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The map label for this gene is arcA [H]

Identifier: 22127595

GI number: 22127595

Start: 4136312

End: 4137028

Strand: Direct

Name: arcA [H]

Synonym: y3721

Alternate gene names: 22127595

Gene position: 4136312-4137028 (Clockwise)

Preceding gene: 22127594

Following gene: 22127597

Centisome position: 89.91

GC content: 48.12

Gene sequence:

>717_bases
ATGCAGACCCCCCACATTCTGATCGTAGAAGACGAGATAGTCACTCGCAACACACTAAAGAGCATTTTCGAGGCGGAAGG
CTACGTTGTTTATGAAGCCAATGATGGGGCAGAAATGCACCATATCCTGTCTGAAAATGACATCAACTTAGTGATCATGG
ACATCAATCTGCCAGGCAAAAATGGCTTGTTGCTAGCACGGGAGCTCCGTGAGCAAGCCAGTGTTGCTCTCATGTTCCTC
ACCGGTCGTGATAACGAAGTTGATAAGATCCTTGGTTTGGAAATTGGTGCTGATGATTACATCACGAAACCTTTCAACCC
ACGTGAATTAACCATCCGTGCCCGTAACCTGCTGTCTCGCACCATGAATCTGAGCAGTGTAGGCGAAGAACGCCGTTTGG
TTGAAAGCTACAAATTTAATGGTTGGGAGCTGGATATCAATAGCCGCTCACTGGTCAGCCCTACGGGTGAGCATTACAAA
CTGCCACGCAGTGAGTTCCGCGCCATGCTGCATTTCTGCGAAAACCCAGGGAAAATTCAATCCCGCGGTGAATTGTTGAA
AAAAATGACCGGTCGCGAGTTGAAACCTCATGACCGTACTGTCGATGTGACTATCCGCCGTATTCGTAAACACTTCGAAT
CTACGCCGGATACACCAGAAATTATCGCCACCATCCACGGTGAAGGCTATCGTTTCTGTGGCGATCTAGAAGAGTAA

Upstream 100 bases:

>100_bases
GATGAATGGGATGACGAGTAACCAGTCAATAAAAATCCTGATATAACAAAGACTTCTGTACTTTCTATTTCTATTTTGTT
GGCAATTTTAGGTAGCAAAC

Downstream 100 bases:

>100_bases
TCTTTCGCGAATAGAGACGGAAAGAGCCAGCACACAGATGCTGGCTTTTTTGTTTTTATATCAAGGCGGCAGAGCCAATC
CCCAGAAGCGCACATCGGTG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MQTPHILIVEDEIVTRNTLKSIFEAEGYVVYEANDGAEMHHILSENDINLVIMDINLPGKNGLLLARELREQASVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLSSVGEERRLVESYKFNGWELDINSRSLVSPTGEHYK
LPRSEFRAMLHFCENPGKIQSRGELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE

Sequences:

>Translated_238_residues
MQTPHILIVEDEIVTRNTLKSIFEAEGYVVYEANDGAEMHHILSENDINLVIMDINLPGKNGLLLARELREQASVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLSSVGEERRLVESYKFNGWELDINSRSLVSPTGEHYK
LPRSEFRAMLHFCENPGKIQSRGELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE
>Mature_238_residues
MQTPHILIVEDEIVTRNTLKSIFEAEGYVVYEANDGAEMHHILSENDINLVIMDINLPGKNGLLLARELREQASVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLSSVGEERRLVESYKFNGWELDINSRSLVSPTGEHYK
LPRSEFRAMLHFCENPGKIQSRGELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=92.8571428571429, Blast_Score=456, Evalue=1e-130,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=42.0600858369099, Blast_Score=187, Evalue=6e-49,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=34.9137931034483, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=33.0472103004292, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=31.4893617021277, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=32.3144104803493, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=32.4444444444444, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=31.5789473684211, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=31.8777292576419, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=30.0884955752212, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI145693140, Length=196, Percent_Identity=33.6734693877551, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=30.0429184549356, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=27.8761061946903, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788550, Length=177, Percent_Identity=26.5536723163842, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27261; Mature: 27261

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPHILIVEDEIVTRNTLKSIFEAEGYVVYEANDGAEMHHILSENDINLVIMDINLPGK
CCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCEEEEEEEECCCC
NGLLLARELREQASVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEEHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLSSVGEERRLVESYKFNGWELDINSRSLVSPTGEHYKLPRSEFRAMLHFCENPGKIQ
HCCHHHCCHHHHHHHHHCCCCEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHCCCCCCH
SRGELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC
>Mature Secondary Structure
MQTPHILIVEDEIVTRNTLKSIFEAEGYVVYEANDGAEMHHILSENDINLVIMDINLPGK
CCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCCEEEEEEEECCCC
NGLLLARELREQASVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEEHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLSSVGEERRLVESYKFNGWELDINSRSLVSPTGEHYKLPRSEFRAMLHFCENPGKIQ
HCCHHHCCHHHHHHHHHCCCCEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHCCCCCCH
SRGELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]