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The map label for this gene is lysA [H]

Identifier: 222523912

GI number: 222523912

Start: 759862

End: 761166

Strand: Reverse

Name: lysA [H]

Synonym: Chy400_0622

Alternate gene names: 222523912

Gene position: 761166-759862 (Counterclockwise)

Preceding gene: 222523913

Following gene: 222523911

Centisome position: 14.45

GC content: 60.61

Gene sequence:

>1305_bases
ATGACACTGGCGTCGCATGTCTGGCCGGAGACGGTAAGTGTTGTTGATGGCCGTTTGTGGATTGGCGGCTGCGATACGGT
TGCGCTGGCCGAACAGTTTGGAACTCCTCTGTATCTGCTTGATGATCTGACGCTGCGCGGTGCGATGCGTGCCTATCGGC
AGGCATTTGCCACCGCCTACCCTGGCCCGTCAATCGTCCATTACGCCGGGAAGGCGCTGTTGAATACGGCGCTGGCCCAG
ATCGTGGCGCAAGAAGGACTGGGGTTGGATGTCGTTTCAGCAACCGAGTTGTTGGTGGCGCAGCGAGCGGGTCTACCGAT
GGATCGGGTTCACCTGCACGGGAATGCGAAGAGTGATCAGGAACTGGAGCGGGCGATTGCGTGGCGGGTTGGGGCGATTG
TCGTTGATAACCTTGACGAATTGCAGCGACTCTGCGCGCTTACATCCCATCTCACCACGCCGCAGGGCGTCTTGTTGCGA
GTGGCGCCCGCTATCGAAGCGGATACGCACGCGCATATCGCTACAGGGAGCGCCACGGCAAAATTCGGCCTGCCCCTGGA
GGCGCTTGATGAGGCTGTCGCTCAAACCCTGGCCGCACCCAGCCTGCGCTGGTTGGGATTGCATGCGCATATCGGCTCGC
AACTCTTTGCGCTTGAACAGGTGACGGCGACCGTTGAGGTGTTGGTGGCGCTGGCTGCGCGGATACGGGATCGCTTTGGT
GTGGCGCCGGTTGAACTCAGTCCTGGCGGTGGTCTGGGTGTGCCGTACACTGCTGATCAGCCGGCAACCGATATTGGTCG
TTATGCGCAGGTGGTGAGTGCGGCGTTGTGTGCAGCCTGTGAACGATACCGGTTACCGTTACCACGCTTGACCGTCGAAC
CAGGCCGTTCCATCGTTGCCCGGGCCGGTGTGGCTTTGTACCGCGTGGTAGGTCGTAAAGGCGAGCACTGGGTGCATATT
GACGGTGGTATGGCCGACAATATTCGTCCGGCCCTTTACGGGGCGCGCTATAGTGCGGTGCTGGCCAATAAGCCGGCTTC
GCCGCCAGCGATGACGGTTAATGTCGGTGGACGTTACTGCGAGTCGGGTGACGTGTTGTTACGCGATATTGCGCTGCCGA
CTGTGCAGCCGGATGATCTGCTGGCAGTGGCAACAGCGGGTGCCTACACGCTGAGTATGTCCAGTACCTATAACCTGGTA
CCGCGTCCGGCCCTCGTCCTGGTTGCCGATGGACAGGCACGTCTGATCCAGCGTCGGGAAACAGAAGCCGATGTGCTGGC
CCGTGATCTGTTGCTGGATCGGTGA

Upstream 100 bases:

>100_bases
GCGCTGAAGTCATTGGTATGGAGCTGGATGCGCTGATCGGCGAGGTGATTGCTGCACTGCGCGCAGCCGCGCCACGGCTG
GGTCTGGCGGGGAATAACGC

Downstream 100 bases:

>100_bases
AGCATACGTCTGTATCGTTAGATCGTAGCAGGTGCGATCTGAACTGCTCGTGGTAGAAGCGAGGTTTGTATGACGCATGC
CCCTCTCTACGGTGGGATTG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTLASHVWPETVSVVDGRLWIGGCDTVALAEQFGTPLYLLDDLTLRGAMRAYRQAFATAYPGPSIVHYAGKALLNTALAQ
IVAQEGLGLDVVSATELLVAQRAGLPMDRVHLHGNAKSDQELERAIAWRVGAIVVDNLDELQRLCALTSHLTTPQGVLLR
VAPAIEADTHAHIATGSATAKFGLPLEALDEAVAQTLAAPSLRWLGLHAHIGSQLFALEQVTATVEVLVALAARIRDRFG
VAPVELSPGGGLGVPYTADQPATDIGRYAQVVSAALCAACERYRLPLPRLTVEPGRSIVARAGVALYRVVGRKGEHWVHI
DGGMADNIRPALYGARYSAVLANKPASPPAMTVNVGGRYCESGDVLLRDIALPTVQPDDLLAVATAGAYTLSMSSTYNLV
PRPALVLVADGQARLIQRRETEADVLARDLLLDR

Sequences:

>Translated_434_residues
MTLASHVWPETVSVVDGRLWIGGCDTVALAEQFGTPLYLLDDLTLRGAMRAYRQAFATAYPGPSIVHYAGKALLNTALAQ
IVAQEGLGLDVVSATELLVAQRAGLPMDRVHLHGNAKSDQELERAIAWRVGAIVVDNLDELQRLCALTSHLTTPQGVLLR
VAPAIEADTHAHIATGSATAKFGLPLEALDEAVAQTLAAPSLRWLGLHAHIGSQLFALEQVTATVEVLVALAARIRDRFG
VAPVELSPGGGLGVPYTADQPATDIGRYAQVVSAALCAACERYRLPLPRLTVEPGRSIVARAGVALYRVVGRKGEHWVHI
DGGMADNIRPALYGARYSAVLANKPASPPAMTVNVGGRYCESGDVLLRDIALPTVQPDDLLAVATAGAYTLSMSSTYNLV
PRPALVLVADGQARLIQRRETEADVLARDLLLDR
>Mature_433_residues
TLASHVWPETVSVVDGRLWIGGCDTVALAEQFGTPLYLLDDLTLRGAMRAYRQAFATAYPGPSIVHYAGKALLNTALAQI
VAQEGLGLDVVSATELLVAQRAGLPMDRVHLHGNAKSDQELERAIAWRVGAIVVDNLDELQRLCALTSHLTTPQGVLLRV
APAIEADTHAHIATGSATAKFGLPLEALDEAVAQTLAAPSLRWLGLHAHIGSQLFALEQVTATVEVLVALAARIRDRFGV
APVELSPGGGLGVPYTADQPATDIGRYAQVVSAALCAACERYRLPLPRLTVEPGRSIVARAGVALYRVVGRKGEHWVHID
GGMADNIRPALYGARYSAVLANKPASPPAMTVNVGGRYCESGDVLLRDIALPTVQPDDLLAVATAGAYTLSMSSTYNLVP
RPALVLVADGQARLIQRRETEADVLARDLLLDR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=415, Percent_Identity=32.289156626506, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46145; Mature: 46013

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLASHVWPETVSVVDGRLWIGGCDTVALAEQFGTPLYLLDDLTLRGAMRAYRQAFATAY
CCCCCCCCCCHHHHCCCEEEECCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCC
PGPSIVHYAGKALLNTALAQIVAQEGLGLDVVSATELLVAQRAGLPMDRVHLHGNAKSDQ
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCHHHEEECCCCCCHH
ELERAIAWRVGAIVVDNLDELQRLCALTSHLTTPQGVLLRVAPAIEADTHAHIATGSATA
HHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCCCCE
KFGLPLEALDEAVAQTLAAPSLRWLGLHAHIGSQLFALEQVTATVEVLVALAARIRDRFG
ECCCCHHHHHHHHHHHHCCCCEEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VAPVELSPGGGLGVPYTADQPATDIGRYAQVVSAALCAACERYRLPLPRLTVEPGRSIVA
CCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHH
RAGVALYRVVGRKGEHWVHIDGGMADNIRPALYGARYSAVLANKPASPPAMTVNVGGRYC
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHCCHHHEEECCCCCCCCEEEEECCCEEC
ESGDVLLRDIALPTVQPDDLLAVATAGAYTLSMSSTYNLVPRPALVLVADGQARLIQRRE
CCCCEEEEECCCCCCCCCCEEEEEECCEEEEEECCCCCCCCCCEEEEEECCHHHHHHHHC
TEADVLARDLLLDR
CHHHHHHHHHHCCC
>Mature Secondary Structure 
TLASHVWPETVSVVDGRLWIGGCDTVALAEQFGTPLYLLDDLTLRGAMRAYRQAFATAY
CCCCCCCCCHHHHCCCEEEECCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCC
PGPSIVHYAGKALLNTALAQIVAQEGLGLDVVSATELLVAQRAGLPMDRVHLHGNAKSDQ
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCHHHEEECCCCCCHH
ELERAIAWRVGAIVVDNLDELQRLCALTSHLTTPQGVLLRVAPAIEADTHAHIATGSATA
HHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCCCCE
KFGLPLEALDEAVAQTLAAPSLRWLGLHAHIGSQLFALEQVTATVEVLVALAARIRDRFG
ECCCCHHHHHHHHHHHHCCCCEEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VAPVELSPGGGLGVPYTADQPATDIGRYAQVVSAALCAACERYRLPLPRLTVEPGRSIVA
CCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHH
RAGVALYRVVGRKGEHWVHIDGGMADNIRPALYGARYSAVLANKPASPPAMTVNVGGRYC
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHCCHHHEEECCCCCCCCEEEEECCCEEC
ESGDVLLRDIALPTVQPDDLLAVATAGAYTLSMSSTYNLVPRPALVLVADGQARLIQRRE
CCCCEEEEECCCCCCCCCCEEEEEECCEEEEEECCCCCCCCCCEEEEEECCHHHHHHHHC
TEADVLARDLLLDR
CHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]