Click here to switch to the map view.

The map label for this gene is yhcY [H]

Identifier: 222526714

GI number: 222526714

Start: 4343885

End: 4346080

Strand: Direct

Name: yhcY [H]

Synonym: Chy400_3485

Alternate gene names: 222526714

Gene position: 4343885-4346080 (Clockwise)

Preceding gene: 222526713

Following gene: 222526715

Centisome position: 82.44

GC content: 59.93

Gene sequence:

>2196_bases
ATGACTGACTCTGCGCATATGGCGGCTGATTCTACTCATCGCACGCTTCCGTTAGGCGATCTGCTGGCATTTGGCGATGC
GTTACGTGCCGACGATACGCCCGAAAGCCTGCTGGCTGAGGTTGTCGAGACCTTACGCCGGATCGTCGGTAGTCCGGCAG
TCTATGCCCGCTTACGCGACCTCGACAGTGATACGCTCTACGCAGTAGCCTTTGCCGGTGTTGATGCACCACTGGTCGAA
CGTTTACGGGCCACACCGATTGGGCCGGCAATCTACCAGCCACTCCTGCGCCCGGAATACCGACAGAGTAGTTCATACCT
GATCCCGGCAGCAGTGCTCCCCCCCGATGTGCCGGATACCGAAGCGATTATTCCGGCCTCGGCACTGTTAACGCCGTTGC
GCGGGCGGGGAGACCGCTTGATCGGCGTCATTGTGCTGGCATGGCCCGATCAACCCGACCTGGTCACTGTGCGTATGGTC
GAAGCGATTGCCCGTCAGGCGGCGCTGGCAGTCGAAAATGTTCGCCTGGCCGAACGGAGCGCCCGCTTGCTGGCGAAAGA
GCAACTGCTGGCTGAACTGGGGCGTGCGGTTGGGGCAACGCTTGATTTGGATACTATTTTGCATCAGACGATTGATCGGC
TGGCTGCTGCATTCGGTAGTGGCCTGGTCGCACTGCTCGATAATCAAGAGACATTAATGGTCGTGGCAGCGGCACCGCCG
CTCGACACATTGATCGGCAGGCAATTGCCGTTACTCTCTGGATCGCTGGCCTGGGTAGTGCAGAGCGGTCAGCCTTTTGT
GGTAGACGATTGTCGGTTGCATGCCCCGGATATGGCTCTGTTCGGCCCCGACATCGCGTCGTGTATCATCGCCCCGTTGC
GGAGTGGTGGTCGGGTGATCGGGATGCTGAGTGTAGTTAGCCGGCAGGCCGGCGTGTTCAGCGACGAAGATGTTGATCTG
CTGGAGGCAATTGCCGCACAGGTGAGTGGGCCGGTCGTCAGCGCACGCCTCTACGCCGAGTCGCAACGACTGGCAGCGCA
GGTGCAGAGGCGTGCCGATCAGCTCGCTGTGCTCAACTCGATTGCCCGCATCGTCACCGCAACGCTCGATCTGCGCGAGT
CGCTGCCACTGGCAACAGAGCAGATACAGCGCGGTTTTGGTTATCCGCAGGTTGACCTCTTCCTGCTCGAAGAAGAGGCC
AATGAGCTGATCCTGGTCGCATCCGCCGGTCGTTATGCACCAGAGCGAGTTGGCTATCGCCAACACATCAATCTGGGACT
GGTCGGACGTGCAGCGCGGAGTGGTCGGATTGTGCGCGCCGAGGATGTCGCGGCAGAAGCAGATTATCTCGGTCTCAGCG
AGCGGCTCGATATTCGTTCAGAGCTGTGTGTACCGCTGATCTCCAATGGCAAGACGCTGGGAGTGCTCAATATTGAATCG
CCCGAACGAGCCGGCCTGACCGAAGAGGATGCAGCGGTACTGGAGACCGTCGCCGATATGCTGGCCGGTGCCGTAGAGAA
TGGGCGCCTCTACCAGCGGGCGCAGCAGGCTGCTGCCCTGGAAGAACGCAATCGCCTCGCCCGTGAATTACACGACAGCG
TTAGTCAGCAGCTCTTCAGTATGACCCTGACCGCACAGGCCGCCCGATCACAGTTCGAGCGGAACCCGGCTCGCGTCCCG
GCCCTGCTCGACCGGCTACACGAGACGGCAACTGCGGCGCTGGCCGAAATGCGTGCCCTAATCTTTCAGTTACGTCCGCC
GGCACTGCGCGACCAGGGACTCGTCGCTGCTATTCAGCAACACGCCCAACATCTGGCCCATCGTGAAGGATTGCGGATAG
AATTAAATGTAATCGGTGATGAGCGCCACGCGCGCGGCATCGAGCAACCCCTCTTTCGGATTGTTCAGGAGGCGCTCAAT
AACATTGTGAAGCATGCAGCCGCCCGCAATGTGCAAATTATGCTCGAATTCAATGCCGATCAGGTTGCGATTCGGGTCAT
TGACGATGGCAAAGGTTTCGATCCGGCGGCTCGCCCCTCTGGCGAAGGCCGACACCTCGGCTTACTCAGCATGCGCGAAC
GCGCAGCAGAATTGGGCGGTTCGTTCAACGTCCATTCTCGTCCTGGGGCCGGTGCCGAGGTTGAGGTTGTCGTGCCACTA
CGTGGTCGTCATGGCAATCTTGAACGACCTGAGTAA

Upstream 100 bases:

>100_bases
GGCGAGGAACGGCACCCATTGTCACCGAACCGGCTGACGAAGATGAGTTGTAATTGCCGGCGGCATATGCGACAATGTGA
ATGATCATAACGAGGTAATC

Downstream 100 bases:

>100_bases
CATGAGATGCGAGACAGGTAATACCAGTTGCTTGACATAATCAGCGACGTGGGAAGGGTAGCAAGAAGGGGGTAGGTGGA
TGGAACAGATTACGGTGCTG

Product: GAF sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 731; Mature: 730

Protein sequence:

>731_residues
MTDSAHMAADSTHRTLPLGDLLAFGDALRADDTPESLLAEVVETLRRIVGSPAVYARLRDLDSDTLYAVAFAGVDAPLVE
RLRATPIGPAIYQPLLRPEYRQSSSYLIPAAVLPPDVPDTEAIIPASALLTPLRGRGDRLIGVIVLAWPDQPDLVTVRMV
EAIARQAALAVENVRLAERSARLLAKEQLLAELGRAVGATLDLDTILHQTIDRLAAAFGSGLVALLDNQETLMVVAAAPP
LDTLIGRQLPLLSGSLAWVVQSGQPFVVDDCRLHAPDMALFGPDIASCIIAPLRSGGRVIGMLSVVSRQAGVFSDEDVDL
LEAIAAQVSGPVVSARLYAESQRLAAQVQRRADQLAVLNSIARIVTATLDLRESLPLATEQIQRGFGYPQVDLFLLEEEA
NELILVASAGRYAPERVGYRQHINLGLVGRAARSGRIVRAEDVAAEADYLGLSERLDIRSELCVPLISNGKTLGVLNIES
PERAGLTEEDAAVLETVADMLAGAVENGRLYQRAQQAAALEERNRLARELHDSVSQQLFSMTLTAQAARSQFERNPARVP
ALLDRLHETATAALAEMRALIFQLRPPALRDQGLVAAIQQHAQHLAHREGLRIELNVIGDERHARGIEQPLFRIVQEALN
NIVKHAAARNVQIMLEFNADQVAIRVIDDGKGFDPAARPSGEGRHLGLLSMRERAAELGGSFNVHSRPGAGAEVEVVVPL
RGRHGNLERPE

Sequences:

>Translated_731_residues
MTDSAHMAADSTHRTLPLGDLLAFGDALRADDTPESLLAEVVETLRRIVGSPAVYARLRDLDSDTLYAVAFAGVDAPLVE
RLRATPIGPAIYQPLLRPEYRQSSSYLIPAAVLPPDVPDTEAIIPASALLTPLRGRGDRLIGVIVLAWPDQPDLVTVRMV
EAIARQAALAVENVRLAERSARLLAKEQLLAELGRAVGATLDLDTILHQTIDRLAAAFGSGLVALLDNQETLMVVAAAPP
LDTLIGRQLPLLSGSLAWVVQSGQPFVVDDCRLHAPDMALFGPDIASCIIAPLRSGGRVIGMLSVVSRQAGVFSDEDVDL
LEAIAAQVSGPVVSARLYAESQRLAAQVQRRADQLAVLNSIARIVTATLDLRESLPLATEQIQRGFGYPQVDLFLLEEEA
NELILVASAGRYAPERVGYRQHINLGLVGRAARSGRIVRAEDVAAEADYLGLSERLDIRSELCVPLISNGKTLGVLNIES
PERAGLTEEDAAVLETVADMLAGAVENGRLYQRAQQAAALEERNRLARELHDSVSQQLFSMTLTAQAARSQFERNPARVP
ALLDRLHETATAALAEMRALIFQLRPPALRDQGLVAAIQQHAQHLAHREGLRIELNVIGDERHARGIEQPLFRIVQEALN
NIVKHAAARNVQIMLEFNADQVAIRVIDDGKGFDPAARPSGEGRHLGLLSMRERAAELGGSFNVHSRPGAGAEVEVVVPL
RGRHGNLERPE
>Mature_730_residues
TDSAHMAADSTHRTLPLGDLLAFGDALRADDTPESLLAEVVETLRRIVGSPAVYARLRDLDSDTLYAVAFAGVDAPLVER
LRATPIGPAIYQPLLRPEYRQSSSYLIPAAVLPPDVPDTEAIIPASALLTPLRGRGDRLIGVIVLAWPDQPDLVTVRMVE
AIARQAALAVENVRLAERSARLLAKEQLLAELGRAVGATLDLDTILHQTIDRLAAAFGSGLVALLDNQETLMVVAAAPPL
DTLIGRQLPLLSGSLAWVVQSGQPFVVDDCRLHAPDMALFGPDIASCIIAPLRSGGRVIGMLSVVSRQAGVFSDEDVDLL
EAIAAQVSGPVVSARLYAESQRLAAQVQRRADQLAVLNSIARIVTATLDLRESLPLATEQIQRGFGYPQVDLFLLEEEAN
ELILVASAGRYAPERVGYRQHINLGLVGRAARSGRIVRAEDVAAEADYLGLSERLDIRSELCVPLISNGKTLGVLNIESP
ERAGLTEEDAAVLETVADMLAGAVENGRLYQRAQQAAALEERNRLARELHDSVSQQLFSMTLTAQAARSQFERNPARVPA
LLDRLHETATAALAEMRALIFQLRPPALRDQGLVAAIQQHAQHLAHREGLRIELNVIGDERHARGIEQPLFRIVQEALNN
IVKHAAARNVQIMLEFNADQVAIRVIDDGKGFDPAARPSGEGRHLGLLSMRERAAELGGSFNVHSRPGAGAEVEVVVPLR
GRHGNLERPE

Specific function: Member of the two-component regulatory system yhcY/yhcZ. Probably activates yhcZ by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=247, Percent_Identity=29.5546558704453, Blast_Score=93, Evalue=8e-20,
Organism=Escherichia coli, GI1788812, Length=226, Percent_Identity=25.2212389380531, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78984; Mature: 78853

