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The map label for this gene is tlyB [H]

Identifier: 222526969

GI number: 222526969

Start: 4669391

End: 4670605

Strand: Direct

Name: tlyB [H]

Synonym: Chy400_3747

Alternate gene names: 222526969

Gene position: 4669391-4670605 (Clockwise)

Preceding gene: 222526968

Following gene: 222526971

Centisome position: 88.62

GC content: 53.83

Gene sequence:

>1215_bases
ATGACAGAAGAGCGCACCATGAAACTGGCCATCCGCGGTGATAAAAATCCTCTTGATCTGGTAGAGAAACGTCTACGCGA
ACAGATTTTTGGCCAGGAACGCGCCATCGAAAGCGTGATTCGCGTCTTAAACCGTTCACGGTTCGGGTTTTCAGCAGGCA
ATAGCCGTCGTCCGCGGGCGACACTCCTCTTCCTTGGCCCGACGGGCGTTGGCAAAACAGCTACTGCCCGGGCACTGGCC
GAACTGCTCCGCCCGGATGGCAGTGCATTTCTCAAGATTGACTGCTCGCTCTTTAGCCAGGGCCACGAGGTGAGTGCACT
GGTTGGTGCGCCGCCGAGTTATGTAGGGCGCGACCAGAAACCGTTGCTCAATCCCGACATTATCGAACAAGAGAACAGTG
TTGTCCTATTCGATGAGATCGAGAAGGGACAACCTGAACTGTGGAACCTCCTGTTGCAAGTGATGGAAGATGGCGAGATT
CTTCTGCTCAATGGTGGCCGACGGGTGAGTTTTCAGCAGAGTATTGTTATTTTCACCACCAATGTCGGTGCTAAAGAGAT
GGTTGATTTTCTTGATCGGCGCACAATTGGATTCCGTACCCCCCATAAAGATGTTGAAGCGACCGGCCGTGAAATCTATC
AAATCGGGTTTGAAGCCTTGCAAAAGGTCTTTCAGCCGGAATGGATCAACCGGCTCGATGAGATTATTGCATTCCGCCCG
CTTTCTGCCGAAACACTCAGCCATGTATTCGACCGGATGATTGCCGAATGCAATCAACAATATCTCCGCTATGCCATTCA
ATTGCGCGTCACACCCGAAGCAAAGGAGTATCTCCTCAATAAAGGGTTTGATTCGCGTTTTGGCGCTCGGCCACTGCGAC
AACGCATCTTGAAAGACATAGAGTCGCCCCTGTCCGATCTTCTTGCCTCGGGCGGTATCCCTGCCGGTAGCCTGGTCGAA
TTGCGCTACACCGGCATTGATCAGCACGGGCAGGCGCTGGAGTTCTACTATACCGAAGCACCAGAATTGATTGAGCGTGC
GGAAGAACTGCGTCAGCGCGACCTGCAACGGATCGCTGTTGGGCAGAGTGACGGCCCCCAACCACCAAGTATCAGCCTGA
CCCACGAACGCAGTAATGCAGCCGAAGGGGGTATTTTCACCACACGCGGCCCACGAGTCACACCACGCCGCGATCCTCAC
TTTGGCGACAAATGA

Upstream 100 bases:

>100_bases
GTGAGAGCCGATTCCCAGTATTGCGCGGCACAAGGCAGCGCTTCACCCGGCACTGGCACAGGTGCATCAGCAAAAGCCGG
TAGCTGTCAGGGGAGGCGTT

Downstream 100 bases:

>100_bases
GTCCAGTATCGCAGCACATTGAAGAGGGCAGGCTGACAACCTGCCCTCTTCAGTACAACCGTGCTTGAGCGACACCGTAT
GGTTCAGATCACCGATACAC

Product: ATPase AAA-2 domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTEERTMKLAIRGDKNPLDLVEKRLREQIFGQERAIESVIRVLNRSRFGFSAGNSRRPRATLLFLGPTGVGKTATARALA
ELLRPDGSAFLKIDCSLFSQGHEVSALVGAPPSYVGRDQKPLLNPDIIEQENSVVLFDEIEKGQPELWNLLLQVMEDGEI
LLLNGGRRVSFQQSIVIFTTNVGAKEMVDFLDRRTIGFRTPHKDVEATGREIYQIGFEALQKVFQPEWINRLDEIIAFRP
LSAETLSHVFDRMIAECNQQYLRYAIQLRVTPEAKEYLLNKGFDSRFGARPLRQRILKDIESPLSDLLASGGIPAGSLVE
LRYTGIDQHGQALEFYYTEAPELIERAEELRQRDLQRIAVGQSDGPQPPSISLTHERSNAAEGGIFTTRGPRVTPRRDPH
FGDK

