Click here to switch to the map view.

The map label for this gene is csd [H]

Identifier: 220932835

GI number: 220932835

Start: 2157082

End: 2158410

Strand: Direct

Name: csd [H]

Synonym: Hore_20010

Alternate gene names: 220932835

Gene position: 2157082-2158410 (Clockwise)

Preceding gene: 220932827

Following gene: 220932836

Centisome position: 83.67

GC content: 40.11

Gene sequence:

>1329_bases
ATGAACACTTATAAAAAATGGAGAGGGCAGGTTGTTGGTGTTAACAAAAAGGTCCCCCTCAGTAATAACAGGCTTTCCAC
CTATGTTAATTTTGATAACGCGGCCACAACCCCACCATTTAAATCGGTAATAGAGCGGATTACTGAATTTGCAGGCTGGT
ATTCCTCCATTCACCGGGGAAAAGGCTATAAATCAAGATTATGTTCTACAATTTATGAAGAGGCCCGCGGGGATATTCTT
AATTTCGTTAAGGCTGATCCCGATTATTATACCCCTATCTATGTTAAAAACACCACCGAAGCAATTAATAAACTGGCCTA
TACCCTGGGTCAGGATACTGATAATAGAAATATTATAATTACAACCTCAATGGAACACCATTCCAACGATTTACCCTGGA
GAAAATACTTTAAGGTAGAATACATAAAGCTGAACGAAAAGGGGCAACTATCTCTTGATGACCTTGAATCAAAACTAATA
AAACACCGGGGCAAGGTAAGACTGGTTACCGTTGGTGGGGCCTCTAATGTAACCGGTTATCTCAACCCGATTTATCAAAT
TGCCGGCCTTGCCCATAAGTACGGGACTGAAGTAATGATCGATGGAGCCCAGTTGATTCCCCACCACCCTGTCGAAATGA
GTCCAAAAAAAGCGGGAGAAAGACTAGATTACCTTGCCTTTTCAGGACATAAAATGTATGCCCCTTTTGGAACGGGAGTC
CTTATAGCCCCTCAAAAAACCTTTGCATCAAATACTCCAGACCAGGTCGGTGGGGGAACAGTTGATATAGTAACCCCTGA
TTTTGTGAGGTGGCATACCCCCCCACATAAAGAAGAAGCTGGCTCTCCCAATTTAATGGGGATAGTAGCCCTGACTGAAG
CCATTAAAATTTTAAATGAATTCGGAATGGAGTCGATTTTGAATCACGAAAAACGGCTGACTGATTATACCCTGAAAAGA
TTAAATAAAATACCTGATGTCATCCTTTATGGAAATAAATTTAATAGTAAGGATAGATTAGGAATTATCCCTTTTAATAT
TGACGGGTTATCCCATGAATCAATAGCCACTATACTGGCCGGTGAAGGTGGTATCGCCGTAAGAAATGGCTGCTTTTGTG
CCCAGCCCTATGTCCAGCAGCTCCTCAATATATCTGAACAGGAAATACGGGCCAGAATAAACAATCCTGACCTACCCCAT
CCCGGTCTGATAAGAATTAGTTTTGGACTATACAATACATTTCAGGAGATTGATAGGTTAATAGATATGGTTAAAGTAAT
AGTCTCAAATAAAGAGTATTATTACAGAAAAACAAAAATTAATTTTTAA

Upstream 100 bases:

>100_bases
ATTTTTATAAAGATTTCTTTTCGACGTTATATTTATGCACAGTAACGATACATGTTGAATATACTAATCTGAGATATAAT
TATAATTCAGGGTGATAGTT

Downstream 100 bases:

>100_bases
CAGGAAAATTGCGAGCATTATTTAACTAAATGTATTTTTCACAAAGTATTATCTATTTTTGAAGAATCAAAAATACCCTC
CATGATAATAATAATAGTAG

Product: Cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MNTYKKWRGQVVGVNKKVPLSNNRLSTYVNFDNAATTPPFKSVIERITEFAGWYSSIHRGKGYKSRLCSTIYEEARGDIL
NFVKADPDYYTPIYVKNTTEAINKLAYTLGQDTDNRNIIITTSMEHHSNDLPWRKYFKVEYIKLNEKGQLSLDDLESKLI
KHRGKVRLVTVGGASNVTGYLNPIYQIAGLAHKYGTEVMIDGAQLIPHHPVEMSPKKAGERLDYLAFSGHKMYAPFGTGV
LIAPQKTFASNTPDQVGGGTVDIVTPDFVRWHTPPHKEEAGSPNLMGIVALTEAIKILNEFGMESILNHEKRLTDYTLKR
LNKIPDVILYGNKFNSKDRLGIIPFNIDGLSHESIATILAGEGGIAVRNGCFCAQPYVQQLLNISEQEIRARINNPDLPH
PGLIRISFGLYNTFQEIDRLIDMVKVIVSNKEYYYRKTKINF

Sequences:

>Translated_442_residues
MNTYKKWRGQVVGVNKKVPLSNNRLSTYVNFDNAATTPPFKSVIERITEFAGWYSSIHRGKGYKSRLCSTIYEEARGDIL
NFVKADPDYYTPIYVKNTTEAINKLAYTLGQDTDNRNIIITTSMEHHSNDLPWRKYFKVEYIKLNEKGQLSLDDLESKLI
KHRGKVRLVTVGGASNVTGYLNPIYQIAGLAHKYGTEVMIDGAQLIPHHPVEMSPKKAGERLDYLAFSGHKMYAPFGTGV
LIAPQKTFASNTPDQVGGGTVDIVTPDFVRWHTPPHKEEAGSPNLMGIVALTEAIKILNEFGMESILNHEKRLTDYTLKR
LNKIPDVILYGNKFNSKDRLGIIPFNIDGLSHESIATILAGEGGIAVRNGCFCAQPYVQQLLNISEQEIRARINNPDLPH
PGLIRISFGLYNTFQEIDRLIDMVKVIVSNKEYYYRKTKINF
>Mature_442_residues
MNTYKKWRGQVVGVNKKVPLSNNRLSTYVNFDNAATTPPFKSVIERITEFAGWYSSIHRGKGYKSRLCSTIYEEARGDIL
NFVKADPDYYTPIYVKNTTEAINKLAYTLGQDTDNRNIIITTSMEHHSNDLPWRKYFKVEYIKLNEKGQLSLDDLESKLI
KHRGKVRLVTVGGASNVTGYLNPIYQIAGLAHKYGTEVMIDGAQLIPHHPVEMSPKKAGERLDYLAFSGHKMYAPFGTGV
LIAPQKTFASNTPDQVGGGTVDIVTPDFVRWHTPPHKEEAGSPNLMGIVALTEAIKILNEFGMESILNHEKRLTDYTLKR
LNKIPDVILYGNKFNSKDRLGIIPFNIDGLSHESIATILAGEGGIAVRNGCFCAQPYVQQLLNISEQEIRARINNPDLPH
PGLIRISFGLYNTFQEIDRLIDMVKVIVSNKEYYYRKTKINF

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=401, Percent_Identity=23.9401496259352, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787970, Length=409, Percent_Identity=32.2738386308068, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=30.5210918114144, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI48994898, Length=412, Percent_Identity=25.9708737864078, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI193211090, Length=455, Percent_Identity=27.6923076923077, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI25143064, Length=407, Percent_Identity=24.5700245700246, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319831, Length=403, Percent_Identity=22.8287841191067, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129463, Length=437, Percent_Identity=24.9427917620137, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 49876; Mature: 49876

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYKKWRGQVVGVNKKVPLSNNRLSTYVNFDNAATTPPFKSVIERITEFAGWYSSIHRG
CCCCHHHCCEEEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
KGYKSRLCSTIYEEARGDILNFVKADPDYYTPIYVKNTTEAINKLAYTLGQDTDNRNIII
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCEEEE
TTSMEHHSNDLPWRKYFKVEYIKLNEKGQLSLDDLESKLIKHRGKVRLVTVGGASNVTGY
EECHHCCCCCCCHHHEEEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHH
LNPIYQIAGLAHKYGTEVMIDGAQLIPHHPVEMSPKKAGERLDYLAFSGHKMYAPFGTGV
HHHHHHHHHHHHHCCCEEEEECHHHCCCCCCCCCHHHHCCCEEEEEECCCEEECCCCCCE
LIAPQKTFASNTPDQVGGGTVDIVTPDFVRWHTPPHKEEAGSPNLMGIVALTEAIKILNE
EEECCHHHCCCCCCHHCCCEEEEECCCCEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHH
FGMESILNHEKRLTDYTLKRLNKIPDVILYGNKFNSKDRLGIIPFNIDGLSHESIATILA
HCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCCCHHEEEEEE
GEGGIAVRNGCFCAQPYVQQLLNISEQEIRARINNPDLPHPGLIRISFGLYNTFQEIDRL
CCCCEEEECCEEECCHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHH
IDMVKVIVSNKEYYYRKTKINF
HHHHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MNTYKKWRGQVVGVNKKVPLSNNRLSTYVNFDNAATTPPFKSVIERITEFAGWYSSIHRG
CCCCHHHCCEEEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
KGYKSRLCSTIYEEARGDILNFVKADPDYYTPIYVKNTTEAINKLAYTLGQDTDNRNIII
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCEEEE
TTSMEHHSNDLPWRKYFKVEYIKLNEKGQLSLDDLESKLIKHRGKVRLVTVGGASNVTGY
EECHHCCCCCCCHHHEEEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHH
LNPIYQIAGLAHKYGTEVMIDGAQLIPHHPVEMSPKKAGERLDYLAFSGHKMYAPFGTGV
HHHHHHHHHHHHHCCCEEEEECHHHCCCCCCCCCHHHHCCCEEEEEECCCEEECCCCCCE
LIAPQKTFASNTPDQVGGGTVDIVTPDFVRWHTPPHKEEAGSPNLMGIVALTEAIKILNE
EEECCHHHCCCCCCHHCCCEEEEECCCCEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHH
FGMESILNHEKRLTDYTLKRLNKIPDVILYGNKFNSKDRLGIIPFNIDGLSHESIATILA
HCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCCCHHEEEEEE
GEGGIAVRNGCFCAQPYVQQLLNISEQEIRARINNPDLPHPGLIRISFGLYNTFQEIDRL
CCCCEEEECCEEECCHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHH
IDMVKVIVSNKEYYYRKTKINF
HHHHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]