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The map label for this gene is manD [H]

Identifier: 221232771

GI number: 221232771

Start: 2013887

End: 2015038

Strand: Reverse

Name: manD [H]

Synonym: SPN23F_20790

Alternate gene names: 221232771

Gene position: 2015038-2013887 (Counterclockwise)

Preceding gene: 221232772

Following gene: 221232770

Centisome position: 90.71

GC content: 44.36

Gene sequence:

>1152_bases
ATGCCTAACTATATTAAAGCGGATCAGTTTTTCTACCCACACGGAGTTCGTCGAGGTGGTTACTTGGAACTTGTGGACGG
CAAGTTTGGGAAACATGTAGAGCAGATTCCTGAAGGGGCTGAGGTGATTGACTATACAGGTTATAGCATTGCCCCAGGTC
TTGTGGATACTCATATTCATGGATATGCAGGTGTAGATGTGATGGACAACAACATTGAAGGTACATTGCATACTATGAGT
GAAGGACTTCTTAGTACCGGTGTTACCAGTTTCTTACCCACAACTTTAACAGCCACTTATGAGCAATTGCTTGCAGTCAC
TGAAAATCTTGGAAACCATTATAAAGAAGCAACAGGTGCTAAGATTCGTGGGATTTATTATGAAGGTCCATATTTCACAG
AAACTTTTAAGGGGGCACAAAATCCAACTTATATGAGAGACCCGGGTGTTGAGGAGTTTCATTCTTGGCAAAAAGCGGCA
AATGGCTTGCTTAATAAAATTGCCCTTGCACCAGAACGTGATGGGGTGGAAGACTTTGTTCGTACAGTTACGGGCGAAGG
TGTGACGGTTGCTCTTGGACATTCAAACGCGACTTTTGATGAAGCCAAAAAAGCAGTCGATGCTGGAGCGAGTGTTTGGG
TGCATGCCTACAATGGAATGCGTGGGTTGACTCACCGTGAATTGGGTATGGTTGGAGCCATGTACCAATTGCCACATACC
TATGCAGAGTTGATCTGTGATGGTCACCACGTAGATCCAAAGGCTTGCGAAATTCTTATCAAACAAAAAGGAACAGAAAA
CATCGCTCTTATCACAGACTGTATGACAGCTGGGGGATTGGAAGACGGAGATTATATGTTGGGAGAATTCCCAGTTGTCG
TTGCAAATGGAACTGCACGCCTCAAATCGACAGGTAACTTGGCAGGTTCTATCCTCAAACTCAAAGATGGTTTGAAGAAT
GTGGTCGAATGGGGAATTGCGAATCCGCATGAAGCAGTCATGATGGCCAGCTTCAACCCAGCTAAATCCGTTCACATCGA
TGACGTCTGTGGCCAAATCCGTGAAGGCTACGACGCTGACTTCATCGTATTAGATAAAGATTTGGAATTGGTAGCAACCT
ATCTAGATGGCGTAAAACGTTATCAAGCATAA

Upstream 100 bases:

>100_bases
CCAAAAAATAGGTCTATACCATTTACAAATAAAAAAGAAAGGTTTATAATGTAATTGACATAATAAATTGTAGAATCAAT
CTTTTAAGGAGGTTAACATT

Downstream 100 bases:

>100_bases
GAGAGAAGGCAGAAGTTAGAGACTAGCTTCTGCTTTTTTATACAGGGTACTTTACTGGTAAATAAAAAGTTAAAAAAATC
ACAAAAAAAGCTTGAAGAAA

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MPNYIKADQFFYPHGVRRGGYLELVDGKFGKHVEQIPEGAEVIDYTGYSIAPGLVDTHIHGYAGVDVMDNNIEGTLHTMS
EGLLSTGVTSFLPTTLTATYEQLLAVTENLGNHYKEATGAKIRGIYYEGPYFTETFKGAQNPTYMRDPGVEEFHSWQKAA
NGLLNKIALAPERDGVEDFVRTVTGEGVTVALGHSNATFDEAKKAVDAGASVWVHAYNGMRGLTHRELGMVGAMYQLPHT
YAELICDGHHVDPKACEILIKQKGTENIALITDCMTAGGLEDGDYMLGEFPVVVANGTARLKSTGNLAGSILKLKDGLKN
VVEWGIANPHEAVMMASFNPAKSVHIDDVCGQIREGYDADFIVLDKDLELVATYLDGVKRYQA

Sequences:

>Translated_383_residues
MPNYIKADQFFYPHGVRRGGYLELVDGKFGKHVEQIPEGAEVIDYTGYSIAPGLVDTHIHGYAGVDVMDNNIEGTLHTMS
EGLLSTGVTSFLPTTLTATYEQLLAVTENLGNHYKEATGAKIRGIYYEGPYFTETFKGAQNPTYMRDPGVEEFHSWQKAA
NGLLNKIALAPERDGVEDFVRTVTGEGVTVALGHSNATFDEAKKAVDAGASVWVHAYNGMRGLTHRELGMVGAMYQLPHT
YAELICDGHHVDPKACEILIKQKGTENIALITDCMTAGGLEDGDYMLGEFPVVVANGTARLKSTGNLAGSILKLKDGLKN
VVEWGIANPHEAVMMASFNPAKSVHIDDVCGQIREGYDADFIVLDKDLELVATYLDGVKRYQA
>Mature_382_residues
PNYIKADQFFYPHGVRRGGYLELVDGKFGKHVEQIPEGAEVIDYTGYSIAPGLVDTHIHGYAGVDVMDNNIEGTLHTMSE
GLLSTGVTSFLPTTLTATYEQLLAVTENLGNHYKEATGAKIRGIYYEGPYFTETFKGAQNPTYMRDPGVEEFHSWQKAAN
GLLNKIALAPERDGVEDFVRTVTGEGVTVALGHSNATFDEAKKAVDAGASVWVHAYNGMRGLTHRELGMVGAMYQLPHTY
AELICDGHHVDPKACEILIKQKGTENIALITDCMTAGGLEDGDYMLGEFPVVVANGTARLKSTGNLAGSILKLKDGLKNV
VEWGIANPHEAVMMASFNPAKSVHIDDVCGQIREGYDADFIVLDKDLELVATYLDGVKRYQA

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=382, Percent_Identity=28.7958115183246, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI224922791, Length=376, Percent_Identity=28.7234042553192, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1786892, Length=354, Percent_Identity=29.3785310734463, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17553768, Length=356, Percent_Identity=27.247191011236, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI19920392, Length=346, Percent_Identity=32.3699421965318, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI281361140, Length=359, Percent_Identity=31.4763231197772, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.1.25 [H]

Molecular weight: Translated: 41698; Mature: 41566

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNYIKADQFFYPHGVRRGGYLELVDGKFGKHVEQIPEGAEVIDYTGYSIAPGLVDTHIH
CCCCCCCCCEECCCCCCCCCEEEEECCCHHHHHHHCCCCCCEEEECCCEECCCCHHHCCC
GYAGVDVMDNNIEGTLHTMSEGLLSTGVTSFLPTTLTATYEQLLAVTENLGNHYKEATGA
CEECCEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KIRGIYYEGPYFTETFKGAQNPTYMRDPGVEEFHSWQKAANGLLNKIALAPERDGVEDFV
EEEEEEECCCEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RTVTGEGVTVALGHSNATFDEAKKAVDAGASVWVHAYNGMRGLTHRELGMVGAMYQLPHT
HHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
YAELICDGHHVDPKACEILIKQKGTENIALITDCMTAGGLEDGDYMLGEFPVVVANGTAR
HHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHCCCCCCCEEECCCCEEEECCCEE
LKSTGNLAGSILKLKDGLKNVVEWGIANPHEAVMMASFNPAKSVHIDDVCGQIREGYDAD
ECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCC
FIVLDKDLELVATYLDGVKRYQA
EEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PNYIKADQFFYPHGVRRGGYLELVDGKFGKHVEQIPEGAEVIDYTGYSIAPGLVDTHIH
CCCCCCCCEECCCCCCCCCEEEEECCCHHHHHHHCCCCCCEEEECCCEECCCCHHHCCC
GYAGVDVMDNNIEGTLHTMSEGLLSTGVTSFLPTTLTATYEQLLAVTENLGNHYKEATGA
CEECCEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KIRGIYYEGPYFTETFKGAQNPTYMRDPGVEEFHSWQKAANGLLNKIALAPERDGVEDFV
EEEEEEECCCEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
RTVTGEGVTVALGHSNATFDEAKKAVDAGASVWVHAYNGMRGLTHRELGMVGAMYQLPHT
HHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
YAELICDGHHVDPKACEILIKQKGTENIALITDCMTAGGLEDGDYMLGEFPVVVANGTAR
HHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHCCCCCCCEEECCCCEEEECCCEE
LKSTGNLAGSILKLKDGLKNVVEWGIANPHEAVMMASFNPAKSVHIDDVCGQIREGYDAD
ECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCC
FIVLDKDLELVATYLDGVKRYQA
EEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969210 [H]