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSAHMAADSTHRTLPLGDLLAFGDALRADDTPESLLAEVVETLRRIVGSPAVYARLRD
CCCCCCCCCCCCCCCCCHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
LDSDTLYAVAFAGVDAPLVERLRATPIGPAIYQPLLRPEYRQSSSYLIPAAVLPPDVPDT
CCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCC
EAIIPASALLTPLRGRGDRLIGVIVLAWPDQPDLVTVRMVEAIARQAALAVENVRLAERS
CCCCCHHHHHCCCCCCCCEEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
ARLLAKEQLLAELGRAVGATLDLDTILHQTIDRLAAAFGSGLVALLDNQETLMVVAAAPP
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCC
LDTLIGRQLPLLSGSLAWVVQSGQPFVVDDCRLHAPDMALFGPDIASCIIAPLRSGGRVI
HHHHHCCCCCCCCCCEEEEEECCCCEEEECCEECCCCCHHCCCHHHHHHHHHHCCCCCEE
GMLSVVSRQAGVFSDEDVDLLEAIAAQVSGPVVSARLYAESQRLAAQVQRRADQLAVLNS
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IARIVTATLDLRESLPLATEQIQRGFGYPQVDLFLLEEEANELILVASAGRYAPERVGYR
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHCCHH
QHINLGLVGRAARSGRIVRAEDVAAEADYLGLSERLDIRSELCVPLISNGKTLGVLNIES
HCCCEEEEECHHCCCCEEEHHHHHHHHHHCCCHHHHCCHHHHCHHHHCCCCEEEEEECCC
PERAGLTEEDAAVLETVADMLAGAVENGRLYQRAQQAAALEERNRLARELHDSVSQQLFS
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTLTAQAARSQFERNPARVPALLDRLHETATAALAEMRALIFQLRPPALRDQGLVAAIQQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
HAQHLAHREGLRIELNVIGDERHARGIEQPLFRIVQEALNNIVKHAAARNVQIMLEFNAD
HHHHHHHHCCCEEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
QVAIRVIDDGKGFDPAARPSGEGRHLGLLSMRERAAELGGSFNVHSRPGAGAEVEVVVPL
EEEEEEEECCCCCCCCCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEE
RGRHGNLERPE
CCCCCCCCCCC
>Mature Secondary Structure 
TDSAHMAADSTHRTLPLGDLLAFGDALRADDTPESLLAEVVETLRRIVGSPAVYARLRD
CCCCCCCCCCCCCCCCHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
LDSDTLYAVAFAGVDAPLVERLRATPIGPAIYQPLLRPEYRQSSSYLIPAAVLPPDVPDT
CCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCC
EAIIPASALLTPLRGRGDRLIGVIVLAWPDQPDLVTVRMVEAIARQAALAVENVRLAERS
CCCCCHHHHHCCCCCCCCEEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
ARLLAKEQLLAELGRAVGATLDLDTILHQTIDRLAAAFGSGLVALLDNQETLMVVAAAPP
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCC
LDTLIGRQLPLLSGSLAWVVQSGQPFVVDDCRLHAPDMALFGPDIASCIIAPLRSGGRVI
HHHHHCCCCCCCCCCEEEEEECCCCEEEECCEECCCCCHHCCCHHHHHHHHHHCCCCCEE
GMLSVVSRQAGVFSDEDVDLLEAIAAQVSGPVVSARLYAESQRLAAQVQRRADQLAVLNS
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IARIVTATLDLRESLPLATEQIQRGFGYPQVDLFLLEEEANELILVASAGRYAPERVGYR
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHCCHH
QHINLGLVGRAARSGRIVRAEDVAAEADYLGLSERLDIRSELCVPLISNGKTLGVLNIES
HCCCEEEEECHHCCCCEEEHHHHHHHHHHCCCHHHHCCHHHHCHHHHCCCCEEEEEECCC
PERAGLTEEDAAVLETVADMLAGAVENGRLYQRAQQAAALEERNRLARELHDSVSQQLFS
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTLTAQAARSQFERNPARVPALLDRLHETATAALAEMRALIFQLRPPALRDQGLVAAIQQ
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
HAQHLAHREGLRIELNVIGDERHARGIEQPLFRIVQEALNNIVKHAAARNVQIMLEFNAD
HHHHHHHHCCCEEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
QVAIRVIDDGKGFDPAARPSGEGRHLGLLSMRERAAELGGSFNVHSRPGAGAEVEVVVPL
EEEEEEEECCCCCCCCCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEE
RGRHGNLERPE
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]