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The map label for this gene is murC

Identifier: 222524101

GI number: 222524101

Start: 1028882

End: 1030267

Strand: Reverse

Name: murC

Synonym: Chy400_0817

Alternate gene names: 222524101

Gene position: 1030267-1028882 (Counterclockwise)

Preceding gene: 222524102

Following gene: 222524100

Centisome position: 19.55

GC content: 61.69

Gene sequence:

>1386_bases
ATGAGCGCGATTGCCCATCTGCTGCTCGACCAGGGTCATACAGTGAGCGGTTCGGACTTGACCGCAAACCACGCTACGGC
TGCACTCCAGGCCCGGGGTGTACAGGTCTGGCGTGGTCATGATCCGGCGTATGTGCAGGGTGCCGATGTTGTTCTGGCGA
CAGCAGCAATTCGTGGCACCCACCCTGAATTAGAGGCGGCTGCGGCGGCAGGGATCCCTCGCCTGAGTCGGGCCGACTTG
TGGCGTCTGTGGTCAGAACAGCGCCCGGTGATTGCTATCGCCGGGACCCATGGCAAGACCACAACCACCGCATTGACAGC
GCTGGCGTTGCGTGGTGCCGGGATCAGGTGTGGTTTTCTGATCGGTGCTGATGTGCCGGCGCTGGGTGGGAGCGCACAAT
GGGGCGATCCAGAAGCACCACTGGTGATCGAAGCCGATGAATACGACCGGGTCTTTCTGGCGCTGACACCGGCGCTGGCG
ATTATTACCAATGTCGAATGGGATCATCCCGATGTCTACCCCACGCCATCTGAGTACACGGCAGCCTTTGCCGCCTTTTC
CCGCCAGGTGCGTGATCCACGCCGGTTACTGGTCTGCGCCGATGATCCCGGTGCCCTCGCTCTTGCCGGGCAGAGTGAAG
CCCGCCTGTACGGGATCGATGAGCACATTGCCACCGATCCGGTCTCTTGTCGACTGGCCCCACTCGACTGGACGGCAAGT
GGGGTGACAGGAACTGCTACCGGTCAACAGTTTGATCTCTGGTACTACGACCGGCGTTCGTTCGGACGACGGCTGGCCGC
GACAGTCACGCTGGCTATTCCTGGTGAACATAATGTACGAAATGCAACCGCAGCACTGGCAGCGGCTGCGCTATGGGGCG
CCGATCTGCGTACAGCCGTCACTGCACTGGCAGAGTATCGTGGCAGTAGCCGCCGGTTTGAGTGGCGGGGTGATGTTGGT
GGGATCACGGTGATTGACGATTATGCCCATCACCCAACCGAGGTGCAGGCCACGCTCCTGGCTGCCCGTCAGCGCTATCC
GGATCGACGACTCATCGTCTATTTGCAACCGCACACCTTCAGCCGTACGCGCAGCCTCTGGGATCAGTGGCCGGCAGCGT
TTCGTGAGGCAGCCGTTGTGCTGGTCGGCGATATTTATCCGGCCCGTGAGCAGGGCGATCCGGTCGCGCTGGCCCAGTCG
CTGGTTGACCATCTGATTGCACACGGTATTCCGGCGCGCTACGCCGGCCCATCGGCGCTTGCGCCATCCGCACTGCTTGC
GGTAGCGCAATCCGGTGATGTTGTGCTGACCCTAGGGGCCGGTGATAGTGATCAGGTGGCAGCAGCGTTTCTCGAACAGT
GCAGCGCAATGTCAGAGGAGAGATGA

Upstream 100 bases:

>100_bases
CGATCTTCTTCATGATTTTAGGGTTGATTATTTTGTTCAACTTTCCGAAGGTTTGGAAACCGTGAGTCACTATCATATCA
TCGGGATTGCCGGAGCAGGG

Downstream 100 bases:

>100_bases
GATGCCAGTTGCATTACCGGTAACGTTATACCCCGATGAGCCAATGGCGCGCCATTCGTCGTGGCGTGCCGGAGGAACGG
CGCGCTATTATGCTGAGCCG

Product: UDP-N-acetylmuramate/alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSAIAHLLLDQGHTVSGSDLTANHATAALQARGVQVWRGHDPAYVQGADVVLATAAIRGTHPELEAAAAAGIPRLSRADL
WRLWSEQRPVIAIAGTHGKTTTTALTALALRGAGIRCGFLIGADVPALGGSAQWGDPEAPLVIEADEYDRVFLALTPALA
IITNVEWDHPDVYPTPSEYTAAFAAFSRQVRDPRRLLVCADDPGALALAGQSEARLYGIDEHIATDPVSCRLAPLDWTAS
GVTGTATGQQFDLWYYDRRSFGRRLAATVTLAIPGEHNVRNATAALAAAALWGADLRTAVTALAEYRGSSRRFEWRGDVG
GITVIDDYAHHPTEVQATLLAARQRYPDRRLIVYLQPHTFSRTRSLWDQWPAAFREAAVVLVGDIYPAREQGDPVALAQS
LVDHLIAHGIPARYAGPSALAPSALLAVAQSGDVVLTLGAGDSDQVAAAFLEQCSAMSEER

Sequences:

