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The map label for this gene is adh [H]

Identifier: 221232770

GI number: 221232770

Start: 2012666

End: 2013724

Strand: Reverse

Name: adh [H]

Synonym: SPN23F_20780

Alternate gene names: 221232770

Gene position: 2013724-2012666 (Counterclockwise)

Preceding gene: 221232771

Following gene: 221232769

Centisome position: 90.65

GC content: 40.98

Gene sequence:

>1059_bases
ATGAAAGCCTATACTTATGTTAAACCAGGACTTGCTTCTTTTGTTGATGTAGACAAACCAGTTATTCGCAAGCCAACAGA
CGCTATTGTGCGTATTGTAAAAACCACTATTTGTGGAACAGACCTCCATATTATCAAAGGGGATGTTCCTACTTGCCAAA
GTGGTACCATTCTTGGCCACGAAGGGATTGGGATTGTTGAAGAAGTTGGGGAAGGAGTTTCCAACTTCAAAAAAGGCGAC
AAGGTCTTGATTTCTTGCGTCTGTGCCTGTGGTAAATGCTACTACTGTAAAAAAGGAATTTATGCCCACTGTGAAGACGA
AGGGGGCTGGATTTTCGGTCACTTGATTGATGGTATGCAGGCTGAATATCTACGTGTCCCTCATGCAGATAATACTCTTT
ACCATACTCCAGAAGACTTGTCAGATGAAGCTTTGGTTATGCTGTCAGACATTCTGCCTACTGGATATGAAATTGGTGTC
TTAAAAGGGAAAGTAGAACCTGGTTGCAGCGTAGCCATTATTGGTTCAGGTCCAGTTGGATTGGCTGCTCTTTTAACAGC
CCAATTCTATTCACCAGCTAAATTGATTATGGTAGACCTAGACGATAACCGCTTGGAAACTGCCCTATCATTCGGTGCGA
CTCATAAGGTTAATTCTTCAGACCCTGAAAAAGCCATTAAAGAAATTTATGATTTGACAGATGGTCGTGGTGTGGATGTC
GCTATCGAAGCTGTTGGTATTCCTGCAACATTTGATTTCTGTCAAAAGATTATCGGTGTAGACGGAACGGTTGCCAACTG
TGGTGTGCATGGTAAACCAGTTGAATTCGATTTAGATAAACTTTGGATTCGCAACATCAATGTAACAACTGGTTTGGTAT
CTACAAATACGACTCCACAATTGTTGAAAGCACTTGAAAGTCATAAGATTGAACCAGAAAAATTGGTAACTCACTATTTC
AAACTCAGTGAAATTGAAAAAGCCTATGAAGTCTTCAGTAAGGCAGCAGACCACCATGCCATTAAGGTCATTATCGAAAA
CGATATCTCAGAAGCCTAA

Upstream 100 bases:

>100_bases
TAAAAAGTTAAAAAAATCACAAAAAAAGCTTGAAGAAACAAAGAAAAAGGCTTACAATTGAACTATAAATATTACAAATA
AAAAAACGGAGGAGTGCTTT

Downstream 100 bases:

>100_bases
GTAGTAAAAATATTTTTGTACATAAGTAAATAGAAATTCAGTCATCCATCAGATGGCTGGATTTTTTATCAAAAAATTAA
GAAATGAGCATATTTCTTTC

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHIIKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGD
KVLISCVCACGKCYYCKKGIYAHCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGV
LKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVNSSDPEKAIKEIYDLTDGRGVDV
AIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEFDLDKLWIRNINVTTGLVSTNTTPQLLKALESHKIEPEKLVTHYF
KLSEIEKAYEVFSKAADHHAIKVIIENDISEA

Sequences:

>Translated_352_residues
MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHIIKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGD
KVLISCVCACGKCYYCKKGIYAHCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGV
LKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVNSSDPEKAIKEIYDLTDGRGVDV
AIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEFDLDKLWIRNINVTTGLVSTNTTPQLLKALESHKIEPEKLVTHYF
KLSEIEKAYEVFSKAADHHAIKVIIENDISEA
>Mature_352_residues
MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHIIKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGD
KVLISCVCACGKCYYCKKGIYAHCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGV
LKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVNSSDPEKAIKEIYDLTDGRGVDV
AIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEFDLDKLWIRNINVTTGLVSTNTTPQLLKALESHKIEPEKLVTHYF
KLSEIEKAYEVFSKAADHHAIKVIIENDISEA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=358, Percent_Identity=29.0502793296089, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI34577061, Length=353, Percent_Identity=30.028328611898, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI4501929, Length=353, Percent_Identity=29.7450424929178, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI156523966, Length=357, Percent_Identity=28.5714285714286, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4501939, Length=357, Percent_Identity=28.5714285714286, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4501933, Length=355, Percent_Identity=28.169014084507, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI262073058, Length=332, Percent_Identity=28.9156626506024, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI71743840, Length=332, Percent_Identity=28.9156626506024, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=27.3458445040214, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI156627571, Length=338, Percent_Identity=25.1479289940828, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786825, Length=377, Percent_Identity=31.8302387267904, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87082125, Length=336, Percent_Identity=30.0595238095238, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787863, Length=341, Percent_Identity=27.8592375366569, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=27.0516717325228, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790045, Length=328, Percent_Identity=26.5243902439024, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788075, Length=364, Percent_Identity=25.2747252747253, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786552, Length=378, Percent_Identity=28.042328042328, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87081918, Length=285, Percent_Identity=32.280701754386, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788407, Length=271, Percent_Identity=28.0442804428044, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI226510992, Length=310, Percent_Identity=25.8064516129032, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790718, Length=310, Percent_Identity=24.5161290322581, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=360, Percent_Identity=28.6111111111111, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=350, Percent_Identity=27.1428571428571, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71997431, Length=343, Percent_Identity=27.1137026239067, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562876, Length=330, Percent_Identity=27.5757575757576, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=327, Percent_Identity=26.9113149847095, Blast_Score=104, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323099, Length=349, Percent_Identity=26.9340974212034, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=362, Percent_Identity=25.6906077348066, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=337, Percent_Identity=28.7833827893175, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=337, Percent_Identity=28.7833827893175, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=377, Percent_Identity=24.6684350132626, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=347, Percent_Identity=24.207492795389, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=28.8409703504043, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17137530, Length=322, Percent_Identity=28.8819875776398, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17737897, Length=321, Percent_Identity=28.6604361370716, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45550770, Length=335, Percent_Identity=23.8805970149254, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221457811, Length=335, Percent_Identity=23.8805970149254, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551930, Length=339, Percent_Identity=23.598820058997, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 38092; Mature: 38092

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHIIKGDVPTCQSGTILGH
CCCCEECCCCHHHHHCCCCCHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECC
EGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYAHCEDEGGWIFGHLIDGMQ
CCCCHHHHHCCHHHHHCCCHHHHHHHHHHCCCCEEECCCCEEEEECCCCEEEEEHHCCCC
AEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGVLKGKVEPGCSVAIIGSGPVG
HHEEECCCCCCCCEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCHH
LAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVNSSDPEKAIKEIYDLTDGRGVDV
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEE
AIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEFDLDKLWIRNINVTTGLVSTNTTPQ
EEEEECCCHHHHHHHHHHCCCCCEEECCCCCCCCEECHHHEEEEECCEEEEEEECCCCHH
LLKALESHKIEPEKLVTHYFKLSEIEKAYEVFSKAADHHAIKVIIENDISEA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHIIKGDVPTCQSGTILGH
CCCCEECCCCHHHHHCCCCCHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECC
EGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYAHCEDEGGWIFGHLIDGMQ
CCCCHHHHHCCHHHHHCCCHHHHHHHHHHCCCCEEECCCCEEEEECCCCEEEEEHHCCCC
AEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGVLKGKVEPGCSVAIIGSGPVG
HHEEECCCCCCCCEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCHH
LAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVNSSDPEKAIKEIYDLTDGRGVDV
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEE
AIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEFDLDKLWIRNINVTTGLVSTNTTPQ
EEEEECCCHHHHHHHHHHCCCCCEEECCCCCCCCEECHHHEEEEECCEEEEEEECCCCHH
LLKALESHKIEPEKLVTHYFKLSEIEKAYEVFSKAADHHAIKVIIENDISEA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]