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The map label for this gene is glxR [H]

Identifier: 222526671

GI number: 222526671

Start: 4288704

End: 4289573

Strand: Reverse

Name: glxR [H]

Synonym: Chy400_3440

Alternate gene names: 222526671

Gene position: 4289573-4288704 (Counterclockwise)

Preceding gene: 222526672

Following gene: 222526667

Centisome position: 81.41

GC content: 59.31

Gene sequence:

>870_bases
ATGAAGATTGCATTAATCGGCCTGGGTTTAATGGGAAGGCCAATGGCGCGTACATTGTTGAAGGCAGGATTCAACGTTAC
CGGCTGGAATCGCTCACCACTCGACCCCGCGCTCACTGAAGGGATACCACTGGCCGCAACACTGGCTGAAGCGGCTCAGG
CCGAGACCCTCATCCTGATGCTCAGCGACTCAACGGCAGTCGCTGAACTCTTAAGCCGGCTTGATCCTCTCTTGCGCGAG
GGGCAGTTAATCATCGACATGGGCAGCTCCGATCCACGTCACTCCCAGACCCATGCCACAACCCTGGCAAACCGCGGCAT
CGGCTGGGTTGATGCACCTGTTTCAGGCGGGCCAGAGGGTGCGGCTGCCGGAACACTGGCCATCATGGTTGGCGGCACGG
CCAGCGATGTCGAACGGGCAGAACCGATCCTTCGTGCATTGGGGCGCCCAACCCACGTTGGCCCGCCGGGTGCCGGACAT
ACAGTAAAAGTCATCAACCAGCTTATTGTCGGCCTGACAATCCAGGCTGTCGCCGAGGCGATGGTTCTGGCCGAAGCCTA
CGGGATCGACCCGGCACTGTTACGAACAGCATTGGCCGGCGGTTTTGCCGACTCAAAAGTGCTCCAGATCCACGGCCAGC
GCATGGCAGCGCGACGCTACACCCCTGGCGGCAAGGTAACCACCCAGCTCAAAGATCTGCGCATGGCCGCAGCAATGGCA
TCGGCAGCAGGCATTGCTTTACCACATCTTAACGACACCATCGCACGCTACGAAACACTGGTAGAGCGCGGCCTGGGTGA
ACTGGATCATTCCGCCTTGCATATCCTGTTAGATGAGAGGCGCGCAAGAGGGGAAAAGGACAACGCTTGA

Upstream 100 bases:

>100_bases
GTGCAGTCGTGCGCTGGGACGATGTTGCCTACGAGACCAATCATCCAACAGTACGACTACGCCGCCTTATGGAGCGCACC
ATGCTGACGGAGACAAGCCA

Downstream 100 bases:

>100_bases
GGTAACCCAAGTTGCCACCTACGCTGTGAGCAGGCTACGGAGGCTGACTGCCAGGATGAACAGCACGACACTGCGCACAA
CACCGTGCGCTGTAACGGTA

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKIALIGLGLMGRPMARTLLKAGFNVTGWNRSPLDPALTEGIPLAATLAEAAQAETLILMLSDSTAVAELLSRLDPLLRE
GQLIIDMGSSDPRHSQTHATTLANRGIGWVDAPVSGGPEGAAAGTLAIMVGGTASDVERAEPILRALGRPTHVGPPGAGH
TVKVINQLIVGLTIQAVAEAMVLAEAYGIDPALLRTALAGGFADSKVLQIHGQRMAARRYTPGGKVTTQLKDLRMAAAMA
SAAGIALPHLNDTIARYETLVERGLGELDHSALHILLDERRARGEKDNA

Sequences:

>Translated_289_residues
MKIALIGLGLMGRPMARTLLKAGFNVTGWNRSPLDPALTEGIPLAATLAEAAQAETLILMLSDSTAVAELLSRLDPLLRE
GQLIIDMGSSDPRHSQTHATTLANRGIGWVDAPVSGGPEGAAAGTLAIMVGGTASDVERAEPILRALGRPTHVGPPGAGH
TVKVINQLIVGLTIQAVAEAMVLAEAYGIDPALLRTALAGGFADSKVLQIHGQRMAARRYTPGGKVTTQLKDLRMAAAMA
SAAGIALPHLNDTIARYETLVERGLGELDHSALHILLDERRARGEKDNA
>Mature_289_residues
MKIALIGLGLMGRPMARTLLKAGFNVTGWNRSPLDPALTEGIPLAATLAEAAQAETLILMLSDSTAVAELLSRLDPLLRE
GQLIIDMGSSDPRHSQTHATTLANRGIGWVDAPVSGGPEGAAAGTLAIMVGGTASDVERAEPILRALGRPTHVGPPGAGH
TVKVINQLIVGLTIQAVAEAMVLAEAYGIDPALLRTALAGGFADSKVLQIHGQRMAARRYTPGGKVTTQLKDLRMAAAMA
SAAGIALPHLNDTIARYETLVERGLGELDHSALHILLDERRARGEKDNA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=307, Percent_Identity=28.6644951140065, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI40556376, Length=256, Percent_Identity=28.90625, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1786719, Length=282, Percent_Identity=39.0070921985816, Blast_Score=183, Evalue=9e-48,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=35.958904109589, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1790315, Length=195, Percent_Identity=36.9230769230769, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=29.5774647887324, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788341, Length=200, Percent_Identity=29.5, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=194, Percent_Identity=32.9896907216495, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17542558, Length=199, Percent_Identity=30.6532663316583, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321695, Length=204, Percent_Identity=27.9411764705882, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=26.530612244898, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=26.530612244898, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=23.4875444839858, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30177; Mature: 30177

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIALIGLGLMGRPMARTLLKAGFNVTGWNRSPLDPALTEGIPLAATLAEAAQAETLILM
CEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHCCCEEEEE
LSDSTAVAELLSRLDPLLREGQLIIDMGSSDPRHSQTHATTLANRGIGWVDAPVSGGPEG
EECCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCC
AAAGTLAIMVGGTASDVERAEPILRALGRPTHVGPPGAGHTVKVINQLIVGLTIQAVAEA
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MVLAEAYGIDPALLRTALAGGFADSKVLQIHGQRMAARRYTPGGKVTTQLKDLRMAAAMA
HHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHHHH
SAAGIALPHLNDTIARYETLVERGLGELDHSALHILLDERRARGEKDNA
HHCCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKIALIGLGLMGRPMARTLLKAGFNVTGWNRSPLDPALTEGIPLAATLAEAAQAETLILM
CEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHCCCEEEEE
LSDSTAVAELLSRLDPLLREGQLIIDMGSSDPRHSQTHATTLANRGIGWVDAPVSGGPEG
EECCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCC
AAAGTLAIMVGGTASDVERAEPILRALGRPTHVGPPGAGHTVKVINQLIVGLTIQAVAEA
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MVLAEAYGIDPALLRTALAGGFADSKVLQIHGQRMAARRYTPGGKVTTQLKDLRMAAAMA
HHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHHHH
SAAGIALPHLNDTIARYETLVERGLGELDHSALHILLDERRARGEKDNA
HHCCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]