Click here to switch to the map view.

The map label for this gene is mvaA [H]

Identifier: 222523545

GI number: 222523545

Start: 297583

End: 298902

Strand: Reverse

Name: mvaA [H]

Synonym: Chy400_0251

Alternate gene names: 222523545

Gene position: 298902-297583 (Counterclockwise)

Preceding gene: 222523547

Following gene: 222523544

Centisome position: 5.67

GC content: 58.41

Gene sequence:

>1320_bases
ATGGGGACTAAGAGTTCTCGCTTACAAGGGTTTTATCAGCTTAATCCATTTGAGCGACTGCAAATGGTGAAATCCTTTGA
TGGATTAGTCGATGAAGACTTACGCGCCTTGCACGGCGGCCATGGTGGTGCGCTCACGATTGAGCGTGCCGATAAAATGA
TTGAGAATGTGATCGGTACCTATAATCTGCCGCTCGGTATCGCGACCAACTTCCGTATCAATGGCCGTGATTATCTGATT
CCGATGGTGGTTGAAGAGCCGTCAATTGTGGCCGGGGCCAGCTACGCGGCGCGGATGGTGCGAGACGGGGGTGGGTTTGA
GACGAGCAGTACCGAACCACTGATGATCGGTCAGGTGCAGTTGGTCAATGTTCGCGACCCCGATCAGGCCCGGCAAACGA
TTTTGTCGCGTAAGGAAGAGATTCTTGCCCTGGCCAATGCGCAAAGTCGTTCGCTGGTCAGTCTGGGTGGCGGAGCACGC
GATGTTGAGGTACGATTCTTCCCCACCAGCCCGATGGGGCCGATGCTGGTTGTGCATTTGATTATCGATTGCCGCGATGC
GATGGGTGCCAACGCGGTGAATACGATGGCCGAGGCGGTCGCACCGCTGCTGGCCGAGATGACCGGTGGTAAGGTCTATC
TGCGCATTCTCTCGAATCTGACCGACCGTCGGCTGGCTCGTGCCCGTTGTGTGGTGCCGGCAGCATCGCTGGCCCGCGAT
GGTTTGAGTGGCGAAGAGGTTGTTGAAGGCATTCTCTGGGCCTATGCGTTTGCTGCGGTCGATCCCTATCGGGCGGCAAC
CCACAACAAGGGCATTATGAACGGCATTGACCCGGTGCTGGTCGCAACCGGTAACGACTGGCGTGCGGTAGAGGCGGGTG
CGCATGCCTACGCCAGCCGCAATGGTCACTATACGTCACTCTCCCATTGGGAGCGTGATGCGCAGGGTGACCTGGTTGGT
ACGCTCGAAATGCCGCTGGCGGTAGGGATCGTGGGTGGCGCAACCAAAGTCCATCCCACCGCCCAGGCCGCGTTGAAACT
GCTCGGTGTGCGTAGCGCTGCTGAACTGGCCGAGGTCTGTGTCGCTGCCGGTCTGGCGAATAATCTGGCGGCGATGCGTG
CTCTGGCCTGTGAGGGTATTCAACAGGGACATATGAGCCTGCATGCCCGCCAGATCGCGATGGCTGCCGGTGCCAGTGGT
ACCCTGGTTGATGAAGTTGCCCGGCGCATGGTCGCCGAGCGGAATATCAAACTGGCGCGTGCTGAAGAGATCATTGCCGA
ACTCGAAGGGCGCACGATAGGTAACCCCACGCACAACTAA

Upstream 100 bases:

>100_bases
TGATAGGTTTTGACAGTTGTTGTTAACCATTTCGCGACTATTGTCGTGGTATCGTAACAGCGGAAGACAAATATATATTG
AGAGAAGGAGGCGTCCTCAT

Downstream 100 bases:

>100_bases
TGTGATACCTCTGGCGGCCTGTTCTGCAGGCCGCCCCGACACCAACAGCGTGATGATGCGCCTGTGTTCACCGGCAGGTT
GGCCGGTGAAGGGACTCTCT

Product: hydroxymethylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MGTKSSRLQGFYQLNPFERLQMVKSFDGLVDEDLRALHGGHGGALTIERADKMIENVIGTYNLPLGIATNFRINGRDYLI
PMVVEEPSIVAGASYAARMVRDGGGFETSSTEPLMIGQVQLVNVRDPDQARQTILSRKEEILALANAQSRSLVSLGGGAR
DVEVRFFPTSPMGPMLVVHLIIDCRDAMGANAVNTMAEAVAPLLAEMTGGKVYLRILSNLTDRRLARARCVVPAASLARD
GLSGEEVVEGILWAYAFAAVDPYRAATHNKGIMNGIDPVLVATGNDWRAVEAGAHAYASRNGHYTSLSHWERDAQGDLVG
TLEMPLAVGIVGGATKVHPTAQAALKLLGVRSAAELAEVCVAAGLANNLAAMRALACEGIQQGHMSLHARQIAMAAGASG
TLVDEVARRMVAERNIKLARAEEIIAELEGRTIGNPTHN

