Click here to switch to the map view.

The map label for this gene is plsC [C]

Identifier: 221230113

GI number: 221230113

Start: 1484313

End: 1486052

Strand: Direct

Name: plsC [C]

Synonym: MLBr_01245

Alternate gene names: 221230113

Gene position: 1484313-1486052 (Clockwise)

Preceding gene: 221230112

Following gene: 221230114

Centisome position: 45.42

GC content: 58.22

Gene sequence:

>1740_bases
ATGAGTGCCTTCGACGAGAACGGGACGCCCAAGTCAGGGCCGGAAGTGCGCTTGCCTGGTTCGGTCGCCGAGATCCTTGC
CAGTCCTGCTGGTCCCCAGGTAGGGGCGTTTTTCGACTTGGATGGGACGCTGGTTGCCGGCTTTACCGCAGTCATCCTTA
CGCACGAGCGTCTGCGACGCTGTGATATGGGTGTGGGAGAATTGCTTTCAATGATTCAGGCTGGTCTGAACCATACACTC
GGGCGCATCGAGTTCGAGGACCTCATCGGTAAGGTTTCCTCGGCGTTGCGCGGACGGTTATTGACTGACTTGGAGGAGAT
CGGCGAGCGGCTGTTTGCCCAGCGCATCGAGTCTCGGATCTACCCTGAAATGCGTAAGCTGGTGCAGGCTCACGTGGCTC
GCGGTCACACCGTGGTGCTCAGCTCGTCGGCCCTGACGATTCAAGTGGGGCCGGTCGCACGTTTTCTGGGTATTGCCCAC
ATGCTCACCAACAAGTTTGAGATCAACGAAGACGGAATGCTCACTGGTGGCGTGGTTAAACCGATCTTGTGGGGTCCGGG
CAAAGCCGCTGCGGTACAACGATTTGCTGCTGAGCATGACATCGACCTCAAGGACAGCTACTTCTACGCTGATGGTGACG
AGGACGTCGCGCTGATGTATCTAGTTGGCAATCCACGGCCGACTAACCCTGAAGGAAAAATGGCTGCCGTCGCCAAACGC
CGTGGCTGGCCGATCTTGAAATTCAACAGCCGTGGCGGCGTTGGTATCGGAGCGCAGTTGCGAACACTGGTCGGCCTGAG
TTCAGTGCTACCACTCGTGGCCGGCGCGGTGGGAATCGGTGTGTTGACTGGTAGCCGTCGGCGGGGTGCCAACTTCTTCA
CCTCTGTCTTTCCCCCGTTGGTGCTCGCGGCCGCGGGGGTGCATCTCAATGTGATCGGGAACGAGAACCTGACCATGCAG
CGTCCCGCCGTGTTCATCTATAACCATCGCAATCAGATTGACCCGCTCATCGCCGGTGCGCTAGTGCGTGGCAATTGGAT
TGCTGTGGCCAAGAAAGAATTGGCAAAGAATCCGATCATCCGCGCGCTCGGCAAATTAACCGACGGTGTGTTTATTGACC
GGGACGATCCGGTCGGCGCGGTAGAGACGTTGCACGCGGTCGAAGACCGGGCCAGGAAGGGACTCTCGATTCTGATGGCC
CCAGAAGGTACCCGATTAGATACCACAGAAGTCGGGCCGTTCAAGAAGGGGCCTTTCCGCATCGCGATGGCGGTCGGGAT
CCCGATTGTTCCGATTGTGTTCCGCAATGCGGAGATCGTCGCCGCTCGAAACTCCAATACGATTAATCCGGGCATGGTCG
ATGTCGCGGTTTTGCCGGCGATTCCGGTTGATGACTGGACTCTTGATGCGTTATCGGAGCGCATTGCCGAGGTGCGTCAG
CTGTATCTGGACATTCTGGCTGACTGGCCGGTCGACGAGCTGCCCAAGGCTGCTCTGTACACCCGGGCAACAAAGGCGAC
GGTGAAAAAGGCGGAGCCAAAAAAGGGCGGTCGCACTTCGGCCGCCAAGACCACCGCTAAGAAGACAGCGACCAAGGCCA
CGGCAGCTAAGACTGCTAACACAGCTGTTACCAAAAGCATGTTGACGCCCCCCACGAGGATATCGGACAAAGAGAACCCG
AAAGTACCTAAGGTCGTTTCCCAAGACCTCGTCGTGAAACAGCCCAGAGAGCGGTCGTGA

Upstream 100 bases:

