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The map label for this gene is argJ

Identifier: 221230214

GI number: 221230214

Start: 1688645

End: 1689868

Strand: Direct

Name: argJ

Synonym: MLBr_01407

Alternate gene names: 221230214

Gene position: 1688645-1689868 (Clockwise)

Preceding gene: 221230213

Following gene: 221230215

Centisome position: 51.67

GC content: 62.58

Gene sequence:

>1224_bases
GTGACCAAAATAGTCGAAATAGTCAATGAGACGCGGCTGCTGCGCGCACAGGGCGTCACCGCCCCTGCGGGCTTTCAGGC
CGCCGGTATCACTGCTGGAATCAAGGTATCGGGGGCCCCGGACCTTGCCCTGGTTTTCAACGAAGGGCCCGACTATGCGG
CCGCTGGAGTATTCACCCGCAACAAGGTCAAGGCTGCTCCGGTGCTGTGGACACAGCGGGTGCTGAGCACCGGTCAGCTA
CGTGCGGTGATTCTCAATTCCGGTGGCGCTAACGCCTGCACCGGACCTGCGGGCTTTCAGGACGCCCACACCACCGCGGA
GGCGGTCGCCGCAGCATTGTCGGATTGGGGAACTGAAACCGGGGCGATCGAGGTTGCCGTCTGCTCCACTGGGCTGATCG
GTGACCGGCTGCCGATGGACAAAGTACTCGCCGGTGTCCGTGCGATCGTGCACAAGATGGCTGGTGGGGTGACCGGAGGT
GACGACGCCGCCCACGCCATCATGACCACCGACACTGTGCCCAAGCAAGTTGCGCTGCACAATCGCAACAAGTGGACGGT
TGGCGGAATGGCCAAAGGCGCGGGCATGTTGGCGCCGTCGCTGGCCACCATGTTGTGTGTGCTCACCACCGATGCGGTCG
TCGAGCCGGCGGCACTTGATCAGGCGCTGCGCCGCGCCACTGCTCATACATTTGACCGACTCGACATTGATGGCTGCTGT
TCCACCAACGACACTGTGCTTCTGCTGGCATCCGGCGCCAGCGGGATCACTCCGCCGCAGGCAGATCTCGACGACGCCGT
ACGGCATGCCTGTGACGACTTGTGCGCACAGTTACAAGCCGACGCCGAGGGCGTTACTAAGCGTGTCACCGTGACCGTCA
TCGGTGCTGCTAGCGACGACGACGCGCTGGTCGCTGCTCGGATGATCGCCCGCGACAACCTGGTCAAGACCGCGGTATTC
GGGTCGGACCCCAACTGGGGACGGGTGCTCGCTGCCGTCGGCATGGCACCGGTCGCACTTGACCCTGACCGACTCTGCAT
GTCGTTCAACGGTGCTGCTGTGTGTATAGATGGAGTCGGTACTCCGTGCGCACGCGACGTGGACCTCTCAACGGCTGATA
TCGATATAACCGTCGACCTACGCATTGGCGACTCCGCTGCCACTATCCGGACCACTGACCTATCGCACACCTATGTCGAA
GAGAATTCGGCCTACAGTTCGTGA

Upstream 100 bases:

>100_bases
ACAATCTCGTCAAGGGCACCGCTGGCGCCGCTGTGCAGTCGATGAACTTAGCGCTGGGTTGGCCGGAAGCAGAGGGCCTT
TCAGTGGTTGGGGTGGCACC

Downstream 100 bases:

>100_bases
CTGTGCTGATGAACCGCACCGGCGACGACGAAACATTGTCGACTCAAGTCAAGGCGGAGGTCTTGGCTGAAGCCCTGCCC
TGGCTGAAGCAGTTGCACGG

Product: bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein

Products: NA

Alternate protein names: Glutamate N-acetyltransferase; Ornithine acetyltransferase; OATase; Ornithine transacetylase; Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTKIVEIVNETRLLRAQGVTAPAGFQAAGITAGIKVSGAPDLALVFNEGPDYAAAGVFTRNKVKAAPVLWTQRVLSTGQL
RAVILNSGGANACTGPAGFQDAHTTAEAVAAALSDWGTETGAIEVAVCSTGLIGDRLPMDKVLAGVRAIVHKMAGGVTGG
DDAAHAIMTTDTVPKQVALHNRNKWTVGGMAKGAGMLAPSLATMLCVLTTDAVVEPAALDQALRRATAHTFDRLDIDGCC
STNDTVLLLASGASGITPPQADLDDAVRHACDDLCAQLQADAEGVTKRVTVTVIGAASDDDALVAARMIARDNLVKTAVF
GSDPNWGRVLAAVGMAPVALDPDRLCMSFNGAAVCIDGVGTPCARDVDLSTADIDITVDLRIGDSAATIRTTDLSHTYVE
ENSAYSS

Sequences:

>Translated_407_residues
MTKIVEIVNETRLLRAQGVTAPAGFQAAGITAGIKVSGAPDLALVFNEGPDYAAAGVFTRNKVKAAPVLWTQRVLSTGQL
RAVILNSGGANACTGPAGFQDAHTTAEAVAAALSDWGTETGAIEVAVCSTGLIGDRLPMDKVLAGVRAIVHKMAGGVTGG
DDAAHAIMTTDTVPKQVALHNRNKWTVGGMAKGAGMLAPSLATMLCVLTTDAVVEPAALDQALRRATAHTFDRLDIDGCC
STNDTVLLLASGASGITPPQADLDDAVRHACDDLCAQLQADAEGVTKRVTVTVIGAASDDDALVAARMIARDNLVKTAVF
GSDPNWGRVLAAVGMAPVALDPDRLCMSFNGAAVCIDGVGTPCARDVDLSTADIDITVDLRIGDSAATIRTTDLSHTYVE
ENSAYSS
>Mature_406_residues
TKIVEIVNETRLLRAQGVTAPAGFQAAGITAGIKVSGAPDLALVFNEGPDYAAAGVFTRNKVKAAPVLWTQRVLSTGQLR
AVILNSGGANACTGPAGFQDAHTTAEAVAAALSDWGTETGAIEVAVCSTGLIGDRLPMDKVLAGVRAIVHKMAGGVTGGD
DAAHAIMTTDTVPKQVALHNRNKWTVGGMAKGAGMLAPSLATMLCVLTTDAVVEPAALDQALRRATAHTFDRLDIDGCCS
TNDTVLLLASGASGITPPQADLDDAVRHACDDLCAQLQADAEGVTKRVTVTVIGAASDDDALVAARMIARDNLVKTAVFG
SDPNWGRVLAAVGMAPVALDPDRLCMSFNGAAVCIDGVGTPCARDVDLSTADIDITVDLRIGDSAATIRTTDLSHTYVEE
NSAYSS

Specific function: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate

COG id: COG1364

COG function: function code E; N-acetylglutamate synthase (N-acetylornithine aminotransferase)

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArgJ family

Homologues:

Organism=Saccharomyces cerevisiae, GI6323707, Length=436, Percent_Identity=36.0091743119266, Blast_Score=225, Evalue=8e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGJ_MYCLE (Q9CC14)

Other databases:

- EMBL:   AL583922
- PIR:   A87085
- RefSeq:   NP_302000.1
- ProteinModelPortal:   Q9CC14
- SMR:   Q9CC14
- MEROPS:   T05.001
- EnsemblBacteria:   EBMYCT00000029122
- GeneID:   910546
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1407
- NMPDR:   fig|272631.1.peg.872
- Leproma:   ML1407
- GeneTree:   EBGT00050000016724
- HOGENOM:   HBG284202
- OMA:   VHENSAY
- ProtClustDB:   PRK05388
- BioCyc:   MLEP272631:ML1407-MONOMER
- BRENDA:   2.3.1.1
- BRENDA:   2.3.1.35
- GO:   GO:0005737
- HAMAP:   MF_01106
- InterPro:   IPR002813
- InterPro:   IPR016117
- PANTHER:   PTHR23100
- TIGRFAMs:   TIGR00120

Pfam domain/function: PF01960 ArgJ; SSF56266 Pept_S58_DmpA/Arg_biosyn_ArgJ

EC number: =2.3.1.35; =2.3.1.1

Molecular weight: Translated: 41764; Mature: 41633

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIVEIVNETRLLRAQGVTAPAGFQAAGITAGIKVSGAPDLALVFNEGPDYAAAGVFTR
CCHHHHHHHHHHEEHHCCCCCCCCCCCCCEEECEEECCCCCEEEEEECCCCCEEECCEEC
NKVKAAPVLWTQRVLSTGQLRAVILNSGGANACTGPAGFQDAHTTAEAVAAALSDWGTET
CCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GAIEVAVCSTGLIGDRLPMDKVLAGVRAIVHKMAGGVTGGDDAAHAIMTTDTVPKQVALH
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHC
NRNKWTVGGMAKGAGMLAPSLATMLCVLTTDAVVEPAALDQALRRATAHTFDRLDIDGCC
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
STNDTVLLLASGASGITPPQADLDDAVRHACDDLCAQLQADAEGVTKRVTVTVIGAASDD
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCC
DALVAARMIARDNLVKTAVFGSDPNWGRVLAAVGMAPVALDPDRLCMSFNGAAVCIDGVG
CHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCEEECHHHHEEECCCCEEEEECCC
TPCARDVDLSTADIDITVDLRIGDSAATIRTTDLSHTYVEENSAYSS
CCCCCCCCCCEEEEEEEEEEEECCCCCEEEEECCCCEEECCCCCCCC
>Mature Secondary Structure 
TKIVEIVNETRLLRAQGVTAPAGFQAAGITAGIKVSGAPDLALVFNEGPDYAAAGVFTR
CHHHHHHHHHHEEHHCCCCCCCCCCCCCEEECEEECCCCCEEEEEECCCCCEEECCEEC
NKVKAAPVLWTQRVLSTGQLRAVILNSGGANACTGPAGFQDAHTTAEAVAAALSDWGTET
CCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GAIEVAVCSTGLIGDRLPMDKVLAGVRAIVHKMAGGVTGGDDAAHAIMTTDTVPKQVALH
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHC
NRNKWTVGGMAKGAGMLAPSLATMLCVLTTDAVVEPAALDQALRRATAHTFDRLDIDGCC
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
STNDTVLLLASGASGITPPQADLDDAVRHACDDLCAQLQADAEGVTKRVTVTVIGAASDD
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCC
DALVAARMIARDNLVKTAVFGSDPNWGRVLAAVGMAPVALDPDRLCMSFNGAAVCIDGVG
CHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCEEECHHHHEEECCCCEEEEECCC
TPCARDVDLSTADIDITVDLRIGDSAATIRTTDLSHTYVEENSAYSS
CCCCCCCCCCEEEEEEEEEEEECCCCCEEEEECCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002