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The map label for this gene is yusP [H]

Identifier: 222526860

GI number: 222526860

Start: 4523217

End: 4525082

Strand: Direct

Name: yusP [H]

Synonym: Chy400_3636

Alternate gene names: 222526860

Gene position: 4523217-4525082 (Clockwise)

Preceding gene: 222526859

Following gene: 222526861

Centisome position: 85.85

GC content: 58.41

Gene sequence:

>1866_bases
ATGACAACCACAACCTCTTCCCCGACTGCTACAACTGTCCGCATTGACTACGCTGTAATGCTCGATCAACGGAGCAAGGT
GCTGATCTTGATCGGAGTCTTGCTGGGTCTGTTTCTCTCGGCACTGGATCAGACGATTGTTTCCACCGCACTCCCGCGCA
TCGTTGCCGATTTGCAGGGGATCGAATTGATCGGCTGGGTCTCAACCAGTTATCTGCTGGCCTCAACGGCGATGGTGCCG
ATCTATGGCAAACTGTCCGATATTTACGGGCGCAAGTACGTTTTGTTGTTCGGGATCGTGGTCTTTCTGCTCGGTTCGCT
ACTATGCGGGCTGGCCGCCGATATGACGCAGTTGGTCGTCTTTCGTGGCTTGCAGGGCTTCGGGGCTGCGGCCCTCACCT
CAACCGCATTTGCGATTCCGGCTGACCTCTTCGCGCCGGCAGAACGGGCACGTTACATGGGGTTGTTCGGCGCAGTGTTC
GGGTTGTCGAGTGTGGTTGGCCCATTCATTGGTGGTCTCTTGACCGACAATCTGAGCTGGCATTGGGTCTTTTTCGTCAA
CCTCCCGCTGGGTGTGATCGCCCTTGGGTTTATCGTTGCCAAATTGCCACGCCTGCACAGTGGGCTTATGCCGGCCATTG
ATTACGCCGGTGCCGCGACTCTGTTGTTGACCGTGATCCCATTCTTGCTGGCACTGACGCTCGACAAGAATGATTATCCG
TGGACATCGCCCCTTATTCTGAGCATGTTTGCCGTCAGTGCCGTCGGCCTCGTTCTCTTCCTCCTGATCGAACGGCGTGC
CGAGTCGCCGATTCTGCCGTTGCATCTGTTCCGCATTCCCACCTTTACGCTGACGGCGTTGATTGGGGTGACGGTAGGAG
CGACTCTGTTTGCGGCGATCTTCTTTCTCTCGCTCTATCTGGTGAATGTGCTGGGGGTAAGTGCGACGGCTGCCGGGACG
ACGCTTATTCCCCTGACGCTGAGTCTGGTGGTGGGGGCGATGGTGTCATCGCAAATCGTGCAGCGCACCGGCAACTATAA
GTGGGTGATCATTGTCGGGATGGCGATCATTGTCGGGTCACTCTGGTGGCTGACGACGCTCACACCGGACACGTCGATCT
GGATGGTGCGCCTGCGAATGATTGCGCTCGGTTTGGGGTTGGGGCCATCAATGCCCATCCTTAATCTGGCAATGCAGAAT
GCAGTGCCGCGCACCGATCTGGGTGCAGCCACTGCCAGTCGACAGTTCTTTCAACAAATCGGCCAGGTGGTGGGGTCGGC
GGTCTTTGGCGCACTGCTTACCGGTGTCCTCACGACGAGCCTGAGCACGAGTCTGGCCCCAATTCAGGCTCAGTTACCGC
CCGATCTGGCAGCCCGCTTCGATAGCAGCGCACTTCGGAACGGCATGAGTGCAGGTGAGGGTGCGAGTGGCGAGGTGGTC
GATCCGGCAGTTCGTATTGAGCAAGCCATTGCCGAACAGTTTGCCGTGCGACGCGATCTTATCACTCGTGCGCTGCGTGA
TGCCGATCCGGCAGCGATTGCCACGTTGCGCAGCGATCCCCAATTGCCGGCGCAGCAGAAGGCGATGCTGGAGATGGTAG
AGACACTACCGGCGGCTGCGCGCGAACAGGCGCTCACGCAGGTGCTTGCCCGGCTGGACGAAGCGGAACAAACGGCACGT
GCCGAAGGTCGTGCGCTGGGTCAACAGATCAGTACTGCTTTGAAGAACGCCTTTACCGACAGCGTCACCACTATCTACCG
GTACGCAGTCTGGCTCGCCGTTATTGGACTGATCCTGGCGCTGTTCATTCCCCAACTGCCGCTTCAGCGCAGCTATGGCC
AGGATTTGCCGCCACTGATGGAGTGA

Upstream 100 bases:

>100_bases
TTTGGTACGTGTTACCCCCAACGTGCCTGCGCGTGTGGGGGCGGCTCTGCCTGTGCCCGATTTTGACTTGTTATGACGAC
GCAGGAGCATGAACAAACCT

Downstream 100 bases:

>100_bases
GTTTCAGGACGTTACCTCGTCCATTTGGGGGAGTGGGGATGGATGTGCTCCAGGGTATTCACCCGCCTCCAGCGGGCTAT
GCATACTGGTGTCAACCACG

Product: EmrB/QacA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MTTTTSSPTATTVRIDYAVMLDQRSKVLILIGVLLGLFLSALDQTIVSTALPRIVADLQGIELIGWVSTSYLLASTAMVP
IYGKLSDIYGRKYVLLFGIVVFLLGSLLCGLAADMTQLVVFRGLQGFGAAALTSTAFAIPADLFAPAERARYMGLFGAVF
GLSSVVGPFIGGLLTDNLSWHWVFFVNLPLGVIALGFIVAKLPRLHSGLMPAIDYAGAATLLLTVIPFLLALTLDKNDYP
WTSPLILSMFAVSAVGLVLFLLIERRAESPILPLHLFRIPTFTLTALIGVTVGATLFAAIFFLSLYLVNVLGVSATAAGT
TLIPLTLSLVVGAMVSSQIVQRTGNYKWVIIVGMAIIVGSLWWLTTLTPDTSIWMVRLRMIALGLGLGPSMPILNLAMQN
AVPRTDLGAATASRQFFQQIGQVVGSAVFGALLTGVLTTSLSTSLAPIQAQLPPDLAARFDSSALRNGMSAGEGASGEVV
DPAVRIEQAIAEQFAVRRDLITRALRDADPAAIATLRSDPQLPAQQKAMLEMVETLPAAAREQALTQVLARLDEAEQTAR
AEGRALGQQISTALKNAFTDSVTTIYRYAVWLAVIGLILALFIPQLPLQRSYGQDLPPLME

Sequences:

>Translated_621_residues
MTTTTSSPTATTVRIDYAVMLDQRSKVLILIGVLLGLFLSALDQTIVSTALPRIVADLQGIELIGWVSTSYLLASTAMVP
IYGKLSDIYGRKYVLLFGIVVFLLGSLLCGLAADMTQLVVFRGLQGFGAAALTSTAFAIPADLFAPAERARYMGLFGAVF
GLSSVVGPFIGGLLTDNLSWHWVFFVNLPLGVIALGFIVAKLPRLHSGLMPAIDYAGAATLLLTVIPFLLALTLDKNDYP
WTSPLILSMFAVSAVGLVLFLLIERRAESPILPLHLFRIPTFTLTALIGVTVGATLFAAIFFLSLYLVNVLGVSATAAGT
TLIPLTLSLVVGAMVSSQIVQRTGNYKWVIIVGMAIIVGSLWWLTTLTPDTSIWMVRLRMIALGLGLGPSMPILNLAMQN
AVPRTDLGAATASRQFFQQIGQVVGSAVFGALLTGVLTTSLSTSLAPIQAQLPPDLAARFDSSALRNGMSAGEGASGEVV
DPAVRIEQAIAEQFAVRRDLITRALRDADPAAIATLRSDPQLPAQQKAMLEMVETLPAAAREQALTQVLARLDEAEQTAR
AEGRALGQQISTALKNAFTDSVTTIYRYAVWLAVIGLILALFIPQLPLQRSYGQDLPPLME
>Mature_620_residues
TTTTSSPTATTVRIDYAVMLDQRSKVLILIGVLLGLFLSALDQTIVSTALPRIVADLQGIELIGWVSTSYLLASTAMVPI
YGKLSDIYGRKYVLLFGIVVFLLGSLLCGLAADMTQLVVFRGLQGFGAAALTSTAFAIPADLFAPAERARYMGLFGAVFG
LSSVVGPFIGGLLTDNLSWHWVFFVNLPLGVIALGFIVAKLPRLHSGLMPAIDYAGAATLLLTVIPFLLALTLDKNDYPW
TSPLILSMFAVSAVGLVLFLLIERRAESPILPLHLFRIPTFTLTALIGVTVGATLFAAIFFLSLYLVNVLGVSATAAGTT
LIPLTLSLVVGAMVSSQIVQRTGNYKWVIIVGMAIIVGSLWWLTTLTPDTSIWMVRLRMIALGLGLGPSMPILNLAMQNA
VPRTDLGAATASRQFFQQIGQVVGSAVFGALLTGVLTTSLSTSLAPIQAQLPPDLAARFDSSALRNGMSAGEGASGEVVD
PAVRIEQAIAEQFAVRRDLITRALRDADPAAIATLRSDPQLPAQQKAMLEMVETLPAAAREQALTQVLARLDEAEQTARA
EGRALGQQISTALKNAFTDSVTTIYRYAVWLAVIGLILALFIPQLPLQRSYGQDLPPLME

