| Definition | Streptococcus pneumoniae ATCC 700669, complete genome. |
|---|---|
| Accession | NC_011900 |
| Length | 2,221,315 |
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The map label for this gene is relA [H]
Identifier: 221232384
GI number: 221232384
Start: 1581152
End: 1583374
Strand: Reverse
Name: relA [H]
Synonym: SPN23F_16460
Alternate gene names: 221232384
Gene position: 1583374-1581152 (Counterclockwise)
Preceding gene: 221232386
Following gene: 221232383
Centisome position: 71.28
GC content: 45.57
Gene sequence:
>2223_bases ATGCCGAAAGAAGTGAATTTAACAGGCGAAGAAGTTGTCGCTTTAACCAAAGAATATTTAACGGAAGAGGATGTTCATTT TGTCCATAAGGCCTTGGTCTATGCTGTTGAATGCCACAGTGGTCAATATCGCAAATCAGGCGAGCCTTATATCATTCACC CTATCCAAGTGGCAGGTATTTTAGCTAAGCTAAAGCTGGATGCTGTAACAGTAGCTTGTGGATTCTTGCATGATGTGGTG GAAGATACAGATGCGACCTTGGACGATTTGGAAAGAGAGTTTGGTCCTGATGTGCGGGTGATTGTTGACGGAGTTACCAA GCTTGGCAAGGTCGAGTACAAATCAATCGAGGAGCAATTAGCGGAAAATCATCGCAAGATGCTCATGGCCATGTCTGAGG ACATCCGCGTTATTTTGGTCAAACTGTCTGACCGCTTGCACAATATGCGGACCCTGAAACATCTTCGAAAAGACAAGCAG GAGCGTATTTCCAAAGAAACCATGGAAATCTATGCCCCACTTGCCCATCGTTTGGGGATTTCCAGTGTCAAATGGGAATT AGAAGACTTGTCTTTCCGTTATCTCAATCCAACGGAGTTTTACAAGATTACCCATATGATGAAGGAAAAGCGCAGGGAGC GTGAGGCCTTGGTGGATGAGGTAGTCACAAAATTAGAGGAGTATACGACAGAACGTCACTTGAAAGGGAAGATTTATGGT CGTCCCAAGCATATTTACTCAATTTTCCGCAAAATGCAGGACAAGAGAAAACGGTTTGAGGAAATCTATGATCTGATTGC TATTCGTTGTATTTTAGATACCCAAAGTGATGTTTATGCCATGCTTGGTTACGTGCATGAATTTTGGAAACCGATGCCAG GTCGCTTCAAAGACTATATTGCCAACCGCAAGGCCAATGGTTATCAGTCTATCCATACGACTGTTTATGGGCCAAAAGGG CCGATTGAATTCCAGATTCGAACCAAGGAAATGCACGAGGTGGCTGAGTACGGGGTTGCGGCTCACTGGGCTTATAAGAA AGGTATAAAGGGGCAAGTTAACAGCAAGGAATCAGCTATTGGAATGAACTGGATCAAGGAGATGATGGAGCTCCAAGACC AGGCTGATGATGCTAAGGAATTTGTGGACTCTGTTAAGGAAAACTATCTGGCTGAGGAGATTTACGTTTTTACCCCAGAT GGAGCTGTCCGTTCCCTTCCCAAAGATTCAGGACCGATTGATTTTGCCTACGAAATCCATACCAAGGTCGGTGAAAAAGC AACTGGTGCCAAGGTCAATGGCCGCATGGTTCCACTGACAACCAAGTTAAAGACAGGGGATCAGGTTGAAATTATCGCCA ACCCGAACTCCTTTGGACCTAGCCGTGACTGGCTCAATATGGTCAAGACTAGCAAGGCGCGCAATAAGATTCGCCAGTTC TTTAAAAACCAAGATAAGGAATTGTCTGTCAACAAGGGTCGTGAGATGCTGATGGCTCAGTTCCAAGAAAATGGCTATGT GGCAAATAAATTTATGGACAAGCGCCACATGGATCAAGTTCTGCAAAAGACCAGTTACAAGACAGAAGACTCCCTCTTTG CGGCCATTGGTTTTGGGGAAATCGGTGCGATTACCGTCTTTAACCGTCTGACTGAAAAGGAACGCCGTGAGGAAGAGCGT GCCAAGGCCAAGGCTGAGGCAGAGGAGCTTGTCAAAGGTGGCGAGGTCAAGGTTGAAAATAAAGAAACTCTCAAGGTCAA GCATGAGGGGGGAGTGGTTATTGAAGGTGCTTCTGGTCTCCTAGTGCGGATTGCTAAGTGTTGTAACCCCGTGCCTGGTG ACGATATTGTTGGCTACATTACCAAGGGTCGTGGTGTGGCTATTCACCGTGTGGACTGTATGAATCTGCGTGCCCAAGAA AACTACGAGCAACGTCTCCTTGATGTGGAATGGGAAGACCAGTACTCTAGCTCAAATAAGGAGTATATGGCCCATATCGA TATCTACGGTCTCAACCGTACAGGACTGTTGAACGATGTACTGCAAGTTCTTTCAAATACAACCAAGAATATTTCAACGG TCAATGCCCAACCAACCAAGGATATGAAGTTTGCTAATATCCATGTGTCCTTCGGTATTGCCAACCTCTCTACACTGACC ACGGTTGTCGATAAAATTAAGAGTGTGCCAGAAGTTTACTCTGTCAAACGGACCAACGGCTAG
Upstream 100 bases:
>100_bases TATCAAGCAATTTTGAATTATTTTTTTCTTATTCTGTTCCAATCTAGTTTTCATATTCTTAAAAAAGTGATAAAATGGTA GGAAGAATTGGAGAGTAGAG
Downstream 100 bases:
>100_bases TTGTCCTAGCTCTTACTAGAAAGGCTATTATGAAAATCATTATCCAACGGGTTAAAAAAGCCCAAGTGAGTATAGAAGGC CAGATTCAGGGAAAAATCAA
Product: GTP pyrophosphokinase
Products: NA
Alternate protein names: GTP pyrophosphokinase; (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; Stringent response-like protein; ppGpp synthase I; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; Penta-phosphate guanosine-3'-pyrophosphohydrolase; (ppGpp)ase [H]
Number of amino acids: Translated: 740; Mature: 739
Protein sequence:
