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The map label for this gene is adhE [H]

Identifier: 221232744

GI number: 221232744

Start: 1988278

End: 1990929

Strand: Reverse

Name: adhE [H]

Synonym: SPN23F_20460

Alternate gene names: 221232744

Gene position: 1990929-1988278 (Counterclockwise)

Preceding gene: 221232745

Following gene: 221232739

Centisome position: 89.63

GC content: 42.57

Gene sequence:

>2652_bases
ATGGCTGATAAAAAAACTGTGACACCAGAGGAAAAGAAACTCGTTGCTGAAAAACACGTAGATGAGTTGGTTCAAAAAGC
TCTAGTTGCCCTTGAAGAAATGCGTAAATTGGATCAAGAGCAAGTTGACTACATCGTTGCCAAAGCATCAGTAGCAGCTT
TGGATGCCCACGGAGAATTGGCTTTACATGCCTTTGAAGAAACAGGACGTGGTGTATTTGAAGATAAAGCAACTAAGAAC
TTGTTTGCCTGTGAACACGTAGTAAACAACATGCGTCACACTAAGACAGTTGGCGTTATCGAAGAAGACGATGTAACAGG
ATTGACTCTTATTGCTGAACCAGTTGGTGTTGTTTGTGGTATTACTCCAACAACAAACCCAACATCAACAGCAATCTTCA
AATCATTGATTTCATTGAAGACACGTAACCCAATCGTCTTTGCCTTCCATCCATCAGCACAAGAATCATCTGCTCATGCA
GCTCGTATCGTCCGCGATGCAGCTATCGCAGCTGGTGCTCCTGAAAACTGTGTGCAATGGATTACTCAACCATCTATGGA
AGCAACAAGTGCCCTTATGAACCACGAAGGTGTTGCAACAATCCTTGCAACAGGTGGTAATGCCATGGTTAAAGCCGCAT
ACTCATGTGGTAAACCAGCTCTTGGGGTAGGTGCCGGAAACGTTCCAGCTTATGTTGAAAAATCAGCAAACATTCGTCAA
GCAGCACACGATATCGTCATGTCTAAATCATTTGATAACGGTATGGTCTGTGCATCTGAACAAGCAGTTATCATTGATAA
AGAAATTTACGATGAATTTGTAGCAGAGTTCAAATCTTACCACACTTACTTTGTAAACAAAAAAGAAAAAGCTCTTCTTG
AAGAGTTCTGCTTCGGCGTCAAAGCAAACAGCAAAAACTGTGCTGGTGCAAAATTGAACGCTGACATCGTTGGTAAACCA
GCAACTTGGATTGCAGAACAAGCAGGATTTACAGTTCCAGAAGGAACAAACATTCTTGCTGCAGAATGTAAAGAAGTTGG
CGAAAATGAGCCATTGACTCGTGAAAAATTGTCACCAGTTATTGCAGTTTTGAAATCTGAAAGCCGTGAAGATGGTATTA
CTAAGGCTCGTCAAATGGTTGAATTTAACGGTCTTGGACACTCAGCAGCTATCCACACAGCTGACGAAGAATTGACTAAA
GAATTTGGTAAAGCTGTTAAAGCTATTCGTGTTATCTGTAACTCACCTTCTACTTTTGGTGGTATCGGGGACGTTTACAA
TGCCTTCTTGCCATCATTGACACTTGGATGTGGTTCTTACGGACGCAACTCAGTTGGGGATAACGTTAGTGCCATTAACC
TCTTGAATATCAAAAAAGTCGGAAGACGGAGAAATAACATGCAATGGATGAAACTTCCTTCAAAAACATACTTTGAACGT
GATTCAATTCAATACCTTCAAAAATGTCGTGACGTTGAACGTGTCATGATCGTTACTGACCATGCCATGGTAGAGCTTGG
TTTCCTTGATCGTATCATCGAACAACTGGACCTTCGTCGCAATAAGGTTGTTTACCAAATCTTTGCGGATGTAGAACCGG
ATCCAGATATCACAACTGTAAACCGTGGTACTGAGATTATGCGTGCCTTCAAACCAGATACCATCATCGCACTCGGTGGT
GGGTCTCCAATGGATGCTGCCAAAGTAATGTGGCTCTTCTACGAGCAACCAGAAGTGGACTTCCGTGACCTTGTCCAAAA
ATTCATGGATATCCGTAAACGTGCCTTCAAGTTCCCATTGCTTGGTAAGAAGACTAAATTCATCGCGATTCCAACTACAT
CTGGTACAGGATCTGAAGTAACACCATTTGCCGTTATCTCTGATAAAGCAAACAACCGTAAATACCCAATCGCTGACTAC
TCATTGACACCAACTGTGGCAATCGTAGATCCTGCTTTGGTATTGACAGTTCCAGGATTTGTTGCTGCTGATACTGGTAT
GGACGTATTGACTCACGCGACAGAAGCATACGTATCACAAATGGCTAGTGACTACACTGATGGTTTAGCACTTCAAGCCA
TTAAATTGGTCTTTGAAAATCTCGAAAGCTCAGTTAAGAATGCAGACTTCCACTCACGTGAGAAAATGCATAACGCTTCA
ACAATCGCTGGTATGGCCTTTGCCAATGCCTTCCTAGGTATTTCTCACTCAATGGCCCATAAGATTGGTGCGCAATTCCA
CACAATCCACGGTCGTACAAATGCTATCTTGCTTCCATACGTTATCCGTTACAACGGTACACGTCCAGCTAAGACAGCAA
CATGGCCTAAGTACAACTACTACCGTGCAGATGAAAAATACCAAGATATCGCACGCATGCTTGGACTTCCAGCTTCTACT
CCAGAAGAAGGGGTTGAATCTTACGCAAAAGCTGTCTACGAACTCGGTGAACGTATTGGGATCCAAATGAATTTTAGAGA
CCAAGGAATTGACGAAAAAGAATGGAAAGAACATTCTCGTGAATTAGCCTTCCTGGCTTATGAAGACCAATGTTCACCAG
CTAACCCACGTCTTCCAATGGTAGACCATATGCAAGAAATCATCGAAGATGCATACTATGGCTACAAAGAAAGACCAGGA
CGCCGTAAATAA

Upstream 100 bases:

>100_bases
ATGTTTATGAAACTGTTTACAAAGTTGAAATAATACGTTATAATAAACTTGTGAAAAAATTAACAAAGGATATCGATCCT
TGAAAGCTGTGGAGGAAAAT

Downstream 100 bases:

>100_bases
TTGTTTATCAGTCTAGAAGCAAGACAAAAACTCAATTTGAGGGAAAGATCCAGTAATTTTTCTATGATAAAAGGCATCCT
ATCAAGGTTTTTGAATACCT

Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH; Pyruvate-formate-lyase deactivase; PFL deactivase [H]

Number of amino acids: Translated: 883; Mature: 882

Protein sequence:

>883_residues
MADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDYIVAKASVAALDAHGELALHAFEETGRGVFEDKATKN
LFACEHVVNNMRHTKTVGVIEEDDVTGLTLIAEPVGVVCGITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSAHA
ARIVRDAAIAAGAPENCVQWITQPSMEATSALMNHEGVATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQ
AAHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAEFKSYHTYFVNKKEKALLEEFCFGVKANSKNCAGAKLNADIVGKP
ATWIAEQAGFTVPEGTNILAAECKEVGENEPLTREKLSPVIAVLKSESREDGITKARQMVEFNGLGHSAAIHTADEELTK
EFGKAVKAIRVICNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVSAINLLNIKKVGRRRNNMQWMKLPSKTYFER
DSIQYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTVNRGTEIMRAFKPDTIIALGG
GSPMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPLLGKKTKFIAIPTTSGTGSEVTPFAVISDKANNRKYPIADY
SLTPTVAIVDPALVLTVPGFVAADTGMDVLTHATEAYVSQMASDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNAS
TIAGMAFANAFLGISHSMAHKIGAQFHTIHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIARMLGLPAST
PEEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSRELAFLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYKERPG
RRK

Sequences:

>Translated_883_residues
MADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDYIVAKASVAALDAHGELALHAFEETGRGVFEDKATKN
LFACEHVVNNMRHTKTVGVIEEDDVTGLTLIAEPVGVVCGITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSAHA
ARIVRDAAIAAGAPENCVQWITQPSMEATSALMNHEGVATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQ
AAHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAEFKSYHTYFVNKKEKALLEEFCFGVKANSKNCAGAKLNADIVGKP
ATWIAEQAGFTVPEGTNILAAECKEVGENEPLTREKLSPVIAVLKSESREDGITKARQMVEFNGLGHSAAIHTADEELTK
EFGKAVKAIRVICNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVSAINLLNIKKVGRRRNNMQWMKLPSKTYFER
DSIQYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTVNRGTEIMRAFKPDTIIALGG
GSPMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPLLGKKTKFIAIPTTSGTGSEVTPFAVISDKANNRKYPIADY
SLTPTVAIVDPALVLTVPGFVAADTGMDVLTHATEAYVSQMASDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNAS
TIAGMAFANAFLGISHSMAHKIGAQFHTIHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIARMLGLPAST
PEEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSRELAFLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYKERPG
RRK
>Mature_882_residues
ADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDYIVAKASVAALDAHGELALHAFEETGRGVFEDKATKNL
FACEHVVNNMRHTKTVGVIEEDDVTGLTLIAEPVGVVCGITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSAHAA
RIVRDAAIAAGAPENCVQWITQPSMEATSALMNHEGVATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQA
AHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAEFKSYHTYFVNKKEKALLEEFCFGVKANSKNCAGAKLNADIVGKPA
TWIAEQAGFTVPEGTNILAAECKEVGENEPLTREKLSPVIAVLKSESREDGITKARQMVEFNGLGHSAAIHTADEELTKE
FGKAVKAIRVICNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVSAINLLNIKKVGRRRNNMQWMKLPSKTYFERD
SIQYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTVNRGTEIMRAFKPDTIIALGGG
SPMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPLLGKKTKFIAIPTTSGTGSEVTPFAVISDKANNRKYPIADYS
LTPTVAIVDPALVLTVPGFVAADTGMDVLTHATEAYVSQMASDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNAST
IAGMAFANAFLGISHSMAHKIGAQFHTIHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIARMLGLPASTP
EEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSRELAFLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYKERPGR
RK

Specific function: This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=270, Percent_Identity=29.2592592592593, Blast_Score=97, Evalue=6e-20,
Organism=Escherichia coli, GI1787493, Length=867, Percent_Identity=47.520184544406, Blast_Score=773, Evalue=0.0,
Organism=Escherichia coli, GI1789163, Length=408, Percent_Identity=33.578431372549, Blast_Score=213, Evalue=4e-56,
Organism=Escherichia coli, GI48994951, Length=366, Percent_Identity=34.4262295081967, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87082107, Length=415, Percent_Identity=32.5301204819277, Blast_Score=182, Evalue=8e-47,
Organism=Escherichia coli, GI1788797, Length=385, Percent_Identity=31.1688311688312, Blast_Score=160, Evalue=5e-40,
Organism=Escherichia coli, GI1789386, Length=384, Percent_Identity=23.6979166666667, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17537053, Length=248, Percent_Identity=29.0322580645161, Blast_Score=108, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321181, Length=418, Percent_Identity=31.3397129186603, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24657991, Length=380, Percent_Identity=27.1052631578947, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR012079 [H]

Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]

EC number: =1.1.1.1; =1.2.1.10 [H]

Molecular weight: Translated: 97288; Mature: 97157

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDYIVAKASVAALDAHGEL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCCE
ALHAFEETGRGVFEDKATKNLFACEHVVNNMRHTKTVGVIEEDDVTGLTLIAEPVGVVCG
EEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEECEEECCCCCCEEEEECCCCEEEE
ITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSAHAARIVRDAAIAAGAPENCVQW
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
ITQPSMEATSALMNHEGVATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQ
HCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHH
AAHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAEFKSYHTYFVNKKEKALLEEFCFGV
HHHHHHHHCCCCCCCEEECCCEEEECHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCC
KANSKNCAGAKLNADIVGKPATWIAEQAGFTVPEGTNILAAECKEVGENEPLTREKLSPV
CCCCCCCCCCEECCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHH
IAVLKSESREDGITKARQMVEFNGLGHSAAIHTADEELTKEFGKAVKAIRVICNSPSTFG
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCC
GIGDVYNAFLPSLTLGCGSYGRNSVGDNVSAINLLNIKKVGRRRNNMQWMKLPSKTYFER
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCEEECCCHHHHCH
DSIQYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTV
HHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCEEC
NRGTEIMRAFKPDTIIALGGGSPMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPL
CCCHHHHHHCCCCEEEEECCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
LGKKTKFIAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGF
CCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCCH
VAADTGMDVLTHATEAYVSQMASDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNAS
HCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHH
TIAGMAFANAFLGISHSMAHKIGAQFHTIHGRTNAILLPYVIRYNGTRPAKTATWPKYNY
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCE
YRADEKYQDIARMLGLPASTPEEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSR
EECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHCC
ELAFLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYKERPGRRK
EEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDYIVAKASVAALDAHGEL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCCE
ALHAFEETGRGVFEDKATKNLFACEHVVNNMRHTKTVGVIEEDDVTGLTLIAEPVGVVCG
EEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEECEEECCCCCCEEEEECCCCEEEE
ITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSAHAARIVRDAAIAAGAPENCVQW
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
ITQPSMEATSALMNHEGVATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQ
HCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHH
AAHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAEFKSYHTYFVNKKEKALLEEFCFGV
HHHHHHHHCCCCCCCEEECCCEEEECHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCC
KANSKNCAGAKLNADIVGKPATWIAEQAGFTVPEGTNILAAECKEVGENEPLTREKLSPV
CCCCCCCCCCEECCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHH
IAVLKSESREDGITKARQMVEFNGLGHSAAIHTADEELTKEFGKAVKAIRVICNSPSTFG
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCC
GIGDVYNAFLPSLTLGCGSYGRNSVGDNVSAINLLNIKKVGRRRNNMQWMKLPSKTYFER
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCEEECCCHHHHCH
DSIQYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTV
HHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCEEC
NRGTEIMRAFKPDTIIALGGGSPMDAAKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPL
CCCHHHHHHCCCCEEEEECCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
LGKKTKFIAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGF
CCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCCH
VAADTGMDVLTHATEAYVSQMASDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNAS
HCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHH
TIAGMAFANAFLGISHSMAHKIGAQFHTIHGRTNAILLPYVIRYNGTRPAKTATWPKYNY
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCE
YRADEKYQDIARMLGLPASTPEEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSR
EECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHCC
ELAFLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYKERPGRRK
EEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]