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The map label for this gene is gyaR [H]

Identifier: 222524172

GI number: 222524172

Start: 1124945

End: 1125925

Strand: Reverse

Name: gyaR [H]

Synonym: Chy400_0891

Alternate gene names: 222524172

Gene position: 1125925-1124945 (Counterclockwise)

Preceding gene: 222524173

Following gene: 222524171

Centisome position: 21.37

GC content: 63.51

Gene sequence:

>981_bases
ATGGAGCGCACAGCCAAACCTCGTGTCTTTGTTACCCGGCGCCTGCCTGAGCCGGCGATGGCTATTCTCCACGAACACTG
TGCTGTATCGCTGTGGGATAACGTGGAAACCCCGATCCCGCGCGATGAATTGTTGCGGGGTGTTGCCATGGTCGAGGGCC
TGCTTTGCCTGATTACTGATCGGATTGATAGCGAGGTCGTGGCCGCCGCTCCTCATCTGCGGGCGGTGTCGATTATGGCG
GTCGGTTACGACAATATTGACCGGGCTGCGCTGGCCGCACGAGGGATTACGCTCACCAACACGCCCGATGTGTTGACCGA
GACAACCGCCGATCTGGCCTGGGCGTTGCTGCTGGCCGCAGCGCGGCGGGTTGTTGAAGGCCAGAAGATGATCGAGCGGG
GAGAATGGGGTCCCTGGTATCCGCTCCAAATGGTCGGCCAGGACATCTATGGCCGGGTGTTGGGTGTGGTCGGTGCCGGA
CGGATCGGGCAGGCGGTGTTGCGGCGCGGGCGCGGGTTTGCGATGCAGTTGCGCTATCACAATCGGCGGCGCAATCCGAC
CCTCGAAGCCGAGATCGGGGCGGAGTATCGCACGCTGGACGATCTGCTGAGCGAGAGTGATGTGGTCGTGGTAACGGCAC
CGCTCACCGCCGAGACGCGGGGGATGTTTGGGGCCGCGCAGTTTGCCCGCATGAAGCCAACCTCTATCTTCGTCAACGTG
GCGCGTGGGCCGCTGGTGCGCGAAGACGACCTGGTGGCCGCGTTACGCGCCGGCAGGCCATGGGCCGCCGGGCTGGATGT
CTTTGAACGCGAGCCAATTGGCCCAGACCATCCACTGCTTACCGTCCCCAATGTGGTGTTGACCCCGCACGTCGGCAGTG
CCACAGTGACCACGCGATTGCGCATGGCGACACTGGCCGCCGAAAACCTGGTGGCCGTGCTGTACGGTCGCCCCACACCG
CATATTGTGCGTCATGAGTGA

Upstream 100 bases:

>100_bases
TACCGGCCCGTCGCGTACCGCCGACATTGAAATGACCCTCTCACTGGGTATTCACGGCCCACCCCAGGTTCACGCCATTC
TGGTCGGTAAAGGGTGATCA

Downstream 100 bases:

>100_bases
TCGTACATCTGGTGTGACAGCAGTCAGGGCACGCCGGTTCGGTATCATCCTGATACTGTGCCTCACCTGGCAGGAGTGAG
GCGCGGTGTCCCTCATCCCA

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MERTAKPRVFVTRRLPEPAMAILHEHCAVSLWDNVETPIPRDELLRGVAMVEGLLCLITDRIDSEVVAAAPHLRAVSIMA
VGYDNIDRAALAARGITLTNTPDVLTETTADLAWALLLAAARRVVEGQKMIERGEWGPWYPLQMVGQDIYGRVLGVVGAG
RIGQAVLRRGRGFAMQLRYHNRRRNPTLEAEIGAEYRTLDDLLSESDVVVVTAPLTAETRGMFGAAQFARMKPTSIFVNV
ARGPLVREDDLVAALRAGRPWAAGLDVFEREPIGPDHPLLTVPNVVLTPHVGSATVTTRLRMATLAAENLVAVLYGRPTP
HIVRHE

Sequences:

>Translated_326_residues
MERTAKPRVFVTRRLPEPAMAILHEHCAVSLWDNVETPIPRDELLRGVAMVEGLLCLITDRIDSEVVAAAPHLRAVSIMA
VGYDNIDRAALAARGITLTNTPDVLTETTADLAWALLLAAARRVVEGQKMIERGEWGPWYPLQMVGQDIYGRVLGVVGAG
RIGQAVLRRGRGFAMQLRYHNRRRNPTLEAEIGAEYRTLDDLLSESDVVVVTAPLTAETRGMFGAAQFARMKPTSIFVNV
ARGPLVREDDLVAALRAGRPWAAGLDVFEREPIGPDHPLLTVPNVVLTPHVGSATVTTRLRMATLAAENLVAVLYGRPTP
HIVRHE
>Mature_326_residues
MERTAKPRVFVTRRLPEPAMAILHEHCAVSLWDNVETPIPRDELLRGVAMVEGLLCLITDRIDSEVVAAAPHLRAVSIMA
VGYDNIDRAALAARGITLTNTPDVLTETTADLAWALLLAAARRVVEGQKMIERGEWGPWYPLQMVGQDIYGRVLGVVGAG
RIGQAVLRRGRGFAMQLRYHNRRRNPTLEAEIGAEYRTLDDLLSESDVVVVTAPLTAETRGMFGAAQFARMKPTSIFVNV
ARGPLVREDDLVAALRAGRPWAAGLDVFEREPIGPDHPLLTVPNVVLTPHVGSATVTTRLRMATLAAENLVAVLYGRPTP
HIVRHE

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=321, Percent_Identity=43.613707165109, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI23308577, Length=289, Percent_Identity=29.0657439446367, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI145580578, Length=309, Percent_Identity=29.7734627831715, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI4557499, Length=309, Percent_Identity=29.7734627831715, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI145580575, Length=352, Percent_Identity=29.8295454545455, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI61743967, Length=309, Percent_Identity=29.126213592233, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557497, Length=309, Percent_Identity=29.126213592233, Blast_Score=109, Evalue=3e-24,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=44.9230769230769, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1789279, Length=240, Percent_Identity=31.6666666666667, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1787645, Length=263, Percent_Identity=27.3764258555133, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081824, Length=159, Percent_Identity=35.2201257861635, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=319, Percent_Identity=30.7210031347962, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=28.9855072463768, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=260, Percent_Identity=36.9230769230769, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6320925, Length=305, Percent_Identity=26.2295081967213, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=272, Percent_Identity=26.8382352941176, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=264, Percent_Identity=28.7878787878788, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=180, Percent_Identity=30, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=165, Percent_Identity=29.0909090909091, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45551003, Length=315, Percent_Identity=41.9047619047619, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI45552429, Length=315, Percent_Identity=41.9047619047619, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24585514, Length=315, Percent_Identity=41.9047619047619, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI28574282, Length=315, Percent_Identity=41.9047619047619, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI28574284, Length=315, Percent_Identity=41.9047619047619, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI28571528, Length=316, Percent_Identity=42.0886075949367, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI28574286, Length=320, Percent_Identity=40.9375, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24585516, Length=307, Percent_Identity=39.0879478827362, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19921140, Length=310, Percent_Identity=29.3548387096774, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646446, Length=312, Percent_Identity=29.1666666666667, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646448, Length=312, Percent_Identity=29.1666666666667, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646452, Length=312, Percent_Identity=29.1666666666667, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646450, Length=312, Percent_Identity=29.1666666666667, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI62472511, Length=312, Percent_Identity=29.1666666666667, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35742; Mature: 35742

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTAKPRVFVTRRLPEPAMAILHEHCAVSLWDNVETPIPRDELLRGVAMVEGLLCLITD
CCCCCCCCEEEEECCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RIDSEVVAAAPHLRAVSIMAVGYDNIDRAALAARGITLTNTPDVLTETTADLAWALLLAA
HCCCHHHHCCCCCEEEEEEEECCCCCHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHH
ARRVVEGQKMIERGEWGPWYPLQMVGQDIYGRVLGVVGAGRIGQAVLRRGRGFAMQLRYH
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEC
NRRRNPTLEAEIGAEYRTLDDLLSESDVVVVTAPLTAETRGMFGAAQFARMKPTSIFVNV
CCCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCHHHCCCHHHHHHHHCCCCEEEEEE
ARGPLVREDDLVAALRAGRPWAAGLDVFEREPIGPDHPLLTVPNVVLTPHVGSATVTTRL
CCCCCCCCCHHHHHHHCCCCCHHCCCHHHCCCCCCCCCEEECCCEEEECCCCCHHHHHHH
RMATLAAENLVAVLYGRPTPHIVRHE
HHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MERTAKPRVFVTRRLPEPAMAILHEHCAVSLWDNVETPIPRDELLRGVAMVEGLLCLITD
CCCCCCCCEEEEECCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RIDSEVVAAAPHLRAVSIMAVGYDNIDRAALAARGITLTNTPDVLTETTADLAWALLLAA
HCCCHHHHCCCCCEEEEEEEECCCCCHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHH
ARRVVEGQKMIERGEWGPWYPLQMVGQDIYGRVLGVVGAGRIGQAVLRRGRGFAMQLRYH
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEC
NRRRNPTLEAEIGAEYRTLDDLLSESDVVVVTAPLTAETRGMFGAAQFARMKPTSIFVNV
CCCCCCCEEEECCCHHHHHHHHHCCCCEEEEEECCCHHHCCCHHHHHHHHCCCCEEEEEE
ARGPLVREDDLVAALRAGRPWAAGLDVFEREPIGPDHPLLTVPNVVLTPHVGSATVTTRL
CCCCCCCCCHHHHHHHCCCCCHHCCCHHHCCCCCCCCCEEECCCEEEECCCCCHHHHHHH
RMATLAAENLVAVLYGRPTPHIVRHE
HHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA