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The map label for this gene is nadC [H]

Identifier: 221230103

GI number: 221230103

Start: 1449375

End: 1450235

Strand: Direct

Name: nadC [H]

Synonym: MLBr_01227

Alternate gene names: 221230103

Gene position: 1449375-1450235 (Clockwise)

Preceding gene: 221230102

Following gene: 221230104

Centisome position: 44.35

GC content: 61.21

Gene sequence:

>861_bases
TTGATAATGCTGTCCGACTGCGAATTCGATGCGGCGCGAGACACTATTCGGCGCGCTCTGCATGAGGATCTACGGTACGG
GCTCGACATCACTACGCAGGCCACCGTGCCGGCTGGTACGGTCGTCACGGGGTCGATGGTGCCTCGCGAGCCGGGTGTGA
TTGCCGGGGTGGATGTGGCGTTGCTGGTCCTCGATGAGGTGTTCGGCGTCGACGGCTACCGGGTTCTCTATCGCGTTGAG
GACGGTGCCCGGTTGCAATCAGGTCAACCACTGCTGACCGTGCAGGCAGCAGCCCGAGGGCTGTTGACGGCTGAGCGGAC
CATGTTGAACCTGGTCTGCCACATGTCCGGGATAGCCACTGTGACGGTGGCCTGGGTTGACGCCGTACGTGGCACAAAAG
CCAAGATCCGAGATACCCGTAAGACGCTTCCTGGTCTGCGTGCGCTGCAGAAGTACGCGGTGCGTGTCGGCGGCGGTGTC
AACCATCGACTGGGGCTCGGTGATACCGCCTTGATCAAGGACAACCATGTTGCCGCTGTAGGATCGGTGGTTGACGCGCT
GCGGGCAGTGAGGGCAGCTGCGCCTGAGCTTCCGTGCGAAGTCGAAGTGGACTCACTCGAGCAGCTTGATGCCATGCTGG
CTGAGGAGCCCGAACTGATCCTGCTGGACAATTTCCCAGTGTGGCAGACACAAGTAGCGGTGCAACGTCGAGACATCCGA
GCACCTACCGTCCTGCTAGAATCATCCGGTGGGCTGAGCCTCGAGAATGCGGCGATCTACGCGGGGACCGGCGTAGATTA
CCTCGCCGTCGGTGCGTTGACTCACTCGGTGCGAATTCTCGACATCGGCTTGGATTTGTAG

Upstream 100 bases:

>100_bases
CAGAGTATCCGGACACCGCGCCAGAACACGCCCGCAGCACTGTGATTCGACTGGCTGACGACCAAAACTTGGTGCGTGCG
GAGGCATTGGCGACGGTGGG

Downstream 100 bases:

>100_bases
GTTTACTCGCGCAGCAATCAATGTGCGGGCCGTGGGTCTGGAAGCGCTGATCCTCTCCCGAATCGCTAGCGATTCGGGAG
AGGATCAGCGCTGCTTCAAT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MIMLSDCEFDAARDTIRRALHEDLRYGLDITTQATVPAGTVVTGSMVPREPGVIAGVDVALLVLDEVFGVDGYRVLYRVE
DGARLQSGQPLLTVQAAARGLLTAERTMLNLVCHMSGIATVTVAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRVGGGV
NHRLGLGDTALIKDNHVAAVGSVVDALRAVRAAAPELPCEVEVDSLEQLDAMLAEEPELILLDNFPVWQTQVAVQRRDIR
APTVLLESSGGLSLENAAIYAGTGVDYLAVGALTHSVRILDIGLDL

Sequences:

>Translated_286_residues
MIMLSDCEFDAARDTIRRALHEDLRYGLDITTQATVPAGTVVTGSMVPREPGVIAGVDVALLVLDEVFGVDGYRVLYRVE
DGARLQSGQPLLTVQAAARGLLTAERTMLNLVCHMSGIATVTVAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRVGGGV
NHRLGLGDTALIKDNHVAAVGSVVDALRAVRAAAPELPCEVEVDSLEQLDAMLAEEPELILLDNFPVWQTQVAVQRRDIR
APTVLLESSGGLSLENAAIYAGTGVDYLAVGALTHSVRILDIGLDL
>Mature_286_residues
MIMLSDCEFDAARDTIRRALHEDLRYGLDITTQATVPAGTVVTGSMVPREPGVIAGVDVALLVLDEVFGVDGYRVLYRVE
DGARLQSGQPLLTVQAAARGLLTAERTMLNLVCHMSGIATVTVAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRVGGGV
NHRLGLGDTALIKDNHVAAVGSVVDALRAVRAAAPELPCEVEVDSLEQLDAMLAEEPELILLDNFPVWQTQVAVQRRDIR
APTVLLESSGGLSLENAAIYAGTGVDYLAVGALTHSVRILDIGLDL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=241, Percent_Identity=35.6846473029046, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1786299, Length=272, Percent_Identity=40.4411764705882, Blast_Score=168, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321162, Length=255, Percent_Identity=32.156862745098, Blast_Score=116, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30553; Mature: 30553

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMLSDCEFDAARDTIRRALHEDLRYGLDITTQATVPAGTVVTGSMVPREPGVIAGVDVA
CEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCCCCCCCEEEHHHHH
LLVLDEVFGVDGYRVLYRVEDGARLQSGQPLLTVQAAARGLLTAERTMLNLVCHMSGIAT
HHHHHHHHCCCCEEEEEEECCCCEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHH
VTVAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRVGGGVNHRLGLGDTALIKDNHVAAV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHH
GSVVDALRAVRAAAPELPCEVEVDSLEQLDAMLAEEPELILLDNFPVWQTQVAVQRRDIR
HHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCC
APTVLLESSGGLSLENAAIYAGTGVDYLAVGALTHSVRILDIGLDL
CCEEEEECCCCCEECCCEEEECCCCHHHHHHHHHHEEEEEEEECCC
>Mature Secondary Structure
MIMLSDCEFDAARDTIRRALHEDLRYGLDITTQATVPAGTVVTGSMVPREPGVIAGVDVA
CEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCCCCCCCEEEHHHHH
LLVLDEVFGVDGYRVLYRVEDGARLQSGQPLLTVQAAARGLLTAERTMLNLVCHMSGIAT
HHHHHHHHCCCCEEEEEEECCCCEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHH
VTVAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRVGGGVNHRLGLGDTALIKDNHVAAV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHH
GSVVDALRAVRAAAPELPCEVEVDSLEQLDAMLAEEPELILLDNFPVWQTQVAVQRRDIR
HHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCC
APTVLLESSGGLSLENAAIYAGTGVDYLAVGALTHSVRILDIGLDL
CCEEEEECCCCCEECCCEEEECCCCHHHHHHHHHHEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]