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The map label for this gene is pntAA [H]

Identifier: 221230902

GI number: 221230902

Start: 3153079

End: 3154182

Strand: Reverse

Name: pntAA [H]

Synonym: MLBr_02636

Alternate gene names: 221230902

Gene position: 3154182-3153079 (Counterclockwise)

Preceding gene: 221230903

Following gene: 221230901

Centisome position: 96.52

GC content: 63.32

Gene sequence:

>1104_bases
ATGACAGAAGCGCAAACGACGGTTGGAGTGGTCGCCGAGTCCGGTTCCGACGAGCGGCGCGTCGCTTTGGTGCCAAAGGC
AGTAGCGTCTCTAGTGAACAGCGGTCTAGCGGTCGTGGTCGAGTCCGGGGCGGGCGAAGGTGCATTGCTTCCCGAGCAGC
TCTACACAGAGGCCGGCGCTCGCATCGGGGACGCGTGGGCTGCCGACATCGTCGTCAAAGTGGCGCCGCCGGCTGCAGCC
GAGGTCGGCCGACTGCGCCGCGGGCAGACGCTGATCGGCTTCCTTGCGTCCCGCAATGCCGACAACTGGATCGGCGAGTT
GAAACGAGCTGGTGTGCAAGCGTTCGCGCTCGAGGCAATCCCGCGCATCTCGCGTGCACAAGTGATGGATGCGCTGTCGT
CGCAGGCTAACGTGACCGGGTATAAAGCAGTGTTGCTTGCGGCTTCTGAGTCTACCCGATTTTTCCCGATGCTGACGACA
GCTGCAGGAACGGTGAAGCCGGCCATCGTGCTGGTGCTCGGCGTCGGGGTGGCAGGTTTGCAAGCGCTGGCGACGGCCAA
GCGCCTTGGCGCGCGCACCACCGGCTACGACGTGCGTCCTGAGGTGGCCGAGCAAGTCCGGTCGGTGGGTGCCCAGTGGC
TTGACGTAGGAATCGAGGCTTCCGGTGCGGGCGGATACGCCCGTGAGCTCACCGCCGACGAACGCGCTCAGCAACAGAAG
GCATTGGAAAAGGCGATCAGCGGATTCGACGTGGTGATTACCACAGCGCTGGTCCCGGGCAAGCCGGCACCGCGGTTGGT
GACCGCTGCGGCGGTGGAGGCGATGAAGCCTGGCAGCGTGGTGGTGGACCTCGCGGGGGAAACCGGTGGCAATTGCGAGC
TCACTGAACCCGGGCAGACGGTGATCAAGCATGATGTCACTATTGCGGCGCCGCTGAATCTGCCGGCAACGATGCCTGAG
CACGCCAGCGAGCTCTACAGCAAGAACATCAAGGCGCTGTTGGACCTACTAATAAAGGATGGCAAGTTTGCCCCGGACTT
TGACGACGAAGTCGTCGCGGAGTCATGTGTGACTCGCGATCGAGAGGACTCCATAGATGTATGA

Upstream 100 bases:

>100_bases
CACACTCAGCTATCAACTTGCTACGCGTCTAGCATGCGGAAACAGGGCAGCAAGGCCAAGGAAATAATACAGGAAAGCAG
AAAGCAATGATGTACGTGCC

Downstream 100 bases:

>100_bases
CGAGTTATTGGCTAACTTGGCGATTCTGGTGTTGTCTGGGTTCGTCGGGTTCGCTGTGATCTCCAAAGTCCCCAATACAC
TGCACACACCGCTGATGTCG

Product: pyridine transhydrogenase subunit alpha1

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTEAQTTVGVVAESGSDERRVALVPKAVASLVNSGLAVVVESGAGEGALLPEQLYTEAGARIGDAWAADIVVKVAPPAAA
EVGRLRRGQTLIGFLASRNADNWIGELKRAGVQAFALEAIPRISRAQVMDALSSQANVTGYKAVLLAASESTRFFPMLTT
AAGTVKPAIVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVAEQVRSVGAQWLDVGIEASGAGGYARELTADERAQQQK
ALEKAISGFDVVITTALVPGKPAPRLVTAAAVEAMKPGSVVVDLAGETGGNCELTEPGQTVIKHDVTIAAPLNLPATMPE
HASELYSKNIKALLDLLIKDGKFAPDFDDEVVAESCVTRDREDSIDV

Sequences:

>Translated_367_residues
MTEAQTTVGVVAESGSDERRVALVPKAVASLVNSGLAVVVESGAGEGALLPEQLYTEAGARIGDAWAADIVVKVAPPAAA
EVGRLRRGQTLIGFLASRNADNWIGELKRAGVQAFALEAIPRISRAQVMDALSSQANVTGYKAVLLAASESTRFFPMLTT
AAGTVKPAIVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVAEQVRSVGAQWLDVGIEASGAGGYARELTADERAQQQK
ALEKAISGFDVVITTALVPGKPAPRLVTAAAVEAMKPGSVVVDLAGETGGNCELTEPGQTVIKHDVTIAAPLNLPATMPE
HASELYSKNIKALLDLLIKDGKFAPDFDDEVVAESCVTRDREDSIDV
>Mature_366_residues
TEAQTTVGVVAESGSDERRVALVPKAVASLVNSGLAVVVESGAGEGALLPEQLYTEAGARIGDAWAADIVVKVAPPAAAE
VGRLRRGQTLIGFLASRNADNWIGELKRAGVQAFALEAIPRISRAQVMDALSSQANVTGYKAVLLAASESTRFFPMLTTA
AGTVKPAIVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVAEQVRSVGAQWLDVGIEASGAGGYARELTADERAQQQKA
LEKAISGFDVVITTALVPGKPAPRLVTAAAVEAMKPGSVVVDLAGETGGNCELTEPGQTVIKHDVTIAAPLNLPATMPEH
ASELYSKNIKALLDLLIKDGKFAPDFDDEVVAESCVTRDREDSIDV

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=358, Percent_Identity=42.4581005586592, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI122939153, Length=358, Percent_Identity=42.4581005586592, Blast_Score=245, Evalue=4e-65,
Organism=Escherichia coli, GI1787887, Length=363, Percent_Identity=41.8732782369146, Blast_Score=266, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17550456, Length=348, Percent_Identity=44.2528735632184, Blast_Score=280, Evalue=8e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38101; Mature: 37970

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAQTTVGVVAESGSDERRVALVPKAVASLVNSGLAVVVESGAGEGALLPEQLYTEAGA
CCCCCCEEEEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHCC
RIGDAWAADIVVKVAPPAAAEVGRLRRGQTLIGFLASRNADNWIGELKRAGVQAFALEAI
CCCCCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHH
PRISRAQVMDALSSQANVTGYKAVLLAASESTRFFPMLTTAAGTVKPAIVLVLGVGVAGL
CCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHH
QALATAKRLGARTTGYDVRPEVAEQVRSVGAQWLDVGIEASGAGGYARELTADERAQQQK
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHCCCEECCCCCCHHHCCHHHHHHHHH
ALEKAISGFDVVITTALVPGKPAPRLVTAAAVEAMKPGSVVVDLAGETGGNCELTEPGQT
HHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCHH
VIKHDVTIAAPLNLPATMPEHASELYSKNIKALLDLLIKDGKFAPDFDDEVVAESCVTRD
HHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
REDSIDV
CCCCCCC
>Mature Secondary Structure 
TEAQTTVGVVAESGSDERRVALVPKAVASLVNSGLAVVVESGAGEGALLPEQLYTEAGA
CCCCCEEEEEECCCCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHCC
RIGDAWAADIVVKVAPPAAAEVGRLRRGQTLIGFLASRNADNWIGELKRAGVQAFALEAI
CCCCCCEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHH
PRISRAQVMDALSSQANVTGYKAVLLAASESTRFFPMLTTAAGTVKPAIVLVLGVGVAGL
CCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHH
QALATAKRLGARTTGYDVRPEVAEQVRSVGAQWLDVGIEASGAGGYARELTADERAQQQK
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHCCCEECCCCCCHHHCCHHHHHHHHH
ALEKAISGFDVVITTALVPGKPAPRLVTAAAVEAMKPGSVVVDLAGETGGNCELTEPGQT
HHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCHH
VIKHDVTIAAPLNLPATMPEHASELYSKNIKALLDLLIKDGKFAPDFDDEVVAESCVTRD
HHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
REDSIDV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]