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The map label for this gene is glpR [H]

Identifier: 22127768

GI number: 22127768

Start: 4351766

End: 4352524

Strand: Reverse

Name: glpR [H]

Synonym: y3897

Alternate gene names: 22127768

Gene position: 4352524-4351766 (Counterclockwise)

Preceding gene: 22127769

Following gene: 22127767

Centisome position: 94.6

GC content: 49.14

Gene sequence:

>759_bases
GTGAAGCAAACGCAGCGGCATGATGCGATTATTGAGCTGGTACGCCTACAAGGTTATGTCAGCACTGAAGAGTTAGTGGA
ACATTTTGCCGTTAGCCCGCAAACCATTCGGCGTGACTTAAATGAGCTGGCCGATCAAAACAAAATTCATCGTCATCATG
GTGGGGCGGCGCTACCGTCCAGTTCGGTCAACGCGGCTTATAACGATCGTAAAGTGATGTGGTCGGAAGAAAAGGCGCGG
ATCGCCCAACGCGTTGCTAGCCAGATCCCAGATGGTGCCACGCTATTTATTGATATTGGCACCACACCCGAAGCGGTCGC
TCATGCGCTGATGAATCATAAAGGTCTGCGAGTGGTCACCAACAATCTGAACGTTGCCACATTGCTGACCGCCAAAGAAG
ACTTTCGCCTTATTCTGGCGGGAGGCGAGGTCCGCACTCGCGATGGTGGGATTATTGGCGAAGCGACCCTGGATTTTATT
TCTCAATTCCGTCTTGATTACGGCATCCTCGGTATCAGTGGTATTGATATGGACGGTTCATTACTGGAGTTTGATTACCA
TGAAGTGCGCACCAAGCGAGCGATTATTGAGAACTCCCGTTGTGTGATGTTGGTAACCGACCATTCTAAATTTGGCCGTA
ACGCGATGGTGAATTTAGGGAACATGAATCTGATCGATTATCTGTTTACCGATCAACAGCCACCAGCCAGTGTGATGAAA
ATCATTGAGCAGCATGAGGTTCAATTGGAGCTTTGTTAG

Upstream 100 bases:

>100_bases
GGTTTAATTATTGGGCTACTAATGGCATTTTGGGATACGCGCAACAGCGCGAGAACCGTACAATAACTGCCTGGCCAACC
AGGCGCATTAGGGGATTATC

Downstream 100 bases:

>100_bases
CGTTTTGGTTTGATCTTGGTGGTTTGGATCGGGTTAGGTGATCGGGTTCGGTGATTTGAGTCGGTGATCGGGTTCGGTTG
TTATGGCTTTACGGCTCACC

Product: DNA-binding transcriptional repressor GlpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MKQTQRHDAIIELVRLQGYVSTEELVEHFAVSPQTIRRDLNELADQNKIHRHHGGAALPSSSVNAAYNDRKVMWSEEKAR
IAQRVASQIPDGATLFIDIGTTPEAVAHALMNHKGLRVVTNNLNVATLLTAKEDFRLILAGGEVRTRDGGIIGEATLDFI
SQFRLDYGILGISGIDMDGSLLEFDYHEVRTKRAIIENSRCVMLVTDHSKFGRNAMVNLGNMNLIDYLFTDQQPPASVMK
IIEQHEVQLELC

Sequences:

>Translated_252_residues
MKQTQRHDAIIELVRLQGYVSTEELVEHFAVSPQTIRRDLNELADQNKIHRHHGGAALPSSSVNAAYNDRKVMWSEEKAR
IAQRVASQIPDGATLFIDIGTTPEAVAHALMNHKGLRVVTNNLNVATLLTAKEDFRLILAGGEVRTRDGGIIGEATLDFI
SQFRLDYGILGISGIDMDGSLLEFDYHEVRTKRAIIENSRCVMLVTDHSKFGRNAMVNLGNMNLIDYLFTDQQPPASVMK
IIEQHEVQLELC
>Mature_252_residues
MKQTQRHDAIIELVRLQGYVSTEELVEHFAVSPQTIRRDLNELADQNKIHRHHGGAALPSSSVNAAYNDRKVMWSEEKAR
IAQRVASQIPDGATLFIDIGTTPEAVAHALMNHKGLRVVTNNLNVATLLTAKEDFRLILAGGEVRTRDGGIIGEATLDFI
SQFRLDYGILGISGIDMDGSLLEFDYHEVRTKRAIIENSRCVMLVTDHSKFGRNAMVNLGNMNLIDYLFTDQQPPASVMK
IIEQHEVQLELC

Specific function: Repressor of the glycerol-3-phosphate regulon [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=252, Percent_Identity=77.7777777777778, Blast_Score=416, Evalue=1e-118,
Organism=Escherichia coli, GI87082344, Length=246, Percent_Identity=41.869918699187, Blast_Score=215, Evalue=2e-57,
Organism=Escherichia coli, GI1788069, Length=251, Percent_Identity=28.6852589641434, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789519, Length=251, Percent_Identity=27.8884462151394, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789059, Length=233, Percent_Identity=30.0429184549356, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI226510968, Length=250, Percent_Identity=28.8, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789170, Length=237, Percent_Identity=27.0042194092827, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787063, Length=224, Percent_Identity=27.6785714285714, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790753, Length=253, Percent_Identity=24.1106719367589, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787540, Length=234, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790635, Length=262, Percent_Identity=22.9007633587786, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28161; Mature: 28161

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTQRHDAIIELVRLQGYVSTEELVEHFAVSPQTIRRDLNELADQNKIHRHHGGAALPS
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHCCCCCCCC
SSVNAAYNDRKVMWSEEKARIAQRVASQIPDGATLFIDIGTTPEAVAHALMNHKGLRVVT
CCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEE
NNLNVATLLTAKEDFRLILAGGEVRTRDGGIIGEATLDFISQFRLDYGILGISGIDMDGS
CCCCEEEEEEECCCCEEEEECCEEEECCCCEEHHHHHHHHHHHHHHHCEEEEECCCCCCC
LLEFDYHEVRTKRAIIENSRCVMLVTDHSKFGRNAMVNLGNMNLIDYLFTDQQPPASVMK
EEECHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCCCEEHHEECCCCCHHHHHH
IIEQHEVQLELC
HHHHHCEEEEEC
>Mature Secondary Structure
MKQTQRHDAIIELVRLQGYVSTEELVEHFAVSPQTIRRDLNELADQNKIHRHHGGAALPS
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHCCCCCCCC
SSVNAAYNDRKVMWSEEKARIAQRVASQIPDGATLFIDIGTTPEAVAHALMNHKGLRVVT
CCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEE
NNLNVATLLTAKEDFRLILAGGEVRTRDGGIIGEATLDFISQFRLDYGILGISGIDMDGS
CCCCEEEEEEECCCCEEEEECCEEEECCCCEEHHHHHHHHHHHHHHHCEEEEECCCCCCC
LLEFDYHEVRTKRAIIENSRCVMLVTDHSKFGRNAMVNLGNMNLIDYLFTDQQPPASVMK
EEECHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCCCEEHHEECCCCCHHHHHH
IIEQHEVQLELC
HHHHHCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8955387; 3045764; 9278503 [H]