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The map label for this gene is cvrA [H]

Identifier: 222523882

GI number: 222523882

Start: 706181

End: 707662

Strand: Direct

Name: cvrA [H]

Synonym: Chy400_0591

Alternate gene names: 222523882

Gene position: 706181-707662 (Clockwise)

Preceding gene: 222523880

Following gene: 222523884

Centisome position: 13.4

GC content: 56.48

Gene sequence:

>1482_bases
ATGACAACTGAACCCCTCTTACTCATAACCGGTCTCCTATTGGCGATTAGTGTTGCTGCGACCCGTGCCTCAAACCGGTT
TGGTGTACCGGCACTGATCCTGTTTATGGCAGTCGGTATGCTGGCCGGTTCTGACGGGCCGGGCGGTATTGCGTTTACCG
ATGCCGGAGTAGCCCAACTGATCGGGGTGATTGCGCTGATCTACATCCTCTTTTCAGGAGGACTGGACACCGACTGGCAG
ATTATCAAACCAGTCCTGACCGAGGGTTTGATTCTGGCGAATGTTGGTGTGCTGGTCAGCACCGTGATTGTTGCGGTTGG
TGCCCACTTTATGCTCGGCTTTGACTGGCCCCTTGCCCTGCTTCTCGGCGCAATCGTCTCGTCCACCGACGCGGCGGCGG
TCTTTAGTGTCATGCGCACGCGAGGGATACATCTCAAGCATCGGCTTGAACCACTCATCGAGCTGGAGTCGGGAAGTAAT
GACCCGATTGCGGTCTTTCTCACCATCGGCTTAACCAACCTGGTGATCAACCCACAGGCATCGCTACTGACCCTTATCCC
GTCTTTTATCATACAGATGATCCTCGGTGCTGCCGGTGGGTACGCCTTTGGCCGGTTGATGATCTGGGTGGTCAACCGCA
TCCGGCTGCAACAGGAAGGGCTGTACGTGGTACTGACGATGGCCCTGACCCTGCTAACCTATGGCTTCACAGCGATCATC
GGCGGCAATGGCTTTCTGGCGGTCTATCTGGCAGGTATCATTCTGGGCAATGCCAATATTGTTCACAAACGGTCTATTCT
CCGTTTCCACGATGGTGTAGCGTGGCTCAGCCAGATTGCCATGTTCTTGATTTTGGGACTGCTGGTCTTTCCATCGCAGC
TACCGGCAGTGGCCGGGCAGGGACTGGCAATGGCACTCTGGCTCGTCTTCGTCGCCCGACCGGTCTCGGTCATTATCGCC
CTGGGCTGGAAACGTCGCTCATTACCGCAACTATTGATGATAGCCTGGGCTGGATTGCGGGGAGCAGTTCCGATTGTGCT
GGCAACCTTCCCGCTGCTGGCCGGCGTTCCCGATGCGCCGCTCCTGTTCAACCTGGTCTTCTTCATCGTCCTGATCTCAG
TCCTCTTGCAAGGTATCTCTATCGGCTGGGTCGCCCGTCGCCTGGGCGTGATGACCGATCAGGCCGAAGTGATAGACAGC
CACCTCTTCGTGCCAGAAGTCAGTGGAGCCAGTCAAATCCTGGAAGCACAAATTCCGCCAGACTCAGCACTGGTTGGCAA
ATCGCTGATCGACGCCGATCTCCCACGCGGCTTACTTATCGTGCAGATTCAGCGTGCAGACGGCTACATTATCCCGAACG
GCAGTACTGTCTTTGCGCCTAATGATCGGCTGGTATTACTGGTGGCACCCACCGCGATGCCGGCGGTGACTGAGCTGTGC
GCCAGTTGTAGTCTGAATCCCATCGGCTCACTGTTGAAGTGA

Upstream 100 bases:

>100_bases
AGTACCTGTTCAAAGTATGTAAGCCAGCTTACCAAACATAGATAATCTGCTTCAGGTACACCTATGCTATGCTAGTAATA
CGAGCATGTTGGAGAGAGCG

Downstream 100 bases:

>100_bases
GGAGAGGCGACGAGCATAGCCGGCGCTACTGCGTGAATGTACGAAATAGCTGCTATGCAGAAGCGAGCACCGTGGGGTAA
GTAGCGGGTAAGCACATATT

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MTTEPLLLITGLLLAISVAATRASNRFGVPALILFMAVGMLAGSDGPGGIAFTDAGVAQLIGVIALIYILFSGGLDTDWQ
IIKPVLTEGLILANVGVLVSTVIVAVGAHFMLGFDWPLALLLGAIVSSTDAAAVFSVMRTRGIHLKHRLEPLIELESGSN
DPIAVFLTIGLTNLVINPQASLLTLIPSFIIQMILGAAGGYAFGRLMIWVVNRIRLQQEGLYVVLTMALTLLTYGFTAII
GGNGFLAVYLAGIILGNANIVHKRSILRFHDGVAWLSQIAMFLILGLLVFPSQLPAVAGQGLAMALWLVFVARPVSVIIA
LGWKRRSLPQLLMIAWAGLRGAVPIVLATFPLLAGVPDAPLLFNLVFFIVLISVLLQGISIGWVARRLGVMTDQAEVIDS
HLFVPEVSGASQILEAQIPPDSALVGKSLIDADLPRGLLIVQIQRADGYIIPNGSTVFAPNDRLVLLVAPTAMPAVTELC
ASCSLNPIGSLLK

