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The map label for this gene is dxs

Identifier: 221229980

GI number: 221229980

Start: 1201255

End: 1203186

Strand: Direct

Name: dxs

Synonym: MLBr_01038

Alternate gene names: 221229980

Gene position: 1201255-1203186 (Clockwise)

Preceding gene: 221229976

Following gene: 221229983

Centisome position: 36.76

GC content: 60.61

Gene sequence:

>1932_bases
ATGCTGGAACAGATCCGCAGGCCCGCTGATCTGCAGCATCTTTCTCAGCAGCAGCTACGGGATCTGGCTGCCGAGATCCG
TGAGCTCCTCGTTCACAAGGTGGCGGCCACCGGGGGACACTTGGGGCCGAACCTGGGTGTTGTCGAACTCACGCTGGCGT
TGCACCGAGTGTTCGACTCACCGCATGATCCGATTATCTTCGACACCGGTCACCAGGCGTACGTCCACAAAATGTTGACG
GGACGCTGTCAGGACTTCGACAGTCTGCGTAAAAAGGCCGGGTTGTCGGGGTACCCGTCTCGCGCCGAGAGCGAACACGA
CTGGGTGGAGTCCAGCCACGCCAGCACGGCGTTATCGTACGCCGACGGTCTGGCTAAGGCATTCGAGCTGGCCGGAAACC
GCAACCGACACGTAGTCGCGGTGGTTGGGGACGGCGCGCTTACCGGTGGTATGTGCTGGGAGGCGCTTAACAATATCGCA
GCAACACCGCGTCCGGTGGTCATCGTAGTCAATGACAATGGTCGCAGTTACGCGCCCACGATTGGCGGTGTAGCCGATCA
CCTCGCCACGCTGCGGCTGCAGCCGGCCTACGAGCGGCTACTTGAGAAGGGGCGTGATGCACTTCACTCTTTGCCGCTGA
TAGGCCAGATCGCTTACCGTTTCATGCACAGTGTCAAAGCCGGTATCAAGGATTCCCTATCGCCGCAGCTGCTGTTCACC
GATCTCGGGCTAAAGTATGTTGGCCCGGTTGATGGTCACGATGAACATGCGGTAGAGGTCGCGTTGCGTAAGGCCCGCGG
CTTCGGTGGCCCGGTGATCGTGCACGTCGTCACCCGCAAGGGTATGGGCTATCCCCCGGCCGAAGCCGATCAAGCCGAAC
AGATGCACACCTGCGGCGTGATGGACCCGACGACCGGGCAACCCACCAAGATTGCTGCTCCTGACTGGACGGCGATCTTT
TCCGATGCCCTCATCGGTTATGCTATGAAGCGACGTGACATTGTGGCTATTACCGCGGCTATGCCGGGCCCTACCGGTCT
AACAGCGTTCGGTCAGTGTTTTCCGGATCGGTTGTTCGATGTCGGGATCGCTGAGCAACACGCGATGACGTCGGCGGCCG
GGTTGGCTATGGGCAGGATGCACCCGGTGGTGGCGATCTATTCGACATTTCTCAACCGGGCGTTCGACCAGATCATGATG
GACGTGGCGCTACACAAGTTGCCTGTTACCATGGTGATTGACCGGGCTGGCATTACCGGTTCGGACGGCCCCAGTCATAA
CGGCATGTGGGATTTGTCGATGCTAGGCATCGTACCGGGGATGCGAGTGGCCGCGCCTCGAGACGCCATTCGGTTGCGCG
AAGAACTCGGTGAGGCGCTTGACGTCGACGACGGTCCGACGGCGATACGATTCCCCAAAGGAGATGTGTGTGAAGATATT
CCGGCTTTGAAGCGCCGATCGGGCGTGGACGTACTCGCGGTGCCGGCTACGGGGTTGGCCCAGGACGTGCTGCTGGTGGG
GGTCGGCGTTTTTGCGTCGATGGCGTTGGCGGTGGCCAAGCGGCTGCACAACCAGGGAATCGGCGTAACAGTGATTGACC
CACGTTGGGTGTTGCCGGTGTGCGACGGTGTTCTCGAACTGGCGCATACCCACAAACTGATCGTCACGCTGGAGGACAAC
GGGGTCAATGGCGGTGTAGGCGCAGCCGTATCTACCGCGCTGCGTCAAGTGGAGATTGACACACCTTGCCGCGATGTTGG
ATTGCCGCAGGAGTTCTACGATCATGCTTCGCGGAGTGAGGTGTTGGCCGATTTGGGGCTGACCGACCAAGACGTCGCCC
GTCGGATCACCGGCTGGGTTGTTGCATTCGGCCATTGCGGTTCCGGTGACGATGCAGGTCAGTACGGTCCGCGGAGCAGC
CAAACCATGTAG