>100_bases
ACGAGGTCCTGGCGTTGGCCGGTGACCCGACACCGCACGCTGTGCCGGCATCGTTTGCTGCGCGGTCCTCCGGTTCGCCG
GCGGGATGGTTGTCGAGCTC

Downstream 100 bases:

>100_bases
CTGAACCGGATGTAGAAATCAGCTCAGTCCTTACCGGTGAAGACACGCTGGTGCTAGCGTCTATGGACACTCCGGCGGAA
ATTGAGCTGGTCATGGATTG

Product: putative transferase

Products: CoA +diacyl-sn-glycerol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MSAFDENGTPKSGPEVRLPGSVAEILASPAGPQVGAFFDLDGTLVAGFTAVILTHERLRRCDMGVGELLSMIQAGLNHTL
GRIEFEDLIGKVSSALRGRLLTDLEEIGERLFAQRIESRIYPEMRKLVQAHVARGHTVVLSSSALTIQVGPVARFLGIAH
MLTNKFEINEDGMLTGGVVKPILWGPGKAAAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKR
RGWPILKFNSRGGVGIGAQLRTLVGLSSVLPLVAGAVGIGVLTGSRRRGANFFTSVFPPLVLAAAGVHLNVIGNENLTMQ
RPAVFIYNHRNQIDPLIAGALVRGNWIAVAKKELAKNPIIRALGKLTDGVFIDRDDPVGAVETLHAVEDRARKGLSILMA
PEGTRLDTTEVGPFKKGPFRIAMAVGIPIVPIVFRNAEIVAARNSNTINPGMVDVAVLPAIPVDDWTLDALSERIAEVRQ
LYLDILADWPVDELPKAALYTRATKATVKKAEPKKGGRTSAAKTTAKKTATKATAAKTANTAVTKSMLTPPTRISDKENP
KVPKVVSQDLVVKQPRERS

Sequences:

>Translated_579_residues
MSAFDENGTPKSGPEVRLPGSVAEILASPAGPQVGAFFDLDGTLVAGFTAVILTHERLRRCDMGVGELLSMIQAGLNHTL
GRIEFEDLIGKVSSALRGRLLTDLEEIGERLFAQRIESRIYPEMRKLVQAHVARGHTVVLSSSALTIQVGPVARFLGIAH
MLTNKFEINEDGMLTGGVVKPILWGPGKAAAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKR
RGWPILKFNSRGGVGIGAQLRTLVGLSSVLPLVAGAVGIGVLTGSRRRGANFFTSVFPPLVLAAAGVHLNVIGNENLTMQ
RPAVFIYNHRNQIDPLIAGALVRGNWIAVAKKELAKNPIIRALGKLTDGVFIDRDDPVGAVETLHAVEDRARKGLSILMA
PEGTRLDTTEVGPFKKGPFRIAMAVGIPIVPIVFRNAEIVAARNSNTINPGMVDVAVLPAIPVDDWTLDALSERIAEVRQ
LYLDILADWPVDELPKAALYTRATKATVKKAEPKKGGRTSAAKTTAKKTATKATAAKTANTAVTKSMLTPPTRISDKENP
KVPKVVSQDLVVKQPRERS
>Mature_578_residues
SAFDENGTPKSGPEVRLPGSVAEILASPAGPQVGAFFDLDGTLVAGFTAVILTHERLRRCDMGVGELLSMIQAGLNHTLG
RIEFEDLIGKVSSALRGRLLTDLEEIGERLFAQRIESRIYPEMRKLVQAHVARGHTVVLSSSALTIQVGPVARFLGIAHM
LTNKFEINEDGMLTGGVVKPILWGPGKAAAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRR
GWPILKFNSRGGVGIGAQLRTLVGLSSVLPLVAGAVGIGVLTGSRRRGANFFTSVFPPLVLAAAGVHLNVIGNENLTMQR
PAVFIYNHRNQIDPLIAGALVRGNWIAVAKKELAKNPIIRALGKLTDGVFIDRDDPVGAVETLHAVEDRARKGLSILMAP
EGTRLDTTEVGPFKKGPFRIAMAVGIPIVPIVFRNAEIVAARNSNTINPGMVDVAVLPAIPVDDWTLDALSERIAEVRQL
YLDILADWPVDELPKAALYTRATKATVKKAEPKKGGRTSAAKTTAKKTATKATAAKTANTAVTKSMLTPPTRISDKENPK
VPKVVSQDLVVKQPRERS

Specific function: Converts Lysophosphatidic Acid (Lpa) Into Phosphatidic Acid By Incorporating An Acyl Moiety At The 2 Position. This Enzyme Can Utilize Either Acyl-CoA Or Acyl-Acyl Carrier Protein As The Fatty Acyl Donor. [C]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serB family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=174, Percent_Identity=28.1609195402299, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI15100175, Length=174, Percent_Identity=28.1609195402299, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI6041665, Length=163, Percent_Identity=29.4478527607362, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1789395, Length=167, Percent_Identity=33.5329341317365, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17564032, Length=189, Percent_Identity=32.8042328042328, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17568319, Length=180, Percent_Identity=28.8888888888889, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320151, Length=240, Percent_Identity=29.1666666666667, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24641614, Length=176, Percent_Identity=30.6818181818182, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24641612, Length=176, Percent_Identity=30.6818181818182, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281364648, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24582856, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24582854, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006383
- InterPro:   IPR006385 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: 2.3.1.51 [C]

Molecular weight: Translated: 62189; Mature: 62058

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFDENGTPKSGPEVRLPGSVAEILASPAGPQVGAFFDLDGTLVAGFTAVILTHERLRR
CCCCCCCCCCCCCCCEECCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
CDMGVGELLSMIQAGLNHTLGRIEFEDLIGKVSSALRGRLLTDLEEIGERLFAQRIESRI
HCCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YPEMRKLVQAHVARGHTVVLSSSALTIQVGPVARFLGIAHMLTNKFEINEDGMLTGGVVK
CHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHHHHHHHHHHCCEEECCCCEEECCCCC
PILWGPGKAAAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKR
CEEECCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHH
RGWPILKFNSRGGVGIGAQLRTLVGLSSVLPLVAGAVGIGVLTGSRRRGANFFTSVFPPL
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
VLAAAGVHLNVIGNENLTMQRPAVFIYNHRNQIDPLIAGALVRGNWIAVAKKELAKNPII
HHHHCCCEEEEECCCCCEEECCEEEEECCCCCCCHHHHHHHHCCCEEEEEHHHHHCCHHH
RALGKLTDGVFIDRDDPVGAVETLHAVEDRARKGLSILMAPEGTRLDTTEVGPFKKGPFR
HHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCEE
IAMAVGIPIVPIVFRNAEIVAARNSNTINPGMVDVAVLPAIPVDDWTLDALSERIAEVRQ
EEEECCCCEEEEEECCCEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
LYLDILADWPVDELPKAALYTRATKATVKKAEPKKGGRTSAAKTTAKKTATKATAAKTAN
HHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TAVTKSMLTPPTRISDKENPKVPKVVSQDLVVKQPRERS
HHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHCCCCCCC
>Mature Secondary Structure 
SAFDENGTPKSGPEVRLPGSVAEILASPAGPQVGAFFDLDGTLVAGFTAVILTHERLRR
CCCCCCCCCCCCCCEECCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
CDMGVGELLSMIQAGLNHTLGRIEFEDLIGKVSSALRGRLLTDLEEIGERLFAQRIESRI
HCCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YPEMRKLVQAHVARGHTVVLSSSALTIQVGPVARFLGIAHMLTNKFEINEDGMLTGGVVK
CHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHHHHHHHHHHCCEEECCCCEEECCCCC
PILWGPGKAAAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKR
CEEECCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHH
RGWPILKFNSRGGVGIGAQLRTLVGLSSVLPLVAGAVGIGVLTGSRRRGANFFTSVFPPL
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHH
VLAAAGVHLNVIGNENLTMQRPAVFIYNHRNQIDPLIAGALVRGNWIAVAKKELAKNPII
HHHHCCCEEEEECCCCCEEECCEEEEECCCCCCCHHHHHHHHCCCEEEEEHHHHHCCHHH
RALGKLTDGVFIDRDDPVGAVETLHAVEDRARKGLSILMAPEGTRLDTTEVGPFKKGPFR
HHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCEE
IAMAVGIPIVPIVFRNAEIVAARNSNTINPGMVDVAVLPAIPVDDWTLDALSERIAEVRQ
EEEECCCCEEEEEECCCEEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
LYLDILADWPVDELPKAALYTRATKATVKKAEPKKGGRTSAAKTTAKKTATKATAAKTAN
HHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TAVTKSMLTPPTRISDKENPKVPKVVSQDLVVKQPRERS
HHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acyl-CoA; acyl-sn-glycerol phosphate [C]

Specific reaction: Acyl-CoA + acyl-sn-glycerol phosphate = CoA +diacyl-sn-glycerol phosphate [C]

General reaction: Acyl group transfer [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]