Sequences:

>Translated_439_residues
MGTKSSRLQGFYQLNPFERLQMVKSFDGLVDEDLRALHGGHGGALTIERADKMIENVIGTYNLPLGIATNFRINGRDYLI
PMVVEEPSIVAGASYAARMVRDGGGFETSSTEPLMIGQVQLVNVRDPDQARQTILSRKEEILALANAQSRSLVSLGGGAR
DVEVRFFPTSPMGPMLVVHLIIDCRDAMGANAVNTMAEAVAPLLAEMTGGKVYLRILSNLTDRRLARARCVVPAASLARD
GLSGEEVVEGILWAYAFAAVDPYRAATHNKGIMNGIDPVLVATGNDWRAVEAGAHAYASRNGHYTSLSHWERDAQGDLVG
TLEMPLAVGIVGGATKVHPTAQAALKLLGVRSAAELAEVCVAAGLANNLAAMRALACEGIQQGHMSLHARQIAMAAGASG
TLVDEVARRMVAERNIKLARAEEIIAELEGRTIGNPTHN
>Mature_438_residues
GTKSSRLQGFYQLNPFERLQMVKSFDGLVDEDLRALHGGHGGALTIERADKMIENVIGTYNLPLGIATNFRINGRDYLIP
MVVEEPSIVAGASYAARMVRDGGGFETSSTEPLMIGQVQLVNVRDPDQARQTILSRKEEILALANAQSRSLVSLGGGARD
VEVRFFPTSPMGPMLVVHLIIDCRDAMGANAVNTMAEAVAPLLAEMTGGKVYLRILSNLTDRRLARARCVVPAASLARDG
LSGEEVVEGILWAYAFAAVDPYRAATHNKGIMNGIDPVLVATGNDWRAVEAGAHAYASRNGHYTSLSHWERDAQGDLVGT
LEMPLAVGIVGGATKVHPTAQAALKLLGVRSAAELAEVCVAAGLANNLAAMRALACEGIQQGHMSLHARQIAMAAGASGT
LVDEVARRMVAERNIKLARAEEIIAELEGRTIGNPTHN

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 46804; Mature: 46673

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00318 HMG_COA_REDUCTASE_2 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTKSSRLQGFYQLNPFERLQMVKSFDGLVDEDLRALHGGHGGALTIERADKMIENVIGT
CCCCCCHHCEEEECCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCC
YNLPLGIATNFRINGRDYLIPMVVEEPSIVAGASYAARMVRDGGGFETSSTEPLMIGQVQ
CCCCEEEEEEEEECCCEEEEEEEECCCCEEECHHHHHHHHHCCCCCCCCCCCCEEEEEEE
LVNVRDPDQARQTILSRKEEILALANAQSRSLVSLGGGARDVEVRFFPTSPMGPMLVVHL
EEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHH
IIDCRDAMGANAVNTMAEAVAPLLAEMTGGKVYLRILSNLTDRRLARARCVVPAASLARD
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHC
GLSGEEVVEGILWAYAFAAVDPYRAATHNKGIMNGIDPVLVATGNDWRAVEAGAHAYASR
CCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCEEEEECCCCEEEHHCCHHHHCC
NGHYTSLSHWERDAQGDLVGTLEMPLAVGIVGGATKVHPTAQAALKLLGVRSAAELAEVC
CCCCCCHHHHCCCCCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHH
VAAGLANNLAAMRALACEGIQQGHMSLHARQIAMAAGASGTLVDEVARRMVAERNIKLAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHH
AEEIIAELEGRTIGNPTHN
HHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GTKSSRLQGFYQLNPFERLQMVKSFDGLVDEDLRALHGGHGGALTIERADKMIENVIGT
CCCCCHHCEEEECCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCC
YNLPLGIATNFRINGRDYLIPMVVEEPSIVAGASYAARMVRDGGGFETSSTEPLMIGQVQ
CCCCEEEEEEEEECCCEEEEEEEECCCCEEECHHHHHHHHHCCCCCCCCCCCCEEEEEEE
LVNVRDPDQARQTILSRKEEILALANAQSRSLVSLGGGARDVEVRFFPTSPMGPMLVVHL
EEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHH
IIDCRDAMGANAVNTMAEAVAPLLAEMTGGKVYLRILSNLTDRRLARARCVVPAASLARD
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHC
GLSGEEVVEGILWAYAFAAVDPYRAATHNKGIMNGIDPVLVATGNDWRAVEAGAHAYASR
CCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCEEEEECCCCEEEHHCCHHHHCC
NGHYTSLSHWERDAQGDLVGTLEMPLAVGIVGGATKVHPTAQAALKLLGVRSAAELAEVC
CCCCCCHHHHCCCCCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHH
VAAGLANNLAAMRALACEGIQQGHMSLHARQIAMAAGASGTLVDEVARRMVAERNIKLAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHH
AEEIIAELEGRTIGNPTHN
HHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]