>740_residues MPKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYRKSGEPYIIHPIQVAGILAKLKLDAVTVACGFLHDVV EDTDATLDDLEREFGPDVRVIVDGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQ ERISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALVDEVVTKLEEYTTERHLKGKIYG RPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQSDVYAMLGYVHEFWKPMPGRFKDYIANRKANGYQSIHTTVYGPKG PIEFQIRTKEMHEVAEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMMELQDQADDAKEFVDSVKENYLAEEIYVFTPD GAVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVEIIANPNSFGPSRDWLNMVKTSKARNKIRQF FKNQDKELSVNKGREMLMAQFQENGYVANKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGEIGAITVFNRLTEKERREEER AKAKAEAEELVKGGEVKVENKETLKVKHEGGVVIEGASGLLVRIAKCCNPVPGDDIVGYITKGRGVAIHRVDCMNLRAQE NYEQRLLDVEWEDQYSSSNKEYMAHIDIYGLNRTGLLNDVLQVLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLT TVVDKIKSVPEVYSVKRTNG
Sequences:
>Translated_740_residues MPKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYRKSGEPYIIHPIQVAGILAKLKLDAVTVACGFLHDVV EDTDATLDDLEREFGPDVRVIVDGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQ ERISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALVDEVVTKLEEYTTERHLKGKIYG RPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQSDVYAMLGYVHEFWKPMPGRFKDYIANRKANGYQSIHTTVYGPKG PIEFQIRTKEMHEVAEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMMELQDQADDAKEFVDSVKENYLAEEIYVFTPD GAVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVEIIANPNSFGPSRDWLNMVKTSKARNKIRQF FKNQDKELSVNKGREMLMAQFQENGYVANKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGEIGAITVFNRLTEKERREEER AKAKAEAEELVKGGEVKVENKETLKVKHEGGVVIEGASGLLVRIAKCCNPVPGDDIVGYITKGRGVAIHRVDCMNLRAQE NYEQRLLDVEWEDQYSSSNKEYMAHIDIYGLNRTGLLNDVLQVLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLT TVVDKIKSVPEVYSVKRTNG >Mature_739_residues PKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYRKSGEPYIIHPIQVAGILAKLKLDAVTVACGFLHDVVE DTDATLDDLEREFGPDVRVIVDGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQE RISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALVDEVVTKLEEYTTERHLKGKIYGR PKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQSDVYAMLGYVHEFWKPMPGRFKDYIANRKANGYQSIHTTVYGPKGP IEFQIRTKEMHEVAEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMMELQDQADDAKEFVDSVKENYLAEEIYVFTPDG AVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVEIIANPNSFGPSRDWLNMVKTSKARNKIRQFF KNQDKELSVNKGREMLMAQFQENGYVANKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGEIGAITVFNRLTEKERREEERA KAKAEAEELVKGGEVKVENKETLKVKHEGGVVIEGASGLLVRIAKCCNPVPGDDIVGYITKGRGVAIHRVDCMNLRAQEN YEQRLLDVEWEDQYSSSNKEYMAHIDIYGLNRTGLLNDVLQVLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLTT VVDKIKSVPEVYSVKRTNG
Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp wh
COG id: COG0317
COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 HD domain [H]
Homologues:
Organism=Homo sapiens, GI38348360, Length=126, Percent_Identity=40.4761904761905, Blast_Score=72, Evalue=3e-12, Organism=Escherichia coli, GI1790082, Length=729, Percent_Identity=39.0946502057613, Blast_Score=550, Evalue=1e-157, Organism=Escherichia coli, GI1789147, Length=700, Percent_Identity=37.2857142857143, Blast_Score=485, Evalue=1e-138, Organism=Caenorhabditis elegans, GI25143118, Length=136, Percent_Identity=39.7058823529412, Blast_Score=69, Evalue=1e-11, Organism=Drosophila melanogaster, GI24650996, Length=131, Percent_Identity=39.6946564885496, Blast_Score=72, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR012675 - InterPro: IPR003607 - InterPro: IPR007685 - InterPro: IPR004811 - InterPro: IPR004095 - InterPro: IPR012676 [H]
Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]
EC number: =2.7.6.5; =3.1.7.2 [H]
Molecular weight: Translated: 84615; Mature: 84484
Theoretical pI: Translated: 7.94; Mature: 7.94
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.1 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYRKSGEPYIIHPIQVAGI CCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEHHHHHHH LAKLKLDAVTVACGFLHDVVEDTDATLDDLEREFGPDVRVIVDGVTKLGKVEYKSIEEQL HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEHHHHHHCCHHHHHHHHHH AENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQERISKETMEIYAPLAHRLGI HHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC SSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALVDEVVTKLEEYTTERHLKGKIYG CHHEEEHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC RPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQSDVYAMLGYVHEFWKPMPGRFKDYI CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHH ANRKANGYQSIHTTVYGPKGPIEFQIRTKEMHEVAEYGVAAHWAYKKGIKGQVNSKESAI HCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHH GMNWIKEMMELQDQADDAKEFVDSVKENYLAEEIYVFTPDGAVRSLPKDSGPIDFAYEIH HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCEEEEECCCCHHHCCCCCCCCCEEEEEEH TKVGEKATGAKVNGRMVPLTTKLKTGDQVEIIANPNSFGPSRDWLNMVKTSKARNKIRQF HHCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH FKNQDKELSVNKGREMLMAQFQENGYVANKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGE HCCCCCCCCHHCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC IGAITVFNRLTEKERREEERAKAKAEAEELVKGGEVKVENKETLKVKHEGGVVIEGASGL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCCEEEECCCHH LVRIAKCCNPVPGDDIVGYITKGRGVAIHRVDCMNLRAQENYEQRLLDVEWEDQYSSSNK HHHHHHHCCCCCCCCCEEEEECCCCEEEEEEHHHCCCHHCCHHHHHCCCCCCCCCCCCCC EYMAHIDIYGLNRTGLLNDVLQVLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLT CEEEEEEEEECCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEEEEEEECHHHHHHHH TVVDKIKSVPEVYSVKRTNG HHHHHHHCCHHHHHHCCCCC >Mature Secondary Structure PKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYRKSGEPYIIHPIQVAGI CCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEEHHHHHHH LAKLKLDAVTVACGFLHDVVEDTDATLDDLEREFGPDVRVIVDGVTKLGKVEYKSIEEQL HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEHHHHHHCCHHHHHHHHHH AENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQERISKETMEIYAPLAHRLGI HHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC SSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALVDEVVTKLEEYTTERHLKGKIYG CHHEEEHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC RPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQSDVYAMLGYVHEFWKPMPGRFKDYI CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHH ANRKANGYQSIHTTVYGPKGPIEFQIRTKEMHEVAEYGVAAHWAYKKGIKGQVNSKESAI HCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHH GMNWIKEMMELQDQADDAKEFVDSVKENYLAEEIYVFTPDGAVRSLPKDSGPIDFAYEIH HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCEEEEECCCCHHHCCCCCCCCCEEEEEEH TKVGEKATGAKVNGRMVPLTTKLKTGDQVEIIANPNSFGPSRDWLNMVKTSKARNKIRQF HHCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH FKNQDKELSVNKGREMLMAQFQENGYVANKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGE HCCCCCCCCHHCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC IGAITVFNRLTEKERREEERAKAKAEAEELVKGGEVKVENKETLKVKHEGGVVIEGASGL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCCEEEECCCHH LVRIAKCCNPVPGDDIVGYITKGRGVAIHRVDCMNLRAQENYEQRLLDVEWEDQYSSSNK HHHHHHHCCCCCCCCCEEEEECCCCEEEEEEHHHCCCHHCCHHHHHCCCCCCCCCCCCCC EYMAHIDIYGLNRTGLLNDVLQVLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLT CEEEEEEEEECCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEEEEEEECHHHHHHHH TVVDKIKSVPEVYSVKRTNG HHHHHHHCCHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8232196 [H]