BacMap

Definition	Mycobacterium leprae Br4923 chromosome, complete genome.
Accession	NC_011896
Length	3,268,071

Click here to switch to the map view.

The map label for this gene is dnaJ [H]

Identifier: 221230825

GI number: 221230825

Start: 2969567

End: 2970733

Strand: Reverse

Name: dnaJ [H]

Synonym: MLBr_02494

Alternate gene names: 221230825

Gene position: 2970733-2969567 (Counterclockwise)

Preceding gene: 221230826

Following gene: 221230824

Centisome position: 90.9

GC content: 59.64

Gene sequence:

>1167_bases
ATGGCCCAGCGTGAATGGGTCGAAAAGGACTTCTACAAGGAGCTAGGCGTTTCCTCTGACGCCAGTCCCGAAGAGATTAA
GCGTGCCTATCGGAAGTTGGCACGCTACCTGCATCCTGACGCGAATCCCGACAACTCCGCTGGTGAACGGTTTAAGGTGG
TGTCTGAGGCGCACAATGTGTTGTCGGATCCGGTCAAGCGCAAAGAGTACGATGAAACTCGCCGGCTGTTTGCCGGCGGC
TGGTTAGGCGGTCGTCGGTTCGACAGTAGTTTTGGTGACTTTGGAATGGGCGGCGACGGTGCTGAGTTCAACCTCAACGA
TTTGTTCGATGCTGCCAGTCGAACCGGGGGCACCAACATCGGTGACTTGTTCGGTGGCTTGTTTGGACGCGGCGCCAGTG
TCCGCCCCAGTAGGCCGCGACGCGGCAACGACCTGGAGACCGAGGCAGATTTGGATTTTGTCGAAGCGGCCAAAGGTGTA
GCGATGCCGCTGCGGCTGACCAGCCCAGCGCCGTGCACCAATTGCCATGGCAGCGGGGCACGTCCGGGAATCAGTCCGAA
AGTGTGTTCCACTTGCAACGGTTCCGGCGTGATCAACCGCAATCAGGGTGCCTTTGGTTTCTCTGAGCCTTGTACCGAAT
GTCGGGGTAGCGGGTCGATCATCGAGCACCCTTGCGAAGAGTGCAAAGGCACCGGGGTTACCACCCGGACCCGAACCATC
AATGTGCGGATCCCGTCCGGTGTCGAAGATGGACAACGGATTCGGCTGGCAGGGCAGGGCGAGGCGGGGTTGCGTGGCGC
TCCGTCGGGTGATCTGTATGTGACGGTCCATGTGCGGCCTGACAAGATCTTTGGTCGAAATGGCGACGACCTCACCGTGA
CCATTCCGGTTAGCTTCACTGAATTAGCTTTGGGCTCAACCCTTTCAGTGCCCACGCTGGACGGAACAGTCGGTGTCCGG
GTGCCAAAAGGTACCTCAGATGGCCGTATCCTGCGGGTACGAGGGCGTGGTGTACCCAAACGCAGTGGTGGCCATGGCGA
CTTGCTTGTCACAGTCAAGGTGGCAGTTCCGCTGAACTTGGAAGGTGCCGCGCAAAAGGCACTGGAGGCCTATGCGGCCG
CCGAGCGGTCAAGTGGTTTCAACCCTCGGGCGGGATGGGGCAGGTAA

Upstream 100 bases:

>100_bases
ATAGTCGCACCTGTCGACAGCACAGCCAAAACCGAGCAAGGTGAACTGGGCGATAACGTGACACCGCACAAGGAGGACGG
TGATTAGGGGGTGACGCGAT

Downstream 100 bases:

>100_bases
TCGGTGATGACTAGAAACTCTAGAGACCCCAGGCAACAAGAATCCCGGACGTTTTTGATCTCGGCGGCTGCTGAGCTAGC
CGGTATGCACGCGCAGACCT

Product: chaperone protein DnaJ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MAQREWVEKDFYKELGVSSDASPEEIKRAYRKLARYLHPDANPDNSAGERFKVVSEAHNVLSDPVKRKEYDETRRLFAGG
WLGGRRFDSSFGDFGMGGDGAEFNLNDLFDAASRTGGTNIGDLFGGLFGRGASVRPSRPRRGNDLETEADLDFVEAAKGV
AMPLRLTSPAPCTNCHGSGARPGISPKVCSTCNGSGVINRNQGAFGFSEPCTECRGSGSIIEHPCEECKGTGVTTRTRTI
NVRIPSGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRNGDDLTVTIPVSFTELALGSTLSVPTLDGTVGVR
VPKGTSDGRILRVRGRGVPKRSGGHGDLLVTVKVAVPLNLEGAAQKALEAYAAAERSSGFNPRAGWGR

Sequences:

>Translated_388_residues
MAQREWVEKDFYKELGVSSDASPEEIKRAYRKLARYLHPDANPDNSAGERFKVVSEAHNVLSDPVKRKEYDETRRLFAGG
WLGGRRFDSSFGDFGMGGDGAEFNLNDLFDAASRTGGTNIGDLFGGLFGRGASVRPSRPRRGNDLETEADLDFVEAAKGV
AMPLRLTSPAPCTNCHGSGARPGISPKVCSTCNGSGVINRNQGAFGFSEPCTECRGSGSIIEHPCEECKGTGVTTRTRTI
NVRIPSGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRNGDDLTVTIPVSFTELALGSTLSVPTLDGTVGVR
VPKGTSDGRILRVRGRGVPKRSGGHGDLLVTVKVAVPLNLEGAAQKALEAYAAAERSSGFNPRAGWGR
>Mature_387_residues
AQREWVEKDFYKELGVSSDASPEEIKRAYRKLARYLHPDANPDNSAGERFKVVSEAHNVLSDPVKRKEYDETRRLFAGGW
LGGRRFDSSFGDFGMGGDGAEFNLNDLFDAASRTGGTNIGDLFGGLFGRGASVRPSRPRRGNDLETEADLDFVEAAKGVA
MPLRLTSPAPCTNCHGSGARPGISPKVCSTCNGSGVINRNQGAFGFSEPCTECRGSGSIIEHPCEECKGTGVTTRTRTIN
VRIPSGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRNGDDLTVTIPVSFTELALGSTLSVPTLDGTVGVRV
PKGTSDGRILRVRGRGVPKRSGGHGDLLVTVKVAVPLNLEGAAQKALEAYAAAERSSGFNPRAGWGR

Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion. Unfolded proteins bind initially to dnaJ; upon

COG id: COG0484

COG function: function code O; DnaJ-class molecular chaperone with C-terminal Zn finger domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain [H]

Homologues:

Organism=Homo sapiens, GI205360838, Length=374, Percent_Identity=33.1550802139037, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI205360840, Length=374, Percent_Identity=33.1550802139037, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI194328760, Length=379, Percent_Identity=31.6622691292876, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI194328758, Length=379, Percent_Identity=31.3984168865435, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4504511, Length=364, Percent_Identity=29.6703296703297, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI5031741, Length=362, Percent_Identity=30.3867403314917, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI7706495, Length=360, Percent_Identity=29.1666666666667, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI194328762, Length=341, Percent_Identity=28.4457478005865, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI23503241, Length=64, Percent_Identity=59.375, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI201862587, Length=64, Percent_Identity=54.6875, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI201862518, Length=64, Percent_Identity=54.6875, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI56549115, Length=64, Percent_Identity=54.6875, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI68077168, Length=81, Percent_Identity=51.8518518518518, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI68077166, Length=81, Percent_Identity=51.8518518518518, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194306642, Length=102, Percent_Identity=43.1372549019608, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI194306640, Length=102, Percent_Identity=43.1372549019608, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4885495, Length=65, Percent_Identity=56.9230769230769, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI17388799, Length=65, Percent_Identity=56.9230769230769, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI5453690, Length=63, Percent_Identity=53.968253968254, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI6631085, Length=64, Percent_Identity=54.6875, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI47777312, Length=85, Percent_Identity=51.7647058823529, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI72534740, Length=65, Percent_Identity=50.7692307692308, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI39204547, Length=175, Percent_Identity=30.8571428571429, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI9558755, Length=145, Percent_Identity=33.7931034482759, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI22749377, Length=64, Percent_Identity=53.125, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1786197, Length=366, Percent_Identity=41.5300546448087, Blast_Score=272, Evalue=2e-74,
Organism=Escherichia coli, GI1787235, Length=381, Percent_Identity=32.0209973753281, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17553096, Length=375, Percent_Identity=30.6666666666667, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17553098, Length=375, Percent_Identity=30.6666666666667, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17507263, Length=386, Percent_Identity=29.7927461139896, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17554644, Length=65, Percent_Identity=61.5384615384615, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17563890, Length=200, Percent_Identity=28.5, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534355, Length=64, Percent_Identity=51.5625, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI212645553, Length=64, Percent_Identity=54.6875, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115532476, Length=71, Percent_Identity=47.887323943662, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17543226, Length=63, Percent_Identity=52.3809523809524, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324265, Length=362, Percent_Identity=31.4917127071823, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6321094, Length=390, Percent_Identity=32.0512820512821, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323870, Length=362, Percent_Identity=30.1104972375691, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323119, Length=388, Percent_Identity=27.0618556701031, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324252, Length=446, Percent_Identity=24.4394618834081, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323813, Length=141, Percent_Identity=41.1347517730496, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322194, Length=66, Percent_Identity=50, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324103, Length=63, Percent_Identity=50.7936507936508, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320888, Length=66, Percent_Identity=46.969696969697, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45552813, Length=386, Percent_Identity=32.1243523316062, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45549272, Length=386, Percent_Identity=32.1243523316062, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI45552811, Length=386, Percent_Identity=32.3834196891192, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI28574949, Length=373, Percent_Identity=27.0777479892761, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646562, Length=362, Percent_Identity=28.7292817679558, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646560, Length=362, Percent_Identity=28.7292817679558, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646558, Length=362, Percent_Identity=28.7292817679558, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646556, Length=362, Percent_Identity=28.7292817679558, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21357547, Length=362, Percent_Identity=28.7292817679558, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI20129487, Length=363, Percent_Identity=28.9256198347107, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24584014, Length=363, Percent_Identity=28.9256198347107, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI85726398, Length=381, Percent_Identity=27.0341207349081, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI19920464, Length=136, Percent_Identity=32.3529411764706, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24654066, Length=65, Percent_Identity=56.9230769230769, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24654070, Length=65, Percent_Identity=56.9230769230769, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24654068, Length=65, Percent_Identity=56.9230769230769, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24654072, Length=65, Percent_Identity=56.9230769230769, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24658562, Length=63, Percent_Identity=57.1428571428571, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24658555, Length=63, Percent_Identity=57.1428571428571, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI161077138, Length=64, Percent_Identity=56.25, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641698, Length=125, Percent_Identity=33.6, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641696, Length=125, Percent_Identity=33.6, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012724
- InterPro:   IPR002939
- InterPro:   IPR001623
- InterPro:   IPR018253
- InterPro:   IPR008971
- InterPro:   IPR015609
- InterPro:   IPR003095
- InterPro:   IPR001305 [H]

Pfam domain/function: PF00226 DnaJ; PF01556 DnaJ_C; PF00684 DnaJ_CXXCXGXG [H]

EC number: NA

Molecular weight: Translated: 41308; Mature: 41176

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00636 DNAJ_1 ; PS50076 DNAJ_2 ; PS00637 DNAJ_CXXCXGXG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQREWVEKDFYKELGVSSDASPEEIKRAYRKLARYLHPDANPDNSAGERFKVVSEAHNV
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LSDPVKRKEYDETRRLFAGGWLGGRRFDSSFGDFGMGGDGAEFNLNDLFDAASRTGGTNI
HHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCH
GDLFGGLFGRGASVRPSRPRRGNDLETEADLDFVEAAKGVAMPLRLTSPAPCTNCHGSGA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCC
RPGISPKVCSTCNGSGVINRNQGAFGFSEPCTECRGSGSIIEHPCEECKGTGVTTRTRTI
CCCCCHHHHHCCCCCCEEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEE
NVRIPSGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRNGDDLTVTIPVSFT
EEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECCHHCCCCCCCEEEEEECCHH
ELALGSTLSVPTLDGTVGVRVPKGTSDGRILRVRGRGVPKRSGGHGDLLVTVKVAVPLNL
HHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEEEECCC
EGAAQKALEAYAAAERSSGFNPRAGWGR
CHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AQREWVEKDFYKELGVSSDASPEEIKRAYRKLARYLHPDANPDNSAGERFKVVSEAHNV
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LSDPVKRKEYDETRRLFAGGWLGGRRFDSSFGDFGMGGDGAEFNLNDLFDAASRTGGTNI
HHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCH
GDLFGGLFGRGASVRPSRPRRGNDLETEADLDFVEAAKGVAMPLRLTSPAPCTNCHGSGA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCC
RPGISPKVCSTCNGSGVINRNQGAFGFSEPCTECRGSGSIIEHPCEECKGTGVTTRTRTI
CCCCCHHHHHCCCCCCEEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEE
NVRIPSGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRNGDDLTVTIPVSFT
EEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECCHHCCCCCCCEEEEEECCHH
ELALGSTLSVPTLDGTVGVRVPKGTSDGRILRVRGRGVPKRSGGHGDLLVTVKVAVPLNL
HHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEEEEECCC
EGAAQKALEAYAAAERSSGFNPRAGWGR
CHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]