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The map label for this gene is orn

Identifier: 221229613

GI number: 221229613

Start: 526303

End: 526950

Strand: Reverse

Name: orn

Synonym: MLBr_00427

Alternate gene names: 221229613

Gene position: 526950-526303 (Counterclockwise)

Preceding gene: 221229614

Following gene: 221229610

Centisome position: 16.12

GC content: 55.56

Gene sequence:

>648_bases
GTGCACGACGAATTAGTGTGGATTGACTGCGAGATGACTGGACTGGACCTGGGTTCGGATCAGTTGATCGAGATCGCAGC
CCTAGTAACCGATGCCGATCTGAACATCCTCGGTGATGGAGTCGATGTCGTAATCCACATCGACAGCACCGCGCTCTCGT
CAATGATTGACGTGGTCGCCGAGATGCACTCACGGTCAGGACTAATTAACGAGGTGGAGTCATCCATCGTCGACCTTGTG
ACCGCCGAGTCGATAGTACTCGATTACATCAACAACCACGTCAAGCAACCGAAGACGGCTCCACTGGCAGGCAATTCGAT
CGCCACTGATCGTTCATTCATCGCCCGTGACATGCCCACTCTGGACTCGTTCCTGCACTATCGGATGATAGACGTCAGCT
CGATTAAAGAACTCTGCCGACGCTGGTACCCGCGCATTTACTTCGGCCAGCCGGCCAAGGGGCTCACTCATCGGGCACTA
GCCGACATTCACGAATCCATCCGGGAGCTGAGATTCTACCGCCGCACTGCGTTTGTTCCCCCACCCGGACCTTCTACCAG
AGAAATCGCGGAAGTAGTGGCTGATCTTTCCGGCACGCCCGCCACGCCAGGAGATATCGATTCAGCCTATGAGCGTCCGA
ACGGTTAA

Upstream 100 bases:

>100_bases
CCCTGCCCCCAGTAATTCCCCATTGCAGTACGACAAACCATCACACTACTTAACAGGGGAAGACCTAGGCAGGTCTCACA
TGCGCCTACTGTAGAGCGCT

Downstream 100 bases:

>100_bases
TATCGACAGCGCCACTCGTTGACCCCTGCCAGGGTCGACCGGCGGCCATGGTGAGTGTAGTTCAGTTGGTAGAGCACCAG
GTTGTGATCCTGGGTGTCGC

Product: oligoribonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MHDELVWIDCEMTGLDLGSDQLIEIAALVTDADLNILGDGVDVVIHIDSTALSSMIDVVAEMHSRSGLINEVESSIVDLV
TAESIVLDYINNHVKQPKTAPLAGNSIATDRSFIARDMPTLDSFLHYRMIDVSSIKELCRRWYPRIYFGQPAKGLTHRAL
ADIHESIRELRFYRRTAFVPPPGPSTREIAEVVADLSGTPATPGDIDSAYERPNG

Sequences:

>Translated_215_residues
MHDELVWIDCEMTGLDLGSDQLIEIAALVTDADLNILGDGVDVVIHIDSTALSSMIDVVAEMHSRSGLINEVESSIVDLV
TAESIVLDYINNHVKQPKTAPLAGNSIATDRSFIARDMPTLDSFLHYRMIDVSSIKELCRRWYPRIYFGQPAKGLTHRAL
ADIHESIRELRFYRRTAFVPPPGPSTREIAEVVADLSGTPATPGDIDSAYERPNG
>Mature_215_residues
MHDELVWIDCEMTGLDLGSDQLIEIAALVTDADLNILGDGVDVVIHIDSTALSSMIDVVAEMHSRSGLINEVESSIVDLV
TAESIVLDYINNHVKQPKTAPLAGNSIATDRSFIARDMPTLDSFLHYRMIDVSSIKELCRRWYPRIYFGQPAKGLTHRAL
ADIHESIRELRFYRRTAFVPPPGPSTREIAEVVADLSGTPATPGDIDSAYERPNG

Specific function: 3'-to-5' exoribonuclease specific for small oligoribonucleotides

COG id: COG1949

COG function: function code A; Oligoribonuclease (3'->5' exoribonuclease)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain

Homologues:

Organism=Homo sapiens, GI224496106, Length=178, Percent_Identity=48.314606741573, Blast_Score=177, Evalue=5e-45,
Organism=Escherichia coli, GI87082382, Length=172, Percent_Identity=45.3488372093023, Blast_Score=151, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17557752, Length=181, Percent_Identity=45.3038674033149, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323088, Length=184, Percent_Identity=39.1304347826087, Blast_Score=125, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21355135, Length=176, Percent_Identity=45.4545454545455, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ORN_MYCLE (O07708)

Other databases:

- EMBL:   Z97179
- EMBL:   AL583918
- PIR:   C86962
- RefSeq:   NP_301398.1
- ProteinModelPortal:   O07708
- SMR:   O07708
- EnsemblBacteria:   EBMYCT00000028503
- GeneID:   909171
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0427
- NMPDR:   fig|272631.1.peg.270
- Leproma:   ML0427
- GeneTree:   EBGT00050000017547
- HOGENOM:   HBG448545
- OMA:   ARRWYPR
- ProtClustDB:   PRK05359
- BioCyc:   MLEP272631:ML0427-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00045
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR022894
- InterPro:   IPR012337
- SMART:   SM00479

Pfam domain/function: PF00929 Exonuc_X-T; SSF53098 RNaseH_fold

EC number: 3.1.-.- [C]

Molecular weight: Translated: 23717; Mature: 23717

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: ACT_SITE 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDELVWIDCEMTGLDLGSDQLIEIAALVTDADLNILGDGVDVVIHIDSTALSSMIDVVA
CCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEECCCEEEEEEECHHHHHHHHHHHH
EMHSRSGLINEVESSIVDLVTAESIVLDYINNHVKQPKTAPLAGNSIATDRSFIARDMPT
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCHH
LDSFLHYRMIDVSSIKELCRRWYPRIYFGQPAKGLTHRALADIHESIRELRFYRRTAFVP
HHHHHHHHHCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PPGPSTREIAEVVADLSGTPATPGDIDSAYERPNG
CCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MHDELVWIDCEMTGLDLGSDQLIEIAALVTDADLNILGDGVDVVIHIDSTALSSMIDVVA
CCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEECCCEEEEEEECHHHHHHHHHHHH
EMHSRSGLINEVESSIVDLVTAESIVLDYINNHVKQPKTAPLAGNSIATDRSFIARDMPT
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCHH
LDSFLHYRMIDVSSIKELCRRWYPRIYFGQPAKGLTHRALADIHESIRELRFYRRTAFVP
HHHHHHHHHCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PPGPSTREIAEVVADLSGTPATPGDIDSAYERPNG
CCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002