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The map label for this gene is nuoE [H]

Identifier: 222524573

GI number: 222524573

Start: 1663270

End: 1663791

Strand: Direct

Name: nuoE [H]

Synonym: Chy400_1297

Alternate gene names: 222524573

Gene position: 1663270-1663791 (Clockwise)

Preceding gene: 222524572

Following gene: 222524574

Centisome position: 31.57

GC content: 57.28

Gene sequence:

>522_bases
ATGACGACACCTGCGACCGATACCACTGCTGACCGGAATCCTCGTCCTGTTGGTGATAATCGCCAAAAGATACTGGAAGC
GACGATGAAACGGTTTCAGTATCAGGGCGATGCGCTGATCGAAGTGTTGCACAAAGCGCAAGAACTGTACGGCTTTCTCT
CGCCAGAGCTGCTCGGTGAGGTTGCCCGTCGCCTCAAGCTGCCACCCAGTCGGGTGTATGGGGTTGCTACCTTTTACCAC
TTCTTCTCACTGGCACCCCAGGGCGAACACAGTTGTACGGTCTGTCTGGGCACTGCCTGCTACGTGCGCGGTGCAGCAAT
CTTGCTGCGTGAACTGGAAGCATTGAGTGGCGTCCAGGCCGGGCGGACAAGTGCAGATGGTCGGTTTTCGCTGCTGACTG
CTCGCTGTCTCGGTGCTTGCGGCATTGCGCCTGCCGTCGTTCTTGATGGGGAAGTGGTTGGTCATGCTGATCGCTCCGAC
CTGAAAGCTCGCATTCAGGCGTTGCTGAAACGCGAGGAGTAA

Upstream 100 bases:

>100_bases
CACCCGTTATTAACAGTTGGTAGTGAATTCTTTCCGCTAAAACAGTTGCAGTCGGGATAGGATCAGGGTAGTGCCCGTGC
ATCAGTTTGGGAGAAGTGCG

Downstream 100 bases:

>100_bases
TGTATGGATCTTCACGAACTGGAAGCGATTGCTGAACGAGAACAGGCACAACGTGCGCGTTTCCGCATCCTCTGCTGCGC
TGCTGCCGGTTGCCAGGCTT

Product: NADH dehydrogenase (ubiquinone) 24 kDa subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MTTPATDTTADRNPRPVGDNRQKILEATMKRFQYQGDALIEVLHKAQELYGFLSPELLGEVARRLKLPPSRVYGVATFYH
FFSLAPQGEHSCTVCLGTACYVRGAAILLRELEALSGVQAGRTSADGRFSLLTARCLGACGIAPAVVLDGEVVGHADRSD
LKARIQALLKREE

Sequences:

>Translated_173_residues
MTTPATDTTADRNPRPVGDNRQKILEATMKRFQYQGDALIEVLHKAQELYGFLSPELLGEVARRLKLPPSRVYGVATFYH
FFSLAPQGEHSCTVCLGTACYVRGAAILLRELEALSGVQAGRTSADGRFSLLTARCLGACGIAPAVVLDGEVVGHADRSD
LKARIQALLKREE
>Mature_172_residues
TTPATDTTADRNPRPVGDNRQKILEATMKRFQYQGDALIEVLHKAQELYGFLSPELLGEVARRLKLPPSRVYGVATFYHF
FSLAPQGEHSCTVCLGTACYVRGAAILLRELEALSGVQAGRTSADGRFSLLTARCLGACGIAPAVVLDGEVVGHADRSDL
KARIQALLKREE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=164, Percent_Identity=32.9268292682927, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1788621, Length=131, Percent_Identity=32.0610687022901, Blast_Score=75, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561328, Length=135, Percent_Identity=37.037037037037, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18859877, Length=167, Percent_Identity=31.7365269461078, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355353, Length=157, Percent_Identity=29.2993630573248, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18801; Mature: 18670

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPATDTTADRNPRPVGDNRQKILEATMKRFQYQGDALIEVLHKAQELYGFLSPELLGE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHH
VARRLKLPPSRVYGVATFYHFFSLAPQGEHSCTVCLGTACYVRGAAILLRELEALSGVQA
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCC
GRTSADGRFSLLTARCLGACGIAPAVVLDGEVVGHADRSDLKARIQALLKREE
CCCCCCCHHHHHHHHHHHHCCCCCCEEECCHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTPATDTTADRNPRPVGDNRQKILEATMKRFQYQGDALIEVLHKAQELYGFLSPELLGE
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHH
VARRLKLPPSRVYGVATFYHFFSLAPQGEHSCTVCLGTACYVRGAAILLRELEALSGVQA
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCC
GRTSADGRFSLLTARCLGACGIAPAVVLDGEVVGHADRSDLKARIQALLKREE
CCCCCCCHHHHHHHHHHHHCCCCCCEEECCHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]