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The map label for this gene is fhs

Identifier: 222526090

GI number: 222526090

Start: 3513116

End: 3514834

Strand: Direct

Name: fhs

Synonym: Chy400_2847

Alternate gene names: 222526090

Gene position: 3513116-3514834 (Clockwise)

Preceding gene: 222526089

Following gene: 222526091

Centisome position: 66.68

GC content: 58.99

Gene sequence:

>1719_bases
ATGAAAACCAGTCTCCAGATCGCTGCCGAAGCCCGGCTAGAGCCAATCGCTGCCATTGCCGAACGGCTTGGCCTGCCTGT
CAGGTACCTCGAACCGTATGGCCGGTACCGCGGCAAGATTGACCTCACCTTTCTTGACGACTACCACGACCGGCCATTGG
GCCGTTATGTCCTGGTCAGCGCAATCACCCCCACACCGCTCGGCGAAGGCAAGACCACAACCGCCATCGGGCTGGCAATG
GCGCTCAATCGCATTGGCAAGCGTGCCGCGGTCACCTTACGCCAATCCTCGTTAGGGCCGGTCTTTGGCATTAAAGGCGG
TGGTGCCGGCGGCGGTTACAGCCAGATCGTGCCCCTTGTCGAAAGCATTCTGCACCTGAACGGCGATATTCACGCTGTAT
CACAGGCGCACAATCAGTTGGCTGCGCTGACCGACAATAGCTGGTATCACGGCAACCCGCTCGATATTGATCCCGACCGG
ATCGAGATTCGCCGGGTTGTTGACGTGAATGATCGCTTTCTGCGCCAGGTGATGATCGGGCTGGGTGGTAAACAGAATGG
TTTTCCTCGTCAGACCGGCTTCGACATCAGTGTCGCAAGTGAACTCATGGCCATTCTGGCGATGGTGAACGGTGTTGGTG
CCCGGGCTGCCTTGCGCGATCTCCGCAGCCGGATCGGTCGTATGGTGGTTGCCTTCCGCCGTGACGGTACACCCATTACT
GCTGAAGATGTGCGTGGTGCCGGGGCGGCGACAGTACTTATGCGTGAGGCGCTCAAACCGAACCTGATGCAGACTATCGA
AAATACACCAGCCCTCATTCATGCCGGGCCATTCGCCAACATTGCCCAGGGTAATTCATCGATCCTGGCCGATCTGATTG
CGTTACGGTGTGCCGATTATGTGGTCACCGAAGCCGGGTTTGGCGTGGATATCGGGGCAGAAAAGTTCTTCAATCTAAAG
TGTCGGGCCAGCGGACTCTGGCCCGATGTGGCGGTCATCGTCGCGACTATTCGGGCGCTGAAGGCGCATAGCGGAAAGTA
CGACATTGTAGCCGGCAAACCGTTGCCGCCTGCCTTACTGCACGAAAATCCCGACGATGTCATCAGCGGTGGCGCCAACC
TGCGGCGCCAGATCGAGAACCTGCACCAGTTCAAGGTACCGGTGATTGTTGCCCTCAATGCATACCCGGAAGACACGCCA
GCAGAGATAGACGCAGTTGCCCACATTGCCACCACTGCCGGCGCTGCTGGCATGGCGGTGAGCAATGTCTATGCCGCAGG
CAGTGCCGGCGGCGTAGACCTGGCCCGCCTGGTTATCGAGATTGCCGAACGACCGGGACCGCGTCCGGTACAGTTTCTCT
ACCCACTGGAGTGGTCGCTGGCCGACAAAATCACCACTATCGCGCATCGCATTTACGGCGCGGCAGCGGTAACGTTCAGC
CCAACAGCAGCCGCCCAACTGGCAGCCCTTGAGGATGCTGGTTTTGGCAATTTACCCATCTGCATGGCGAAAACGCATCT
CAGCCTGAGCCACGATCCGGCCTTGCGCGGTGCACCGGAAGGCTTCACCTTCCCGATTCGCGAGGTGCGCCTCAGTGCTG
GTGCCGGATTCATCTTGCCGATTGCCGGCACGACAGTCACGATGCCGGGTCTGGGTGCCCATCCAGCGGCCCATCAGATT
GACATTGATGACGAGGGGAATATTGTTGGTCTGTTTTAG

Upstream 100 bases:

>100_bases
CCGACCGAACGAGTCGGTTGCCATCGTCGATTTACAGACAGCCACTCGCGTCCTGGCCCTCACTGCCCTTCGCTTCTGCG
GTTACGATGAGGAATAGTTG

Downstream 100 bases:

>100_bases
TGAAGGTTGGGCTGGTCATTGCGGAAAAGATTGTTGCCAGTTTAACCAACGGGGGAACAAGCAACCCATACGTCGCTTCT
GAATGTTGCTTTGACATCGA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MKTSLQIAAEARLEPIAAIAERLGLPVRYLEPYGRYRGKIDLTFLDDYHDRPLGRYVLVSAITPTPLGEGKTTTAIGLAM
ALNRIGKRAAVTLRQSSLGPVFGIKGGGAGGGYSQIVPLVESILHLNGDIHAVSQAHNQLAALTDNSWYHGNPLDIDPDR
IEIRRVVDVNDRFLRQVMIGLGGKQNGFPRQTGFDISVASELMAILAMVNGVGARAALRDLRSRIGRMVVAFRRDGTPIT
AEDVRGAGAATVLMREALKPNLMQTIENTPALIHAGPFANIAQGNSSILADLIALRCADYVVTEAGFGVDIGAEKFFNLK
CRASGLWPDVAVIVATIRALKAHSGKYDIVAGKPLPPALLHENPDDVISGGANLRRQIENLHQFKVPVIVALNAYPEDTP
AEIDAVAHIATTAGAAGMAVSNVYAAGSAGGVDLARLVIEIAERPGPRPVQFLYPLEWSLADKITTIAHRIYGAAAVTFS
PTAAAQLAALEDAGFGNLPICMAKTHLSLSHDPALRGAPEGFTFPIREVRLSAGAGFILPIAGTTVTMPGLGAHPAAHQI
DIDDEGNIVGLF

Sequences:

>Translated_572_residues
MKTSLQIAAEARLEPIAAIAERLGLPVRYLEPYGRYRGKIDLTFLDDYHDRPLGRYVLVSAITPTPLGEGKTTTAIGLAM
ALNRIGKRAAVTLRQSSLGPVFGIKGGGAGGGYSQIVPLVESILHLNGDIHAVSQAHNQLAALTDNSWYHGNPLDIDPDR
IEIRRVVDVNDRFLRQVMIGLGGKQNGFPRQTGFDISVASELMAILAMVNGVGARAALRDLRSRIGRMVVAFRRDGTPIT
AEDVRGAGAATVLMREALKPNLMQTIENTPALIHAGPFANIAQGNSSILADLIALRCADYVVTEAGFGVDIGAEKFFNLK
CRASGLWPDVAVIVATIRALKAHSGKYDIVAGKPLPPALLHENPDDVISGGANLRRQIENLHQFKVPVIVALNAYPEDTP
AEIDAVAHIATTAGAAGMAVSNVYAAGSAGGVDLARLVIEIAERPGPRPVQFLYPLEWSLADKITTIAHRIYGAAAVTFS
PTAAAQLAALEDAGFGNLPICMAKTHLSLSHDPALRGAPEGFTFPIREVRLSAGAGFILPIAGTTVTMPGLGAHPAAHQI
DIDDEGNIVGLF
>Mature_572_residues
MKTSLQIAAEARLEPIAAIAERLGLPVRYLEPYGRYRGKIDLTFLDDYHDRPLGRYVLVSAITPTPLGEGKTTTAIGLAM
ALNRIGKRAAVTLRQSSLGPVFGIKGGGAGGGYSQIVPLVESILHLNGDIHAVSQAHNQLAALTDNSWYHGNPLDIDPDR
IEIRRVVDVNDRFLRQVMIGLGGKQNGFPRQTGFDISVASELMAILAMVNGVGARAALRDLRSRIGRMVVAFRRDGTPIT
AEDVRGAGAATVLMREALKPNLMQTIENTPALIHAGPFANIAQGNSSILADLIALRCADYVVTEAGFGVDIGAEKFFNLK
CRASGLWPDVAVIVATIRALKAHSGKYDIVAGKPLPPALLHENPDDVISGGANLRRQIENLHQFKVPVIVALNAYPEDTP
AEIDAVAHIATTAGAAGMAVSNVYAAGSAGGVDLARLVIEIAERPGPRPVQFLYPLEWSLADKITTIAHRIYGAAAVTFS
PTAAAQLAALEDAGFGNLPICMAKTHLSLSHDPALRGAPEGFTFPIREVRLSAGAGFILPIAGTTVTMPGLGAHPAAHQI
DIDDEGNIVGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI36796743, Length=613, Percent_Identity=47.3083197389886, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI222136639, Length=626, Percent_Identity=45.3674121405751, Blast_Score=502, Evalue=1e-142,
Organism=Homo sapiens, GI310124614, Length=103, Percent_Identity=45.6310679611651, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17568737, Length=625, Percent_Identity=46.24, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17568739, Length=625, Percent_Identity=46.24, Blast_Score=484, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6321643, Length=620, Percent_Identity=46.6129032258064, Blast_Score=508, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6319558, Length=625, Percent_Identity=43.68, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI62472483, Length=626, Percent_Identity=44.2492012779553, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=626, Percent_Identity=44.2492012779553, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24645718, Length=626, Percent_Identity=44.2492012779553, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=626, Percent_Identity=44.2492012779553, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_CHLAA (A9WIW3)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001636229.1
- ProteinModelPortal:   A9WIW3
- SMR:   A9WIW3
- GeneID:   5827104
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_2634
- HOGENOM:   HBG677721
- OMA:   VVASEVM
- ProtClustDB:   CLSK983690
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60580; Mature: 60580

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSLQIAAEARLEPIAAIAERLGLPVRYLEPYGRYRGKIDLTFLDDYHDRPLGRYVLVS
CCCCEEEHHHHHCCHHHHHHHHHCCCEEHHCHHHHCCCEEEEEEECCCCCCCCCCEEEEE
AITPTPLGEGKTTTAIGLAMALNRIGKRAAVTLRQSSLGPVFGIKGGGAGGGYSQIVPLV
ECCCCCCCCCCCHHHHHHHHHHHHHCCHHEEEEECCCCCCEEEECCCCCCCCHHHHHHHH
ESILHLNGDIHAVSQAHNQLAALTDNSWYHGNPLDIDPDRIEIRRVVDVNDRFLRQVMIG
HHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
LGGKQNGFPRQTGFDISVASELMAILAMVNGVGARAALRDLRSRIGRMVVAFRRDGTPIT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEECCCCCCC
AEDVRGAGAATVLMREALKPNLMQTIENTPALIHAGPFANIAQGNSSILADLIALRCADY
HHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
VVTEAGFGVDIGAEKFFNLKCRASGLWPDVAVIVATIRALKAHSGKYDIVAGKPLPPALL
HHCCCCCCCCCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
HENPDDVISGGANLRRQIENLHQFKVPVIVALNAYPEDTPAEIDAVAHIATTAGAAGMAV
CCCCHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHH
SNVYAAGSAGGVDLARLVIEIAERPGPRPVQFLYPLEWSLADKITTIAHRIYGAAAVTFS
HHHEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEC
PTAAAQLAALEDAGFGNLPICMAKTHLSLSHDPALRGAPEGFTFPIREVRLSAGAGFILP
CHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHEECCCCCEEEE
IAGTTVTMPGLGAHPAAHQIDIDDEGNIVGLF
ECCCEEECCCCCCCCCCCEEEECCCCCEEEEC
>Mature Secondary Structure
MKTSLQIAAEARLEPIAAIAERLGLPVRYLEPYGRYRGKIDLTFLDDYHDRPLGRYVLVS
CCCCEEEHHHHHCCHHHHHHHHHCCCEEHHCHHHHCCCEEEEEEECCCCCCCCCCEEEEE
AITPTPLGEGKTTTAIGLAMALNRIGKRAAVTLRQSSLGPVFGIKGGGAGGGYSQIVPLV
ECCCCCCCCCCCHHHHHHHHHHHHHCCHHEEEEECCCCCCEEEECCCCCCCCHHHHHHHH
ESILHLNGDIHAVSQAHNQLAALTDNSWYHGNPLDIDPDRIEIRRVVDVNDRFLRQVMIG
HHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
LGGKQNGFPRQTGFDISVASELMAILAMVNGVGARAALRDLRSRIGRMVVAFRRDGTPIT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEECCCCCCC
AEDVRGAGAATVLMREALKPNLMQTIENTPALIHAGPFANIAQGNSSILADLIALRCADY
HHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
VVTEAGFGVDIGAEKFFNLKCRASGLWPDVAVIVATIRALKAHSGKYDIVAGKPLPPALL
HHCCCCCCCCCCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
HENPDDVISGGANLRRQIENLHQFKVPVIVALNAYPEDTPAEIDAVAHIATTAGAAGMAV
CCCCHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHH
SNVYAAGSAGGVDLARLVIEIAERPGPRPVQFLYPLEWSLADKITTIAHRIYGAAAVTFS
HHHEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEC
PTAAAQLAALEDAGFGNLPICMAKTHLSLSHDPALRGAPEGFTFPIREVRLSAGAGFILP
CHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHEECCCCCEEEE
IAGTTVTMPGLGAHPAAHQIDIDDEGNIVGLF
ECCCEEECCCCCCCCCCCEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA