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The map label for this gene is tabA [H]

Identifier: 221232702

GI number: 221232702

Start: 1939480

End: 1940730

Strand: Reverse

Name: tabA [H]

Synonym: SPN23F_19980

Alternate gene names: 221232702

Gene position: 1940730-1939480 (Counterclockwise)

Preceding gene: 221232703

Following gene: 221232701

Centisome position: 87.37

GC content: 45.16

Gene sequence:

>1251_bases
ATGAAAACACCATTTATCAATAGAGAAGAGTTAGAAGCGATTGTTGCCGAGTTCCCGACTCCCTTTCACTTGTATGATGA
GAAGGGGATTCGTGAGAAGGCAAGAGCCGTCAACCAAGCTTTTTCGTGGAACAAGGGCTTTAAGGAATATTTTGCAGTTA
AGGCTACTCCAACTCCAGCTATTTTGAAAATTCTCCAAGAAGAAGGTTGTGGTGTGGACTGCTCTAGTTATGTAGAGCTT
TTGATGAGCCATAAACTGGACTTTCTGGGTTCTGAGATTATGTTCTCTTCCAACAACACGCCAGACAAGGAATACGCCTA
TGCACGTGAATTGGGTGCGACCATTAACTTGGATGCCTTTGAAGATATTGAACATCTGGAGAGAGTAGCAGGCATTCCAG
AAATCATCTCTTGTCGTTATAATCCTGGAGGCGTTTTTGAACTGGGGACAGACATTATGGACAATCCTGGGGAGGCTAAG
TTTGGCATGACCAAGGACCAGCTCTTTGAAGCCTTTGCTATCTTGAAGGAAAAAGGAGCCAAGACTTTTGGGATTCACTC
CTTCCTAGCGTCCAATACCGTGACCCATCTCTATTATCCAGAGTTGGCTCGTCAGCTCTTTGAACTGGCTGTTGAAATCA
AGGAAAAGTTGGGCATTTGGCTAGACTTTATCAATCTTTCTGGCGGTATTGGTGTTAATTATCGTCCAGACCAGGAGCCG
AACGATATCGCCTTGATTGGTGAGGGAGTTCGTAAGGTGTATGAAGAAGTTCTTACGTCAGCAGGTCTTGGTCAGGTCAA
GATTTTCACCGAATTGGGTCGTTTTATGCTGGCACCTCACGGTGCTCTAGTCACAAGAGTGACTCATAAGAAGGAAACCT
ACCGTACCTATCTAGGTGTGGATGCCTCAGCAGTCAACCTCATGCGTCCAGCTATGTACGGAGCTTACCATCATATTAGC
AACGTGACCCATCCAGATGGACCAGCTGAAGCGGTAGATGTGGTTGGTTCACTCTGTGAAAACAATGATAAATTTGCAGT
CAATCGCGAACTGCCTCATACAGAAATCGGTGATTTGCTGGTAATTCATGATACAGGTGCCCACGGATTTTCAATGGGCT
ACCAGTATAATGCCAAATTACGTTCTGCGGAAATCCTCTATACCGAAGAAGGTAAAGCCCGTCAAATCCGCCGTGCAGAG
CGCCCTGAGGACTATTTTGCAACCTTATATGGCTTCGATTTTGAAGAATAA

Upstream 100 bases:

>100_bases
TGAGGTTGGCAATATCTTTGACGAAGATAAATAAGAGATAGAACTAAAGGTTGGAACGATTGTCCCAGCCTTTCTTTGCA
AACAGAATAGAAGGAAGCTT

Downstream 100 bases:

>100_bases
TCTGATAATAGATTGAAAATGAAATTGAAAAACAGATTGCTTTCTAAAAAATAGGCAAAAATCTTGTTTTTCCTTCAAGT
CGTGATATAATAAAACTATA

Product: pyridoxal-dependent decarboxylase

Products: L-lysine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWNKGFKEYFAVKATPTPAILKILQEEGCGVDCSSYVEL
LMSHKLDFLGSEIMFSSNNTPDKEYAYARELGATINLDAFEDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPGEAK
FGMTKDQLFEAFAILKEKGAKTFGIHSFLASNTVTHLYYPELARQLFELAVEIKEKLGIWLDFINLSGGIGVNYRPDQEP
NDIALIGEGVRKVYEEVLTSAGLGQVKIFTELGRFMLAPHGALVTRVTHKKETYRTYLGVDASAVNLMRPAMYGAYHHIS
NVTHPDGPAEAVDVVGSLCENNDKFAVNRELPHTEIGDLLVIHDTGAHGFSMGYQYNAKLRSAEILYTEEGKARQIRRAE
RPEDYFATLYGFDFEE

Sequences:

>Translated_416_residues
MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWNKGFKEYFAVKATPTPAILKILQEEGCGVDCSSYVEL
LMSHKLDFLGSEIMFSSNNTPDKEYAYARELGATINLDAFEDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPGEAK
FGMTKDQLFEAFAILKEKGAKTFGIHSFLASNTVTHLYYPELARQLFELAVEIKEKLGIWLDFINLSGGIGVNYRPDQEP
NDIALIGEGVRKVYEEVLTSAGLGQVKIFTELGRFMLAPHGALVTRVTHKKETYRTYLGVDASAVNLMRPAMYGAYHHIS
NVTHPDGPAEAVDVVGSLCENNDKFAVNRELPHTEIGDLLVIHDTGAHGFSMGYQYNAKLRSAEILYTEEGKARQIRRAE
RPEDYFATLYGFDFEE
>Mature_416_residues
MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWNKGFKEYFAVKATPTPAILKILQEEGCGVDCSSYVEL
LMSHKLDFLGSEIMFSSNNTPDKEYAYARELGATINLDAFEDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPGEAK
FGMTKDQLFEAFAILKEKGAKTFGIHSFLASNTVTHLYYPELARQLFELAVEIKEKLGIWLDFINLSGGIGVNYRPDQEP
NDIALIGEGVRKVYEEVLTSAGLGQVKIFTELGRFMLAPHGALVTRVTHKKETYRTYLGVDASAVNLMRPAMYGAYHHIS
NVTHPDGPAEAVDVVGSLCENNDKFAVNRELPHTEIGDLLVIHDTGAHGFSMGYQYNAKLRSAEILYTEEGKARQIRRAE
RPEDYFATLYGFDFEE

Specific function: Involved in tabtoxin production and pathogenicity [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=415, Percent_Identity=30.1204819277108, Blast_Score=139, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: 4.1.1.20

Molecular weight: Translated: 46649; Mature: 46649

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWNKGFKEYFAVKATPTPA
CCCCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCCHHHEEEECCCCHH
ILKILQEEGCGVDCSSYVELLMSHKLDFLGSEIMFSSNNTPDKEYAYARELGATINLDAF
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCEECCHHH
EDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPGEAKFGMTKDQLFEAFAILKEKGA
HHHHHHHHHHCCCHHHEEECCCCCCEEECCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
KTFGIHSFLASNTVTHLYYPELARQLFELAVEIKEKLGIWLDFINLSGGIGVNYRPDQEP
CHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCC
NDIALIGEGVRKVYEEVLTSAGLGQVKIFTELGRFMLAPHGALVTRVTHKKETYRTYLGV
CCEEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
DASAVNLMRPAMYGAYHHISNVTHPDGPAEAVDVVGSLCENNDKFAVNRELPHTEIGDLL
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEE
VIHDTGAHGFSMGYQYNAKLRSAEILYTEEGKARQIRRAERPEDYFATLYGFDFEE
EEECCCCCCEECCEEECCCCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWNKGFKEYFAVKATPTPA
CCCCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCCHHHEEEECCCCHH
ILKILQEEGCGVDCSSYVELLMSHKLDFLGSEIMFSSNNTPDKEYAYARELGATINLDAF
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCEECCHHH
EDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPGEAKFGMTKDQLFEAFAILKEKGA
HHHHHHHHHHCCCHHHEEECCCCCCEEECCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
KTFGIHSFLASNTVTHLYYPELARQLFELAVEIKEKLGIWLDFINLSGGIGVNYRPDQEP
CHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCC
NDIALIGEGVRKVYEEVLTSAGLGQVKIFTELGRFMLAPHGALVTRVTHKKETYRTYLGV
CCEEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
DASAVNLMRPAMYGAYHHISNVTHPDGPAEAVDVVGSLCENNDKFAVNRELPHTEIGDLL
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEE
VIHDTGAHGFSMGYQYNAKLRSAEILYTEEGKARQIRRAERPEDYFATLYGFDFEE
EEECCCCCCEECCEEECCCCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: D-Lysine; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1.7 {meso-2,6-diamininoheptanedioate}} [C]

Substrates: meso-2,6-diaminoheptanedioate

Specific reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2

General reaction: Decarboxylation [C]

Inhibitor: 2, 3-Diaminopropionic acid; Glutamic acid; L-Cystine; L-Lysine; Penicillamine [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1515668 [H]