>Translated_461_residues
MSAIAHLLLDQGHTVSGSDLTANHATAALQARGVQVWRGHDPAYVQGADVVLATAAIRGTHPELEAAAAAGIPRLSRADL
WRLWSEQRPVIAIAGTHGKTTTTALTALALRGAGIRCGFLIGADVPALGGSAQWGDPEAPLVIEADEYDRVFLALTPALA
IITNVEWDHPDVYPTPSEYTAAFAAFSRQVRDPRRLLVCADDPGALALAGQSEARLYGIDEHIATDPVSCRLAPLDWTAS
GVTGTATGQQFDLWYYDRRSFGRRLAATVTLAIPGEHNVRNATAALAAAALWGADLRTAVTALAEYRGSSRRFEWRGDVG
GITVIDDYAHHPTEVQATLLAARQRYPDRRLIVYLQPHTFSRTRSLWDQWPAAFREAAVVLVGDIYPAREQGDPVALAQS
LVDHLIAHGIPARYAGPSALAPSALLAVAQSGDVVLTLGAGDSDQVAAAFLEQCSAMSEER
>Mature_460_residues
SAIAHLLLDQGHTVSGSDLTANHATAALQARGVQVWRGHDPAYVQGADVVLATAAIRGTHPELEAAAAAGIPRLSRADLW
RLWSEQRPVIAIAGTHGKTTTTALTALALRGAGIRCGFLIGADVPALGGSAQWGDPEAPLVIEADEYDRVFLALTPALAI
ITNVEWDHPDVYPTPSEYTAAFAAFSRQVRDPRRLLVCADDPGALALAGQSEARLYGIDEHIATDPVSCRLAPLDWTASG
VTGTATGQQFDLWYYDRRSFGRRLAATVTLAIPGEHNVRNATAALAAAALWGADLRTAVTALAEYRGSSRRFEWRGDVGG
ITVIDDYAHHPTEVQATLLAARQRYPDRRLIVYLQPHTFSRTRSLWDQWPAAFREAAVVLVGDIYPAREQGDPVALAQSL
VDHLIAHGIPARYAGPSALAPSALLAVAQSGDVVLTLGAGDSDQVAAAFLEQCSAMSEER

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=460, Percent_Identity=35, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1790680, Length=475, Percent_Identity=28.6315789473684, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1786276, Length=291, Percent_Identity=28.5223367697594, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_CHLAA (A9WG70)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001634380.1
- ProteinModelPortal:   A9WG70
- SMR:   A9WG70
- GeneID:   5824837
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_0753
- HOGENOM:   HBG476594
- OMA:   YHEFLGD
- ProtClustDB:   CLSK974974
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49190; Mature: 49059

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIAHLLLDQGHTVSGSDLTANHATAALQARGVQVWRGHDPAYVQGADVVLATAAIRGT
CHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEECCCCCEEECCCEEEEEEECCCC
HPELEAAAAAGIPRLSRADLWRLWSEQRPVIAIAGTHGKTTTTALTALALRGAGIRCGFL
CCHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEE
IGADVPALGGSAQWGDPEAPLVIEADEYDRVFLALTPALAIITNVEWDHPDVYPTPSEYT
ECCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEHHCHHHEEECCCCCCCCCCCCCHHHH
AAFAAFSRQVRDPRRLLVCADDPGALALAGQSEARLYGIDEHIATDPVSCRLAPLDWTAS
HHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCEEEECHHHHCCCCCCEEEECCCCCCC
GVTGTATGQQFDLWYYDRRSFGRRLAATVTLAIPGEHNVRNATAALAAAALWGADLRTAV
CCEECCCCCEEEEEEECHHHHCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHH
TALAEYRGSSRRFEWRGDVGGITVIDDYAHHPTEVQATLLAARQRYPDRRLIVYLQPHTF
HHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCC
SRTRSLWDQWPAAFREAAVVLVGDIYPAREQGDPVALAQSLVDHLIAHGIPARYAGPSAL
HHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
APSALLAVAQSGDVVLTLGAGDSDQVAAAFLEQCSAMSEER
CCHHHHHEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAIAHLLLDQGHTVSGSDLTANHATAALQARGVQVWRGHDPAYVQGADVVLATAAIRGT
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEECCCCCEEECCCEEEEEEECCCC
HPELEAAAAAGIPRLSRADLWRLWSEQRPVIAIAGTHGKTTTTALTALALRGAGIRCGFL
CCHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEE
IGADVPALGGSAQWGDPEAPLVIEADEYDRVFLALTPALAIITNVEWDHPDVYPTPSEYT
ECCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEHHCHHHEEECCCCCCCCCCCCCHHHH
AAFAAFSRQVRDPRRLLVCADDPGALALAGQSEARLYGIDEHIATDPVSCRLAPLDWTAS
HHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCEEEECHHHHCCCCCCEEEECCCCCCC
GVTGTATGQQFDLWYYDRRSFGRRLAATVTLAIPGEHNVRNATAALAAAALWGADLRTAV
CCEECCCCCEEEEEEECHHHHCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHH
TALAEYRGSSRRFEWRGDVGGITVIDDYAHHPTEVQATLLAARQRYPDRRLIVYLQPHTF
HHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCC
SRTRSLWDQWPAAFREAAVVLVGDIYPAREQGDPVALAQSLVDHLIAHGIPARYAGPSAL
HHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
APSALLAVAQSGDVVLTLGAGDSDQVAAAFLEQCSAMSEER
CCHHHHHEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA