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The map label for this gene is pntB [H]

Identifier: 221230900

GI number: 221230900

Start: 3151333

End: 3152751

Strand: Reverse

Name: pntB [H]

Synonym: MLBr_02634

Alternate gene names: 221230900

Gene position: 3152751-3151333 (Counterclockwise)

Preceding gene: 221230901

Following gene: 221230899

Centisome position: 96.47

GC content: 58.91

Gene sequence:

>1419_bases
ATGAACTACTTCGTGATCGGCCTCTACATTCTTGCGTTCGCATTGTTCATCACCGGCTTGATGGGCCTGACCGGGCCCAG
GACCGCGGTGTCCGGCAACTTGATCGCTGCGGTCGGTATGACCATTGCCGTGGCGGCGACGCTGGTCAAGATTCGGCACA
CCGAGCAGTGGGTATTGATCATTGCCGCCCTGGTGGTGGGCATCGTCCTTGGCTTCCCTCCGGCACGGCTGACTAAGGTG
ACTGCGATGCCCCAGCTGGTGGCGTTCTTCAACGGCGTTGGCGGTGGAACGGTCGCGCTTATTGCACTGTCGGAGTTCAT
CGAGACTAGCGGCTTTTCGGAATTTCAGCATCACGAGTCGCCAACTGTGCATATCGTGGTGGCCTCGCTGTTCGCCGCGA
TCATAGGGTCGATCTCGTTCTGGGGATCGATCATTGCGTTCGGTAAGTTGCAGGAGACAATCTCCGGATTCCCAATCGGT
TTTGGCAAAGTCCAGCAGCCTATCAATTTGCTACTGTTGGTCGGCGCCATAGTCGCCGCAGTGGTCATCGGTCTGCACGC
GCAGCCCGGATCCGCTGGGGCCTCGTTGTGGTGGATGATCGGGTTGCTGGTCGCCGCTGGCGTATTAGGCCTGATGGTGG
TGCTGTCAATCGGCGGCGCCGACATGCCGGTGGTCATCTCCTTACTCAACGCTATGACTGGGCTCTCAGCTGCTGCGACG
GGCCTGGCGCTGAACAATACCGCAATCATCGTGGCCGGCATGATCGTCGGCGCGTCCGGCTCGATCCTGACCAATCTCAT
GGCCAAGGCGATGAACCGCTCCATACCCGCGATCGTCGCAGGAGGTTTCGGTAGCGGTGGCGTGGCACCCAGCCGTGACG
GTGACAAGCAAGTCAAATCCACCTCGGCAGCCGATGCGGCGATCCAGATGGCTTACGCCAACCAGGTGATCGTGGTGCCG
GGCTACGGGCTGGCGGTCGCGCAGGCCCAGCACGTTGTCAAAGACATGGCGTCCTTGCTGGAGAACAAAGGTGTGCCGGT
GAGTTACGCGATTCACCCGGTTGCTGGCCGGATGCCCGGACACATGAATGTGTTGCTGGCTGAAGCAGAGGTCGACTACG
ACGCCATGAAGGACATGGACGACATCAACGATGAGTTCGCTCGTACCGATGTTGTGATTGTCATCGGCGCCAACGACGTC
ACCAACCCGGCGGCCCGTAACGAGACAGCCAGCCCGATCTATGGGATGCCGATCCTGAATGTTGATAAAGCGAAGTCGGT
TATAGTGCTTAAGAGGTCGATGAACTCCGGATTTGCGGGCATTGACAACCGGCTATTCTACGCCGACGGTACCACCATGT
TGTTCGGTGATGCCAAACAGTCGGTGACTGAGGTCACTGAGGAACTGAAGGTGCTATAG

Upstream 100 bases:

>100_bases
TCGGGGGTTTTATCGTCACCGACCGGATGCTGGGTATGTTCAGGGGTAAGAAGAAGGCCTCGGCCGTCAAAACCGAAAAA
GCAGCAGAATCGGTGGCCAA

Downstream 100 bases:

>100_bases
CCTTAGGTCGAAACTAAGCCGAGTTGAAGTGCTGCGGCGCCCTAGACGGGAGGAAGATATCCGTTGCCATCGGTAACCCC
GCGGAAGCTCCATGTTAGGT

Product: pyridine transhydrogenase subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNYFVIGLYILAFALFITGLMGLTGPRTAVSGNLIAAVGMTIAVAATLVKIRHTEQWVLIIAALVVGIVLGFPPARLTKV
TAMPQLVAFFNGVGGGTVALIALSEFIETSGFSEFQHHESPTVHIVVASLFAAIIGSISFWGSIIAFGKLQETISGFPIG
FGKVQQPINLLLLVGAIVAAVVIGLHAQPGSAGASLWWMIGLLVAAGVLGLMVVLSIGGADMPVVISLLNAMTGLSAAAT
GLALNNTAIIVAGMIVGASGSILTNLMAKAMNRSIPAIVAGGFGSGGVAPSRDGDKQVKSTSAADAAIQMAYANQVIVVP
GYGLAVAQAQHVVKDMASLLENKGVPVSYAIHPVAGRMPGHMNVLLAEAEVDYDAMKDMDDINDEFARTDVVIVIGANDV
TNPAARNETASPIYGMPILNVDKAKSVIVLKRSMNSGFAGIDNRLFYADGTTMLFGDAKQSVTEVTEELKVL

Sequences:

>Translated_472_residues
MNYFVIGLYILAFALFITGLMGLTGPRTAVSGNLIAAVGMTIAVAATLVKIRHTEQWVLIIAALVVGIVLGFPPARLTKV
TAMPQLVAFFNGVGGGTVALIALSEFIETSGFSEFQHHESPTVHIVVASLFAAIIGSISFWGSIIAFGKLQETISGFPIG
FGKVQQPINLLLLVGAIVAAVVIGLHAQPGSAGASLWWMIGLLVAAGVLGLMVVLSIGGADMPVVISLLNAMTGLSAAAT
GLALNNTAIIVAGMIVGASGSILTNLMAKAMNRSIPAIVAGGFGSGGVAPSRDGDKQVKSTSAADAAIQMAYANQVIVVP
GYGLAVAQAQHVVKDMASLLENKGVPVSYAIHPVAGRMPGHMNVLLAEAEVDYDAMKDMDDINDEFARTDVVIVIGANDV
TNPAARNETASPIYGMPILNVDKAKSVIVLKRSMNSGFAGIDNRLFYADGTTMLFGDAKQSVTEVTEELKVL
>Mature_472_residues
MNYFVIGLYILAFALFITGLMGLTGPRTAVSGNLIAAVGMTIAVAATLVKIRHTEQWVLIIAALVVGIVLGFPPARLTKV
TAMPQLVAFFNGVGGGTVALIALSEFIETSGFSEFQHHESPTVHIVVASLFAAIIGSISFWGSIIAFGKLQETISGFPIG
FGKVQQPINLLLLVGAIVAAVVIGLHAQPGSAGASLWWMIGLLVAAGVLGLMVVLSIGGADMPVVISLLNAMTGLSAAAT
GLALNNTAIIVAGMIVGASGSILTNLMAKAMNRSIPAIVAGGFGSGGVAPSRDGDKQVKSTSAADAAIQMAYANQVIVVP
GYGLAVAQAQHVVKDMASLLENKGVPVSYAIHPVAGRMPGHMNVLLAEAEVDYDAMKDMDDINDEFARTDVVIVIGANDV
TNPAARNETASPIYGMPILNVDKAKSVIVLKRSMNSGFAGIDNRLFYADGTTMLFGDAKQSVTEVTEELKVL

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=469, Percent_Identity=37.5266524520256, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI122939153, Length=469, Percent_Identity=37.5266524520256, Blast_Score=278, Evalue=8e-75,
Organism=Escherichia coli, GI1787886, Length=471, Percent_Identity=43.5244161358811, Blast_Score=342, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17550456, Length=465, Percent_Identity=36.3440860215054, Blast_Score=282, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48827; Mature: 48827

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYFVIGLYILAFALFITGLMGLTGPRTAVSGNLIAAVGMTIAVAATLVKIRHTEQWVLI
CCEEEHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
IAALVVGIVLGFPPARLTKVTAMPQLVAFFNGVGGGTVALIALSEFIETSGFSEFQHHES
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCC
PTVHIVVASLFAAIIGSISFWGSIIAFGKLQETISGFPIGFGKVQQPINLLLLVGAIVAA
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VVIGLHAQPGSAGASLWWMIGLLVAAGVLGLMVVLSIGGADMPVVISLLNAMTGLSAAAT
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHH
GLALNNTAIIVAGMIVGASGSILTNLMAKAMNRSIPAIVAGGFGSGGVAPSRDGDKQVKS
CEEECCCEEEEEEEHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHH
TSAADAAIQMAYANQVIVVPGYGLAVAQAQHVVKDMASLLENKGVPVSYAIHPVAGRMPG
HHHHHHHHEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
HMNVLLAEAEVDYDAMKDMDDINDEFARTDVVIVIGANDVTNPAARNETASPIYGMPILN
CCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
VDKAKSVIVLKRSMNSGFAGIDNRLFYADGTTMLFGDAKQSVTEVTEELKVL
CCCCCEEEEEEECCCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYFVIGLYILAFALFITGLMGLTGPRTAVSGNLIAAVGMTIAVAATLVKIRHTEQWVLI
CCEEEHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
IAALVVGIVLGFPPARLTKVTAMPQLVAFFNGVGGGTVALIALSEFIETSGFSEFQHHES
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCC
PTVHIVVASLFAAIIGSISFWGSIIAFGKLQETISGFPIGFGKVQQPINLLLLVGAIVAA
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VVIGLHAQPGSAGASLWWMIGLLVAAGVLGLMVVLSIGGADMPVVISLLNAMTGLSAAAT
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHH
GLALNNTAIIVAGMIVGASGSILTNLMAKAMNRSIPAIVAGGFGSGGVAPSRDGDKQVKS
CEEECCCEEEEEEEHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHH
TSAADAAIQMAYANQVIVVPGYGLAVAQAQHVVKDMASLLENKGVPVSYAIHPVAGRMPG
HHHHHHHHEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
HMNVLLAEAEVDYDAMKDMDDINDEFARTDVVIVIGANDVTNPAARNETASPIYGMPILN
CCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
VDKAKSVIVLKRSMNSGFAGIDNRLFYADGTTMLFGDAKQSVTEVTEELKVL
CCCCCEEEEEEECCCCCCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]