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=410, Percent_Identity=27.5609756097561, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI87081983, Length=416, Percent_Identity=29.3269230769231, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789042, Length=321, Percent_Identity=29.2834890965732, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788710, Length=322, Percent_Identity=28.8819875776398, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1788392, Length=342, Percent_Identity=31.8713450292398, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790146, Length=172, Percent_Identity=31.9767441860465, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323735, Length=332, Percent_Identity=31.6265060240964, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6322958, Length=484, Percent_Identity=26.0330578512397, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6319770, Length=380, Percent_Identity=24.2105263157895, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6321663, Length=152, Percent_Identity=35.5263157894737, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325455, Length=252, Percent_Identity=26.984126984127, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319783, Length=394, Percent_Identity=24.6192893401015, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324954, Length=417, Percent_Identity=24.7002398081535, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323520, Length=415, Percent_Identity=23.6144578313253, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 66257; Mature: 66126

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTTSSPTATTVRIDYAVMLDQRSKVLILIGVLLGLFLSALDQTIVSTALPRIVADLQG
CCCCCCCCCEEEEEEEHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IELIGWVSTSYLLASTAMVPIYGKLSDIYGRKYVLLFGIVVFLLGSLLCGLAADMTQLVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRGLQGFGAAALTSTAFAIPADLFAPAERARYMGLFGAVFGLSSVVGPFIGGLLTDNLSW
HHCCCCCCHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
HWVFFVNLPLGVIALGFIVAKLPRLHSGLMPAIDYAGAATLLLTVIPFLLALTLDKNDYP
EEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WTSPLILSMFAVSAVGLVLFLLIERRAESPILPLHLFRIPTFTLTALIGVTVGATLFAAI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFLSLYLVNVLGVSATAAGTTLIPLTLSLVVGAMVSSQIVQRTGNYKWVIIVGMAIIVGS
HHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHH
LWWLTTLTPDTSIWMVRLRMIALGLGLGPSMPILNLAMQNAVPRTDLGAATASRQFFQQI
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GQVVGSAVFGALLTGVLTTSLSTSLAPIQAQLPPDLAARFDSSALRNGMSAGEGASGEVV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHCCCCCCCCCCCCCC
DPAVRIEQAIAEQFAVRRDLITRALRDADPAAIATLRSDPQLPAQQKAMLEMVETLPAAA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
REQALTQVLARLDEAEQTARAEGRALGQQISTALKNAFTDSVTTIYRYAVWLAVIGLILA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFIPQLPLQRSYGQDLPPLME
HHHCCCCCCHHCCCCCCCCCC
>Mature Secondary Structure 
TTTTSSPTATTVRIDYAVMLDQRSKVLILIGVLLGLFLSALDQTIVSTALPRIVADLQG
CCCCCCCCEEEEEEEHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IELIGWVSTSYLLASTAMVPIYGKLSDIYGRKYVLLFGIVVFLLGSLLCGLAADMTQLVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRGLQGFGAAALTSTAFAIPADLFAPAERARYMGLFGAVFGLSSVVGPFIGGLLTDNLSW
HHCCCCCCHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
HWVFFVNLPLGVIALGFIVAKLPRLHSGLMPAIDYAGAATLLLTVIPFLLALTLDKNDYP
EEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WTSPLILSMFAVSAVGLVLFLLIERRAESPILPLHLFRIPTFTLTALIGVTVGATLFAAI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFLSLYLVNVLGVSATAAGTTLIPLTLSLVVGAMVSSQIVQRTGNYKWVIIVGMAIIVGS
HHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHH
LWWLTTLTPDTSIWMVRLRMIALGLGLGPSMPILNLAMQNAVPRTDLGAATASRQFFQQI
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GQVVGSAVFGALLTGVLTTSLSTSLAPIQAQLPPDLAARFDSSALRNGMSAGEGASGEVV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHCCCCCCCCCCCCCC
DPAVRIEQAIAEQFAVRRDLITRALRDADPAAIATLRSDPQLPAQQKAMLEMVETLPAAA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
REQALTQVLARLDEAEQTARAEGRALGQQISTALKNAFTDSVTTIYRYAVWLAVIGLILA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFIPQLPLQRSYGQDLPPLME
HHHCCCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]