Click here to switch to the map view.

The map label for this gene is comEC [H]

Identifier: 222526078

GI number: 222526078

Start: 3498351

End: 3499865

Strand: Direct

Name: comEC [H]

Synonym: Chy400_2835

Alternate gene names: 222526078

Gene position: 3498351-3499865 (Clockwise)

Preceding gene: 222526077

Following gene: 222526080

Centisome position: 66.4

GC content: 58.48

Gene sequence:

>1515_bases
ATGAATCTGATTCGACTCGCAATCGGTTGGCTGGTCGGGATTGGCCTGGCAGGTTCGTTCAATGTTCCGTTGCCCTGGTG
GCTGATTGTGGCTACCGTGGCGCTGGTGGGGTTACCGTTTGACCGCAGCTCTCAACGCTGGCTGGCCCTCTCGGTGCTGT
GCTGCGCGTTGGGAGGTGTTCGTTTTCATGTTGCTCAACCCCTGATCGGCCCGCAGCATATTGAGCGTTGGGCTGATACT
AACCGTCTCACTCTGGTTGGCTATGTAGCAGAGGAACCCCGCCGTGATGATCGGGGTCAGCAACTTGTTGTCGAAGTTAC
CCATACCCGCACCTCCGAACGGTTCGTTATGACGGAAGGGCGGGTTCTGGTGCGGGTACCGCCCTATCCGCCATATTATC
CAGGCGACCGGCTCTGGCTGGAAGGAGATCTGAGCAGGCCGGCTACTGCACAGCGGGTAGGGGAATTTGACTACCGGGTC
TACCTGGCGCGGCGCAATATCTTCGTGCTCATGCATCGGCCCACAGTGATCCGGCAACTCGACAAGCCGGTCACGAATTG
GGGGATAAAACAGATCAGTCAGTTCCGTGAACATTGTCGGCAGATTATCTTGCGCCTCTTACCCGAACCCCAGGCAGCGC
TGACAATTGGGATTTTGCTCGGTATTCAGGCCGGGTTACCAGAAACCACCCGCACGGCTTTCGCAGCGACCGGAACATCG
CATATTCTGGTTGTTTCAGGCTGGAATTTCAGCATTGCCGCAGCAGCGCTGGCAGCCCTGGCCCGATTGTTGCGCCTGCC
GCCCTGGCCCGCCTTCTGGCTGAGTCTGGCAATCATGTGGATATATGCCGGTTTCACCGGTGCTTCAGCAGCCGTTATAC
GGGCGGCAATGATGGCGAGTCTTGCGCTTTTGGCCCGCACCGCCGAGCGGCAGAGTGAACCCTGGCGCCTGTTGCTGGCT
GCATGCTGGCTGTTAACCCTGATCAATCCGCAAACACTGTGGGATTTAGGCTTCCAGTTATCGGCGCTGGCTACGGCCAG
TCTGTTCGCATTTGGCAAGCCGGTTGATCACTGGCTGGATACGGTACGCTGGCCCCCTCATCCGGTGGTAGATGCGATGC
GCGAGGCACTCGGTGCAACCCTGGCTGCCCAGGTCTTGACCCTGCCGCTGATGCTCTACCACTTCGGGAATCTCTCCCTC
ATCGCTCCGCTGGCCAATATTGTGATCGTACCGGTTGTTCCTTTTGCCATGTTACTCGGTGGTTGTGCCCTTCTCGGTGG
TCTGGTCTGGCTACCGTTGGGTCAGTGGCTGGCGCTGTGTGCCTGGCTCCCGCTAAGCTGGATCAACAGCGTTGCGATGT
TGCTGGCAGAGCCGGCGTGGGCCGTTGTCCGACTCCCGGTGTTTCCACTCTGGCTATTAGTCGTTATGTATGTCGTGATT
GCCAGTGTCTGGTGGCGATGGGTACGAGATGATGGGCAGGTAAATGCTGCGGCTGTCAGATCATCCGTGGACTGA

Upstream 100 bases:

>100_bases
TTGAAGCTGAGTCATAATATTTGCCATACATCGTGCGCACCTTTGCCTGGGTCTGAACGGTATCTTTTATAGTACCGCGT
TTTTGACAACAGGCAAAGCG

Downstream 100 bases:

>100_bases
TACTCACTGCACGCTTACGGGAATGAGAGGTTGCTACTCTCAAGGTACGCGACATAGGCATTCCCCTGGGAGCGCGCGCC
TCCGGCGCGCTCATCAGTGG

Product: ComEC/Rec2-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MNLIRLAIGWLVGIGLAGSFNVPLPWWLIVATVALVGLPFDRSSQRWLALSVLCCALGGVRFHVAQPLIGPQHIERWADT
NRLTLVGYVAEEPRRDDRGQQLVVEVTHTRTSERFVMTEGRVLVRVPPYPPYYPGDRLWLEGDLSRPATAQRVGEFDYRV
YLARRNIFVLMHRPTVIRQLDKPVTNWGIKQISQFREHCRQIILRLLPEPQAALTIGILLGIQAGLPETTRTAFAATGTS
HILVVSGWNFSIAAAALAALARLLRLPPWPAFWLSLAIMWIYAGFTGASAAVIRAAMMASLALLARTAERQSEPWRLLLA
ACWLLTLINPQTLWDLGFQLSALATASLFAFGKPVDHWLDTVRWPPHPVVDAMREALGATLAAQVLTLPLMLYHFGNLSL
IAPLANIVIVPVVPFAMLLGGCALLGGLVWLPLGQWLALCAWLPLSWINSVAMLLAEPAWAVVRLPVFPLWLLVVMYVVI
ASVWWRWVRDDGQVNAAAVRSSVD

Sequences:

>Translated_504_residues
MNLIRLAIGWLVGIGLAGSFNVPLPWWLIVATVALVGLPFDRSSQRWLALSVLCCALGGVRFHVAQPLIGPQHIERWADT
NRLTLVGYVAEEPRRDDRGQQLVVEVTHTRTSERFVMTEGRVLVRVPPYPPYYPGDRLWLEGDLSRPATAQRVGEFDYRV
YLARRNIFVLMHRPTVIRQLDKPVTNWGIKQISQFREHCRQIILRLLPEPQAALTIGILLGIQAGLPETTRTAFAATGTS
HILVVSGWNFSIAAAALAALARLLRLPPWPAFWLSLAIMWIYAGFTGASAAVIRAAMMASLALLARTAERQSEPWRLLLA
ACWLLTLINPQTLWDLGFQLSALATASLFAFGKPVDHWLDTVRWPPHPVVDAMREALGATLAAQVLTLPLMLYHFGNLSL
IAPLANIVIVPVVPFAMLLGGCALLGGLVWLPLGQWLALCAWLPLSWINSVAMLLAEPAWAVVRLPVFPLWLLVVMYVVI
ASVWWRWVRDDGQVNAAAVRSSVD
>Mature_504_residues
MNLIRLAIGWLVGIGLAGSFNVPLPWWLIVATVALVGLPFDRSSQRWLALSVLCCALGGVRFHVAQPLIGPQHIERWADT
NRLTLVGYVAEEPRRDDRGQQLVVEVTHTRTSERFVMTEGRVLVRVPPYPPYYPGDRLWLEGDLSRPATAQRVGEFDYRV
YLARRNIFVLMHRPTVIRQLDKPVTNWGIKQISQFREHCRQIILRLLPEPQAALTIGILLGIQAGLPETTRTAFAATGTS
HILVVSGWNFSIAAAALAALARLLRLPPWPAFWLSLAIMWIYAGFTGASAAVIRAAMMASLALLARTAERQSEPWRLLLA
ACWLLTLINPQTLWDLGFQLSALATASLFAFGKPVDHWLDTVRWPPHPVVDAMREALGATLAAQVLTLPLMLYHFGNLSL
IAPLANIVIVPVVPFAMLLGGCALLGGLVWLPLGQWLALCAWLPLSWINSVAMLLAEPAWAVVRLPVFPLWLLVVMYVVI
ASVWWRWVRDDGQVNAAAVRSSVD

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 55943; Mature: 55943

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIRLAIGWLVGIGLAGSFNVPLPWWLIVATVALVGLPFDRSSQRWLALSVLCCALGGV
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
RFHVAQPLIGPQHIERWADTNRLTLVGYVAEEPRRDDRGQQLVVEVTHTRTSERFVMTEG
CEEHHCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCEEEEECC
RVLVRVPPYPPYYPGDRLWLEGDLSRPATAQRVGEFDYRVYLARRNIFVLMHRPTVIRQL
EEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCEEEEEEECCEEEEEECCHHHHHH
DKPVTNWGIKQISQFREHCRQIILRLLPEPQAALTIGILLGIQAGLPETTRTAFAATGTS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHEECCCC
HILVVSGWNFSIAAAALAALARLLRLPPWPAFWLSLAIMWIYAGFTGASAAVIRAAMMAS
EEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LALLARTAERQSEPWRLLLAACWLLTLINPQTLWDLGFQLSALATASLFAFGKPVDHWLD
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHCCCCHHHHHH
TVRWPPHPVVDAMREALGATLAAQVLTLPLMLYHFGNLSLIAPLANIVIVPVVPFAMLLG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GCALLGGLVWLPLGQWLALCAWLPLSWINSVAMLLAEPAWAVVRLPVFPLWLLVVMYVVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ASVWWRWVRDDGQVNAAAVRSSVD
HHHHHHHHCCCCCEEHHHHHCCCC
>Mature Secondary Structure
MNLIRLAIGWLVGIGLAGSFNVPLPWWLIVATVALVGLPFDRSSQRWLALSVLCCALGGV
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
RFHVAQPLIGPQHIERWADTNRLTLVGYVAEEPRRDDRGQQLVVEVTHTRTSERFVMTEG
CEEHHCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCCEEEEECC
RVLVRVPPYPPYYPGDRLWLEGDLSRPATAQRVGEFDYRVYLARRNIFVLMHRPTVIRQL
EEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCEEEEEEECCEEEEEECCHHHHHH
DKPVTNWGIKQISQFREHCRQIILRLLPEPQAALTIGILLGIQAGLPETTRTAFAATGTS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHEECCCC
HILVVSGWNFSIAAAALAALARLLRLPPWPAFWLSLAIMWIYAGFTGASAAVIRAAMMAS
EEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LALLARTAERQSEPWRLLLAACWLLTLINPQTLWDLGFQLSALATASLFAFGKPVDHWLD
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHCCCCHHHHHH
TVRWPPHPVVDAMREALGATLAAQVLTLPLMLYHFGNLSLIAPLANIVIVPVVPFAMLLG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GCALLGGLVWLPLGQWLALCAWLPLSWINSVAMLLAEPAWAVVRLPVFPLWLLVVMYVVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ASVWWRWVRDDGQVNAAAVRSSVD
HHHHHHHHCCCCCEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]