Upstream 100 bases:

>100_bases
ACCAGTATTCGTGACTCACCGCAGACTGACGCTACCAAAGCGGTGGCTCGGTTATCCGTTTGGTGCCCCCACCCTTGCGT
TACCTGAGTACAATAACGGA

Downstream 100 bases:

>100_bases
CTTGGGCCTGGCGACGATCCGGATCGTCAGATTCATTTTCGTATCAAAACTATTGACGTAAGAATACACTATTTCCCACT
GGATCCGCGCAATGTGGGCT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLT
GRCQDFDSLRKKAGLSGYPSRAESEHDWVESSHASTALSYADGLAKAFELAGNRNRHVVAVVGDGALTGGMCWEALNNIA
ATPRPVVIVVNDNGRSYAPTIGGVADHLATLRLQPAYERLLEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFT
DLGLKYVGPVDGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMHTCGVMDPTTGQPTKIAAPDWTAIF
SDALIGYAMKRRDIVAITAAMPGPTGLTAFGQCFPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYSTFLNRAFDQIMM
DVALHKLPVTMVIDRAGITGSDGPSHNGMWDLSMLGIVPGMRVAAPRDAIRLREELGEALDVDDGPTAIRFPKGDVCEDI
PALKRRSGVDVLAVPATGLAQDVLLVGVGVFASMALAVAKRLHNQGIGVTVIDPRWVLPVCDGVLELAHTHKLIVTLEDN
GVNGGVGAAVSTALRQVEIDTPCRDVGLPQEFYDHASRSEVLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQYGPRSS
QTM

Sequences:

>Translated_643_residues
MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLT
GRCQDFDSLRKKAGLSGYPSRAESEHDWVESSHASTALSYADGLAKAFELAGNRNRHVVAVVGDGALTGGMCWEALNNIA
ATPRPVVIVVNDNGRSYAPTIGGVADHLATLRLQPAYERLLEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFT
DLGLKYVGPVDGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMHTCGVMDPTTGQPTKIAAPDWTAIF
SDALIGYAMKRRDIVAITAAMPGPTGLTAFGQCFPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYSTFLNRAFDQIMM
DVALHKLPVTMVIDRAGITGSDGPSHNGMWDLSMLGIVPGMRVAAPRDAIRLREELGEALDVDDGPTAIRFPKGDVCEDI
PALKRRSGVDVLAVPATGLAQDVLLVGVGVFASMALAVAKRLHNQGIGVTVIDPRWVLPVCDGVLELAHTHKLIVTLEDN
GVNGGVGAAVSTALRQVEIDTPCRDVGLPQEFYDHASRSEVLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQYGPRSS
QTM
>Mature_643_residues
MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLT
GRCQDFDSLRKKAGLSGYPSRAESEHDWVESSHASTALSYADGLAKAFELAGNRNRHVVAVVGDGALTGGMCWEALNNIA
ATPRPVVIVVNDNGRSYAPTIGGVADHLATLRLQPAYERLLEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFT
DLGLKYVGPVDGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMHTCGVMDPTTGQPTKIAAPDWTAIF
SDALIGYAMKRRDIVAITAAMPGPTGLTAFGQCFPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYSTFLNRAFDQIMM
DVALHKLPVTMVIDRAGITGSDGPSHNGMWDLSMLGIVPGMRVAAPRDAIRLREELGEALDVDDGPTAIRFPKGDVCEDI
PALKRRSGVDVLAVPATGLAQDVLLVGVGVFASMALAVAKRLHNQGIGVTVIDPRWVLPVCDGVLELAHTHKLIVTLEDN
GVNGGVGAAVSTALRQVEIDTPCRDVGLPQEFYDHASRSEVLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQYGPRSS
QTM

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=258, Percent_Identity=29.8449612403101, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI4507521, Length=258, Percent_Identity=29.8449612403101, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI225637459, Length=256, Percent_Identity=27.734375, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI225637461, Length=256, Percent_Identity=27.734375, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI225637463, Length=256, Percent_Identity=27.734375, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI133778974, Length=635, Percent_Identity=23.7795275590551, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1786622, Length=616, Percent_Identity=39.1233766233766, Blast_Score=429, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17539652, Length=281, Percent_Identity=30.2491103202847, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666278, Length=600, Percent_Identity=25.8333333333333, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45551847, Length=598, Percent_Identity=24.9163879598662, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45550715, Length=598, Percent_Identity=24.9163879598662, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24645119, Length=229, Percent_Identity=32.7510917030568, Blast_Score=89, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_MYCLB (B8ZQW9)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503396.1
- ProteinModelPortal:   B8ZQW9
- SMR:   B8ZQW9
- EnsemblBacteria:   EBMYCT00000086145
- GeneID:   7326762
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016269
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68864; Mature: 68864

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPNLGVVELTLALHRVFDS
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
PHDPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAGLSGYPSRAESEHDWVESSHASTALSY
CCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ADGLAKAFELAGNRNRHVVAVVGDGALTGGMCWEALNNIAATPRPVVIVVNDNGRSYAPT
HHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEECCC
IGGVADHLATLRLQPAYERLLEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFT
CCHHHHHHHHHEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
DLGLKYVGPVDGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMHTCGV
ECCCEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCC
MDPTTGQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAAMPGPTGLTAFGQCFPDRLFD
CCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
VGIAEQHAMTSAAGLAMGRMHPVVAIYSTFLNRAFDQIMMDVALHKLPVTMVIDRAGITG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
SDGPSHNGMWDLSMLGIVPGMRVAAPRDAIRLREELGEALDVDDGPTAIRFPKGDVCEDI
CCCCCCCCEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHH
PALKRRSGVDVLAVPATGLAQDVLLVGVGVFASMALAVAKRLHNQGIGVTVIDPRWVLPV
HHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
CDGVLELAHTHKLIVTLEDNGVNGGVGAAVSTALRQVEIDTPCRDVGLPQEFYDHASRSE
HHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCHHHHHCCHHHH
VLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQYGPRSSQTM
HHHHCCCCHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPNLGVVELTLALHRVFDS
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
PHDPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAGLSGYPSRAESEHDWVESSHASTALSY
CCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ADGLAKAFELAGNRNRHVVAVVGDGALTGGMCWEALNNIAATPRPVVIVVNDNGRSYAPT
HHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEECCC
IGGVADHLATLRLQPAYERLLEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFT
CCHHHHHHHHHEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
DLGLKYVGPVDGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMHTCGV
ECCCEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCC
MDPTTGQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAAMPGPTGLTAFGQCFPDRLFD
CCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
VGIAEQHAMTSAAGLAMGRMHPVVAIYSTFLNRAFDQIMMDVALHKLPVTMVIDRAGITG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
SDGPSHNGMWDLSMLGIVPGMRVAAPRDAIRLREELGEALDVDDGPTAIRFPKGDVCEDI
CCCCCCCCEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHH
PALKRRSGVDVLAVPATGLAQDVLLVGVGVFASMALAVAKRLHNQGIGVTVIDPRWVLPV
HHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
CDGVLELAHTHKLIVTLEDNGVNGGVGAAVSTALRQVEIDTPCRDVGLPQEFYDHASRSE
HHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCHHHHHCCHHHH
VLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQYGPRSSQTM
HHHHCCCCHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA