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The map label for this gene is hmuU [H]

Identifier: 222525865

GI number: 222525865

Start: 3254143

End: 3255207

Strand: Direct

Name: hmuU [H]

Synonym: Chy400_2618

Alternate gene names: 222525865

Gene position: 3254143-3255207 (Clockwise)

Preceding gene: 222525864

Following gene: 222525866

Centisome position: 61.76

GC content: 57.37

Gene sequence:

>1065_bases
ATGAGTGTGACGTCCGTTGCTCCTGGCCTCCGCTTACGTTTTGCCGGGCGGGGCTGGTTATTGCCGATACTGGCAGTGGT
CTTGTCTGTAGCATTCTTGTTGGGGGTCGGTATTGGTGCGGTGGCCGTTCCGCCTGATGTGGTAGTAGCCATTCTGTTGA
GCAAGATCGGTGTTTCAGTTGAAACAGCGGTTTCGCAACAACAGATGGCAGTGTTATGGAATATTCGTCTGCCACGAGTC
GTGCTCGGCGGGTTGGTCGGTGCAGCGCTGGCGGTAAGTGGAGCACTCTTGCAGGGGATTTTCCGTAATCCCCTGGCCGA
CCCCGGTTTGATCGGGGTGAGTAGCGGGGCAGCGCTGGGAGCTGTCTTCACCATCATTAGTGGTCTGGCAGTATTTGGTA
TCTACACCTTACCGGTTGCTGCATTCCTGGCCGGCGCTGCAACGACACTGCTCGTTTACCGACTGTCGCGCCGGCATGGT
CGAACCGATGTGGCGATGCTCTTGCTGGTTGGTCTGGCACTTAATGCATTAGCGGGGGCAACAACCGGTCTGCTGACCTA
CCTTGCCGATGATGATCAGTTGCGTTCGATTGTCTTTTGGACACTGGGTGGATTGGGGGGAGCGCTGTGGGAGACGGTTC
TGGCTGCGACTCCGCCAATTCTGATCGTGCTTGTGTTAGCGCCGAGGCTGGGATTTTATCTCAATCTCTTTGCACTGGGT
GAGGCGGAAGCCCGCCATCTTGGTGTGAATGTGGAGTGGATTAAGCGGGCAGCGGTGTTGATGGCGGCGCTGGCGACCGG
TGCAGCGGTCGCGCTGACCGGGCCAATCGGGTTTATCGGTCTGATTGTTCCCCATATGGTGCGTCTGACTATCGGTCCCG
ATCATCGCTGGCTCATTCCAGCCTGTGCCTTTGGTGGCGCAACCCTGTTGATCCTGGCCGATCTGCTGGCTCGTACACTG
GCAGCACCGGCTGAAATTCCGGTAGGGCTTTTCACTTCTTTCGCGGGTGGGCCATTCTTTCTGGCCTTGATCTTGCGTAC
ACGCCGACACTATGGCTTCAGTTGA

Upstream 100 bases:

>100_bases
TCGATGATCTCTATCTGTTGGGGATGGGGCCACGCACCGGTCAGGCATTGGCCGATCTGGTGGCAGCATTCAAGGATGCT
GTAGCACAAACGGGTGGATC

Downstream 100 bases:

>100_bases
GATGGAAGGAGACAGCATGATCACAACTGCAAATCGCATCTTTGTTCATCCCGACTATGCAGACCTGTTTGAAGAGACAT
TCCGCAATCGTGCCCGTCTG

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSVTSVAPGLRLRFAGRGWLLPILAVVLSVAFLLGVGIGAVAVPPDVVVAILLSKIGVSVETAVSQQQMAVLWNIRLPRV
VLGGLVGAALAVSGALLQGIFRNPLADPGLIGVSSGAALGAVFTIISGLAVFGIYTLPVAAFLAGAATTLLVYRLSRRHG
RTDVAMLLLVGLALNALAGATTGLLTYLADDDQLRSIVFWTLGGLGGALWETVLAATPPILIVLVLAPRLGFYLNLFALG
EAEARHLGVNVEWIKRAAVLMAALATGAAVALTGPIGFIGLIVPHMVRLTIGPDHRWLIPACAFGGATLLILADLLARTL
AAPAEIPVGLFTSFAGGPFFLALILRTRRHYGFS

Sequences:

>Translated_354_residues
MSVTSVAPGLRLRFAGRGWLLPILAVVLSVAFLLGVGIGAVAVPPDVVVAILLSKIGVSVETAVSQQQMAVLWNIRLPRV
VLGGLVGAALAVSGALLQGIFRNPLADPGLIGVSSGAALGAVFTIISGLAVFGIYTLPVAAFLAGAATTLLVYRLSRRHG
RTDVAMLLLVGLALNALAGATTGLLTYLADDDQLRSIVFWTLGGLGGALWETVLAATPPILIVLVLAPRLGFYLNLFALG
EAEARHLGVNVEWIKRAAVLMAALATGAAVALTGPIGFIGLIVPHMVRLTIGPDHRWLIPACAFGGATLLILADLLARTL
AAPAEIPVGLFTSFAGGPFFLALILRTRRHYGFS
>Mature_353_residues
SVTSVAPGLRLRFAGRGWLLPILAVVLSVAFLLGVGIGAVAVPPDVVVAILLSKIGVSVETAVSQQQMAVLWNIRLPRVV
LGGLVGAALAVSGALLQGIFRNPLADPGLIGVSSGAALGAVFTIISGLAVFGIYTLPVAAFLAGAATTLLVYRLSRRHGR
TDVAMLLLVGLALNALAGATTGLLTYLADDDQLRSIVFWTLGGLGGALWETVLAATPPILIVLVLAPRLGFYLNLFALGE
AEARHLGVNVEWIKRAAVLMAALATGAAVALTGPIGFIGLIVPHMVRLTIGPDHRWLIPACAFGGATLLILADLLARTLA
APAEIPVGLFTSFAGGPFFLALILRTRRHYGFS

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=279, Percent_Identity=40.5017921146953, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1790740, Length=283, Percent_Identity=40.6360424028269, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1790741, Length=279, Percent_Identity=36.9175627240143, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1786805, Length=318, Percent_Identity=36.1635220125786, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786804, Length=323, Percent_Identity=34.0557275541796, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786347, Length=281, Percent_Identity=32.7402135231317, Blast_Score=98, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36604; Mature: 36473

Theoretical pI: Translated: 10.92; Mature: 10.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTSVAPGLRLRFAGRGWLLPILAVVLSVAFLLGVGIGAVAVPPDVVVAILLSKIGVSV
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHH
ETAVSQQQMAVLWNIRLPRVVLGGLVGAALAVSGALLQGIFRNPLADPGLIGVSSGAALG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHH
AVFTIISGLAVFGIYTLPVAAFLAGAATTLLVYRLSRRHGRTDVAMLLLVGLALNALAGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TTGLLTYLADDDQLRSIVFWTLGGLGGALWETVLAATPPILIVLVLAPRLGFYLNLFALG
HHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEC
EAEARHLGVNVEWIKRAAVLMAALATGAAVALTGPIGFIGLIVPHMVRLTIGPDHRWLIP
CCHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHEEEECCCCCEEEH
ACAFGGATLLILADLLARTLAAPAEIPVGLFTSFAGGPFFLALILRTRRHYGFS
HHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVTSVAPGLRLRFAGRGWLLPILAVVLSVAFLLGVGIGAVAVPPDVVVAILLSKIGVSV
CCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHH
ETAVSQQQMAVLWNIRLPRVVLGGLVGAALAVSGALLQGIFRNPLADPGLIGVSSGAALG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHH
AVFTIISGLAVFGIYTLPVAAFLAGAATTLLVYRLSRRHGRTDVAMLLLVGLALNALAGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TTGLLTYLADDDQLRSIVFWTLGGLGGALWETVLAATPPILIVLVLAPRLGFYLNLFALG
HHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEC
EAEARHLGVNVEWIKRAAVLMAALATGAAVALTGPIGFIGLIVPHMVRLTIGPDHRWLIP
CCHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHEEEECCCCCEEEH
ACAFGGATLLILADLLARTLAAPAEIPVGLFTSFAGGPFFLALILRTRRHYGFS
HHHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]