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The map label for this gene is murB

Identifier: 222524100

GI number: 222524100

Start: 1027987

End: 1028880

Strand: Reverse

Name: murB

Synonym: Chy400_0816

Alternate gene names: 222524100

Gene position: 1028880-1027987 (Counterclockwise)

Preceding gene: 222524101

Following gene: 222524099

Centisome position: 19.53

GC content: 57.61

Gene sequence:

>894_bases
ATGCCAGTTGCATTACCGGTAACGTTATACCCCGATGAGCCAATGGCGCGCCATTCGTCGTGGCGTGCCGGAGGAACGGC
GCGCTATTATGCTGAGCCGGCCACACCCGATGAAGCCATTGCGCTGGCGGCCTGGGCCAGAGAGCAACAGTTACCGTTGA
TCTGGATCGGTCGCGGAACGAATTTACTTGTACGCGACGAAGGGTTTGACGGCGTGATTGCGTCGTATCGCGGGCAACGC
TGGGAACTGATCGAACACGGCGAGACTGCTGAAGTATGGATTGAAGCCGGTGCGCCAATGGCCGGAACGGCCCGGCGGCT
GGCGGCAATGGGATGGGCCGGTCTGGAGTGGGCCGAGGGGCTGCCCGGTGCAGTCGGTGGCGCAATTGTTGGCAATGCCG
GTTGTTATGGCGGGAGTGTAGCCGAAGTGCTCATTACTGCTGATCTGCTGCTCAATGGTAGCGAATGCGTTGAATGGTCG
GTACACGATCTGGCATACACGTATCGCGAGAGTGTACTCAAACAACTGCTGCATACCGGGATTCCACCGCTGGTACTGGC
CGGCCGCTTCCGCTTGCAGCGCGGTGATCCGGCGGCATTGACGGCGCGGATGAAAGCGATTGCTGCCGAACGCAAACAGA
AGACACCGGCAGGTAGTTCGTGCGGCAGTGTCTTCAAAAATCCGGCAGGCGATTTTGCCGGTCGTCTGATCGAGGCTGCC
GGTCTAAAGGGTGTACGGATCGGTGATGCAGAGATTAGTACATTGCACGCCAATTACATTATCAATCGTGGGCAGGCCCG
GGCCGCCGATATTTTGGCGTTAATTGATCTGGCTCGCACAAAAGTTGCTGATCAATTTGGGATTACGCTTCAGCTCGAAG
TGCGGATTATTTAG

Upstream 100 bases:

>100_bases
CAATCCGGTGATGTTGTGCTGACCCTAGGGGCCGGTGATAGTGATCAGGTGGCAGCAGCGTTTCTCGAACAGTGCAGCGC
AATGTCAGAGGAGAGATGAG

Downstream 100 bases:

>100_bases
AGGCTGAGATGATCAAAATAGTGAATGAAATACCGAAAAGTGATCAGTATAAACGAAACAATAAGCAAAATTGGATCGCC
ATGCTCGTTGTTGTAGATAA

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MPVALPVTLYPDEPMARHSSWRAGGTARYYAEPATPDEAIALAAWAREQQLPLIWIGRGTNLLVRDEGFDGVIASYRGQR
WELIEHGETAEVWIEAGAPMAGTARRLAAMGWAGLEWAEGLPGAVGGAIVGNAGCYGGSVAEVLITADLLLNGSECVEWS
VHDLAYTYRESVLKQLLHTGIPPLVLAGRFRLQRGDPAALTARMKAIAAERKQKTPAGSSCGSVFKNPAGDFAGRLIEAA
GLKGVRIGDAEISTLHANYIINRGQARAADILALIDLARTKVADQFGITLQLEVRII

Sequences:

>Translated_297_residues
MPVALPVTLYPDEPMARHSSWRAGGTARYYAEPATPDEAIALAAWAREQQLPLIWIGRGTNLLVRDEGFDGVIASYRGQR
WELIEHGETAEVWIEAGAPMAGTARRLAAMGWAGLEWAEGLPGAVGGAIVGNAGCYGGSVAEVLITADLLLNGSECVEWS
VHDLAYTYRESVLKQLLHTGIPPLVLAGRFRLQRGDPAALTARMKAIAAERKQKTPAGSSCGSVFKNPAGDFAGRLIEAA
GLKGVRIGDAEISTLHANYIINRGQARAADILALIDLARTKVADQFGITLQLEVRII
>Mature_296_residues
PVALPVTLYPDEPMARHSSWRAGGTARYYAEPATPDEAIALAAWAREQQLPLIWIGRGTNLLVRDEGFDGVIASYRGQRW
ELIEHGETAEVWIEAGAPMAGTARRLAAMGWAGLEWAEGLPGAVGGAIVGNAGCYGGSVAEVLITADLLLNGSECVEWSV
HDLAYTYRESVLKQLLHTGIPPLVLAGRFRLQRGDPAALTARMKAIAAERKQKTPAGSSCGSVFKNPAGDFAGRLIEAAG
LKGVRIGDAEISTLHANYIINRGQARAADILALIDLARTKVADQFGITLQLEVRII

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=306, Percent_Identity=25.8169934640523, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_CHLAA (A9WG69)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001634379.1
- ProteinModelPortal:   A9WG69
- SMR:   A9WG69
- GeneID:   5824836
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_0752
- HOGENOM:   HBG686573
- OMA:   LESSKIP
- ProtClustDB:   PRK14649
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 31748; Mature: 31617

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 169-169 ACT_SITE 223-223 ACT_SITE 293-293

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVALPVTLYPDEPMARHSSWRAGGTARYYAEPATPDEAIALAAWAREQQLPLIWIGRGT
CCEEEEEEECCCCCHHHCCCCCCCCEEEEEECCCCCHHHEEHHHHHHCCCCCEEEEECCC
NLLVRDEGFDGVIASYRGQRWELIEHGETAEVWIEAGAPMAGTARRLAAMGWAGLEWAEG
EEEEEECCCCCHHHHCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHCC
LPGAVGGAIVGNAGCYGGSVAEVLITADLLLNGSECVEWSVHDLAYTYRESVLKQLLHTG
CCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCHHEEEHHHHHHHHHHHHHHHHHHHCC
IPPLVLAGRFRLQRGDPAALTARMKAIAAERKQKTPAGSSCGSVFKNPAGDFAGRLIEAA
CCHHEEECCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHC
GLKGVRIGDAEISTLHANYIINRGQARAADILALIDLARTKVADQFGITLQLEVRII
CCCCEEECCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEC
>Mature Secondary Structure 
PVALPVTLYPDEPMARHSSWRAGGTARYYAEPATPDEAIALAAWAREQQLPLIWIGRGT
CEEEEEEECCCCCHHHCCCCCCCCEEEEEECCCCCHHHEEHHHHHHCCCCCEEEEECCC
NLLVRDEGFDGVIASYRGQRWELIEHGETAEVWIEAGAPMAGTARRLAAMGWAGLEWAEG
EEEEEECCCCCHHHHCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHCC
LPGAVGGAIVGNAGCYGGSVAEVLITADLLLNGSECVEWSVHDLAYTYRESVLKQLLHTG
CCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCHHEEEHHHHHHHHHHHHHHHHHHHCC
IPPLVLAGRFRLQRGDPAALTARMKAIAAERKQKTPAGSSCGSVFKNPAGDFAGRLIEAA
CCHHEEECCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHC
GLKGVRIGDAEISTLHANYIINRGQARAADILALIDLARTKVADQFGITLQLEVRII
CCCCEEECCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA