWYNPGGSVKDRPALWMIRDGERRGLLR
CCHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCC
PGVRIADATSGNTGIAYATIGAALGYGVTLAMPANASIERRRILRALGAELILTDPAEGM
CCCEEEECCCCCCCEEHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCH
DAAITTIRQLVAEHPDRYFYPDQYSNPANPQAHYETTGPEIWQQTDGRVTHFVAALGTSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCC
TFMGTSRRLREYNPAIRLIAVQPDSPYHALEGVKHMASTRIVPAIYRPEQADAIVEVRSE
CCCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCC
DAFAMARHLARRAGLLVGISAAANVVAAARVAREVGQGVVVTILCDSANRYLSERFWEEP
HHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCC
GFAEGAGI
CCCCCCCC
>Mature Secondary Structure 
TTLLDLVGQTPLLPLHHVLDLPAGVELYGKAEWYNPGGSVKDRPALWMIRDGERRGLLR
CHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCC
PGVRIADATSGNTGIAYATIGAALGYGVTLAMPANASIERRRILRALGAELILTDPAEGM
CCCEEEECCCCCCCEEHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCH
DAAITTIRQLVAEHPDRYFYPDQYSNPANPQAHYETTGPEIWQQTDGRVTHFVAALGTSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCC
TFMGTSRRLREYNPAIRLIAVQPDSPYHALEGVKHMASTRIVPAIYRPEQADAIVEVRSE
CCCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCC
DAFAMARHLARRAGLLVGISAAANVVAAARVAREVGQGVVVTILCDSANRYLSERFWEEP
HHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCC
GFAEGAGI
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]