Sequences:

>Translated_493_residues
MTTEPLLLITGLLLAISVAATRASNRFGVPALILFMAVGMLAGSDGPGGIAFTDAGVAQLIGVIALIYILFSGGLDTDWQ
IIKPVLTEGLILANVGVLVSTVIVAVGAHFMLGFDWPLALLLGAIVSSTDAAAVFSVMRTRGIHLKHRLEPLIELESGSN
DPIAVFLTIGLTNLVINPQASLLTLIPSFIIQMILGAAGGYAFGRLMIWVVNRIRLQQEGLYVVLTMALTLLTYGFTAII
GGNGFLAVYLAGIILGNANIVHKRSILRFHDGVAWLSQIAMFLILGLLVFPSQLPAVAGQGLAMALWLVFVARPVSVIIA
LGWKRRSLPQLLMIAWAGLRGAVPIVLATFPLLAGVPDAPLLFNLVFFIVLISVLLQGISIGWVARRLGVMTDQAEVIDS
HLFVPEVSGASQILEAQIPPDSALVGKSLIDADLPRGLLIVQIQRADGYIIPNGSTVFAPNDRLVLLVAPTAMPAVTELC
ASCSLNPIGSLLK
>Mature_492_residues
TTEPLLLITGLLLAISVAATRASNRFGVPALILFMAVGMLAGSDGPGGIAFTDAGVAQLIGVIALIYILFSGGLDTDWQI
IKPVLTEGLILANVGVLVSTVIVAVGAHFMLGFDWPLALLLGAIVSSTDAAAVFSVMRTRGIHLKHRLEPLIELESGSND
PIAVFLTIGLTNLVINPQASLLTLIPSFIIQMILGAAGGYAFGRLMIWVVNRIRLQQEGLYVVLTMALTLLTYGFTAIIG
GNGFLAVYLAGIILGNANIVHKRSILRFHDGVAWLSQIAMFLILGLLVFPSQLPAVAGQGLAMALWLVFVARPVSVIIAL
GWKRRSLPQLLMIAWAGLRGAVPIVLATFPLLAGVPDAPLLFNLVFFIVLISVLLQGISIGWVARRLGVMTDQAEVIDSH
LFVPEVSGASQILEAQIPPDSALVGKSLIDADLPRGLLIVQIQRADGYIIPNGSTVFAPNDRLVLLVAPTAMPAVTELCA
SCSLNPIGSLLK

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=461, Percent_Identity=39.2624728850325, Blast_Score=271, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 52124; Mature: 51993

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEPLLLITGLLLAISVAATRASNRFGVPALILFMAVGMLAGSDGPGGIAFTDAGVAQL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHH
IGVIALIYILFSGGLDTDWQIIKPVLTEGLILANVGVLVSTVIVAVGAHFMLGFDWPLAL
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LLGAIVSSTDAAAVFSVMRTRGIHLKHRLEPLIELESGSNDPIAVFLTIGLTNLVINPQA
HHHHHHCCCHHHHHHHHHHHCCCCHHHHHCHHEEECCCCCCCEEEEEEECHHHEEECCCH
SLLTLIPSFIIQMILGAAGGYAFGRLMIWVVNRIRLQQEGLYVVLTMALTLLTYGFTAII
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEE
GGNGFLAVYLAGIILGNANIVHKRSILRFHDGVAWLSQIAMFLILGLLVFPSQLPAVAGQ
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCHHHHCC
GLAMALWLVFVARPVSVIIALGWKRRSLPQLLMIAWAGLRGAVPIVLATFPLLAGVPDAP
HHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCH
LLFNLVFFIVLISVLLQGISIGWVARRLGVMTDQAEVIDSHLFVPEVSGASQILEAQIPP
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCC
DSALVGKSLIDADLPRGLLIVQIQRADGYIIPNGSTVFAPNDRLVLLVAPTAMPAVTELC
CHHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCEEECCCCCEEEEECCCCHHHHHHHH
ASCSLNPIGSLLK
HHCCCCHHHHHCC
>Mature Secondary Structure 
TTEPLLLITGLLLAISVAATRASNRFGVPALILFMAVGMLAGSDGPGGIAFTDAGVAQL
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHH
IGVIALIYILFSGGLDTDWQIIKPVLTEGLILANVGVLVSTVIVAVGAHFMLGFDWPLAL
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LLGAIVSSTDAAAVFSVMRTRGIHLKHRLEPLIELESGSNDPIAVFLTIGLTNLVINPQA
HHHHHHCCCHHHHHHHHHHHCCCCHHHHHCHHEEECCCCCCCEEEEEEECHHHEEECCCH
SLLTLIPSFIIQMILGAAGGYAFGRLMIWVVNRIRLQQEGLYVVLTMALTLLTYGFTAII
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEE
GGNGFLAVYLAGIILGNANIVHKRSILRFHDGVAWLSQIAMFLILGLLVFPSQLPAVAGQ
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCHHHHCC
GLAMALWLVFVARPVSVIIALGWKRRSLPQLLMIAWAGLRGAVPIVLATFPLLAGVPDAP
HHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCH
LLFNLVFFIVLISVLLQGISIGWVARRLGVMTDQAEVIDSHLFVPEVSGASQILEAQIPP
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCC
DSALVGKSLIDADLPRGLLIVQIQRADGYIIPNGSTVFAPNDRLVLLVAPTAMPAVTELC
CHHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCEEECCCCCEEEEECCCCHHHHHHHH
ASCSLNPIGSLLK
HHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA