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The map label for this gene is fadA2 [H]

Identifier: 221230854

GI number: 221230854

Start: 3057354

End: 3058727

Strand: Reverse

Name: fadA2 [H]

Synonym: MLBr_02564

Alternate gene names: 221230854

Gene position: 3058727-3057354 (Counterclockwise)

Preceding gene: 221230858

Following gene: 221230851

Centisome position: 93.59

GC content: 59.17

Gene sequence:

>1374_bases
ATGCTCGGAGAGACACGGAGATTACAAGTGGCCCCTGCAAGTTCTGTGGCAAGTGACAAGACTATTCAGAGGACCACGTT
CGCTAAGCAAAGAGTCGCCGTGTTGGGCGGCAATAGGATCCCGTTCGCGAGATCAAATGGCGCCTATGCCGAAGCGTCCA
ACCAGGACATGTTCTCCGCGGCTCTAAGTGGTCTGGTGGACCGATTCGGGCTGGCCGGCGAACGATTGGACATGGTGATC
GGCGGTGCTGTGCTCAAGCACAGCCGCGACTTCAACCTGATGCGTGAATGCGTGTTGGGGTCGCAACTGTCGCCATACAC
ACCTGCGTTCGACCTGCAGCAGGCTTGTGCAACTGGTCTGCAGGCGGCGATTGTGGCAGCTGATGGCATTGCAGCTGGCC
GCTATGAGGTGGCCGTTGCCGGCGGAGTCGACACCACTTCGGACGTGCCGATCAGCCTGGGTGACAACCTGCGCCGCAAC
CTGCTGAAGCTGCGCCGATCCAAATCCAACGTGCAACGGCTGAAGCTGGTGGGCGCATTGCCTGCCAATATCGGGGTCGA
AATCCCCGCCAACAGTGAGCCCCGCACTGGGCTGTCCATGGGAGAACACGCCGCCATCACCGCCAAGAAAATGGGGATCA
AGCGGGTCGATCAAGACGAGCTGGCTGCCGCTAGCCATCGCAATATGGCCTCCGCTTACGATCGGGGCTTCTTCGACGAT
CTGGTCACGCCGTTTCTGGGGCTCTACCGCGATGACAATCTACGGCCCAACTCTCATGTGGAAAAGTTAGCCACGTTGCG
CCCGGTTTTCGGAGTTCAGGCCGGTGATGCGACGATGACGGCGGGAAATTCTACTTCGCTGACCGACGGCGCTTCGGTAG
CGTTGCTCGCCACCGAGCAATGGGTTGCTGCGCATTCGTTGACCCCGTTTGCTTACTGGGTAGATGCGGAGATCGCCGCG
GTTGATTACGTCAGCGGAAATGACGGCCTGCTGATGGCGCCGACTTACGCGGTACCTCGGCTGTTAGCCCGCAACGGGCT
GAGCTTTCAGGATTTCGACTTCTACGAAATTCACGAGGCATTTGCCTCGGTGGTGCTGGCGCATTTGCAGGCGTGGGAGT
CCGAGGAGTATTGCCGGCAGTGTCTGGGCCTCGATACCGCTCTTGGCCCGATCGACCGGTCCAAGCTCAATGTCAATGGT
TCATCATTGGCTGCCGGTCATCCCTTTGCTGCCACGGGTGGACGTATCCTTGTTCAGACTGCAAAACAACTTGCTGAGCA
GAAGGCAACGCAAAAAGGTTGCGGGCCGATGCGGGCTTTGATTTCGGTCTGTGCCGCCGGCGGCCAAGGTGTAGCTGTGA
TTCTGGAGGCTTGA

Upstream 100 bases:

>100_bases
CTGCCTTCCGTTTAAGCCAAACCTTATCGAGGTAAATAAACTTACTTGAGAGTAAGAACAGCGGGTAGTGTGACTCCCAA
CAGCTTATCCCCTAACTGAT

Downstream 100 bases:

>100_bases
TGTCAGGTCACCAGCTGACCTAACCACGAAGCGATGACCGGCGGTGGCGCGAGAATTTTGTGCTGCGCGGTTGGTCCTTA
CGCTAGATGGATATTCGATG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLGETRRLQVAPASSVASDKTIQRTTFAKQRVAVLGGNRIPFARSNGAYAEASNQDMFSAALSGLVDRFGLAGERLDMVI
GGAVLKHSRDFNLMRECVLGSQLSPYTPAFDLQQACATGLQAAIVAADGIAAGRYEVAVAGGVDTTSDVPISLGDNLRRN
LLKLRRSKSNVQRLKLVGALPANIGVEIPANSEPRTGLSMGEHAAITAKKMGIKRVDQDELAAASHRNMASAYDRGFFDD
LVTPFLGLYRDDNLRPNSHVEKLATLRPVFGVQAGDATMTAGNSTSLTDGASVALLATEQWVAAHSLTPFAYWVDAEIAA
VDYVSGNDGLLMAPTYAVPRLLARNGLSFQDFDFYEIHEAFASVVLAHLQAWESEEYCRQCLGLDTALGPIDRSKLNVNG
SSLAAGHPFAATGGRILVQTAKQLAEQKATQKGCGPMRALISVCAAGGQGVAVILEA

Sequences:

>Translated_457_residues
MLGETRRLQVAPASSVASDKTIQRTTFAKQRVAVLGGNRIPFARSNGAYAEASNQDMFSAALSGLVDRFGLAGERLDMVI
GGAVLKHSRDFNLMRECVLGSQLSPYTPAFDLQQACATGLQAAIVAADGIAAGRYEVAVAGGVDTTSDVPISLGDNLRRN
LLKLRRSKSNVQRLKLVGALPANIGVEIPANSEPRTGLSMGEHAAITAKKMGIKRVDQDELAAASHRNMASAYDRGFFDD
LVTPFLGLYRDDNLRPNSHVEKLATLRPVFGVQAGDATMTAGNSTSLTDGASVALLATEQWVAAHSLTPFAYWVDAEIAA
VDYVSGNDGLLMAPTYAVPRLLARNGLSFQDFDFYEIHEAFASVVLAHLQAWESEEYCRQCLGLDTALGPIDRSKLNVNG
SSLAAGHPFAATGGRILVQTAKQLAEQKATQKGCGPMRALISVCAAGGQGVAVILEA
>Mature_457_residues
MLGETRRLQVAPASSVASDKTIQRTTFAKQRVAVLGGNRIPFARSNGAYAEASNQDMFSAALSGLVDRFGLAGERLDMVI
GGAVLKHSRDFNLMRECVLGSQLSPYTPAFDLQQACATGLQAAIVAADGIAAGRYEVAVAGGVDTTSDVPISLGDNLRRN
LLKLRRSKSNVQRLKLVGALPANIGVEIPANSEPRTGLSMGEHAAITAKKMGIKRVDQDELAAASHRNMASAYDRGFFDD
LVTPFLGLYRDDNLRPNSHVEKLATLRPVFGVQAGDATMTAGNSTSLTDGASVALLATEQWVAAHSLTPFAYWVDAEIAA
VDYVSGNDGLLMAPTYAVPRLLARNGLSFQDFDFYEIHEAFASVVLAHLQAWESEEYCRQCLGLDTALGPIDRSKLNVNG
SSLAAGHPFAATGGRILVQTAKQLAEQKATQKGCGPMRALISVCAAGGQGVAVILEA

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=462, Percent_Identity=36.7965367965368, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI167614485, Length=437, Percent_Identity=29.2906178489703, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI148539872, Length=434, Percent_Identity=27.6497695852535, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4557237, Length=451, Percent_Identity=25.4988913525499, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI4501853, Length=440, Percent_Identity=26.8181818181818, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1788683, Length=401, Percent_Identity=36.6583541147132, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082165, Length=436, Percent_Identity=28.6697247706422, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787663, Length=438, Percent_Identity=29.2237442922374, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788554, Length=429, Percent_Identity=31.4685314685315, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI48994986, Length=439, Percent_Identity=28.7015945330296, Blast_Score=126, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=36, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17535921, Length=440, Percent_Identity=26.3636363636364, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI133906874, Length=438, Percent_Identity=27.1689497716895, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI25147385, Length=434, Percent_Identity=25.1152073732719, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=457, Percent_Identity=27.3522975929978, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325229, Length=442, Percent_Identity=26.4705882352941, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17137578, Length=465, Percent_Identity=36.3440860215054, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI17648125, Length=441, Percent_Identity=27.891156462585, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24655093, Length=441, Percent_Identity=26.530612244898, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24640423, Length=438, Percent_Identity=24.8858447488584, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 48438; Mature: 48438

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGETRRLQVAPASSVASDKTIQRTTFAKQRVAVLGGNRIPFARSNGAYAEASNQDMFSA
CCCCCCEEEECCCCHHCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCHHHHH
ALSGLVDRFGLAGERLDMVIGGAVLKHSRDFNLMRECVLGSQLSPYTPAFDLQQACATGL
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCH
QAAIVAADGIAAGRYEVAVAGGVDTTSDVPISLGDNLRRNLLKLRRSKSNVQRLKLVGAL
HEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PANIGVEIPANSEPRTGLSMGEHAAITAKKMGIKRVDQDELAAASHRNMASAYDRGFFDD
CCCCCEECCCCCCCCCCCCCCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHH
LVTPFLGLYRDDNLRPNSHVEKLATLRPVFGVQAGDATMTAGNSTSLTDGASVALLATEQ
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCEEEEEEHH
WVAAHSLTPFAYWVDAEIAAVDYVSGNDGLLMAPTYAVPRLLARNGLSFQDFDFYEIHEA
HHHHHCCCCEEEEECCEEEEEEEEECCCCEEECCHHHHHHHHHHCCCCCCCCCHHHHHHH
FASVVLAHLQAWESEEYCRQCLGLDTALGPIDRSKLNVNGSSLAAGHPFAATGGRILVQT
HHHHHHHHHHHCCCHHHHHHHHCCCHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHH
AKQLAEQKATQKGCGPMRALISVCAAGGQGVAVILEA
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MLGETRRLQVAPASSVASDKTIQRTTFAKQRVAVLGGNRIPFARSNGAYAEASNQDMFSA
CCCCCCEEEECCCCHHCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCHHHHH
ALSGLVDRFGLAGERLDMVIGGAVLKHSRDFNLMRECVLGSQLSPYTPAFDLQQACATGL
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCH
QAAIVAADGIAAGRYEVAVAGGVDTTSDVPISLGDNLRRNLLKLRRSKSNVQRLKLVGAL
HEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PANIGVEIPANSEPRTGLSMGEHAAITAKKMGIKRVDQDELAAASHRNMASAYDRGFFDD
CCCCCEECCCCCCCCCCCCCCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHH
LVTPFLGLYRDDNLRPNSHVEKLATLRPVFGVQAGDATMTAGNSTSLTDGASVALLATEQ
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCEEEEEEHH
WVAAHSLTPFAYWVDAEIAAVDYVSGNDGLLMAPTYAVPRLLARNGLSFQDFDFYEIHEA
HHHHHCCCCEEEEECCEEEEEEEEECCCCEEECCHHHHHHHHHHCCCCCCCCCHHHHHHH
FASVVLAHLQAWESEEYCRQCLGLDTALGPIDRSKLNVNGSSLAAGHPFAATGGRILVQT
HHHHHHHHHHHCCCHHHHHHHHCCCHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHH
AKQLAEQKATQKGCGPMRALISVCAAGGQGVAVILEA
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]