Sequences:

>Translated_404_residues
MTEERTMKLAIRGDKNPLDLVEKRLREQIFGQERAIESVIRVLNRSRFGFSAGNSRRPRATLLFLGPTGVGKTATARALA
ELLRPDGSAFLKIDCSLFSQGHEVSALVGAPPSYVGRDQKPLLNPDIIEQENSVVLFDEIEKGQPELWNLLLQVMEDGEI
LLLNGGRRVSFQQSIVIFTTNVGAKEMVDFLDRRTIGFRTPHKDVEATGREIYQIGFEALQKVFQPEWINRLDEIIAFRP
LSAETLSHVFDRMIAECNQQYLRYAIQLRVTPEAKEYLLNKGFDSRFGARPLRQRILKDIESPLSDLLASGGIPAGSLVE
LRYTGIDQHGQALEFYYTEAPELIERAEELRQRDLQRIAVGQSDGPQPPSISLTHERSNAAEGGIFTTRGPRVTPRRDPH
FGDK
>Mature_403_residues
TEERTMKLAIRGDKNPLDLVEKRLREQIFGQERAIESVIRVLNRSRFGFSAGNSRRPRATLLFLGPTGVGKTATARALAE
LLRPDGSAFLKIDCSLFSQGHEVSALVGAPPSYVGRDQKPLLNPDIIEQENSVVLFDEIEKGQPELWNLLLQVMEDGEIL
LLNGGRRVSFQQSIVIFTTNVGAKEMVDFLDRRTIGFRTPHKDVEATGREIYQIGFEALQKVFQPEWINRLDEIIAFRPL
SAETLSHVFDRMIAECNQQYLRYAIQLRVTPEAKEYLLNKGFDSRFGARPLRQRILKDIESPLSDLLASGGIPAGSLVEL
RYTGIDQHGQALEFYYTEAPELIERAEELRQRDLQRIAVGQSDGPQPPSISLTHERSNAAEGGIFTTRGPRVTPRRDPHF
GDK

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=351, Percent_Identity=27.3504273504274, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1787109, Length=329, Percent_Identity=35.5623100303951, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1788943, Length=302, Percent_Identity=34.4370860927152, Blast_Score=186, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6320464, Length=315, Percent_Identity=34.9206349206349, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6323002, Length=287, Percent_Identity=32.0557491289199, Blast_Score=143, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 45538; Mature: 45406

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEERTMKLAIRGDKNPLDLVEKRLREQIFGQERAIESVIRVLNRSRFGFSAGNSRRPRA
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
TLLFLGPTGVGKTATARALAELLRPDGSAFLKIDCSLFSQGHEVSALVGAPPSYVGRDQK
EEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCEEEEECCCHHHCCCCCC
PLLNPDIIEQENSVVLFDEIEKGQPELWNLLLQVMEDGEILLLNGGRRVSFQQSIVIFTT
CCCCCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECEEEEEEE
NVGAKEMVDFLDRRTIGFRTPHKDVEATGREIYQIGFEALQKVFQPEWINRLDEIIAFRP
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
LSAETLSHVFDRMIAECNQQYLRYAIQLRVTPEAKEYLLNKGFDSRFGARPLRQRILKDI
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
ESPLSDLLASGGIPAGSLVELRYTGIDQHGQALEFYYTEAPELIERAEELRQRDLQRIAV
HHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHC
GQSDGPQPPSISLTHERSNAAEGGIFTTRGPRVTPRRDPHFGDK
CCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEERTMKLAIRGDKNPLDLVEKRLREQIFGQERAIESVIRVLNRSRFGFSAGNSRRPRA
CCCCEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
TLLFLGPTGVGKTATARALAELLRPDGSAFLKIDCSLFSQGHEVSALVGAPPSYVGRDQK
EEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCEEEEECCCHHHCCCCCC
PLLNPDIIEQENSVVLFDEIEKGQPELWNLLLQVMEDGEILLLNGGRRVSFQQSIVIFTT
CCCCCHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECEEEEEEE
NVGAKEMVDFLDRRTIGFRTPHKDVEATGREIYQIGFEALQKVFQPEWINRLDEIIAFRP
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
LSAETLSHVFDRMIAECNQQYLRYAIQLRVTPEAKEYLLNKGFDSRFGARPLRQRILKDI
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
ESPLSDLLASGGIPAGSLVELRYTGIDQHGQALEFYYTEAPELIERAEELRQRDLQRIAV
HHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHC
GQSDGPQPPSISLTHERSNAAEGGIFTTRGPRVTPRRDPHFGDK
CCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7968456 [H]